Track 1: Conocimiento clínico y gestión de la innovación: de la idea al mercado 1.1. El proceso de la innovación

1. Harvard-MIT Biomedical Engineering Center
Innovation at MIT:
The Center,
What is Examples of translational research
unique
about it?
- Education
and internationalization
- Research Mercedes Balcells, PhD
- Industry
- International Research
MIT Scientist, Harvard-MIT Biomedical Engineering Center
Professora Titular, Institut Químic de Sarrià
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
1

2. Harvard-MIT Biomedical Engineering Center
FROM
3. Hosting 1-2 international students at MIT
FROM TO
1. Studying structure-function Pervasis, Inc
(Cambridge, US)
?
relationship in a blood vessel
A
Medical device
engineering
(stents, sensors,
2. Studying mechanotransduction balloons…)
pathways
C D
(Barcelona, Spain)
TO
A MIT-Spain
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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3. Harvard-MIT Biomedical Engineering Center
What we have learned:
• Train students to carry their engineering and scientific expertise from the
laboratory bench to the patient's bedside and to bring clinical insights from the
patient's bedside to the laboratory bench.
• Establish partnerships that facilitate collaborations across disciplines and
leverage the strengths of multiple institutions.
• A change in paradigm - from “pure” research to innovation - requires
developing an innovation ecosystem that promotes entrepreneurship; this does
not happen in a year or two.
• Internationalize, internationalize, internationalize
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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4. Harvard-MIT Biomedical Engineering Center
• Advance human health through academic excellence
in education and research that integrates science,
engineering and medicine.
• Educate outstanding minds, cultivate leaders, create
knowledge, and generate cost-effective preventative,
diagnostic, and therapeutic innovations.
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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5. Harvard-MIT Biomedical Engineering Center
EDUCATION
MD, PhD Programs
Harvard
Train students to carry their
engineering and scientific
expertise from the laboratory
US Harvard-MIT
bench to the patient's bedside
Academia BMEC and to bring clinical insights from
the patient's bedside to the
US MIT laboratory bench.
Hospitals
40MD, 15PhD, 5MD/PhD, 5MBA
“teaches you how medical doctors
think and how they talk”
Kay Furman, HST PhD candidate
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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6. Harvard-MIT Biomedical Engineering Center
RESEARCH
Harvard Investigators have special access
to both universities' world-class
resources and to Harvard Medical
School's teaching hospitals.
US Harvard-MIT
BMEC This partnership facilitates
Academia
collaborations across disciplines
US and leverages the strengths of
MIT
Hospitals multiple institutions.
As a result, our researchers
accomplish more than they could
independently.
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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7. Harvard-MIT Biomedical Engineering Center
TISSUE ENGINEERED ENDOTHELIAL CELLS
Allogeneic EC
CELL NUMBER/105
10
8
6
4
1 x 4 x 0.3cm3
Matrix 2
0 0 7 14
TIME (days)
Viability Assay
Viability
Ox-LDL
AcLDL Uptake
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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8. Harvard-MIT Biomedical Engineering Center
STRUCTURE/FUNCTION RELATIONSHIP
Intima (Endothelium)
Connective tissue
Media (Smooth Muscle)
VASCULAR REPAIR
Adventitia (Fibroblasts)
Paracrine regulation
of arterial repair in vivo
Ox-LDL
Viability
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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9. Harvard-MIT Biomedical Engineering Center
MECHANOTRANSDUCTION
ENVIRONMENT MATTERS
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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10. Harvard-MIT Biomedical Engineering Center
MODELS OF HEALTH AND DISEASE
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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11. Harvard-MIT Biomedical Engineering Center
ACHIEVEMENTS
Smart hardware
EKG, monitors
Harvard Intensive care unit medicine
Space medicine
Software
Hospital and clinical
Harvard-MIT
Integrated functional biology
BMEC Devices
Drugs
US MIT Gene therapy
Hospitals US Tissue and cell engineering
Industry
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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12. Harvard-MIT Biomedical Engineering Center
“MIT INNOVATION ECOSYSTEM”
SEBC
Enterprise MIT Sloan
I-Teams Forum
Academia
$700 million
VCPE 100K
research/year competition
Enterpreneurship
Deshpande Center
Center
Industry
MIT TLO
MIT VMS
Commercial
Enterprise
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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13. Harvard-MIT Biomedical Engineering Center
Deshpande Center (2002)
• Gift of $17.5MM from Desh and
Jaishree Deshpande
• Have raised additional $4MM since
from donors, corporations
• Grants: - 500 proposals
- 72 projects
- $11+MM grants
• Results: - 200+ faculty/students
- 100+ volunteers (catalyst program)
- 22 start-ups + 1 license
- Capital >$180 MM
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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14. Harvard-MIT Biomedical Engineering Center
Spinouts
 Active Spectrum Test Equipment
 Beam Power Amplifiers for Wireless
 Brontes(3M) Dental Imaging
 ERC Titanium production
 Entra Drug delivery
 Hepregen Drug Discovery
 Molecular Stamping Nano Production
 Myomo Stroke Rehabilitation
 Pervasis Tissue Repair
 Pufco Secure Processors
 QD vision Displays
 Sentina Auto Sensors
 Taris Biomedical Drug Delivery
 1366 Solar Cells
 Vertica Database Software
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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15. Harvard-MIT Biomedical Engineering Center
“MIT INNOVATION ECOSYSTEM”
SEBC
Enterprise MIT Sloan
I-Teams Forum
Academia
$700 million
International? VCPE
International?
100K
research/year competition
Enterpreneurship
Deshpande Center
Center
Industry
MIT TLO
MIT VMS
International? International? Commercial
Enterprise
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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16. MISTI
MISTI – MIT
International Science
and Technology
Initiatives - is MIT's
primary international
program.
MISTI connects MIT
students and faculty
with research and
innovation around the
world.
MIT International Science and Technology Initiatives

17. MISTI
network in Brazil China
14 countries Switzerland
Chile
Spain
Russia France
Mexico Germany
Korea India
Japan Italy Israel

18. MISTI Internships abroad
700
600
500
400
300
200
100
0

19. Harvard-MIT Biomedical Engineering Center
Today MIT-Spain is
5.5 1 4 170 14 55 18 70
years partner sponsors “host” events projects professors visitors
321 14
STRATEGIC PARTNER
La Cambra de Barcelona
MIT-SPAIN
SPONSORS
HOST INSTITUTIONS Fundació Empreses IQS
La Cambra de Barcelona
(~50) La Caixa
Posimat
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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20. Harvard-MIT Biomedical Engineering Center
Brigham and Women’s Hospital
Prof. Vacanti
Harvard-MIT Biomedical Engineering
Center Agata Gelabertó
Prof. Edelman, Dr. Balcells Albert Milé
- Boston - Sant Joan de Déu
Dr. Claveria/Dr. Parri
- Barcelona -
The Vanderbilt
Bill
Wilkerson
Center
Dr. Eavey
- Nashville-
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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21. Harvard-MIT Biomedical Engineering Center
What we have learned:
• Train students to carry their engineering and scientific expertise from the
laboratory bench to the patient's bedside and to bring clinical insights from the
patient's bedside to the laboratory bench.
• Establish partnerships that facilitate collaborations across disciplines and
leverage the strengths of multiple institutions.
• A change in paradigm - from “pure” research to innovation - requires
developing an innovation ecosystem that promotes entrepreneurship; this does
not happen in a year or two.
• Internationalize, internationalize, internationalize
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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22. Harvard-MIT Biomedical Engineering Center
This work has been possible thanks to the support from
Ministerio de Ciencia e Innovación (BFU2009--‐09804)
The Barcelona Chamber of Commerce
Fundació Empreses Institut Químic de Sarrià
Posimat
Special thanks to
MIHealth Committee and Fira de Barcelona
… and an open invitation to collaborate with us
77 Massachusetts Avenue E25-438 | Cambridge MA 02139 USA
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