Eskayef Bangladesh Limited At a glance

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Nazmul Hasan Mahmud

A brief about Eskayef Bangladesh Limited. THIS IS STRICTLY COPYRIGHT PROTECTED

Health & Medicine

What's hot

Macrolides

JagirPatel3

Fluoroquinolones

Zainab&Sons

These are synthetic antimicrobial having a quinolones structure. These are active against most of the gram negative bacteria. In 1960s the first membered of this group, Nalidixic acid, was introduced . Flouroquinolones have: High potency Expanded antimicrobial spectrum Better tissue penetration Good tolerability profile Very low resistance development 1. NALIDIXIC ACID It was the first member in quinolones. It was active against gram negative bacteria. It acts by inhibiting bacterial DNA gyrase. It is bacterial in nature. It is given orally. It attains good concentration in gut, lumen, hence useful in diarrhea. NALIDIXIC ACID CONTD… It is most commonly seen in children. And causes neurological toxicity present as headache, drowsiness and vertigo and contraindicated in infants and G6PD deficient patients. It is given in a dose of 0.5-1g TDS/QID 2. FLUOROQUINOLONES Fluoroquinolones are quinolones antimicrobials having one or more fluorine substituitions. The first generation fluoroquinolones have one fluoro substitution and were developed in 1980s. The second generation fluoroquinolones have additional fluoroquinolones have additional fluoro substitution, which extended the antimicrobial activity and were developed in 1990s. MECHANISM OF ACTION The fluoroquinolones inhibits the enzyme DNA gyrase in Gram-negative micro-organism and topoisomerase IV in gram positive micro-organism. This lead to the bactericidal effects of fluoroquinolones. RESISTANCE The resistance to fluoroquinolones develops when the bacteria produce a DNA gyrase or topoisomerase IV which have reduced affinity for fluoroquinolones or the bacteria produce efflux pumps across bacterial memberane which shunt out the fluoroquinolones from the bacterial cells. CLASSIFICATION FIRST GENERATION FLOUROQUINOLONES : Norfloxacin Ofloxacin Ciprofloxacin Pefloxacin SECOND GENERATION FLUOROQUINOLONES: Levofloxacin Moxifloxacin Lomefloxacin Gemifloxacin Sparfloxacin Prulifloxacin PHARMACOKINETICS These are given both by oral and intravenous route. These have good absorption, when given empty stomach and food delays the absorption. These drugs have good tissue penetrability. These are excreted in urine by glomerular filtration as well as tubular secretion. INDICATIONS Bacterial gastroenteritis Typhoid fever UTI Gonorrhoea Chancroid Bone, Soft tissue and gynaecological infections Respiratory infections Tuberculosis Gram negative septicemia and meningitis Conjuctivitis COMMON ADVERSE EFFECTS GI SYSTEM: Nausea, vomiting, bad taste and anorexia CNS: Headache, anxiety, insomnia, restlessness and impairment of concentrations. Skin: Rash, photosensitivity Contraindicated in pregnancy. They should be used in caution in children as a few cases of joint pain and swelling have been reported and a risk of cartilage damage is suspended. FIRST GENERATION FLUROQUINOLONES SECOND GENERATION FLUROQUINOLONES DRUG INTERACTIONS Antacids decrease the absorption

QUINOLONES.pptx

NEHA BHARTI

Antimicrobial Resistance (AMR)

Dr. Amer Ali Khaleel /HMU

Tetracyclines and chloramphenicol ppt

Moses Omongin

Penicillin

CutiePie35

PLATELET ACTIVATING FACTORS: MECHANISM OF ACTION AND CLINICAL USES

vikasaagrahari007

Polymyxins revisted

PathKind Labs

Drugs Used for treatment of Constipation & Diarrhoea

anujrims

Therapeutic indications Tavanic is indicated in adults for the treatment of the following infections (see sections 4.4 and 5.1): • Acute bacterial sinusitis • Acute exacerbations of chronic bronchitis • Community-acquired pneumonia • Complicated skin and soft tissue infections For the above-mentioned infections Tavanic should be used only when it is considered inappropriate to use antibacterial agents that are commonly recommended for the initial treatment of these infections. • Pyelonephritis and complicated urinary tract infections (see section 4.4) • Chronic bacterial prostatitis • Uncomplicated cystitis (see section 4.4) • Inhalation Anthrax: post exposure prophylaxis and curative treatment (see section 4.4) Tavanic may also be used to complete a course of therapy in patients who have shown improvement during initial treatment with intravenous levofloxacin. Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Tavanic levofloxacin

Ahmed Elrheem

Imipenem cilastatin training

Mohammad Masum Chowdhury

Glucocorticoids

OPTOM FASLU MUHAMMED

Laxatives purgatives

Ravish Yadav

Introduction History Classification Mode of action Bacterial cell structure Beta-lactum drugs – Classification Structure Mechanism of action Penicillin Introduction History Classification Mode of action Bacterial cell structure Beta-lactum drugs – Classification Structure Mechanism of action Penicillin Cephalosporin Carbapenem Monobactum Beta-lactum inhibitors Resistance Applied aspect

Beta lactam Antibiotics

Shefali Jaiswal

Anthelmintics Pharmacology

Zulcaif Ahmad

Laxatives and Purgatives

Koppala RVS Chaitanya

Aminoglycosides

DrSahilKumar

Market survey on azithromycin and amoxicillin with clavulanic acid

Mitesh Shah

Lincosamides

Shilpa Harak

Antibiotics

elsanimadhan

What's hot (20)

Macrolides

Fluoroquinolones

QUINOLONES.pptx

Antimicrobial Resistance (AMR)

Tetracyclines and chloramphenicol ppt

Penicillin

PLATELET ACTIVATING FACTORS: MECHANISM OF ACTION AND CLINICAL USES

Polymyxins revisted

Drugs Used for treatment of Constipation & Diarrhoea

Tavanic levofloxacin

Imipenem cilastatin training

Glucocorticoids

Laxatives purgatives

Beta lactam Antibiotics

Anthelmintics Pharmacology

Laxatives and Purgatives

Aminoglycosides

Market survey on azithromycin and amoxicillin with clavulanic acid

Lincosamides

Antibiotics

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