1. Aarkstore.com Research Report on Chinese Chemosynthetic Polypeptide Drug
Industry, 2012
Chemosynthetic polypeptide drugs are drugs combining the certain amino acids in
chemical methods, which are characterized by favorable curable effects, few side-
effects, high specificities and other advantages.
In the pharmaceutical industry, chemosynthetic polypeptides are the focus of
attentions. On one hand, the indications of polypeptide drugs are in wide range and
the curative effects are obvious, mainly for the application of tumor, metabolism,
cardiovascular diseases, infectious diseases, etc. On the other hand, the
development-success ratio of polypeptide drugs is high compared to that of
traditional drugs and the approval ratio is also obviously higher than that of
micromolecule chemical drugs. According to historical data, the approval ratio of
polypeptide drugs in clinical research is 23 % to 26 %. As the rapid development
of biochemical technologies and generic engineering field, polypeptide drugs are
likely to replace the existing medicines.
By the end of 2011, there were 68 polypeptide drugs approved to the market (at
least to sell in one country)globally, among which there were 51 treatment drugs
mainly used in 14 cure fields, i.e., tumors, immunoregulation, cardiovascular
diseases, metabolism, etc. In 2011, the total sales was about USD 20.8 billion. At
present, there are over 140 polypeptide drugs globally amidst the clinical trial and
also 500 to 600 drugs are at the stage of research before clinical work. In the
perspective of history, there were 1.2 new polypeptide drug candidates entering
clinical research period annually in the 70s of 20th century. The number of new
polypeptide drug candidates was separately 4.6 in the 80s and 9.7 in the 90s.
During 2000 and 2008, it was 16.8, with a steady increasing trend.
China's polypeptide drugs start late. A batch of multinational corporations did not
introduce polypeptide drugs to China's market until the 1990s. It develops into
relatively mature technologies and supporting industries nowadays. According to
incomplete statistics, pharmaceutical enterprises specializing in the production of
biochemical and biological drugs reaches over 400, among which about 80%
produce polypeptide drug preparations or active pharmaceutical ingredients in
varying types. The number of manufacturers is gradually on the rise. With the
constant improvement of the R&D ability of China's polypeptide drugs, China's
polypeptide drugs are fast developing.
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