7. • Step #1: The kidney
takes the drugs from the
blood and puts them into
the urine
8. • Step #2: Fat soluble
drugs go back into the
blood while others stay in
the urine
9. • Step #3 : Those fat
soluble drugs then enter
back into the liver, and
are then pumped from
the blood into the
kidneys and then into
the urine
Le, J. (2014, May 1). Drug Excretion. Retrieved September 5, 2014, from
http://www.merckmanuals.com/professional/clinical_pharmacology/pharmacokinetics/drug_
excretion.html
10. • Step #4: The
urine then
travels through
the ureters and
bladder and out
into the real
world!
Silverthorn, D.E. (2012). Human physiology: An integrated approach.
Location: Publisher
-Excretion is defined as the removal of drugs from the body
Excretion. (2014, January 1). Retrieved September 5, 2014, from http://www.thefreedictionary.com/excretion
It is the last step in a drugs journey through the body- proceeded by absorption, distribution and metabolism
Excretion occurs through-
-the kidneys
-the skin & sweat
-saliva
-through expired air
-and bile with is stored in the gallbladder!
But the renal excretion through the kidneys is the most important.
Lehne, R (2013). Pharmokinetics. In Pharmacology for nursing care (8th ed., pp. 26-46). St. Louis, Mo.: Elsevier Saunders.
Step #1: the kidney takes the drugs from the blood and into the urine
Step #2: Fat soluble drugs go back into the blood while others stay in the urine
#3: those fat soluble drugs then enter back into the liver, are metabolized, and then pumped from the blood into the kidneys and then into the urine
Le, J. (2014, May 1). Drug Excretion. Retrieved September 5, 2014, from http://www.merckmanuals.com/professional/clinical_pharmacology/pharmacokinetics/drug_excretion.html
The urine then travels through the ureters and the bladder and out into the real world!
Silverthorn, D.E. (2012). Human physiology: An integrated approach. Location: Publisher
Since the kidneys are a major part of drug excretion, the nurse needs to take into account the age of the patient and whether the kidneys are healthy or damaged. No one wants a sad, unhealthy kidney
Age of patient- since kidneys of newborns are not fully developed, they wont be able to excrete drugs as well as adults. This should be accounted for when medicating an infant
If the kidneys are damaged, like in renal failure patients, there may be increased drug response and toxicty. Oh no!
As you can see and now understand, excretion and the kidneys play an important role in staying healthy & happy!
Mr. Kidney is so excited you decided to stop by and hopes to see you again soon!