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Two Colleges, one Health
- 1. COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES Two Colleges, One Health! Sue VandeWoude, DVM! Associate Dean for Research CVMBS, CSU! November 7, 2013!
- 2. Overview! • Introduction to CSU and CVMBS! • Research Programs in CVMBS! • U of N-CSU affinities and ongoing partnerships! • CSU One Health Initiative and Grant Opportunities! • Student Initiatives! • Summary!
- 3. Where in the World is Colorado?
- 4. Colorado State University • Land grant institution for CO! • Founded 1870 ! • Class I Carnegie Research Institution! • Ranks 2nd in research funding among public institutions w/out a medical school! !
- 5. CVMBS Organization! Colorado State University College of Veterinary Medicine and Biomedical Sciences Biomedical Sciences (BMS) Environmental & Radiological Health Sciences (ERHS) Microbiology, Immunology & Pathology (MIP) Clinical Sciences (CS) Veterinary Teaching Hospital (VTH) Veterinary Diagnostic Laboratory (VDL) COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES 7 other Colleges
- 6. Key Personnel! • Dean: Dr. Mark Stetter! • Assoc Dean PVM: Dr. Dean Hendrickson; Senior Director PVM services: Dr. Christine Hardy ! • Assoc Dean Research: Dr. Sue VandeWoude! • Dean for Undergraduate Education: Dr. Kenneth Blehm! • BMS DH: Dr. Colin Clay! • CS DH: Dr. Chris Orton! • ERHS DH: Dr.Jac Nickoloff! • MIP DH: Dr. Gregg Dean! • VDL Director: Dr. Barb Powers! • VTH Director: Dr. Tim Hackett!
- 7. Mark Stetter Dean Hendrickson Christine Hardy Kenneth Blehm Sue VandeWoude
- 8. CVMBS Degree Programs! • Professional Veterinary Medicine ! • 3 Undergraduate Degrees! • 3 Non-thesis MS Programs! • Thesis Based MS and PhD Programs! • Internships, Residencies (Combined)!
- 9. Research Training for Veterinarians! • Pre-doctoral: Summer research program, combined DVM/PhD program! ! • Post-doctoral: residency, residency/PhD, residency/MS, post-DVM PhD training! ! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES
- 10. Campus Presence! South Campus! !Veterinary Teaching Hospital! !Diagnostic Medical Center! !Equine Orthopaedic Research Center! !
- 11. Campus Presence! Main Campus! !Anatomy! !Environmental Health! !Microbiology! !Pathology! !Physiology! !
- 12. Campus Presence! Foothills Campus! !Regional Biocontainment Laboratory! !Research Innovation Center (GMP facility)! !Animal Reproduction Biotechnology Laboratory! !Equine Reproductive Laboratory! ! Local Partners! !CDC VBDL! !USDA NWRC! !NPS! !CDOW! ! ! !!
- 13. CVMBS Research Statistics! >225 faculty! >$50M research expenditures FY13! – 6 of 12 University Distinguished Professors! – 4 of 16 Programs of Research and Scholarly Excellence! – Infectious Disease Supercluster! – Cancer Supercluster! ! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES
- 14. Research Sponsors! • National Institutes of Health: ~63%! • United States Dept of Agriculture: ~6%! • USAID and other federal ~14%! • Corporations and Foundations: ~16%! • State of Colorado: ~1%!
- 15. US research funding trends! • Funding levels are at historical lows—less than 5% of all applicants receive funding in most competitive solicitations! • There are no longer Congressional “earmarks”! • Fewer programs provide funds for eqpt, facilities! • Interdisciplinary, collaborative programs on the rise!
- 16. Areas of Emphasis: BMS! • Animal Reproductive Biotechnology Laboratory! – Equine Reproductive Laboratory (Equine Institute*)! – Reproductive Endocrinology Laboratory! ! • Molecular, Cell, & Integrative Neuroscience! • Cardiovascular Research Center!
- 17. Areas of Emphasis: CS! • Animal Cancer Center ! • Animal Population Health Institute! • Integrated Livestock Management! • Center for Immune and Regenerative Medicine! • Center for Companion Animal Health! • Musculoskeletal Research Center! – Orthopaedic Research Center (Equine)! – Small Ruminant Orthopaedic Laboratory! – Orthopeadic Bioengineering Laboratory! Livestock Institute*
- 18. Veterinary Teaching Hospital! Small animal, Equine, Livestock, Zoologic Medicine and Surgery!
- 19. Areas of Emphasis: ERHS! • Center for Environmental Medicine! • Cancer Biology Program! • Intermountain Center for Agricultural Health and Safety! • School of Public Health! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES
- 20. Areas of Emphasis: MIP! • Mycobacterial Research Laboratory! • Arthropod-borne Infectious Disease Laboratory! • Prion Research Institute! • Rocky Mountain Regional Center for Excellence and Biocontainment Laboratory (Biodefense)! • Retroviral pathogenesis/therapy! • RNA biology! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES
- 21. USAID Innovation Lab! • Formerly known as ‘Livestock CRSP’! • Feed the Future Innovation Lab: Adapting Livestock Systems to Climate Change! !http://lcccrsp.org! • Richard Bowen, DVM, PhD, Director!
- 22. Veterinary Diagnostic Laboratory! Bacteriology, Virology, Chem/ Toxicology, Clinical Pathology, Avian Diagnostics, Molecular Diagnostics, Parasitology, BSL3, Histopathology, Necropsy, Clinical Immunology, Pathology! !
- 23. New CVMBS Research-related Initiatives! • One Health! • Clinical Trials Center! • Heavy Ion Therapy Cancer Center! • Livestock Institute! • Equine Institute! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES
- 24. Basic Research Pre-Clinical Research (normal animals) Veterinary Clinical Trails (animal disease) Human Clinical Trails (Phase I & II) New Human Therapy / Device New Veterinary Therapy / Device Translational Research “One Medicine”
- 25. Pre-Clinical Research Capabilities orthopedics, neurosurgery, stem cells, tissue-engineering, transcatheter cardiovascular devices, minimally-invasive surgery, cancer, drug delivery Veterinary Clinical Trials Center Cancer, Regenerative Medicine, Sports & Rehabilitation, Neuromusculoskeletal, Cardiovascular, Infectious Diseases, Internal Medicine, Specialty Medicine, Critical Care
- 26. Heavy Ion Therapy Cancer Center! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES
- 27. “One Health”! COLLEGE OF VETERINARY MEDICINE & BIOMEDICAL SCIENCES Animal Health Environmental Health Human Health Colleges of: Agriculture Business Engineering Health and Human Sciences Liberal Arts Natural Resources Natural Sciences Vet Med and Biomedical Sciences
- 28. One Health! ! ! "the collaborative effort of multiple disciplines — working locally, nationally, and globally — to attain optimal health for people, animals and the environment" Slide courtesy of M. Stetter
- 29. Collaborative Partnerships Requirements (Sue’s opinion)! • Good planning! • Mutual development/Mutual benefit! • Trust! • Good communications! • A collaborative facilitating leader who is detail oriented! • Consideration of collaborator needs/thoughts!
- 30. One Health Projects at CSU: Examples of International (and one local) Projects!
- 31. Novel mosquito control measures Drs. Brian Foy and Bill Black Studies in Senegal Slide courtesy of M. Stetter Vector Borne Disease
- 32. Agro-‐ecosystem/One Health Rice & Beans Dr. Elizabeth Ryan-‐ studies in US, Asia, Africa Slide courtesy of M. Stetter
- 33. Mycobacterium tuberculosis The second most deadly infectious disease in the world (after HIV/AIDS) TB claims 1.4 million lives annually (1 person dies of TB every 22 seconds) Estimated TB incidence rates (WHO - 2000) Slide courtesy of M. Stetter
- 34. • 20 Laboratories – 30,000 sq ft • Staff of 165 • The largest Tb academic research group • 197 candidate TB vaccines • > 200 candidate TB drugs • Research on zoonoses • 70 scientific articles & book chapters published annually • 50 conferences given worldwide annually Slide courtesy of M. Stetter
- 35. Tuberculosis-a zoonosis! Dr. Francisco Olea-Popelka
- 36. Local Concerns: Drugs in Wastewater Effluents! Slide courtesy of M. Stetter
- 37. Saturdays Weekends Center for Environmental Medicine Slide courtesy of M. Stetter
- 38. One World – One Health Slide courtesy of M. Stetter
- 39. Building an Initiative…! • Steering Committee! • Survey of 100+ faculty in 8 colleges, 5 agencies, vet organizations (USDA, CDC, NPS, CDOW, AAVMC, etc) ! • Infectious disease, veterinary medicine, ecology, sociology, and environmental issues !
- 40. Survey Findings: Top 5 One Health Issues ! • Infectious/Zoonotic Disease! • Food Safety/Security! • Wildlife/Ecosystem/Environmental Issues! • Climate Change! • Human Impact! Most neglected area: Systemic Solutions!
- 41. Recent Outcomes! • One Health Retreat to develop focus areas! • CSU International Colloquium on One Health: 1000 participants! • Panel at Davos, Switzerland One Health; University Initiatives in One Health: a Global Perspective ! • College and Student sessions at US National Vet College Association Meeting !
- 42. Ongoing Efforts! • Director and Development officer for the “CSU One Health Institute”! • Gates One Health Grant Initiative Workshop! • Discussions with University partners, sponsors and funding agencies!
- 43. CSU CVMBS- U of N partnerships! Historical USAID collaboration between CSU Vet school and U of N!
- 44. Strategic Partnership signed November 2012 !
- 45. Visits since Dec 2012! • Feb 2013 Prof Jesse Njoka! • May 2013 Prof Peter Mbithi! • July-Aug 2013 Drs. Joyce Berry, Lou Swanson, Craig Beyrouty! • Oct 2013 Kelvin Momanyi! • Nov 2013 Sue V/Dick B! • Nov 2013 Anna Fagre/Michael Marricle!
- 46. Future Visits from CSU to UoN! • Elizabeth Ryan, PhD; rice bran nutrition to enhance GI health! • Kristy Pabilonia, DVM, PhD; Veterinary Microbiology and Diagnostics; Avian Diseases! • Sushan Han, DVM, PhD; Veterinary Pathology with emphasis on livestock and wildlife disease! • Francisco Olea-Popelka, BVSc, PhD; Veterinary Epidemiology; Bovine TB!
- 47. Davos One Health Conference! • University Initiatives in One Health: a Global Perspective ! • Dean Mark Stetter, Session Leader and Host! • Prof Peter Mbithi, Discussant!
- 48. Post-Doctoral Training! • Prepared NIH-Fogarty D43 training grant application! • PI: Elizabeth Ryan, ; Co-PI: Jan Leach, Lorann Stallones: 31 CSU faculty, 19 U of N faculty with 6 letters of support! • CSU VPR has provided 2 post-doctoral positions for 2 years in Agro-EcoSystem Health!
- 49. Advertisement Plan: International Candidates widely solicited! • Rollins School of Public Health! • Associated Schools of Public Health! • Environmental Health Perspectives! • School of Global Environmental Sustainability! • Journal of Science! • CSU jobs website! • CVMBS website! • ERHS website! • Solicitation of Colleagues University of Nairobi Solicitation at professional meetings and conferences!
- 50. Postdoctoral Search Status! • Drs. Ryan, Stallones, Leach comprised search committee! • Application screening of many applicants resulted in identification of 2 African candidates as best qualified! • If approved by U of N faculty, will participate in CSU-U of N mentorship program in Agroecosystem health!
- 51. U of N mentor team…! • Prof Jane Njenga! • Prof S. R. Mbugua! • Prof Peter Lamuka!
- 52. CSU Vet Student “One Health Club” linkage with U of N Vet Student Assn! Anna Fagre, Michael Marricle, Kelvin Momanyi In the Poudre Canyon near Fort Collins, CO
- 53. New Collaborations! • Prof Dick Bowen and several faculty (Brucellosis, Camel medicine)! • Profs Andrew Thaiyah and Francisco Olea-Popelka (TB)! • Profs Elizabeth Ryan and Jane Njenga!
- 54. CSU and U of N One Health Initiatives! • Ongoing dialogue among all partners!!! • Many cross training opportunities! • Funding Opportunities will be essential to drive the program!
- 55. Low Hanging Fruit! • Take advantage of:! – Energy and enthusiasm of students! – ‘Telemedicine’ and web based knowledge exchange! – Dryland Center linkages! – Small internally funded grants when possible!
- 56. Potential Sponsors! • Bill and Melinda Gates Foundation:! www.grandchallenges.org/ GrantOpportunities/Pages/default.aspx! • Postdoctoral Fellowship Program Opportunity for Young African Scientists! • The “One Health” Concept: Bringing Together Human and Anima Health for New Solutions! !
- 57. Gates One Health Grant! “Novel and innovative ideas within the concept of One Health to address the issues in the following areas, ranging from early discovery concepts to delivery of solutions to measurement of impact: ! • Specific human and livestock diseases,! • Health service delivery; ! • Measurement of impact.”! Due November 12, 2013 at 11:30 a.m. Pacific Standard Time. $100,000 US dollars for 18 month period.!
- 58. Additional Potential Sponsors! • NIH/Fogarty! • NSF Ecology of Infectious Disease, others! • USAID! • Small internal grants?! • Private Donations/Industry!
- 59. CSU One Health Club! • Mission: ! To encourage increased collaboration among students, faculty, and community members in interdisciplinary health sciences fields, in order to gain a greater appreciation and understanding for the inextricable link between animal, human, and environmental health.!
- 60. Building a Partnership! • “Come join One Health Club and the CSU International Veterinary Students' Association as we welcome Kelvin Momanyi to speak about his experiences as a veterinary student in Kenya and the development of an exchange program between CSU and the University of Nairobi, Kenya.”!
- 61. Our Students are the Future!
- 62. Thank you for the extreme hospitality!! Questions?!