www.mycli.com
The Italian Brand for the skin1. Quality2. Pharmaceutical approuch and   experience3. Italian brand power: Luxury   feelin...
Esthetic Line the products foraging treatment that really workwithout side effects
Dermatologic Line dermatologicproductsfor skin diseases and sensitive skins
CleanserOP LIQUID SOAPFluid soap without irritating and allergenic detergents; it isspecifically formulated for intolerant...
Cleanser                 Features: absolutely free from allergenic substances;OP LIQUID SOAP                 Physiological...
CleanserOP LIQUID SOAPGraphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP l...
CleanserOP GENTLE BODY CLEANSEROP Gentle Body Cleanser is the latest answer from Mac Pharma researchin order to clean the ...
CleanserOP GENTLE BODY CLEANSER                   Characteristics: absolutely free from allergenic                   subst...
CleanserOP GENTLE BODY CLEANSERGraphs describing the improvement of the skin feeling after 4 weeks application twice perda...
Moisturizer and lenitiveOP LENITIVE CREAMThe product contains several molecules suitable to modulate the most importantsig...
MoisturizerOP LENITIVE CREAM                    Features: Effective mix of polidocanol and liqorice                    ext...
MoisturizerOP LENITIVE CREAMGraphs describing the improvement of the skin feeling after 4 weeks application twice perday o...
Prevention Anti Aging OP REBUILDING SERUM AGE This is a new anti-age serum with a liposome based vehicle composed of the m...
Prevention Anti AgingOP REBUILDING SERUM AGE              Features: anti-age serum for face and neck with silky texture;  ...
Prevention Anti AgingOP REBUILDING SERUM AGEGraphs of the results after 4 weeks application twice per day of OP rebuilding...
Treatment BodyOP HYDRA SVELT A new brand based on synergy of active ingredients such as Panthenol, Hyaluronic Acid, Shea B...
Treatment BodyOP HYDRA SVELT           Features: The high concentration of Jaluronic Acid ensures a constant           moi...
Treatment BodyOP HYDRA SVELT Graphs of the results of the skin after 4 weeks application twice per day of OP hydra svelt. ...
Extra CareOP LIGHTENING CREAMThe formulation contains innovative active compounds capable to inhibit themelanic pigments b...
Extra CareOP LIGHTENING CREAM                  Characteristics: emulsion with association of Acethylcistein,              ...
Extra CareGraphs of the results after 6 weeks application twice per day of OP Lightening cream.University of Pavia – Italy
Extra Care OP SOFT PEEL New formulation for a soft daily exfoliation and skin surface renewal. It contains mandelic acid, ...
Extra Care OP SOFT PEEL                Features: Film former and riepetilizing agent and sweet                tensioactive...
Extra Care OP SOFT PEEL Graphs of the results after 4 weeks application twice per day of OP soft peeling. University of Pa...
Sun Booster OP BRONZ SVELT This product, born from nanoemulsion technology, is capable to induce a deep absorption of acti...
Sun Booster OP BRONZ SVELT                  Features: Nano-structured lipogel completely vegetable                  able t...
Sun Booster OP BRONZ SVELT Graphs results after 4 weeks application twice per day of OP bronz svelt. University of Pavia –...
NutraceuticalOP BIOREPAIR PLUSBiorepair plus is a nutritional supplement indicated to prevent skinaging and the most frequ...
NutraceuticalOP BIOREPAIR PLUS                    Features: thanks to the synergy of these substances, OP                 ...
NutraceuticalOP BIOREPAIR PLUSGraphs of the results after 4 weeks of OP Biorepair plus’ use University of Pavia – Italy   ...
Biomedical  OP EMOLLIENT FOAM (14% Zinc Oxide)Thanks to the Panthenol this new brand foam can improve epithelia restoratio...
Biomedical OP EMOLLIENT FOAM (14% Zinc Oxide)                Features: highest concentration of micronized zinc oxide;    ...
Biomedical OP EMOLLIENT FOAM (14% Zinc Oxide) Efficacy                           CosmeticGraphs of the results after 1 wee...
BiomedicalOP HAND AND FEET CREAM 20% UREA Op Hands and feet cream is a new A/O dermatologic formulation specifically formu...
BiomedicalOP HAND AND FEET CREAM 20% UREA       Characteristics: A/O emulsion with high percentage of Urea and lanolin    ...
BiomedicalOP HAND AND FEET CREAM 20% UREAGraphs of the results after 5 weeks application twice per day of OP Hand and feet...
BiomedicalOP SAFETY GEL This innovative nano-structured formulation is realized with a patented nano- emulsifier and conta...
BiomedicalOP SAFETY GEL          Characteristics: New nanostructured lipogel containing high purification          hyaluro...
BiomedicalOP SAFETY GELGraphs of the results after 4 weeks application twice per day of Safety gel. University ofPavia – I...
BiomedicalOP C-KADERM Silicon based lipogel specifically formulated to prevent and manage hypertrofic scars and Keloids. I...
BiomedicalOP C-KADERM         Features: New lipogel containing high purification silicon polymers         acting as film-f...
BiomedicalOP C-KADERMStudy of the citotoxicity and evaluation on wound healing of C-kaderm - EVIC HISPANIA -February 2004 ...
IngredientsOP LIQUID SOAP 250 ML - INCIAqua, Cocamidopropylbetaine, Coco Glucoside, PEG-18 Glyceril Oleate/Cocoate, Glycol...
IngredientsOP SOFT PEEL - INCIAqua, Mandelic Acid, Propylene glycol, PEG-40 Hydrogenated Castor Oil, Phytic Acid, Hydroxye...
IngredientsOP EMOLLIENT FOAM – INCIAqua, Zinc Oxid, PEG-8 Caprylic/Capric Glycerides, Isobutane, Glycerin, Propane, Polyso...
OP PLURIATTIVO 3 STAMINAL AGE  REVOLUTION                   1
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION                               •Innovative features                               ...
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION• Liquid cristals technology;• Centella asiatica staminale cells;• Innovative asso...
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION                          LIQUID CRISTALS• Technology capable to promote high stab...
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION                                 CENTELLA ASIATICA                                ...
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OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION                    GLUCOSAMINE• Main brick of GAG (jaluronic acid, condroitin  su...
•   Glucosamine: an ingredient with skin and other benefits.•   Bissett DL.•   Procter & Gamble Co., Miami Valley Laborato...
Br J Dermatol. 2010 Feb 1;162(2):435-41. Epub 2009 Aug 28.Reduction in the appearance of facial hyperpigmentation after us...
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION• Treatment of atrophic, aplastic and oxidized skin; highly photo-damaged skin  (p...
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION• Protocol for face and neck aging;• Association with CELAZOME;• Association with ...
OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION                                           13
OP PLURIATTIVO 3 CORPO            BODY CREAMAntiage revolution for body careMY Cli, Scientific Affairs and Formulation    ...
The product              2
Innovative features• Liquid crystals technology;• Silky and vanishing sensoriality;• Very fast absorption (body lotion wit...
Innovative features                     Liquid cristals • Technology capable to ensure high stability of   the emulsions, ...
Innovative features         ELASTOCELLTM (5% w/w)  • Synthetic molecule produced starting from    L-Cysteine (Inci: Lysine...
Innovative features                  RESVERATROL (1% w/w)•   Phytoextrogen extracted from Vitis Vinifera seeds and    skin...
Arch Biochem Biophys. 2011 Apr 15;508(2):164-70. Epub 2011 Jan 4.The grape antioxidant resveratrol for skin disorders: Pro...
Arch Dermatol Res. 2010 Mar;302(2):71-83. Epub 2009 Nov 7.Skin photoprotection by natural polyphenols: anti-inflammatory, ...
J Drugs Dermatol. 2010 Dec;9(12):1523-6.Dose-dependent antioxidant function of resveratrol demonstrated via modulation of ...
Biofactors. 2010 Sep;36(5):342-9.Effect of resveratrol on endothelial cell function: Molecular mechanisms.Schmitt CA, Heis...
Innovative features             ESCIN (0,6% w/w)•   Steroidic Saponine extracted from Horse chestnut seeds    and cortex;•...
Innovative features     RETINIL PALMITATE (0,6% w/w) •   Esterified Retinol with palmitic acid (simmetry with Ascorbyl    ...
Br J Dermatol. 2008 Mar;158(3):472-7. Epub 2007 Dec 6.Repair of photoaged dermal matrix by topical application of a cosmet...
Innovative features                    CENTELLA ASIATICA (0,5% w/w)                          (Vegetal stem cells)•   Gluco...
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Innovative features           SALICYLYC ACID (0,5% w/w) • b-hydroxyacid with keratolytic and dermo-   purifying activity; ...
Indications•   The most effective body lotion in the Italian market for the concentration and    activity of the active mo...
Op estero mycli
Op estero mycli
Op estero mycli
Op estero mycli
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Op estero mycli

  1. 1. www.mycli.com
  2. 2. The Italian Brand for the skin1. Quality2. Pharmaceutical approuch and experience3. Italian brand power: Luxury feeling and Technology for high standing products4. Effort and Support
  3. 3. Esthetic Line the products foraging treatment that really workwithout side effects
  4. 4. Dermatologic Line dermatologicproductsfor skin diseases and sensitive skins
  5. 5. CleanserOP LIQUID SOAPFluid soap without irritating and allergenic detergents; it isspecifically formulated for intolerant and stressed skin especiallyafter dermatological and surgical treatments. It cleans gently theskin, maintaining the epidermal surface lipids and reducingirritation thanks to Jojoba Oil and Vitamin E.Completely hypo-allergenic and physiological pH.Indications: It is indicated for sensitive and intolerant skin,suffering cleansing with common soap or detergents. You shoulduse the product in case of several skin diseases and afterdermatological or surgical practice such us chemical peelings orother medical practice.Apply a small amount of fluid soap on skin and massage. Rinse itup with abundant water.Size: 250 ml
  6. 6. Cleanser Features: absolutely free from allergenic substances;OP LIQUID SOAP Physiological pH; Advantages: you can use it for any kind of skin problem, after surgery and also like make up remover to avoid irritation; Benefits: daily skin cleaning for any kind of skin; Target: Pediatrists, General Prac., Aesthetic Doctors, Dermatologists, Plastic Surgeons, Beauticians; Main Competitor: Eucerin fluid Price: $15.00 Size: 200 ml
  7. 7. CleanserOP LIQUID SOAPGraphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP liquid sensible skin soap after laser therapy. University of Pavia – Italy 100% 100% 91% % of satisfied volunteers 82% 82% 81% 81% 80% 73% 60% 40% 20% 0%
  8. 8. CleanserOP GENTLE BODY CLEANSEROP Gentle Body Cleanser is the latest answer from Mac Pharma researchin order to clean the sensitive and intollerant skins.Sensible skin is very sensitive to the external aggressions both for the lackof barrier skin lipids and for hypersensitivity to the normal externalstimulations. OP gentle Body Cleanser cleans sweetly even the moresensible skin without sensitization favouring the replenish of importantfatty acids capable to restore the integrity and function of skin barrier.Indications: Physiological cleaning of sensible and reactive skin in courseof irritative and allergic dermatitis such DAC, DIC Atopic dermatitis and incase of aesthetic and dermatologic treatments. OP Gentle Body Clenaseris indicated for all the skin type and also for children both for the faceand for the bodySize: 500 ml
  9. 9. CleanserOP GENTLE BODY CLEANSER Characteristics: absolutely free from allergenic substances; Physiological pH; Advantages: can be applied on any kind of “untreatable” skin; Benefits: effective cleanser, daily usage for any kind of skin; Target: Pediatrists, General Prac., Aesthetics Doctors, Dermatologists, Plastic Surgeons, Beauticians. Main Competitor: Aveeno Emulave Sensitive fluid Price: $20.00 Size: 400 ml
  10. 10. CleanserOP GENTLE BODY CLEANSERGraphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP liquid sensible skin soap after laser therapy. University of Pavia – Italy 100% 100% 91% % of satisfied volunteers 90% 82% 81% 80% 72% 70% 60% 40% 20% 0%
  11. 11. Moisturizer and lenitiveOP LENITIVE CREAMThe product contains several molecules suitable to modulate the most importantsigns of skin irritation and inflammation after dermatological and surgicalpractices or photo-induced skin burning.It works normalizing excessive vasodilatation, inhibiting inflammatory skin signsand induce an anaesthetic effect against skin pain and burning.Very high absorbing vehicle and hypo-allergenic.Indications: This cream contains molecules suitable to reduce inflammation,itching, burning in case of several skin conditions such excessive sun exposition,dermatological or surgical skin practices such chemical peeling, laser therapy,dermo-abrasion. Polidocanol induces a mild skin anaesthesia, glycyrrhetic acidreduces inflammation signs and Rutin restores dermis vascular systemphysiology.Apply two or more time a day with a small massage.Size: 50 ml
  12. 12. MoisturizerOP LENITIVE CREAM Features: Effective mix of polidocanol and liqorice extract; Advantages: Daily action to restore and protect the skin from any kind of irritations and pollution with moisturizing effect; Benefits: protect sensitive skin, restore wellness after dermatologic treatments, reduce discomfort of atopic and allergic skin; Target: Dermatologists, Plastic Surgeons, Pediatrists, General Prac., Aesthetics Doctors, Beauticians; Main Competitor: Lichtena, Giuliani Pharma Size 50ml Price 25,00 Euro
  13. 13. MoisturizerOP LENITIVE CREAMGraphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP lenitive cream skin after laser therapy. University of Pavia – Italy 100% 92% % of satisfied volunteers 89% 85% 80% 78% 75% 70% 60% 40% 20% 0%
  14. 14. Prevention Anti Aging OP REBUILDING SERUM AGE This is a new anti-age serum with a liposome based vehicle composed of the most effective anti-age molecules available. This lipidic serum allows to replace effectively the lost skin lipids, to induce the restoration of the metabolic processes of the skin, to enhance the antioxidant activity within the skin cells. Particularly indicated for the treatment of eye contour skin marks, fine wrinkles, atrophy and poor skin hydration and elasticity. Indications: OP REBUILDING SERUM is indicated for a daily care of skin face, to prevent aging signs, to enhance skin tone and pigmentation uniformity. Size: 75 ml
  15. 15. Prevention Anti AgingOP REBUILDING SERUM AGE Features: anti-age serum for face and neck with silky texture; Advantages: it’s capable to induce a strong filling and smoothing action; Benefits: It’s easy to absorbe and ensures an immediate lifting effect. Thanks to Trylagen-KGF active principle it boost up collagen synthesis, uniformes skin pigmentation and inibits enzymatic destruction. Target: Pharmacists, customers. Main Competitor: EC 30 - 5 senses system- 30 ml € 130,00
  16. 16. Prevention Anti AgingOP REBUILDING SERUM AGEGraphs of the results after 4 weeks application twice per day of OP rebuilding serum age.University of Pavia – Italy % of satisfied volunteers 100% 85% 78% 80% 69% 60% 60% 40% 20% 0%
  17. 17. Treatment BodyOP HYDRA SVELT A new brand based on synergy of active ingredients such as Panthenol, Hyaluronic Acid, Shea Butter, Olive leaf flavonoids and PCA working closely with the skin to moisturize, rebuild and restore the naturally protective hydro-lipidic film. The high concentration of Jaluronic Acid ensures a constant moisturizing level over a long period of time, whilst Shea Butter and Olive leaf flavonoids help to induce a deep sensation of comfort and suppleness. Directions: Apply all over the body making sure the skin is thoroughly cleaned and massage until fully absorbed. Size: 250 ml
  18. 18. Treatment BodyOP HYDRA SVELT Features: The high concentration of Jaluronic Acid ensures a constant moisturizing level over a long period of time, whilst Shea Butter and Olive Oil help induce a deep sensation of comfort and suppleness. Advantages: Easily absorbed, OP Hydra Svelt is ideal after bath or shower to smooth the skin stressed by sun, wind and pollutants or simply naturally dry; Benefits:If used regularly, improve the firmness, hydration and elasticity of your skin. Target: Pharmacists, customers. Main Competitor: HYDRA – FLASH Spécial Corps Formule Intensive - Sisley – 200 ml. – 98.00 Euro
  19. 19. Treatment BodyOP HYDRA SVELT Graphs of the results of the skin after 4 weeks application twice per day of OP hydra svelt. University of Pavia – Italy 100% 98% % of satisfied volunteers 87% 90% 80% 60% 40% 20% 0%
  20. 20. Extra CareOP LIGHTENING CREAMThe formulation contains innovative active compounds capable to inhibit themelanic pigments biosynthesis and mainly to induce the production of clearestpigments able to camouflage with the normal colour of the skin.It furthermore contains Liquorice extract which shows reduction of melanicpigmentation and anti-bruise and sun burns preventing actions;Indications: This formulation is particularly indicated to treat melanic skinspots thanks to its unique and innovative way of action capable to reducemelanin skin synthesis and anyway to produce clearer melanins;Apply this formulation twice a day with light massage.Size: 50 ml
  21. 21. Extra CareOP LIGHTENING CREAM Characteristics: emulsion with association of Acethylcistein, Sodium ascorbyl phosphate and Glabridin from Liquorice capable to reduce melanic spots, melasma and eumelanic synthesis; Advantages: effective cosmetic treatment in case of melasma, sun induced skin spots and chemical peeling; Benefits: it reduces production of eumelanins, bleaches skin spots physiologically and maintains uniform skin pigmentation; Target: Dermatologists, Plastic Surgeons, Pediatrists, General Prac., Aesthetics Doctors, Beauticians. Main Competitor: NeoStrata Bionic Skin Lightening Cream. size 30 ml
  22. 22. Extra CareGraphs of the results after 6 weeks application twice per day of OP Lightening cream.University of Pavia – Italy
  23. 23. Extra Care OP SOFT PEEL New formulation for a soft daily exfoliation and skin surface renewal. It contains mandelic acid, an a-hydroxyacid with good cheratoplastic activity and safe skin behaviour. In combination with allantoin, resveratrol and mild glucosidic surfactants it acts as exfoliating and normalizing skin tissue even in case of excessive sensibility and irritation. It has been formulated for the preparation and maintenance of the professional chemical peeling and to improve skin surface appearance and homogenise skin pigmentation. Indications: This formulation is particularly indicated for the preparation and maintenance of chemical peeling. It can be applied as detergent and to uniform skin surface and pigmentation. Size: 100 ml;
  24. 24. Extra Care OP SOFT PEEL Features: Film former and riepetilizing agent and sweet tensioactive agent for a mild face cleansing; Advantages: it improves capillaries resistance and neutralize free oxigen radicals; help to uniform cutaneous colour and to inhibit excessive melanic activity; Benefits: It mantains peeling effect for a long time and safety; Target: Pharmacists, customers Main Competitor: Perfectionist Peel 2-Step Enzyme Activating Treatment 50 ml - Estée Lauder - € 94,00
  25. 25. Extra Care OP SOFT PEEL Graphs of the results after 4 weeks application twice per day of OP soft peeling. University of Pavia – Italy 100% 93% 94% % of satisfied volunteers 88% 80% 60% 40% 20% 0%
  26. 26. Sun Booster OP BRONZ SVELT This product, born from nanoemulsion technology, is capable to induce a deep absorption of active ingredients (kinetic analisys with Diclofenac sodium salt). The active molecule is a liphophilic Tyrosine capable to stimulate physiologic melanins synthesis; Viscous gelified form with more than 65% of eudermal lipids. The nano-structurated lipogel is completely vegetable based (Patent). Paraben and IMU free. Structure similar to the healthy horny layer (protein-lipids domains). Indications: Skin pigmentation modulator: without UV exposure, poor uniform skin colour, localized acromie; Tan sublimating: Natural or artificial UV exposure (UV-A and UV-B), lenitive after-sun and melanic pigmentation mantainance Size: 200 ml
  27. 27. Sun Booster OP BRONZ SVELT Features: Nano-structured lipogel completely vegetable able to increase sun tanning physiologically; Advantages: increasing sun tanning uniformity and lasting; Benefits: More rapid and safe sun tanning; Target: Pharmacists, customers Competitors: Attiva-Bronz – ROUGJ – 125 ml - € 18,00
  28. 28. Sun Booster OP BRONZ SVELT Graphs results after 4 weeks application twice per day of OP bronz svelt. University of Pavia – Italy 100% 93% 94% % of satisfied volunteers 80% 72% 60% 40% 20% 0%
  29. 29. NutraceuticalOP BIOREPAIR PLUSBiorepair plus is a nutritional supplement indicated to prevent skinaging and the most frequent phenomena such as wrinklesformation, atrophy, melanic spots and sagging. It contains the mostpowerful ingredients to sustain skin metabolism, improve skinfirmness and reduce oxidative damage. Thanks to its oro-solubleform with good taste and flavour it results nice to take.Contains:Glutathion, an antioxidant enzyme to maintain cells healthy;Glucosamine, the main brick of glucosaminoglycans such as Hyaluronic acid,Lipoic Acid, an enzyme cofactor effective to prevent skin aging and reduce wrinkles depth;B Vitamins, to improve cell metabolism;Ascorbic Acid, to boost up collagen maturation and epithelia restoaration;Betacaroten, to prevent sun damage and sustain skin trophism;Directions: One sachet a day possibly far from meals, simply dissolved in the mouth or glass ofwater.
  30. 30. NutraceuticalOP BIOREPAIR PLUS Features: thanks to the synergy of these substances, OP BIOREPAIR PLUS is ideal as an anti-oxidant and trophic nutritional support for the skin tissues during beauty medical and surgery treatments; Advantages: an effective nutritional answer to skin aging problems, for successful and safe exposure to the sun and to reduce cell aging according to the most recent biochemistry- research breakthroughs; Benefits: In this powder formulation, soluble in the mouth, it offers high bio-availability of active ingredients (under-the- tongue absorption) and has a pleasant taste. Target: Pharmacists, customers. Main Competitor: Inneov Re-Age Fermete (20 days) – 28.00 € - each day: 1,40 €
  31. 31. NutraceuticalOP BIOREPAIR PLUSGraphs of the results after 4 weeks of OP Biorepair plus’ use University of Pavia – Italy 100% 95% % of satisfied volunteers 80% 85% 80% 60% 40% 20% 0%
  32. 32. Biomedical OP EMOLLIENT FOAM (14% Zinc Oxide)Thanks to the Panthenol this new brand foam can improve epithelia restorationin case of invasive skin treatment and bruise conditions.The formulation is based, also, on high concentration (14%) micronized oxidezinc and Vit. E in an innovative vehicle capable to transfer the microgranules ofactive oxide zincum, deeply in the epidermal layer. The greatly enhancedcontact surface developed by micronization of oxide zinc allows to treat wideskin areas with relatively small mousse amount.Indications: This light and soft foam contains micronized zinc oxide andVitamine E and it is specifically formulated to treat sensitive, irritate andbruised skin specially in paediatrics.Its quick and complete penetration allows to induce an effective epitheliarestoration.Apply several times a day with a mild massage on the skin involved.Size: 30 ml
  33. 33. Biomedical OP EMOLLIENT FOAM (14% Zinc Oxide) Features: highest concentration of micronized zinc oxide; Advantages: fast action for all Skin irritations without white effect; Benefits: rapid relief after any skin injury; Target: Pediatrists, General Prac., Aesthetics Doctors, Dermatologists, Plastic Surgeons, Beauticians. Main Competitor: Obagi Derm Healthy Skin Protection 9% Micronized Zinc Oxide SPF 35 3 oz Price: $32.00
  34. 34. Biomedical OP EMOLLIENT FOAM (14% Zinc Oxide) Efficacy CosmeticGraphs of the results after 1 week application twice per day of OP foam after lasertherapy. University of Pavia – Italy 100% 100% 91% 91% % of satisfied volunteers 82% 82% 80% 73% 73% 60% 40% 20% 0%
  35. 35. BiomedicalOP HAND AND FEET CREAM 20% UREA Op Hands and feet cream is a new A/O dermatologic formulation specifically formulated for all the skin conditions characterizes by severe dryness and scaling. This formulation is based on lanolin alcool 5% and Urea 20% that in synergy with an W/O vehicle is capable to restore skin lipids and physiologic skin moisture. By mean of an-effective emollient proprieties Op Hands and Feet cream improves all the signs of altered skin barrier in case of several dermatologic conditions such as xerosys, itching, atopic dermatitis, psoriasis and severe scaling. This formulation is particularly and especially indicated for the treatment of hand-feet syndrome which can occur in case of oncological therapy such as 5FU. Indications: sever scaling and dry skin conditions. Size: 50 ml
  36. 36. BiomedicalOP HAND AND FEET CREAM 20% UREA Characteristics: A/O emulsion with high percentage of Urea and lanolin alcohol. It creates a barrier on the skin and improves skin dryness and elasticity in case of severe skin impairments, hands-feet syndrome, xerosys. Advantages: very fast skin signs improving (dryness, scaling) and long lasting protection Benefits: reduce discomfort and hands-feets impairment in case of dermatosys induced by chemotherapic drugs. Very effective also in course of exfoliative skin diseases such as psoryasis, ichthyosis, atopic dermatitis Target: Dermatologists, Oncologist, General Prac.. Main Competitor: no products competitors with 20% of Urea
  37. 37. BiomedicalOP HAND AND FEET CREAM 20% UREAGraphs of the results after 5 weeks application twice per day of OP Hand and feet cream.University of Pavia – Italy 100% 93% % of satisfied volunteers 88% 79% 80% 68% 60% 40% 20% 0%
  38. 38. BiomedicalOP SAFETY GEL This innovative nano-structured formulation is realized with a patented nano- emulsifier and contains natural oils, emollients and lenitive terpens. This formulation is a nano-gel with up to 70% of oils and inside its water core contains an effective concentration of hyaluronidase, an enzyme capable to soften deep dermal tissue and solve the most common aesthetic side effects concerned with sclerotherapy (extravasayion, inflammation) and with dermal filler implantation (hyaluronic acid accumulation, inflammation and oedema). Thanks to its specificity on hyaluronic acid breakage and to the high absorption nano-sized structured vehicle, SAFETY GEL could be considered the elective topic treatment for all the main aesthetic treatments side effects. It is completely safe, not allergenic, and adapt for all skin type. Indications: The product is indicated for sclerotherapy side effects, oedema after hylauronic acid implants, skin inflammation; Size: 20 ml
  39. 39. BiomedicalOP SAFETY GEL Characteristics: New nanostructured lipogel containing high purification hyaluronidase (350 UI). It acts promoting high absorption of enzyme into the skin and favouring reabsorption of oedemas, dermal hyaluronic acid accumulation and to improve signs and symptoms of irritations after sclerotherapy extravasation. Advantages: innovative and high performing nanogel; deep absorption of hyaluronidase into dermo-epidermal tissue; preservants free; high skin tollerability; Benefits: dermatologic formulation to treat most frequent side effects in dermatologic practice. Target: Plastic Surgeons and Aesthetics Doctors. Main Competitor: no products competitors
  40. 40. BiomedicalOP SAFETY GELGraphs of the results after 4 weeks application twice per day of Safety gel. University ofPavia – Italy 94% 100% 93% 94% % of satisfied volunteers 88% 80% 79% 60% 40% 20% 0%
  41. 41. BiomedicalOP C-KADERM Silicon based lipogel specifically formulated to prevent and manage hypertrofic scars and Keloids. It acts as film forming onto the skin surface, reducing scar extension, hydrating scar tissue, reducing scar redness and discomfort. Musqueta oil improves skin tissue normalization, reduces inflammation and favours skin epithelia restoration. Indications: cosmetic manage of hypertrophyc scars in case of surgical treatment, aesthetic treatment and small dermatologic surgery; Size: 20 ml
  42. 42. BiomedicalOP C-KADERM Features: New lipogel containing high purification silicon polymers acting as film-folmer. Elective formulation to manage hyperthrophic scars and keloids. Thanks to Rosa Mosqueta Oil it acts as a skin epithelia restoring and moisturizer. Advantages: innovative and high performing silicon based lipogel; high hydrating properties, emollient, scar tissue emollient and depigmenting; Benefits: dermatologic formulation to treat most frequent abnormalities of scarring. Target: Plastic Surgeons and Aesthetics Doctors Main Competitor: Dermatix gel 15 g - Valeant - € 40,00
  43. 43. BiomedicalOP C-KADERMStudy of the citotoxicity and evaluation on wound healing of C-kaderm - EVIC HISPANIA -February 2004 - Barcelona 200% Dermal human fibroblast 200% 160% 160% migration 120% 100% 80% 40% 0%
  44. 44. IngredientsOP LIQUID SOAP 250 ML - INCIAqua, Cocamidopropylbetaine, Coco Glucoside, PEG-18 Glyceril Oleate/Cocoate, Glycol Distearate, Buxus Chinensis, Hydrolyzed WheatProtein, Sodium Chloride, Citric Acid, Disodium Edta, Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Sodium Dehydroacetate.OP GENTLE BODY CLEANSER - INCIAqua, Coco Glucoside, Cocamidopropyl Betaine PEG-18 Glyceryl Oleate/Cocoate, Glycol Distearate, Simmondsia Chinensis Oil, SodiumChloride, Hydrolyzed Wheat Protein, Citric Acid, Disodium EDTA, Sodium Benzoate, Sodium Dehydroacetate, Parfum.OP LENITIVE CREAM - INCIAqua, Octyl Palmitate, C12-20 Acid PEG-8 Ester, Glycerin, Cetearyl Alcohol, Glyceryl Stearate, Ruscus Aculeatus, Glycyrrhetinic Acid, Laureth-9,Allantoin, Tocopheryl Acetate, Bisabolol, Lecithin, Tocopherol, Ascorbyl Palmitate, Citric Acid, Dimethicone, Phenoxyethanol, Methylparaben,Ethylparaben, Propylparaben, Disodium Edta, Sodium Dehydroacetate.OP HYDRA SVELT - INCIAqua, C12-15 Alkyl Benzoate, Glycerin, Caprylic/Capric Triglyceride, Hexamethyldisiloxane, Triticum Vulgare Germ Oil, Butyrospermum ParkiiButter, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Panthenol, Phenoxyethanol, Olive OilPeg-8 Esters, Polysorbate 20, Arginine, Cetearyl Glucoside, Bisabolol, Anthemis Nobilis, Sodium Pca, Urea, Xanthan Gum, Lactose, Glucose,Sucrose, Sorbitol, Ascorbyl Palmitate, Hydrolyzed Collagen, Choleth-15, Glyceryl Oleate, Sodium Hyaluronate, Glycine, Ceteth-15, Oleth-40,Fructose, Lactic Acid, Bht, Bha, Hexylene Glycol, Methoxydiglycol, MagnesiumChloride, Potassium Chloride, Imidazolidinyl Urea, Sodium Hydroxide, Disodium Edta, Citric Acid, Geraniol, Linalool.OP LIGHTENING CREAM - INCIAqua, Octyl Palmitate, Glyceryl Stearate, Sodium Ascorbyl Phospate, Steareth-2, Tocopheryl Acetate, Glycerin, Steareth-21, Acetylcisteine,Glycyrrhizza Glabra, Cetearyl Alcohol, Lecithin, Tocopherol, Ascorbyl Palmitate, Citric Acid, Dimethicone, Sodium Hydroxymethylglicinate,Disodium Edta, Sodium Dethydroacetate, Lactic Acid.
  45. 45. IngredientsOP SOFT PEEL - INCIAqua, Mandelic Acid, Propylene glycol, PEG-40 Hydrogenated Castor Oil, Phytic Acid, Hydroxyethylcellulose, Coco glucoside, SodiumHydroxide, Retinyl Palmitate, Polygonium Cuspidatum Extract, Allantoin, Bisabolol, Chamomilla Recutita Extract, Lactic Acid, Sodium PCA,Lecithin, Tocopherol, Ascorbyl palmitate, Citric acid.OP BRONZ SVELT - INCIPotassium Lauroyl Oat Amino Acids, Palm Glycerydes, Capryloyl Glycine, Ethylexyl Isononanoate, Dicapryl Ether, Capryloyl Tyrosine,Potassium Sorbate, Sodium Benzoate, Parfum.OP BIOREPAIR plus - INCIFruttosio, Aromi, Vitamina C, Maltodestrine da Mais, Acidificante: Acido Citrico, Glucosamina solfato 2KCl, Antiagglomerante: biossido disilicio, Acido -lipoico, Niacina, Taurina, Vitamina E acetato 50%, Glutatione, Licopene al 6% (da estratto secco di Pomodoro-Licopersicumlesculentum frutto), succo di melone concentrato (Cucumis melo frutto), Acido folico, Vitamina B12
  46. 46. IngredientsOP EMOLLIENT FOAM – INCIAqua, Zinc Oxid, PEG-8 Caprylic/Capric Glycerides, Isobutane, Glycerin, Propane, Polysorbate 80, Panthenol, Butane, Tocopheryl Acetate,Benzyl Alcohol, Disodium Lauriminodipropionate Tocopheryl Phosphates, Hydrogenated Lecithin, Potassium Sorbate.OP HAND/FEET CREAM - INCIPetrolatum, Aqua, Urea, Lanolin Alcohol, Sorbitan Isostearate, Polyglyceryl-3 Ricinoleate, Sodium laccate, Lactic Acid, Magnesium Sulfate,Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben.OP SAFETY GEL - INCIAqua, Ethylexyl Isononanoate, Palm Glycerides, Dicaprylyl Ether, Capriloyl Glycine, Potassium Lauroyl Wheat Amino Acids, bisabobol, Lecithin,hyaluronidase, Potassium Sorbate, Sodium Benzoate, Disodium EDTA.
  47. 47. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION 1
  48. 48. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION •Innovative features •Indications •Marketing strategies MY CLI Direzione scientifica-R&S Andrea Fratter 2
  49. 49. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION• Liquid cristals technology;• Centella asiatica staminale cells;• Innovative association between Nicotinamide and Glucosamine for the structural restoration of dermal layer and bleaching of melanic spots; 3
  50. 50. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION LIQUID CRISTALS• Technology capable to promote high stability to the formulations, high skin feeling and boost up penetration of active compounds;• Liquid cristals overcome the concept of classic emulsion in which a water phase and an oily one are mixed together;• Liquid cristals are “small islands” in which water and oil mix together thanks to particular emulsifiers: as like in a cream box there are milions of microscopic droplets of active principles; 4
  51. 51. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION CENTELLA ASIATICA (vegetal stem cells) • Glucosides extracted from this plant show a vigorous action in the inhibiting of jaluronidase, enzyme involved in jaluronic acid destruction; • Association with Glucosamine is particularly inteersting because represents the brick of jaluronic acid and promote its biosynthesys; it is possible to reduce physiologic jaluronic acid degradation and so inducing an “endo-filler” effect; • Centella asiatica is widely employed in dermatology as epithelia restoration agent, scar promoting and blood vessels protector; • An innovative biotechnological technique is capable to isolate Centella asiatica stem cells highly enriched in active molecules. This technique allows to maintain plant phyto-complex with an high active principles content (up to 50% of glucosides on the plant weight) (Patent, IRB); 5
  52. 52. 6
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  54. 54. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION GLUCOSAMINE• Main brick of GAG (jaluronic acid, condroitin sulphate);• An adequate introduction of Glucosamine (at less 100 mg/die) permits a correct turn-over of dermal matrix (water embedded in dermal matrix);• Glucosamine promotes sinovial liquid rigeneration (cartilages protection);• Particularly indicated the assumption for at least one month before a dermal filler injection or chemical peeling to improve esthetic result;• It works as melanic bleaching in sinergy with nicotinamide; 8
  55. 55. • Glucosamine: an ingredient with skin and other benefits.• Bissett DL.• Procter & Gamble Co., Miami Valley Laboratories, Cincinnati, OH 45252, USA. bissett.dl@pg.com• Both glucosamine and its derivative N-acetyl glucosamine are amino-monosaccharides that serve key biochemical functions on their own and as substrate precursors for the biosynthesis of polymers such as glycosaminoglycans (e.g., hyaluronic acid) and for the production of proteoglycans. Glucosamine has an excellent safety profile and has been shown to provide benefits in several clinical disorders. Glucosamine compounds have been reported to have several beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acid synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation. Mechanistically, glucosamine also has both anti-inflammatory and chondroprotective effects. Clinical trials have shown benefit in using oral glucosamine supplementation to improve symptoms and slow the progression of osteoarthritis in humans. Glucosamine has also been used to prevent and treat osteoarthritis in animals. Based on other observations, glucosamine has been suggested for additional clinical uses, including treatment of inflammatory bowel disease, migraine headaches, and viral infections. The current clinical uses for topical and oral glucosamine compounds and the mechanistic rationale for these uses are reviewed here. 9
  56. 56. Br J Dermatol. 2010 Feb 1;162(2):435-41. Epub 2009 Aug 28.Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination oftopical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlledtrial.Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL.Harvard Medical School, Boston, MA 02114, USA. harvardskinstudies@partners.orgAbstractBACKGROUND: Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermalpigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulationsreduced the appearance of hyperpigmentation. OBJECTIVES: To assess the effect of a combination ofniacinamide and NAG in a topical moisturizing formulation on irregular facial pigmentation, including specificdetection of changes in colour features associated with melanin. METHODS: This was a 10-week, double-blind,vehicle-controlled, full-face, parallel-group clinical study conducted in women aged 40-60 years. After a 2-week washout period, subjects used a daily regimen of either a morning sun protection factor (SPF) 15sunscreen moisturizing lotion and evening moisturizing cream each containing 4% niacinamide + 2% NAG (testformulation; n = 101) or the SPF 15 lotion and cream vehicles (vehicle control; n = 101). Product-inducedchanges in apparent pigmentation were assessed by capturing digital photographic images of the womenafter 0, 4, 6 and 8 weeks of product use and evaluating the images by algorithm-based computer imageanalysis for coloured spot area fraction, by expert visual grading, and by chromophore-specific imageanalysis based on noncontact SIAscopy for melanin spot area fraction and melanin chromophore evenness.RESULTS: By all four measures, the niacinamide + NAG formulation regimen was significantly (P < 0.05) moreeffective than the vehicle control formulation regimen in reducing the detectable area of facial spots and theappearance of pigmentation. CONCLUSIONS: A formulation containing the combination of niacinamide +NAG reduced the appearance of irregular pigmentation including hypermelaninization, providing an effectbeyond that achieved with SPF 15 sunscreen. 10
  57. 57. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION• Treatment of atrophic, aplastic and oxidized skin; highly photo-damaged skin (pigmentations, poor hydration, wrinkles);• Neck and decolletè (main districts of application);• Rich and nourishing formulation, very nice sensoriality and good misturizing properties;• This formulation is to be considered effectively a filler boosting formulation capable to enhance dermal filler duration and reduce its degradation (very important to associate BIOREPAIR PLUS); 11
  58. 58. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION• Protocol for face and neck aging;• Association with CELAZOME;• Association with ULTRA ANTIOXIDANT FORMULA (face)• Association with BIOREPAIR PLUS; 12
  59. 59. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION 13
  60. 60. OP PLURIATTIVO 3 CORPO BODY CREAMAntiage revolution for body careMY Cli, Scientific Affairs and Formulation Manager Andrea Fratter Pharm. D, PhD Cosmetic Sciences 1
  61. 61. The product 2
  62. 62. Innovative features• Liquid crystals technology;• Silky and vanishing sensoriality;• Very fast absorption (body lotion with high “spreading value” lipids): Average “spreading value”: 1500 mm2/10 min;• Association of ElastocellTM (Inci: Lysine Carboxymethyl Cysteinate) and Reboescin-salTM (Patent pending), active blend of pure trans-Resveratrol, Escin, Salicylyc Acid, Retinol and Centella Asiatica Stem Cells ; 3
  63. 63. Innovative features Liquid cristals • Technology capable to ensure high stability of the emulsions, very good sensoriality feeling and improve active compounds skin penetration; • Liquid cristals are “small islands” in which water and oil create a unique continous phase thanks to peculiar emulsifying agents: in a cream box there are bilions of microscopic emulsion droplets entrapping active compounds; 4
  64. 64. Innovative features ELASTOCELLTM (5% w/w) • Synthetic molecule produced starting from L-Cysteine (Inci: Lysine Carboxymethyl Cysteinate) capable to induce a complete renovation of epidermal layer and improve skin elasticity up to 30% after 3 weeks of application); • Patented molecule capable to improve skin distensibility, surface smoothness and rejuvenate epidermis; • Very useful and effective to improve skin quality of the body in course of aging, cellulitis and poor elasticity; 5
  65. 65. Innovative features RESVERATROL (1% w/w)• Phytoextrogen extracted from Vitis Vinifera seeds and skin and from Poligonum Cuspidatum roots;• One of the most investigated natural substances;• Scientifically and clinically clarified its phytoextrogenic, cardiovascular protective and onco-preventive activities;• Highly effective to improve structure and health of mature skin (menopausa) and in the management of severe aging skin conditions, especially if photo- damaged;• Very good skin penetration at the contrary of the sistemic absorption; 7
  66. 66. Arch Biochem Biophys. 2011 Apr 15;508(2):164-70. Epub 2011 Jan 4.The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges.Ndiaye M, Philippe C, Mukhtar H, Ahmad N.SourceDepartment of Dermatology, University of Wisconsin, Madison, WI 53706, USA.AbstractResveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have bothchemopreventive and therapeutic effects against many diseases and disorders, including thoseof the skin. Studies have shown protective effects of resveratrol against ultraviolet radiation-mediated oxidative stress and cutaneous damages including skin cancer. Because many of theskin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears tohave promise and prospects against a wide range of cutaneous disorders including skin agingand skin cancers. However, there are a few roadblocks in the way of this promising agentregarding its translation from the bench to the bedside. This review discusses the promise andprospects of resveratrol in the management of skin disorders and the associated challenges.
  67. 67. Arch Dermatol Res. 2010 Mar;302(2):71-83. Epub 2009 Nov 7.Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repairmechanisms.Nichols JA, Katiyar SK.SourceDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard,Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA.AbstractEpidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiationin various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disordersare caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc.The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit,reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety ofpolyphenols or phytochemicals, most of which are dietary supplements, have been reported topossess substantial skin photoprotective effects. This review article summarizes thephotoprotective effects of some selected polyphenols, such as green tea polyphenols, grapeseed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation,oxidative stress and DNA damage, etc., with a focus on mechanisms underlying thephotoprotective effects of these polyphenols. The laboratory studies conducted in animalmodels suggest that these polyphenols have the ability to protect the skin from the adverseeffects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols mayfavorably supplement sunscreens protection, and may be useful for skin diseases associatedwith solar UV radiation-induced inflammation, oxidative stress and DNA damage.
  68. 68. J Drugs Dermatol. 2010 Dec;9(12):1523-6.Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygenspecies in normal human skin fibroblasts in vitro.Jagdeo J, Adams L, Lev-Tov H, Sieminska J, Michl J, Brody N.SourceDepartment of Dermatology, SUNY Downstate, Brooklyn, NY 11203, USA. Derm_Research@yahoo.comAbstractThe study of free radicals is particularly relevant in the context of human skin carcinogenesis and photoagingbecause of their ability to induce DNA mutations and damaging lipid peroxidation byproducts. Therefore, itis important to identify and evaluate agents with the ability to modulate intracellular free radicals.Significant interest exists in evaluating the chemotherapeutic and anti-oxidant properties of resveratrol(trans-3,4,5-trihydroxystilbene). Resveratrol is a phytoalexin, a naturally occurring compound derived fromthe skin of grapes and other plants. Resveratrol was selected for evaluation because of demonstratedchemopreventive and chemotherapeutic properties in a murine skin cancer model and other human cancermodels through a variety of mechanisms. However, the intracellular anti-oxidant properties of resveratrolon free radicals in human skin cells in vitro is not well characterized. The purpose of this research is toinvestigate the ability of resveratrol to modulate the hydrogen peroxide-induced upregulation of reactiveoxygen species (ROS) free radicals in normal human skin fibroblast cells in vitro. Hydrogen peroxide is a wellknown generator of free radicals that occurs during endogenous and UV-induced oxidation processes in thehuman skin and was used to upregulate ROS in normal human skin fibroblast cells. Using a flow cytometry-based assay, the results demonstrate highly significant (P<0.001) dose-dependent reduction of intracellularhydrogen peroxide-upregulated ROS by resveratrol at 0.01%, 0.001% and 0.0001% concentrations in humanskin fibroblasts in vitro.
  69. 69. Biofactors. 2010 Sep;36(5):342-9.Effect of resveratrol on endothelial cell function: Molecular mechanisms.Schmitt CA, Heiss EH, Dirsch VM.SourceWolfson Institute for Biomedical Research, University College London, United Kingdom.AbstractThe polyphenolic natural product resveratrol (RV), best known for its occurrence in grape skinand red wine, is considered a candidate drug for prevention and treatment of cardiovasculardiseases. This review aims to summarize the molecular effects of RV on endothelial cells,which line the inner walls of blood vessels and play a key role in the development of thosediseases. We describe how RV enhances endothelial nitric oxide production, improvesendothelial redox balance and inhibits endothelial activation in response to pro-inflammatoryand metabolic insults. Furthermore, we summarize effects of RV on endothelial senescence,apoptosis, endothelin-1 release, and endothelial progenitor cell function. As many of RVsactions seem to be mediated by SIRT₁, different mechanistic possibilities how RV may lead toSIRT₁ activation are discussed.
  70. 70. Innovative features ESCIN (0,6% w/w)• Steroidic Saponine extracted from Horse chestnut seeds and cortex;• Very effective molecule in the protection and trophism of veno-linfatic vessels, to reduce and absorb oedema, soft tissue congestion and imbibition and to prevent connective fibrosis (cellulitis);• In form of hydrogel at percentage of 1 and 2% is considered drug (REPARIL GEL);• Very effective and quick to reduce dermal and adipose soft tissue infiltration in course of cellulitis;• The most effective molecule in the topical treatment of cellulitis; 13
  71. 71. Innovative features RETINIL PALMITATE (0,6% w/w) • Esterified Retinol with palmitic acid (simmetry with Ascorbyl Palmitate); • One of the tree biological active form of Vitamina A (Retinol, Retinaldheyde, Retinoic acid); • It is converted in the skin to Retinoic acid acting as dermal renoving agent (boosting up of hyaluronic acid, collagen, amorphous substance synthesys); • Very high percentage (0,6% w/w) equivalent to Retinoic acid at 0,05% w/w (Retin-A); usually it is employed at no more than 0,2% w/w; • Very good skin penetration and rapid onset of esthetic and dermo-plastic effect; 15
  72. 72. Br J Dermatol. 2008 Mar;158(3):472-7. Epub 2007 Dec 6.Repair of photoaged dermal matrix by topical application of a cosmetic antiageing product.Watson RE, Long SP, Bowden JJ, Bastrilles JY, Barton SP, Griffiths CE.SourceDermatological Sciences Research Group, The University of Manchester, Manchester M13 9PT, UK.rachel.watson@manchester.ac.ukAbstractBACKGROUND:Photoaged skin is characterized by coarse and fine wrinkles. The mechanism of wrinkle formation appears to involvechanges to components of the dermal extracellular matrix. Topical treatment with all-trans retinoic acid (RA) can repairphotoaged dermal matrix; this is regarded as the gold standard against which repair agents are judged. To date, little isknown regarding the ability of over-the-counter antiageing products to repair photoaged skin.OBJECTIVES:We used a modified occluded patch test to ascertain whether topical applications of cosmetic antiageing products are ableto repair photoaged human skin.METHODS:Commercially available test products [basic moisturizer, antiageing cream containing different active complex levels (6%active: lipopentapeptide, white lupin peptides, antioxidants, retinyl palmitate; 2% active: lipopentapeptide, white lupinpeptides, antioxidants)] were applied under occlusion for 12 days prior to biopsy and histological assessment in photoagedvolunteers (n=9). RA was used as a positive control.RESULTS:In agreement with previous studies, the patch-test study revealed that RA produced significant fibrillin-1 deposition in thepapillary dermis (P<0.01) but had little effect on procollagen I or matrix metalloproteinase-1 expression. The 6% total activecomplex formulation, however, increased the deposition of fibrillin-1 and procollagen I (P<0.01, P<0.05, respectively).CONCLUSIONS:This study indicates that in an in vivo 12-day patch test an over-the-counter cosmetic product can induce changes inphotoaged dermal extracellular matrix, which are indicative of repair.
  73. 73. Innovative features CENTELLA ASIATICA (0,5% w/w) (Vegetal stem cells)• Glucosydes extracted from this plant show a vigorous action of inhibition of the enzymes involved in the degradation of hyaluronic acid (hyaluronidase);• It is possible to induce a lower hyaluronic acid degradation so promoting an “endo-filler effect”;• Centella asiatica is widely employed in dermatology as epithelium restoration agent, scarring promoting agent and phlebotonic (Madecassoside, Roche Posai);• This innovative biotechnological technique is capable to select and reproduce meristem vegetal cells of Centella asiatica;• This technology allows to maintain phytocomplex of the plant so improving its properties and promoting the production of an high percentage of active molecules (up to 50% in weight, Patented technology by IRB); 17
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  76. 76. Innovative features SALICYLYC ACID (0,5% w/w) • b-hydroxyacid with keratolytic and dermo- purifying activity; • It works reducing horny layer cells cohesion and promoting their physiological detachment; • Works as skin penetration/absorption enhancer; • Favours skin surface uniformity; 20
  77. 77. Indications• The most effective body lotion in the Italian market for the concentration and activity of the active molecules introduced;• Treatment of body skin aging, aplastic skin and severe dermal structure lost, elasticity and firmness;• Very effective for the mature skin during and after menopausa;• Very good sensoriality features, very quick absorption; it can be applied few minutes before dress (not greasy, not sticky);• It is advisable to apply the product at least one time per day (the best is 2 applications per day for the first week), after shower or bath to improve penetration; 21

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