1. Seminar On Synopsis For M.Pharm Dissertation By MULE MADHAV SHESHERAO Under the Guidance of Guide Mr. Kshirsagar R. V. Asst. Professor School of pharmacy SRTMU Nanded Industrial Guide Mr. N. K. Shinde Senior Executive Lupin Research Park School of Pharmacy, SRTMU, Nanded .
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6. Antidepressant drug is used orally for the treatment of patients with depression, caused by chemical imbalance on any other reasons. One of the major problems of this drug is its very poor biological half life (4hrs), which results in poor bioavailability after oral administration. Antidepressant drug and its active metabolite inhibit the neuronal uptake of norepinephrine, serotonin and to a lesser extent dopamine . Hence it lacks the adverse anticholinergic, sedative and cardiovascular effects of tricyclic antidepressants. It also requires low dose and it has less dopamine reuptake activity as compared to other antidepressant drug.
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9. Margret Chandra et al, (2009): “formulation and evaluation of sustained release matrix tablets of zidovudine”. By using Kollidon SR, Hydroxypropyl methylcellulose K15M, K100M as matrix former. Punit B. Parejiya et al, (2010): “Development and Characterization of Once a Daily Tablet Formulation of Aceclofenac” Matrix tablets were prepared by direct compression of Kollidon SR varying proportion with fixed percentage of aceclofenac. MD. Selim Reza et al, (2008): “Development of Theophylline Sustained Release Dosage Form Based on Kollidon SR” Four matrix tablet formulations were prepared by dry blending and direct compression of Kollidon SR and HPMC-15cps. Walid Sakr et al, (2009) Effect of Kollidon SR on the release of Albuterol Sulphate from matrix tablets evaluate Kollidon SR for the development of extended release Albuterol Sulphate matrix tablets.
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11. Sr no Parameter Description 1 Category Antidepressant 2 Solubility 572mgl of water 3 Half life 5 hour 4 Mol. Wt. 313.87 5 pka 0.43 6 Dose 75 mgay 7 Bioavailibility 45%
12. 1. Pre-compression Parameter . a) Bulk density b) Tapped density c) Compressibility Index and Hausner’s Ratio d) Angle of repose (θ) 2. Post- compression parameters. a) Weight variation b) Disintegration Test c) Friability d) Hardness and Thickness e) Dissolution Study f) Assay
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