Opioid Analgesics Receptors, Ligands, Effects

OPIOID ANALGESICS Dennis Paul, Ph.D. MEB 7154

Opioid Receptor Subtypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Endogenous Opioids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Opioid receptors, endogenous ligands and function: Mu receptors Mu 1 : B-endorphin, endomorphin enkephalin Mu 2 : B-endorphin, endomorphin Kappa receptors Kappa 1 : dynorphins Kappa 2 & 3 : dynorphins , unknown Delta receptors Delta 1 : enkephalins , dynorphins Delta 2 : enkephalins

Cloned Opioid Receptors ,[object Object],[object Object],[object Object]

In vivo assays: ,[object Object],[object Object],[object Object]

Analgesic Assays ,[object Object],[object Object],[object Object],[object Object]

Reinforcing Properties ,[object Object],[object Object]

Stimulus Properties ,[object Object],[object Object]

II Opioid Agonists ,[object Object],[object Object],[object Object],[object Object]

Desirable properties of morphine as an analgesic ,[object Object],[object Object],[object Object]

Undesirable properties of morphine as an analgesic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Tolerance ,[object Object],[object Object],[object Object],[object Object]

Multiple sites of action ,[object Object],[object Object],[object Object]

Metabolism of morphine ,[object Object],[object Object],[object Object]

Heroin ,[object Object],[object Object],[object Object]

Hydromorphone (Dilaudid) ,[object Object],[object Object],[object Object]

Oxymorphone (Numorphan) ,[object Object]

Codeine ,[object Object],[object Object],[object Object],[object Object]

Oxycodone ,[object Object],[object Object],[object Object]

Hydrocodone and Dihydrocodeine ,[object Object]

Mixtures containing Codeine ,[object Object],[object Object]

Synthetic compounds ,[object Object],[object Object],[object Object],[object Object],[object Object]

Meperidine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fentanyl ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fentanyl derivatives ,[object Object],[object Object],[object Object]

Methadone ,[object Object],[object Object],[object Object],[object Object]

LAAM ,[object Object],[object Object]

Propoxyphene ,[object Object],[object Object],[object Object],[object Object]

Opioid Antagonists ,[object Object],[object Object],[object Object]

Signs of Overdose ,[object Object],[object Object],[object Object],[object Object],[object Object]

Naloxone ,[object Object],[object Object]

Naltrexone ,[object Object],[object Object],[object Object],[object Object]

Nalmefene ,[object Object],[object Object],[object Object]

Mixed agonist-antagonists ,[object Object],[object Object],[object Object],[object Object]

Nalorphine and Cyclazocine ,[object Object],[object Object],[object Object],[object Object]

Pentazocine ,[object Object],[object Object],[object Object]

Butorphanol ,[object Object],[object Object],[object Object],[object Object]

Nalbuphine ,[object Object],[object Object],[object Object],[object Object]

Partial agonist: Buprenorphine ,[object Object],[object Object],[object Object],[object Object]

Tramadol ,[object Object],[object Object],[object Object],[object Object]

Dependence and Withdrawal ,[object Object],[object Object],[object Object],[object Object],[object Object]

Other factors that influence the effectiveness of opioid treatment ,[object Object],[object Object],[object Object]

Salvinorin A ,[object Object],[object Object],[object Object]

Opioid Analgesics Receptors, Ligands, Effects

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