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Opioids
1. DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC
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10. No effect Decrease contraction δ Mouse vas deferens No effect Decrease contraction u Guinea pig ileum Isolated organ bioassays Inhibit u, δ Dopamine Inhibit u Acetylcholine Neurotransmitter release Decrease release Increase release u and/or δ Growth hormone Decrease release Increase release u Prolactin Hormone regulation Increase κ Diuresis No effect Increase u, κ Sedation Decrease feeding Increase feeding u, κ, δ Feeding No effect Increase κ Psychotomimesis No effect Decrease transit u, κ Gastrointestinal tract No effect Decrease u Respiratory function No effect Analgesic u, κ, δ Spinal No effect Analgesic u, κ, δ Supraspinal Analgesia Antagonist Agonist RECEPTOR SUBTYPE
11. Mu and Kappa Receptor Activation Physical Dependence Decrease GI motility Dysphoria Euphoria Respiratory Depression Analgesia Kappa Mu-2 Mu-1 Response
![[object Object],Opioids: Narcotic: imprecise term suggesting "narcosis": indicated of a somnolent state Opioid analgesic: analgesia (pain absence) without resulting in loss of consciousness/sleep Opioids: Definition all natural/ semisynthetic opium alkaloid derivatives synthetic agents other drugs whose opioid-like effects are blocked by naloxone -nonselective opioid receptor antagonist Source: Opium from the opium poppy Constituents: morphine codeine Thebaine : nonanalgesic Papaverine -- nonanalgesic, vasodilator](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)