Btm7 inflammation
•
0 likes•295 views
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.for more details please visit www.indiandentalacademy.com
Recommended
Recommended
More Related Content
What's hot
What's hot (20)
Viewers also liked
Viewers also liked (7)
Similar to Btm7 inflammation
Similar to Btm7 inflammation (20)
More from Indian dental academy
More from Indian dental academy (20)
Recently uploaded
Recently uploaded (20)
Btm7 inflammation
- 1. The role of inflammation in orthodontic tissue remodeling www.indiandentalacademy.com
- 2. Hypothesis Orthodontic forces strain paradental tissues, causing release of vasoactive neurotransmitters from trigeminal nerve endings, which stimulate endothelial cells to bind circulating leukocytes, thus triggring an inflammatory reaction in both areas of PDL tension and compression. www.indiandentalacademy.com
- 61. 7 days, control, CGRP www.indiandentalacademy.com
- 62. 7 days, control, CGRPwww.indiandentalacademy.com
- 63. 7 days, tension, CGRP www.indiandentalacademy.com
- 64. 7 days, tension, CGRP www.indiandentalacademy.com
- 65. 7 days, compression, CGRPwww.indiandentalacademy.com
- 66. 7 days, compression, CGRP www.indiandentalacademy.com
- 67. 28 days, tension, CGRPwww.indiandentalacademy.com
- 68. 28 days, compression, CGRPwww.indiandentalacademy.com
- 69. 28 days, compression, CGRP www.indiandentalacademy.com
- 78. What could possibly be the role of CGRP in tooth movement? Aside from being a vasoactive neurotransmitter, ushering leukocytes into the strained PDL, we found it bound to osteoblasts, fibroblasts, and osteoclasts. In PDL tension sites it may promote apposition of new alveolar bone, while in compression sites it may act as a signal for slowing down or terminating bone resorption. www.indiandentalacademy.com
- 80. Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non- leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. www.indiandentalacademy.com
- 81. Cytokines In our in vivo and in vitro experiments we targeted cytokines that had been found to affect the processes of bone remodeling. This list included interleukin 1 (IL-1), IL- 2, IL-3, IL-6, gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α). www.indiandentalacademy.com
- 92. Immunhistochemical localization of IL-1α and IL-1β in cat paradental tissues during tooth movement www.indiandentalacademy.com
- 97. 3 hours, control, IL-1αwww.indiandentalacademy.com
- 98. 3 hours, compression, IL-1α www.indiandentalacademy.com
- 99. 3 hours, compression, IL-1α www.indiandentalacademy.com
- 100. 3 hours, compression, IL-1α www.indiandentalacademy.com
- 101. 6 hours, control, IL-1αwww.indiandentalacademy.com
- 102. 6 hours, tension, IL-1αwww.indiandentalacademy.com
- 103. 6 hours, compression, IL-1α www.indiandentalacademy.com
- 104. 56 days, compression, IL-1α www.indiandentalacademy.com
- 109. 56 days, apical root resorption, IL-1αwww.indiandentalacademy.com
- 110. Summary The main findings were: 1. In terms of cellular staining intensity for IL-1α, there was no significant difference between paradental cells near untreated (control) canines and cells in areas of PDL tension or compression. www.indiandentalacademy.com
- 111. Summary 2. In terms of the number of PDL cells stained for IL-1α, it was clearly much greater in strained than in control PDL. This observation applied to both areas of compression and tension, and to both fibroblasts and osteoblasts. www.indiandentalacademy.com
- 112. Summary 3. Extensive root resorption was found in canines treated by mechanical forces for 56 days. The numerous odontoclasts in the resorptive lacunae were stained distinctly for IL-1α. www.indiandentalacademy.com
- 113. Conclusions 1. The main effect of orthodontic forces on the IL-1α concentration in strained PDL cells is an increase in the number of positively stained cells in areas of tension and compression. This increase may result from the effect of the force itself, from local effects of paracrines and autocrines, or from both. www.indiandentalacademy.com
- 114. Conclusions 2. The positive staining of odontoclasts for IL-1α suggests that this cytokine participates actively in the process of orthodontic root resorption. It is, therefore, reasonable to propose that blocking the IL-1α receptors may reduce the risk for this destructive activity. www.indiandentalacademy.com
- 126. Localization of IL-1β in paradental tissues during tooth movement www.indiandentalacademy.com
- 129. 1 hour, compression, IL-1β www.indiandentalacademy.com
- 130. 1 hour, compression, IL-1β www.indiandentalacademy.com
- 131. 1 hour, tension, IL-1β www.indiandentalacademy.com
- 132. 1 hour, tension, IL-1β www.indiandentalacademy.com
- 147. Localization of TNF-α in paradental tissues during tooth movement www.indiandentalacademy.com
- 149. 7 days, tension, TNF-α www.indiandentalacademy.com
- 150. 7 days, compression, TNF-α www.indiandentalacademy.com
- 151. 28 days, control, TNF-α www.indiandentalacademy.com
- 152. 28 days, tension, TNF-α www.indiandentalacademy.com
- 153. 28 days, compression, TNF-α www.indiandentalacademy.com
- 161. Summary of findings Significant increases in cellular staining intensity for TNF-α were found in PDL fibroblasts and osteoblasts at both sites of compression and tension. These increases did not occur in the early hours after the application of force, like in the case of IL-1, but rather 12-24 hours later. www.indiandentalacademy.com
- 162. Interpretation of findings 1. The increased concentrations of TNF-α in sites of PDL tension and compression suggest that this cytokine participates in modulating both processes of resorption and apposition. It probably promotes the former and inhibits the latter. www.indiandentalacademy.com
- 163. Interpretation of findings 2. The relatively late onset of TNF-α increases suggests that its synthesis results from activation of late- responding genes. Our in vitro experiments revealed that TNF-α inhibits the effect of IL-1β in PDL fibroblasts. This inhibition can be avoided if TNF-α arrives late. www.indiandentalacademy.com
- 164. What do the experiments with cytokines tell us? These experiments support the hypothesis that inflammation is an integral part of the biological mechanism of tissue remodeling in orthodontics. Clinically, this hypothesis is supported by the presence of at least two of the cardinal signs of inflammation: pain and reduced function. www.indiandentalacademy.com
- 166. Growth factors and orthodontic tissue remodeling www.indiandentalacademy.com
- 167. Growth factors Proteins involved in cell differentiation and growth. They are essential to the cell cycle, and are thus vital elements in the life of animals from conception to death. Among other things, they mediate fetal development, play a role in maintenance and repair of tissues, stimulate production of blood cells, and, gone awry, participate in cancerous processes. www.indiandentalacademy.com
- 183. Localization of EGF in paradental tissues during tooth movement www.indiandentalacademy.com
- 184. 24 hours, control, EGF www.indiandentalacademy.com
- 185. 24 hours, tension, EGF www.indiandentalacademy.com
- 186. 24 hours, compression, EGF www.indiandentalacademy.com
- 187. 24 hours, compression, EGF www.indiandentalacademy.com
- 188. 7 days, tension, EGFwww.indiandentalacademy.com
- 189. 7 days, compression, EGF www.indiandentalacademy.com
- 211. A response to this statement Ignoring physiological data in orthodontic practice is tantamount to neglect, that may endanger the well being of our patients. After all, the mouth and face are part of the human body. We may wish that our patients behave like typodonts, but they don’t! Therefore, orthodontics based on mechanics alone is like a one hand clapping… www.indiandentalacademy.com
- 219. Concluding comment Normal life is based upon a continuous balance between numerous physiological, psychological, and socio-economic variables. When therapy is required for correction of an anomaly, the physician or dentist evaluate these factors in terms of their potential effects on the diagnosis, treatment planning, and the outcome of therapy. www.indiandentalacademy.com
- 220. Concluding comment In orthodontics, where the application of mechanical forces to teeth is the chief therapeutic tool, research has revealed that inflammation is an important part of the biological response to force, suggesting that this process is a good research target for those who wish to improve clinical efficacy and safety. www.indiandentalacademy.com
Editor's Notes
- α