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Flavio Guzmán
Flavio Guzmán
Health & Medicine
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Antiviral Drugs: HIV treatment Zach Laucis April 17 th , 2007
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
History ,[object Object],[object Object],[object Object]
History ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure and life cycle of HIV ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Structure and life cycle of HIV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Structure and life cycle of HIV ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
HIV Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Nucleoside Reverse Transcriptase Inhibitors NRTIs ,[object Object],[object Object]
NRTIs Abacavir ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Abacavir
NRTIs Zidovudine ,[object Object],[object Object],[object Object],[object Object],Zidovudine
NRTIs Lamivudine ,[object Object],[object Object],[object Object],[object Object],Lamivudine
Non-nucleoside Reverse Transcriptase Inhibitors NNRTIs ,[object Object],[object Object],[object Object],[object Object]
NNRTIs Nevirapine ,[object Object],[object Object],[object Object],[object Object],Tyr-181 Tyr-188 Leu-100 Val-106 Val-179 Nevirapine
NNRTIs Delavirdine ,[object Object],[object Object],[object Object],Pro-236 Lys-103 Lys-103 Tyr-181 Tyr-188 Tyr -188 Trp-229
Protease inhibitors PIs ,[object Object],[object Object],[object Object],[object Object],[object Object],Tehrahedral intermediate N OH OH
PIs 4 3 Gly-48 Gly-48 Asp-29 Asp-29 Gly-48’ Gly-48’ Gly-27 Gly-27’ Asp-29’ Asp-29’ Asp-25 Asp-25’ Catalytic Region Flap Region Ile-50 Ile-50’ H-O-H 1 2 1’ 2’ 3’ 4’
PIs Saquinavir ,[object Object],[object Object],[object Object],[object Object],S3 S1 S2 S2’ S1’
PIs Nelfinavir ,[object Object],[object Object],[object Object],S3 S1 S2’ S1’ S2
PIs Ritonavir ,[object Object],[object Object],[object Object],[object Object],[object Object],P3 P2’
Statistics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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