Ischemic colitis is the most common form of intestinal ischemia. It manifests as a spectrum of injury from transient self-limited ischemia involving the mucosa and submucosa to acute fulminant ischemia with transmural infarction that may progress to necrosis and death. Although there are a variety of causes, the most common mechanism is an acute, self-limited compromise in intestinal blood flow.
4. Ischaemic colitis refers to inflammation of the colon
secondary to vascular insufficiency and ischaemia. It is
sometimes considered under the same spectrum
of intestinal ischaemia. The severity and consequences
of the disease are highly variable.
Ischemic colitis encompasses a number of clinical
entities, all with an end result of insufficient blood
supply to a segment or the entire colon.
5. Ischemic colitis is the most common form of
gastrointestinal (GI) ischemia, accounting for 50 to
60% of all cases and occurring with an incidence of
4.5 to 44 cases per 100,000 person years.
It accounts for 1 in 2000 hospital admissions. The
causes of ischemic colitis are numerous, but all
lead to diminished perfusion of the colon, which in
turn leads to mucosal injury or even full-thickness
necrosis.
9. The SMA and IMA communicate through the Marginal Artery
of ‘Drummond’, runs in the mesentery close to the bowel
along the splenic flexure.
Points of communication between collateral arteries
are at higher risk for ischemia
These points are:
the splenic flexure
the recto sigmoid junction
However any segment of the colon may be
involved.
10. WATERSHED AREAS
Areas that are prone to Ischemia during
hypoperfusion & these areas lack in Anastomosis or
they have small amount of blood flow.
(1) the splenic flexure
(called as Griffitt’s Point)
between the SMA and IMA blood supply
(2) the distal sigmoid colon
(called as Sudek’s Point)
between the IMA and hypogastric artery supply
Limited collateral networks and are more
vulnerable to low flow states
11.
12. Right Vs. Left
• The vasa recta are smaller and less
developed in the right colon
• These vessels are sensitive to
vasospasm
This explains the susceptibility of the
right colon to ischemia
14. Colonic blood supply
The colon receives blood from both the superior and
inferior mesenteric arteries.
The blood supply from these two major arteries overlap
with abundant collateral circulation.
There are vascular “weak” points, at the borders of the
territory supplied by each of these arteries.
These watershed areas are most vulnerable to ischemia
when blood flow decreases, as they have the fewest
vascular collaterals.
The rectum receives blood from both the inferior
mesenteric artery and the internal iliac arteries.
The rectum is rarely involved with colonic ischemia due
to this dual blood supply.
15. Development of ischemia—
Under ordinary conditions, the colon receives between
10% and 35% of the total cardiac output.
If blood flow to the colon drops by more than about
50%, ischemia will develop.
The arteries feeding the colon are very sensitive to
vasoconstrictors.
As a result, during periods of low blood pressure, the
arteries feeding the colon clamp down vigorously.
A similar process can result from vasoconstricting drugs
such as ergotamine, cocaine, or vasopressors.
This vasoconstriction can result in non-occlusive
ischemic colitis.
16. Different pathological outcomes include :
gangrenous (15-20%)
non-gangrenous (80-85%):
reversible
non-reversible
(chronic colitis, stricture formation)
17. The majority of patients (85%) develop non-gangrenous
ischemia, which is usually transient and resolves without
sequelae. Only a minority of these patients develop
long-term complications, which include persistent
segmental colitis and the development of a stricture.
Approximately 15% of patients with colonic ischemia
develop gangrene, the consequences of which are life-
threatening sepsis, bowel infarction, and death.
Reversible colopathy
Transient colitis
Chronic colitis
Stricture
Gangrene
Fulminant universal colitis
25. Others
Long distance running
Dialysis
Neurogenic
Spontaneous in young adults
Infections (CMV, E. coli O157:H7)
Airplane flight
26. RISK FACTORS
Suspect for Ischemic Colitis if:
Older than 60
Hemodialysis
Hypertension
Hypoalbuminemia
Diabetes Mellitus
Constipation-induced Medications
The presence 4 or more risk factors was 100% predictive
of Ischemic Colitis.
(Park CJ et al,2007)
28. SIGNS & SYMPTOMS
Three progressive phases of Ischemic Colitis have been
described:
A Hyperactive Phase occurs first in which the primary
symptoms are severe abdominal pain & the passage of
bloody stools. Many patients get better & do not progress
beyond this phase.
A Paralytic Phase if ischemia continues. In this phase the
abdominal pain becomes more widespread, the belly
becomes more tender to the touch & the bowel motility
decreases resulting in abdominal bloating, no further bloody
stools & absent bowel sounds on exam.
Finally, a Shock Phase can develop as fluids start to leak
through the damaged colon lining. This can result in shock &
metabolic acidosis with dehydration & low blood pressure,
rapid heart rate & confusion.
30. • Regardless of the mechanism, the
disease follows the same course.
• Depending on the cause and severity,
the morphologic pattern can be
divided into 3 groups:
31. 1. Transient Ischemia
Mucosal infarction in which ischemic damage is
confined to the mucosa
2. Partial thickness ischemia
Mural infarction in which the injury extends from
the mucosa into the muscularis mucosa
3. Full thickness infarction
Transmural infarction
32. • Transient Ischemia/ Partial Thickness
Result of hypoperfusion rather than occlusive
disease.
May involve any part of the gut and is usually
patchy and segmental.
• Full thickness
Result of thrombosis or embolism of SMA
More common in the small bowel, dependent on
the mesenteric blood supply.
Usually involves a long segment of bowel, tends
to occur in the 2 watershed territories.
34. LABS
Labs will be Normal in mild cases
Severe ischemia or necrosis may
produce:
- leukocytosis,
-metabolic acidosis,
-or an elevated lactate.
35. ABDOMINAL X RAY
Abdominal radiographs are often normal, but signs
include:
dilatation due to ileus
'thumbprinting' due to mucosal
oedema/haemorrhage
localised intramural gas (pneumatosis coli) if
necrotic
free intraperitoneal gas if perforated
38. BARIUM ENEMA
Contrast enema is abnormal in 90% but is rarely
used for diagnostic purposes:
segmental region of abnormality
'thumbprinting' which is classically obliterated by air
insufflation
spasm
ulcerations 'serated mucosa'
stricture from fibrosis as a late complication of
ischaemia
44. ERECT RADIOGRAPH OBTAINED AFTER A DOUBLE-CONTRAST BARIUM ENEMA STUDY SHOWS A
STRICTURE AT THE SPLENIC FLEXURE.
45. CT
Contrast enhanced imaging is the modality of choice. Features
include:
segmental region of abnormality
symmetrical or lobulated thickening of bowel wall
irregularly narrowed lumen
submucosal oedema may produce low-density ring bordering
lumen (target sign)
Irregular narrowing of the bowel lumen as a result of mucosal
edema (thumbprinting)
intramural or portal venous gas
mesenteric oedema
superior mesenteric artery or vein thrombus/occlusion may be
demonstrated
Nonspecific signs of bowel ischemia, including bowel
obstruction, mesenteric edema and ascites
49. CONTRAST-ENHANCED CT IN PATIENTS WITH ACUTE OCCLUSIVE IC: HOMOGENEOUS LEFT COLONIC
INVOLVEMENT WITH DISAPPEARANCE OF THE LUMEN (ARROW) AND HYPERPERFUSION OF THE
MUCOSA IN CORONAL PLANE.
50. PATIENT WITH EMBOLIC IMA OCCLUSION IN ACUTE PHASE:
LEFT COLONIC WALL THICKENING (WHITE ARROW) WITH EVIDENCE OF “LITTLE
ROSE” SIGN OR TARGET ASPECT, PERICOLIC FLUID WAS ALSO PRESENT (CURVED ARROW)
51. AIR-CONTAINING, CYSTIC LUCENCIES ARE SEEN IN BOWEL WALL IN PROXIMAL DESCENDING
COLON (WHITE CIRCLE) AND IN THE WALL OF
THE LARGE BOWEL IN THE LOWER ABDOMEN (BLACK ARROWS).
53. MRI
Sensitivity of MRI in the detection of bowel
ischemia is comparable to that of CT
MRI may be useful in depicting bowel-wall changes
and in demonstrating mesenteric vascular
abnormalities.
As with CT, the additional use of contrast
enhancement allows an assessment of the dynamic
changes in the bowel wall.
54. ULTRASONOGRAPHY
Bowel gas frequently prevents the visualization of
colonic changes, which are usually most marked
around the splenic flexure.
The bowel wall becomes thickened, and nodular
and intramural hemorrhage and edema give rise to
areas of reduced echogenicity.
Echogenic areas may be seen in the bowel wall;
these may reflect either areas of infarction infiltrate
or clot.
58. COLOR DOPPLER USG
Color flow Doppler sonography is effective in
demonstrating flow disturbances associated with
tortuosity and stenosis at the origin of the celiac
axis.
59. NONSTRATIFIED THICKENING OF BOWEL WALL OF DESCENDING AND SIGMOID COLONS (S) AND ALTERED PERICOLIC
FAT (WHITE ARROWS). BARELY VISIBLE COLOR DOPPLER FLOW (ONLY ONE COLOR PIXEL) IS SEEN (BLACK ARROW).
ALSO NOTE VASCULAR ENGORGEMENT (ARROWHEADS).
60. ANGIOGRAPHY
Angiography has a limited role in the diagnosis of
colonic ischemia, in most cases colonic blood flow
has already returned to normal by the time of
symptom onset.
However, angiography may be indicated if the
clinical examination and other studies can not
exclude small bowel ischemia due to acute
proximal mesentric thrombus or embolus
Can show mesenteric artery occlusion if present.
61.
62.
63.
64.
65.
66. INFERIOR MESENTERIC ANGIOGRAM SHOWS A STENOSIS OF MORE THAN 50% AT THE ORIGIN OF
THE LEFT COLIC ARTERY ASSOCIATED WITH A POSTSTENOTIC DILATATION
67. NUCLEAR MEDICINE
Increased uptake of Tc99m (V) DMSA (pentavalent
techenetium-99m dimercaptosuccinic acid) tracer in
the ischaemic bowel may be present but is
unreliable.
68. COLONOSCOPY
The procedure of choice if the diagnosis remains
unclear
Findings at colonoscopy depend on the stage and
severity of ischemia.
- Early stages of ischemia, petechial hemorrhages
are interspersed with areas of pale, edematous
mucosa.
- Later, segmental erythema, +/-ulcerations and
bleeding
Colonoscopy is preferable to contrast enemas since it is
more sensitive in detecting mucosal lesions, permits
biopsies to be obtained, and does not interfere with
subsequent angiography.
70. Ischemic colitis usually gets better on its own
within two to three days. In more-severe cases,
complications can include:
Tissue death (gangrene) resulting from
diminished blood flow
Hole (perforation) in intestine or persistent
bleeding
Bowel inflammation (segmented ulcerating
colitis)
Bowel obstruction (ischemic stricture)
72. Imaging differential considerations include:
other colitides
o ulcerative colitis
o Crohn colitis
o infective colitis: pseudomembranous, amebiasis,
schistosomiasis
o radiation colitis
intramural haemorrhage
diverticulitis
lymphoma or carcinoma
73. The features considered atypical in
inflammatory bowel diseases , such as
1. segmental distribution of the disease,
infrequent rectal involvement,
2. high rate of spontaneous recovery,
low rate of recurrence,
3. lack of adequate response to usual inflammatory
bowel disease therapy,
4. frequent progression to fibrotic stenosis with
delayed obstruction
The features above are now recognized as
characteristic of colonic ischemia.
74. CLINICALLY
Ulcerative colitis
Bloody diarrhea
Crohn’s colitis
Perianal lesions common; frank bleeding less
frequent than in ulcerative colitis
Ischemic Colitis
Older age groups; vascular disease; sudden
onset, often painful
77. Treatment of the patient is dictated by the
severity of the ischemia .
78. 1. Transient Ischemia
Treated symptomatically
Observation with :
Bowel rest, IVF, O2 and optomise cardiac function
2. Partial thickness ischemia
Close observation, IVF, broad-spectrum antibiotics
If stricture develops and is symptomatic, resection
may be required.
3. Full thickness infarction
Surgical resection
79. Full thickness/Gangrenous infarction
• Approximately 20% of patients with IC will
require surgery because of peritonitis or
clinical deterioration despite conservative
management
• Emergency resection of non viable bowel is
required and colostomy is usually done.
81. Always consider the diagnosis of ischemic colitis
whenever contemplating the diagnosis of
inflammatory bowel disease in the elderly.
Thumbprinting of the colon on plain abdominal
radiographs suggests ischemic colitis.
CT with oral & IV contrast is the imaging modality of
choice to assess distribution & phase of Colitis
82. Finding on CT or MRI (e.g., bowel wall thickening,
edema, thumbprinting, pericolonic fat stranding) are
suggestive of IC, but not specific for diagnosis
CT (MRI) findings of colonic pneumatosis & porto-
mesentric venous gas are highly suggestive of
transmural colonic infarction, but not dignostic
Common findings (good prognosis) are non-specific
& more specific findings (bad prognosis) are
Uncommon
83. Evaluation is by CT & Colonoscopy not
Angiography
CT scan is the initial screening test; may help determine
prognosis
Colonoscopy is the test of choice for confirming
diagnosis; may help determine prognosis
Antibiotics for moderate to severe Ischemic Colitis
Surgical consultation is warranted in all cases of
suspected Ischemic Colitis.