1. HOST AGENT ENVIRONMENT
72 years old stressful environment
Smoker (25 packs years)
Exercise, exertional activities, cold, exposure to allergens, pulmonary infection, inhaled irritants, stress, smoking, pollutants
IgE Production and attachment to mast cells in the lungs
Re-exposure to antigen
Idiopathic or Nonallergic Asthma
Release pre-formed mediators that open tight junctions
Nerve endings are stimulated by some factors or antigen
Antigen enter the mucosa
Increase amount of acetlycholine is release Activation of mucosal mast cells
Release of Mediators: Histamine, bradykinine, SRS-A
Bronchoconstriction
Airway Hyperresponsiveness
Increase Vascular Permeability Further release of Bronchospasm Basement membrane Decrease number
Leukocytes (Neutroplhis, Underlying the of mucus by goblet
Eosinophil, Basophils) Mucosal epithelium cells in mucosa and
Mucosal Edema Chest - Wheezes is thickened and Hypertrophy of
there is hypertrophy Submandibular glands
Intense inflammation
Of bronchial walls Peak flow variability - Dyspnea
RR – 28cpm Excessive mucus
production
Productive cough
Bronchial Asthma – Pathophysiology PRESENTED BY: DAVE JAY S. MANRIQUEZ, RN.
