What Is A Male

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What Is A Male

  1. 1. What is a male <ul><li>Genetic basis </li></ul><ul><li>Gonadal basis </li></ul><ul><li>Structural basis </li></ul>
  2. 2. Genetic basis <ul><li>Egg contributes an X </li></ul><ul><li>23 chromosome pairs </li></ul><ul><li>Female is XX –both sex chromosomes same </li></ul><ul><li>Sperm gives a Y or an X </li></ul><ul><li>23 chromosome pairs </li></ul><ul><li>Male has X and Y </li></ul><ul><li>Sex of child determined by the “dad” </li></ul>
  3. 3. division <ul><li>All body cells have 46 chromosomes </li></ul><ul><li>Sex cells ( sperm or egg) have only 23 </li></ul><ul><li>During development of sex cells, division occurs (meiosis)  only 23 chromosomes </li></ul>
  4. 5. Male vs. female <ul><li>Autosomes same (22 ) pairs </li></ul><ul><li>Sex chromosomes not same </li></ul><ul><li>Major differences on the “Y” chromosome </li></ul><ul><li>SRY segment </li></ul>
  5. 6. SRY <ul><li>Responsible for testes formation </li></ul><ul><li>Testosterone production </li></ul><ul><li>Sex characteristics </li></ul><ul><li>Sperm function </li></ul>
  6. 7. The Gonadal Basis Gonads give a sexual identity Males testes develop at week 7 Ovaries at week 12
  7. 8. Structural Basis <ul><li>Before 6 weeks embryo has possibility to become either sex. </li></ul><ul><li>Mullerian ducts  fallopian tubes/ uterus </li></ul><ul><li>Wolffian ducts  sperm making ducts </li></ul>
  8. 9. Female is the default model <ul><li>Testes, if present  androgenic hormones and MIS ( mullerian inhibiting substance) </li></ul><ul><li>Also, 5 alpha reductase changes testosterone into DHT, another form of testosterone </li></ul><ul><li>T, MIS and DHT are responsible for making a male and female structure deterioration. </li></ul><ul><li>Receptors respond to these chemicals  male organ and physiology </li></ul>
  9. 10. Female <ul><li>In absence of T, MIS or DHT…………….a female </li></ul><ul><li>Forms initially. </li></ul><ul><li>Y SRY sperm production </li></ul><ul><li>Testosterone male ducts </li></ul><ul><li>MIS mullerian duct disintegrate </li></ul><ul><li>proteins to regulate dna </li></ul>

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