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Mirror Neurons
  & Autism
   Yung-Tsai Chu
    2012/06/04
Outline
   Basic Neuro-Physiological Properties

   Function Overview

   Dysfunction of Mirror Neurons and Autism
    Spectrum Disorder (ASD)
BASIC NEURO-
PHYSIOLOGICAL PROPERTIES
Mirror Neurons
Now…
Illustration

        Motor Order     Motor
           (from
        Premotor a.)
                       Neuron


        Observation     Mirror
         (Sensory      Neurons
           Input)
The Parieto-Frontal Mirror Network
 Sensorimotor Integration
 Basis of Imitation
FUNCTION OVERVIEW OF
MIRROR NEURONS
Function Overview
   Sensorimotor Integration

   Understanding the goal and intention

   Empathy

   Speech
Understanding the intention
Empathy
Speech
   “r” V.S “f”

   Different tongue muscle activity

   Language Learning
Mirror Neuron System

             Sensory




      Cognition        Motor
MIRROR NEURONS &
AUTISM SPECTRUM DISORDER
Autism Spectrum Disorder (ASD)
   Characteristics of ASD
       Isolation and Lack of Empathy


   Rationale: “Mirror neurons appear to be
    performing precisely the same functions that are
    disrupted in autism.”
EEG evidence
EEG evidence
Correlation
Explanations for Symptoms
 Not able to understand Intentions
 Lack of empathy
 Problems understanding metaphors
       get a grip on yourself : to get control of your thoughts
   Poor Social Skills
Take-Home Message
 MNS is a network that can reflect what you
  observe and somehow activate motor areas
  (sensorimotor integration)
 Functions of MNS includes imitation,
  understanding of intentions, empathy, language
  learning etc.
 Dysfunction of MNS may be the cause of Autism
  Disorder
Reference
   Rizzolatti G and Fabbri-Destro M(2008) The mirror system and its
    role in social cognition.
   Massimo G et al. (2004) Modulation of premotor mirror neuron
    activity during observation of unpredictable grasping movements
   Rizzolatti G, Sinigaglia C (2010) The functional role of the parieto-
    frontal mirror circuit: interpretations and misinterpretations.
   Iacoboni M, Dapretto M. 2006. The mirror neuron system and the
    consequences of its dysfunction.
   Maddalena F-D et al.(2008) Mirror Neurons and Mirror Systems in
    Monkeys and Humans
   Singer T et al.(2004) Empathy for pain involves the affective but not
    sensory components of pain
Reference
   Fadiga L.et al.(2002) Speech listening specifically modulates the
    excitability of tongue muscles: a TMS study.
   Vilayanur SR, Lindsay MO. 2007. Broken Mirrors: A Theory of
    Autism
   Oberman LM et al. (2005) EEG evidence for mirror neuron
    dysfunction in autism spectrum disorders
   Mirella D. et al.(2005) Understanding emotions in others: mirror
    neuron dysfunction in children with autism spectrum disorders.
   Luigi C et al. (2007) Impairment of actions chains in autism and its
    possible role in intention understanding

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Mirror neurons

  • 1. Mirror Neurons & Autism Yung-Tsai Chu 2012/06/04
  • 2. Outline  Basic Neuro-Physiological Properties  Function Overview  Dysfunction of Mirror Neurons and Autism Spectrum Disorder (ASD)
  • 6. Illustration Motor Order Motor (from Premotor a.) Neuron Observation Mirror (Sensory Neurons Input)
  • 7. The Parieto-Frontal Mirror Network  Sensorimotor Integration  Basis of Imitation
  • 9. Function Overview  Sensorimotor Integration  Understanding the goal and intention  Empathy  Speech
  • 12. Speech  “r” V.S “f”  Different tongue muscle activity  Language Learning
  • 13. Mirror Neuron System Sensory Cognition Motor
  • 14. MIRROR NEURONS & AUTISM SPECTRUM DISORDER
  • 15. Autism Spectrum Disorder (ASD)  Characteristics of ASD  Isolation and Lack of Empathy  Rationale: “Mirror neurons appear to be performing precisely the same functions that are disrupted in autism.”
  • 19. Explanations for Symptoms  Not able to understand Intentions  Lack of empathy  Problems understanding metaphors  get a grip on yourself : to get control of your thoughts  Poor Social Skills
  • 20. Take-Home Message  MNS is a network that can reflect what you observe and somehow activate motor areas (sensorimotor integration)  Functions of MNS includes imitation, understanding of intentions, empathy, language learning etc.  Dysfunction of MNS may be the cause of Autism Disorder
  • 21. Reference  Rizzolatti G and Fabbri-Destro M(2008) The mirror system and its role in social cognition.  Massimo G et al. (2004) Modulation of premotor mirror neuron activity during observation of unpredictable grasping movements  Rizzolatti G, Sinigaglia C (2010) The functional role of the parieto- frontal mirror circuit: interpretations and misinterpretations.  Iacoboni M, Dapretto M. 2006. The mirror neuron system and the consequences of its dysfunction.  Maddalena F-D et al.(2008) Mirror Neurons and Mirror Systems in Monkeys and Humans  Singer T et al.(2004) Empathy for pain involves the affective but not sensory components of pain
  • 22. Reference  Fadiga L.et al.(2002) Speech listening specifically modulates the excitability of tongue muscles: a TMS study.  Vilayanur SR, Lindsay MO. 2007. Broken Mirrors: A Theory of Autism  Oberman LM et al. (2005) EEG evidence for mirror neuron dysfunction in autism spectrum disorders  Mirella D. et al.(2005) Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders.  Luigi C et al. (2007) Impairment of actions chains in autism and its possible role in intention understanding