The Neuropeptide Neuromedin U Receptor NMUR-1 Maintains Insulin Signaling Homeostasis
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2022 Undergraduate Research Symposium: Rahi Shah Graduate co-author: Deniz Sifoglu Insulin signaling plays multiple roles in animal homeostasis. For example, it regulates development, metabolism, immunity and animal survival. Because of its importance in animal physiology, it is crucial that insulin signaling is neither overactive nor underactive during the course of an animal's lifespan. We have previously proposed that the neuropeptide neuromedin U receptor NMUR-1 ensures the homeostasis of insulin signaling itself. To elucidate how NMUR-1 maintains the levels of insulin signaling, we are testing whether NMUR-1 regulates the expression of different insulin-like peptides (ILPs). Currently, it remains controversial that the Drosophila and mammalian neuromedin U receptors inhibit insulin signaling. Thus, our studies might resolve the contradictory data present in the current literature. Instead of simply acting as an inhibitor, NMUR-1 might modulate the neuronal expression of different ILPs that can act as agonists or antagonists of the insulin receptor in response to specific environmental cues.
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Quantum Artificial Intelligence (QAI) is an emerging field that could lead to a dramatic decrease in computational power consumption. QAI uses quantum computers which have some key advantages allowing for computational tasks not possible to do with classical computers.
The most intuitive way to create QAI is to mimic a neuron, this model is referred to as a quantum perceptron. Current quantum perceptron models require the use of fault-tolerant quantum computers. However, today’s quantum computers are still noisy and prone to errors, which limits the practical implementation of previously proposed quantum perceptron models.
In this research we implement a quantum perceptron made for today’s quantum computers, this is done by lowering the error threshold and improving the training procedure. The model is implemented on IBM’s quantum simulator and is applied to a pattern recognition task.
Everyday Discrimination, Gender Differences in Major Lifetime Discrimination,...
Everyday Discrimination, Gender Differences in Major Lifetime Discrimination,...Wayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Basma Adel
Graduate co-author: Jacqueline Rodriguez-Stanley
An individual’s perception of their discriminatory experiences has an important impact on their depressive symptoms. Some studies have shown that higher levels of perceived discrimination led to worse mental health conditions, including depressive symptoms and anxiety. Discrimination is the unfair treatment of an individual by others based on their gender, race, sexual orientation, age, and other factors. Our empirical study investigated the relationship between everyday discrimination, major lifetime discrimination, and depressive symptoms using data from 211 older African American adults in the Health among Older adults Living in Detroit (HOLD) study.
The double disadvantage hypothesis explains that individuals who are disadvantaged in one stratification are disadvantaged in other stratifications including race, gender, and other factors. We implemented this hypothesis in our investigation and found that men reported experiencing more major lifetime discriminatory experiences than women. Study results also revealed that there was a significant positive correlation between everyday discrimination and major discrimination experiences and depressive symptoms. However, gender did not moderate this relationship.
Our findings add to the existing literature by having investigated this relationship in older African American adults. Future studies should explore how various coping styles in men affect how they handle stressors, including discriminatory events. Studies should also investigate sex differences regarding how men and women process their thoughts and emotions through coping methods and seeking out social support.Who is Your Role Model?
2022 Undergraduate Research Symposium: Dylan Wollschlager, Edlira Sako, Paris Simpson, Fatima Naeem, Dina Abbas
Graduate co-authors: Alana Keller, Bridget Murphy, Mareena Atalla
Role models include the person(s) one looks up to or wants to be like. Prior research is focused on role models' impact on children's health behaviors such as diet and exercise. Evidence suggests that children with a healthy role model tend to be healthier themselves. (Coto et al. 2019)
There is little inquiry into how role models influence children’s psychological health (e.g., general emotional wellbeing, prosocial behavior), furthermore, there is no research looking at how the accessibility (e.g., family member v. celebrity) of role models impacts psychological health. The purpose of this study was to explore the statistical relationship between the accessibility of role models and children’s well-being and prosocial behavior.
The sample includes 51 school-aged children (40 % girls) (M = 12.08 years, SD = 2.14) from the Downtown Boxing Gym afterschool program in Detroit. Data was collected as part of a needs assessment, using the strengths and difficulties questionnaire (Goodman, 1997) along with measures designed by the family and child study group.
The results of an independent-samples t-test showed that there was no significant difference in emotion measure scores between the accessible (M = 8.87, SD = 3.01) and inaccessible groups (M = 8.83, SD = 2.37), t(52) = .053, p = .96. The results of an independent-samples t-test showed that there was no significant difference in prosocial behavior scores between the accessible group (M = 15.23, SD = 2.36) and the inaccessible group (M = 14.57, SD = 1.88), t(52) = 1.114, p = .27.
Chronic Escalating Fentanyl Administration Induces Differences in Initial Cog...
Chronic Escalating Fentanyl Administration Induces Differences in Initial Cog...Wayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Majd Yahya
Graduate co-author: Cameron Davidson
Opioid addiction is a prominent issue that impacts many people across the world. Several studies detail opioid addiction patterns; however, few studies have investigated long-term cognitive effects of fentanyl following its abstinence. This study explores this shortcoming utilizing a chronic escalating dose of fentanyl model.
Male and female Wistar rats had three daily subcutaneous injections (3h intertrial-interval) of either saline (control), low- or high-dose fentanyl, over 12 days. Following saline or fentanyl exposure, rats were subjected to a nine-day abstinence period followed by a five-day Barnes maze assay. The Barnes maze is a circular platform containing 20 uniformly spaced holes along its edge, with only one hole containing a hidden box. Latency and distance traveled to enter the box were measured. All animals experienced two trials per day. Day one consisted of an acquisition phase where rats explored the maze and were guided to the hidden zone if they did not enter it themselves. Days two through five utilized aversive stimuli (120-watt light and 80 dB white noise) which were terminated once rats entered the goal box.
Results demonstrated that the high-dose fentanyl rats took significantly longer time to reach the hidden zone on day one in comparison to saline- or low-exposed rats, however, this varied by sex. This data suggests that initial exploratory behavior was subtly impacted by our exposure paradigm, but this effect was transitory. Analyses of collected brain tissue assessing neurochemical differences are to be conducted. Future investigations parsing the cognitive impact of synthetic, semi-synthetic, and organic opioids are planned.Traumatic Brain Injury and Hypoxia Produces Long-term Visual Deficits in Rats
Traumatic Brain Injury and Hypoxia Produces Long-term Visual Deficits in RatsWayne State University College of Liberal Arts and Sciences
This study investigated whether rats exposed to traumatic brain injury and hypoxia experience long-term visual deficits. Rats received a brain injury and were then exposed to hypoxia, mimicking severe human brain injuries. The rats underwent several visual tests over time, including forelimb placement, foot splay, visual cliff, object recognition, and light/dark box tests. In all tests, injured rats performed worse than uninjured rats, showing visual deficits. In foot splay and light/dark box tests, rats tested later showed greater impairment, suggesting visual function continued to decline over time. The results support that brain-injured rats exposed to hypoxia experience visual deficits that remain or worsen over time.Searching for Rocks and Rings Around Young Stars.pptx
Searching for Rocks and Rings Around Young Stars.pptxWayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Emily Elizondo
Young stellar objects are often surrounded by gas and dust that has been left over from the initial formation of the star. This environment can become a breeding ground for planetary formation, as the gas and dust will evolve into the planetary systems that we see today. One way to directly study the building blocks of planets is to search for eclipses of young stars by their circumstellar material.
Using the list of pre-main-sequence stars from Zari et al. 2018, we analyzed the light curves of these targets from the Kilodegree Extremely Little Telescope (KELT) survey. This project aims to find eclipses of young stars by their circumstellar disk or some other component (secondary circumstellar disk, larger dust clump), and measure the rotation periods of this sample. We created vetting pages for the 1250 targets in this sample and then visually inspected every page looking for large (>10%) dimming events that lasted anywhere from weeks to months, consistent with an extended source eclipsing the system.
From this effort, we identified a 200-day-long 85% deep eclipse of the known young star system V773 Tau. We will present our search for eclipses of young stars and rotation periods, and discuss the current interpretation of the V773 Tau eclipse.The Influence of Prenatal Care Adequacy on Infant Mortality Rate Disparities ...
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The document summarizes a literature review analyzing the role of prenatal care (PNC) in racial disparities in infant mortality rates (IMRs) between Black and White populations. It finds that Black mothers are more likely to receive inadequate or no PNC compared to White mothers, and have a higher IMR. Studies examined the influence of PNC adequacy and timing of initiation on IMR outcomes. A specific PNC intervention program, the Special Supplemental Nutrition Program for Women, Infants, and Children, was found to effectively reduce the IMR racial disparity by improving outcomes for Black infants.Your Skill Boost Masterclass: Strategies for Effective Upskilling
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2022 Undergraduate Research Symposium: Mary Tooma
Graduate co-author: Emily Graham LeRose
This research was conducted to investigate the underlying etiological cause(s) and/or psychosocial contributions to suicidal ideation as highly self-reported among individuals with a developmental stutter.
A comprehensive literature review was completed to explore two of the hypothesized components thought to increase risk for suicidal ideation in this population; genetic heritability of suicidal ideation and the presence of co-morbid mental health disorders arising as a result of having a stutter (i.e., depression, anxiety, etc.). Additionally, an empirical review was completed for recommendations to improve overall outcomes in therapy for individuals who stutter.
Results from this investigation of the literature found the most empirical support for a connection between high rates of co-morbid mental health disorders and suicidal ideation in individuals who stutter. Additionally, a therapeutic approach titled "Attachment-Based Family Therapy" has been shown to be highly effective in treating individuals, particularly adolescents, who experience suicidal ideation and depression.Iridium (III) Complexes as Sensors for Cytochrome P450 Enzymes
Iridium (III) Complexes as Sensors for Cytochrome P450 EnzymesWayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Justin Ahrens
Graduate co-author: Maddy Denison
The main goal of this project is to use IrIII complexes to monitor cytochrome P450 (CYP) activity. CYP P450 metabolism determines how quickly drugs are excreted from the body and what kind of dose is required for pharmaceuticals to be effective.
Existing probes for CYPs are non-fluorescent, but when CYPs metabolize them, they are “turned on” and fluoresce. Even though these probes are able to monitor metabolism, once they are metabolized and “turned on” they cannot be reversed or turned off. Therefore, this is no current way to monitor dynamic changes in CYP activity continuously over time.
The Kodanko laboratory is addressing this unmet need by developing IrIII complexes that are reversible sensors of CYP enzymes. A chiral resolution strategy with enantioenriched ligands was used to prepare four analogs of IrIII complexes with different stereochemistry. These complexes were evaluated as emissive sensors in human liver hepatocytes to establish which IrIII complex is the lead compound for sensing CYP in living cells. Results from this multi-disciplinary study will be reported.Mental Health and Incarceration
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Misuse of Analgesics and How They Contribute to the Opioid Epidemic
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This document summarizes a presentation on how CRNAs can better help and understand their patients. It discusses several ways for CRNAs to improve patient care and understanding, such as understanding how the healthcare system works to help patients with affordable treatment options, staying updated on new technologies, learning to communicate collaboratively with anesthesiologists, and understanding patients' financial stresses. The presentation also reviews 6 articles on related topics and identifies some limitations in finding relevant sources. It concludes that sharing this information could help medical staff better understand and care for patients to reduce their emotional and physical stress.The Male and Female Gaze in Film Theory
2022 Undergraduate Research Symposium: Ma'ldah Sheikh
The male gaze is a point of view in literary and digital media. It is from the viewing pleasure and perspective of heterosexual men. This form of content is predominantly characterized by the objectification and sexualization of women and other minority groups. The female gaze is meant to oppose the male gaze in cinema, but there are many controversies pertaining to this within the film discourse community.
Many theorists debate that there is no such thing as the female gaze, while others argue that even with the existence of the female gaze, the male gaze can never truly be reversed.
WSU CAPS Resource: Mental Health Screening Utilization
WSU CAPS Resource: Mental Health Screening UtilizationWayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Vivian Truong
Young adults (18-25) have the highest prevalence (29.4%) of any mental illness and the lowest rate of receiving mental health services (38.9%; NIMH). WSU CAPS provides Wayne State students with an online mental health screening opportunity. The numbers of screenings were of interest for this project.
COVID-19 has been shown to negatively impact students’ social and academic engagement, as a result, screening usage during the pandemic was expected to increase. Additionally, the literature on gender and racial/ethnic disparities in mental health service utilization suggest that screening tools may be used less by men and underrepresented minorities. We also expected gender and racial disparities in use, despite the anonymity provided by online screening.
We examined screening use during the pandemic from 3/15/2020 to 6/15/2021 in comparison with pre-pandemic use from 3/15/2018 to 6/15/2019. It is found that the rate of screening is slightly elevated during the pandemic. Secondly, the rate of screening use among different demographic groups, specifically racial/ethnic groups, and gender groups during the fall of 2020 was explored. Of the 897 screenings that were completed, White completed more than 50% of them. Black students were less likely to be screened (12.2% versus 14.8%, p < .01), as were Hispanic students (3.3% versus 5%, p < .001).
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Are Health Awareness Months Dedicated to Urological Diseases Effective at Inc...Wayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Shane Tinsley
Introduction: Disease-specific health awareness (HA) campaigns have rapidly developed as an important avenue to improve patient education and ideally outcomes. Our study objective was to understand the impact of urological HA months on engaging public search interests in the United States.
Methods: We utilized Google Trends to examine public health interest in urologic conditions during monthly awareness campaigns over a 17-year period (2004-2021). Relative Search Volume (RSV) during the annual HA campaign months relative to non-health awareness (NHA) campaign months was calculated. Differences between HA-RSV and NHA-RSV months were compared using t-test.
Results: Although small increases in public interest were noted for certain diseases (prostate cancer in November, testicular cancer in April and erectile dysfunction), there was interestingly a comparative decrease in RSV for other diseases (bladder cancer, prostate cancer in September, testicular cancer in November, kidney cancer, benign prostate hyperplasia and male infertility) in their respective HA months; however, none of these differences were statistically significant (p > 0.05).
Conclusion: Our study did not find a significant difference in public interest of any urological diseases during their respective HA campaign months. This highlights the critical need for further research to investigate potential improvements in campaign methodology during dedicated HA months to better achieve their goals of increased public health engagement.Adolescent Suicide to School Psychologists
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2022 Undergraduate Research Symposium: Avery Bacheller
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2022 Undergraduate Research Symposium: Taha Kader
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Graduate co-author: Kelsey L. Canada
Automated hippocampal subfield segmentation methods have led to exponential growth in the literature. Although automated segmentation is perfectly reliable, deviations from anatomical definitions are common and weaken their validity.
To address the lack of guidance for quality control (QC) of automated segmentation methods, we developed a taxonomy of errors and two-step protocol for 1) identification and 2) manual correction. Raters examined segmentations from a customized atlas to identify errors in six categories with severity ratings; only major severity errors are manually corrected in order to minimize introducing human error.
The QC procedure was developed and cross-validated with an independent sample on two MRI scanners. Raters had excellent agreement in QC decisions between- and within-raters on all regions, manual corrections introduced less than 3% error and were unrelated to participant demographic.
The feasible and reliable QC procedure allows confident interpretation of hippocampal subfield segmentations, and potential applications to other brain regions.Identification of Novel Inhibitors Targeting KRAS-SOS1 Interactions by Struct...
Identification of Novel Inhibitors Targeting KRAS-SOS1 Interactions by Struct...Wayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Neel Patel and Mariana Sierra
The Kristen Rat Sarcoma (KRAS) protein, encoded by the KRAS gene, is a signal transducer that plays a crucial role in regulating cell proliferation. KRAS mutations have been known to cause lung, colorectal, and pancreatic cancers. Previously, KRAS was considered an “undruggable” target. However, with better understanding of the protein’s biology paired with advanced new technologies, the FDA approved the first KRAS inhibitor (sotorasib) for lung cancer patients with the KRASG12C mutation in 2021, expressing the recent interest of targeted drugs for KRAS.
In clinical trials, sotorasib proved ineffective for pancreatic and colorectal cancers with the G12C mutation. Irrespective of mutant identity, oncogenic KRAS requires activation by the guanine nucleotide exchange factor (GEF) Son of Sevenless 1 (SOS1), highlighting an exploitable vulnerability with broad therapeutic applicability. The goal of this study is to develop novel pan-KRAS inhibitors by targeting the KRAS-SOS1 interactions through computational modeling. To start, we applied Gaussian accelerated molecular dynamics (GaMD) simulation, an advanced conformational sampling method, to collect the nature of the KRAS protein motion in solution. Then, the clustering analysis method was used to assemble KRAS conformational structures into ten groups for later virtual screening and docking simulations.
We aim to address 20 to 30 compounds to later be experimentally assessed for their (1) ability to disrupt the KRAS-SOS1 interactions and (2) cytotoxicity in KRAS mutation-bearing cell lines. The work will provide insights in the drug efficacy of KRAS inhibitors and give rise to a novel set of KRAS candidates to be used in clinical oncogenic treatments.Implementation of a Quantum Perceptron
2022 Undergraduate Research Symposium: Lucas Huss
Quantum Artificial Intelligence (QAI) is an emerging field that could lead to a dramatic decrease in computational power consumption. QAI uses quantum computers which have some key advantages allowing for computational tasks not possible to do with classical computers.
The most intuitive way to create QAI is to mimic a neuron, this model is referred to as a quantum perceptron. Current quantum perceptron models require the use of fault-tolerant quantum computers. However, today’s quantum computers are still noisy and prone to errors, which limits the practical implementation of previously proposed quantum perceptron models.
In this research we implement a quantum perceptron made for today’s quantum computers, this is done by lowering the error threshold and improving the training procedure. The model is implemented on IBM’s quantum simulator and is applied to a pattern recognition task.
Everyday Discrimination, Gender Differences in Major Lifetime Discrimination,...
Everyday Discrimination, Gender Differences in Major Lifetime Discrimination,...Wayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Basma Adel
Graduate co-author: Jacqueline Rodriguez-Stanley
An individual’s perception of their discriminatory experiences has an important impact on their depressive symptoms. Some studies have shown that higher levels of perceived discrimination led to worse mental health conditions, including depressive symptoms and anxiety. Discrimination is the unfair treatment of an individual by others based on their gender, race, sexual orientation, age, and other factors. Our empirical study investigated the relationship between everyday discrimination, major lifetime discrimination, and depressive symptoms using data from 211 older African American adults in the Health among Older adults Living in Detroit (HOLD) study.
The double disadvantage hypothesis explains that individuals who are disadvantaged in one stratification are disadvantaged in other stratifications including race, gender, and other factors. We implemented this hypothesis in our investigation and found that men reported experiencing more major lifetime discriminatory experiences than women. Study results also revealed that there was a significant positive correlation between everyday discrimination and major discrimination experiences and depressive symptoms. However, gender did not moderate this relationship.
Our findings add to the existing literature by having investigated this relationship in older African American adults. Future studies should explore how various coping styles in men affect how they handle stressors, including discriminatory events. Studies should also investigate sex differences regarding how men and women process their thoughts and emotions through coping methods and seeking out social support.Who is Your Role Model?
2022 Undergraduate Research Symposium: Dylan Wollschlager, Edlira Sako, Paris Simpson, Fatima Naeem, Dina Abbas
Graduate co-authors: Alana Keller, Bridget Murphy, Mareena Atalla
Role models include the person(s) one looks up to or wants to be like. Prior research is focused on role models' impact on children's health behaviors such as diet and exercise. Evidence suggests that children with a healthy role model tend to be healthier themselves. (Coto et al. 2019)
There is little inquiry into how role models influence children’s psychological health (e.g., general emotional wellbeing, prosocial behavior), furthermore, there is no research looking at how the accessibility (e.g., family member v. celebrity) of role models impacts psychological health. The purpose of this study was to explore the statistical relationship between the accessibility of role models and children’s well-being and prosocial behavior.
The sample includes 51 school-aged children (40 % girls) (M = 12.08 years, SD = 2.14) from the Downtown Boxing Gym afterschool program in Detroit. Data was collected as part of a needs assessment, using the strengths and difficulties questionnaire (Goodman, 1997) along with measures designed by the family and child study group.
The results of an independent-samples t-test showed that there was no significant difference in emotion measure scores between the accessible (M = 8.87, SD = 3.01) and inaccessible groups (M = 8.83, SD = 2.37), t(52) = .053, p = .96. The results of an independent-samples t-test showed that there was no significant difference in prosocial behavior scores between the accessible group (M = 15.23, SD = 2.36) and the inaccessible group (M = 14.57, SD = 1.88), t(52) = 1.114, p = .27.
Chronic Escalating Fentanyl Administration Induces Differences in Initial Cog...
Chronic Escalating Fentanyl Administration Induces Differences in Initial Cog...Wayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Majd Yahya
Graduate co-author: Cameron Davidson
Opioid addiction is a prominent issue that impacts many people across the world. Several studies detail opioid addiction patterns; however, few studies have investigated long-term cognitive effects of fentanyl following its abstinence. This study explores this shortcoming utilizing a chronic escalating dose of fentanyl model.
Male and female Wistar rats had three daily subcutaneous injections (3h intertrial-interval) of either saline (control), low- or high-dose fentanyl, over 12 days. Following saline or fentanyl exposure, rats were subjected to a nine-day abstinence period followed by a five-day Barnes maze assay. The Barnes maze is a circular platform containing 20 uniformly spaced holes along its edge, with only one hole containing a hidden box. Latency and distance traveled to enter the box were measured. All animals experienced two trials per day. Day one consisted of an acquisition phase where rats explored the maze and were guided to the hidden zone if they did not enter it themselves. Days two through five utilized aversive stimuli (120-watt light and 80 dB white noise) which were terminated once rats entered the goal box.
Results demonstrated that the high-dose fentanyl rats took significantly longer time to reach the hidden zone on day one in comparison to saline- or low-exposed rats, however, this varied by sex. This data suggests that initial exploratory behavior was subtly impacted by our exposure paradigm, but this effect was transitory. Analyses of collected brain tissue assessing neurochemical differences are to be conducted. Future investigations parsing the cognitive impact of synthetic, semi-synthetic, and organic opioids are planned.Traumatic Brain Injury and Hypoxia Produces Long-term Visual Deficits in Rats
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This study investigated whether rats exposed to traumatic brain injury and hypoxia experience long-term visual deficits. Rats received a brain injury and were then exposed to hypoxia, mimicking severe human brain injuries. The rats underwent several visual tests over time, including forelimb placement, foot splay, visual cliff, object recognition, and light/dark box tests. In all tests, injured rats performed worse than uninjured rats, showing visual deficits. In foot splay and light/dark box tests, rats tested later showed greater impairment, suggesting visual function continued to decline over time. The results support that brain-injured rats exposed to hypoxia experience visual deficits that remain or worsen over time.Searching for Rocks and Rings Around Young Stars.pptx
Searching for Rocks and Rings Around Young Stars.pptxWayne State University College of Liberal Arts and Sciences
2022 Undergraduate Research Symposium: Emily Elizondo
Young stellar objects are often surrounded by gas and dust that has been left over from the initial formation of the star. This environment can become a breeding ground for planetary formation, as the gas and dust will evolve into the planetary systems that we see today. One way to directly study the building blocks of planets is to search for eclipses of young stars by their circumstellar material.
Using the list of pre-main-sequence stars from Zari et al. 2018, we analyzed the light curves of these targets from the Kilodegree Extremely Little Telescope (KELT) survey. This project aims to find eclipses of young stars by their circumstellar disk or some other component (secondary circumstellar disk, larger dust clump), and measure the rotation periods of this sample. We created vetting pages for the 1250 targets in this sample and then visually inspected every page looking for large (>10%) dimming events that lasted anywhere from weeks to months, consistent with an extended source eclipsing the system.
From this effort, we identified a 200-day-long 85% deep eclipse of the known young star system V773 Tau. We will present our search for eclipses of young stars and rotation periods, and discuss the current interpretation of the V773 Tau eclipse.The Influence of Prenatal Care Adequacy on Infant Mortality Rate Disparities ...
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The document summarizes a literature review analyzing the role of prenatal care (PNC) in racial disparities in infant mortality rates (IMRs) between Black and White populations. It finds that Black mothers are more likely to receive inadequate or no PNC compared to White mothers, and have a higher IMR. Studies examined the influence of PNC adequacy and timing of initiation on IMR outcomes. A specific PNC intervention program, the Special Supplemental Nutrition Program for Women, Infants, and Children, was found to effectively reduce the IMR racial disparity by improving outcomes for Black infants.More from Wayne State University College of Liberal Arts and Sciences (20)
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Pride Month Slides 2024 David Douglas School District
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The Neuropeptide Neuromedin U Receptor NMUR-1 Maintains Insulin Signaling Homeostasis
- 1. The Neuropeptide Neuromedin U Receptor NMUR-1 Maintains Insulin Signaling Homeostasis Presented by: Rahi Shah Alcedo Lab
- 2. NMUR-1 has opposing effects on pharyngeal health and survival depending upon DAF-2 insulin receptor activity (Sifoglu, 2021)
- 3. NMUR-1 might regulate insulin receptor signaling through ILP agonists and antagonists
- 4. ILP DAF-28 regulates longevity in response to specific environmental cues and overlap in expression with NMUR-1 NMUR-1 has no effect on DAF-28 in ASI sensory neurons What about in other DAF-28-expressing neuorns? neurons?