1. Treatment of breast cancer Dr.Syed Alam Zeb

9. Since criteria for menopausal status vary widely, some studies have substituted age older than 50 years as a surrogate for the postmenopausal state.

41. Risk Categories for Women With Node-Negative Breast Cancer Low risk (has all listed factors) Intermediate risk High risk (has at least 1 listed factor) Tumor size ≤ 1cm 1-2 cm >2 cm ER or PR Status positive positive negative Tumor grade Grade 1 grade 1-2 grade 2-3

43. Adjuvant systemic treatment for node negative postmenopausal women Patient group Low risk Intermediate risk High risk ER-positive or PR-positive None or tamoxifen T ± C T ± C ER-negative or PR-negative — — Chemotherapy Older than 70 years None or tamoxifen T ± C T. Consider chemotherapy if ER-negative or PR-negative

45. Adjuvant systemic treatment for node positive postmenopausal women Patient group Treatments ER or PR-positive T ± C ER-negative or PR-negative Chemotherapy Older than 70 years Tamoxifen alone; consider chemotherapy if receptor-negative