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Dr Laurie Sullivan FRANZCO
Melbourne, Australia
Corneal Clinic, RVEEH, East Melbourne
Bayside Eye Specialists
Lasersight
 To you, for your interest
 To Gerard and the University of Sydney for asking
me to contribute
There is a commentary for this presentation so I
hope you have your sound working
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 2
 No financial interest, apart from the odd free travel
to the B&L Technolas user group meeting
 I use the B&L Technolas Z 100 excimer laser, and
the Amadeus mechanical microkeratome, and
Intralase femtosecond laser keratome
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 3
I understand that by now, you have already covered:
 Overview of Refractive Surgery:  History, classification, terminology
 Anatomy, Physiology, Pharmacology, Pathology ,Corneal Wound Healing
 Corneal Imaging: Topography, Orbscan, Pentacam, Aberrometry
 Ocular and Systemic Disease relevant to Refractive Surgery
 Patient Assessment and Evaluation
 Principles of Laser Technology including Excimer, Femtosecond, Thermal
and Conductive Keratoplasty
 Principles and Practice of LASIK
 Principles and Practice of PRK/LASEK
So I am going to assume a fair bit or prior knowledge on your part.  
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 4
= Differing refractive powers at differing axes
(meridia)
 Due to non-spherical (often “toric”) refractive
surface(s)
 Synonyms: “cylinder”, “toric”
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 5
 Corneal astigmatism
◦ Regular or Irregular.
Only regular astigmatism is remediable with refractive
surgery. Irregular corneal astigmatism requires rigid
contact lens or surgery to regularise the surface.
◦ Symmetrical or non-symmetrical
 Intraocular (“lenticular”) astigmatism
◦ Refractive astigmatism without corresponding corneal
curvatures
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 6
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 7
Cornea:
 Manual or automated keratometry
 Corneal topography (videokeratography)
Refractive:
 Subjective and objective refraction
 Wavefront analysis
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 8
 Computerised video-keratography
 A means of describing, depicting (“mapping”), and
quantifying corneal shape and/or power
 Placido disc imaging the basis of many
topographers.
 Also slit scanning and Scheimpflug imaging in
more recent machines.
 These later technologies include posterior corneal
shape and thickness maps
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 9
 Warm (redred) colours indicate a relatively
steepersteeper curvature or more anterioranterior elevation
 Cool (blueblue) colours indicate a relatively flatterflatter
curvature or more posteriorposterior elevation
 Corneal curvatures are numerically described in
dioptres (which are derived mathematically from
the radii of curvature which are what is actually
measured)
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 10
 Keratoconus (KCN) and pellucid marginal corneal
degeneration (PMCD) will often evidence
astigmatism
 Ectasia is a risk if these conditions are operated
upon
 Beware asymmetric corneas, drooping against-Beware asymmetric corneas, drooping against-
the-rule astigmatism (“C sign” or “pinch sign”), andthe-rule astigmatism (“C sign” or “pinch sign”), and
exaggerated posterior corneal surface elevationexaggerated posterior corneal surface elevation
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 11
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 12
 A means of obtaining a detailed refractive map of
the entire optical system through the pupil
 Can quantify higher order optical aberrations
(especially coma and spherical) as well as sphere
and cylinder
 Most excimer lasers may use this information to
drive the refractive correction, but it should be used
only if it corresponds to the patient’s subjective
refraction.
 Iris registration (imaging) improves the accuracy of
the alignment of the laser’s astigmatic correction
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 13
 Toric (“cylindrical”) spectacle lens
 Contact lenses
◦ Rigid: imposes a spherical surface over the cornea +/-
toric surface of the contact lens itself
◦ Soft: toric contact lens surface(s)
 Refractive surgery: mainly excimer laser,
intraocular lenses, or corneal incisions.
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 14
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 15
 Corneal options
◦ Steepen the flat axis (“remove tissue”; excimer laser,
corneal shrinkage techniques E.g. thermal keratoplasty)
◦ Flatten the steep axis (“add tissue”; astigmatic
keratotomy incisions, intracorneal ring segment insertion
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 16
 Prior to the advent of the excimer laser AK was
the main method of correcting astigmatism, often
in association with Radial Keratotomy (RK) for
correction of myopia
 Early excimer lasers were only able to treat
spherical error so AK was often used in
conjunction
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 17
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 18
AK
incision
RK
incision
 AK nomograms were developed to improve predictability.
 Increased patient age, incision length, depth and number are
important determinants of increased effect
 Incisions closer to the corneal apex have more effect
 Incisions near the limbus are called Limbal Relaxing Incisions
(LRIs) and are used in cataract surgery
 “Coupling” describes the observation that an incision will
cause flattening in the axis of the incision and also steepening
in the axis at 90° to the incision. This occurs because the
cornea is a closed physical system, limited by the limbus
Lindstrom RL, Lindquist TD. Surgical correction of postoperative astigmatism. Cornea 1988;
7:138–148
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 19
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 20
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 21
 A guarded micrometer diamond blade is
generally set at 95-100% of thinnest local
pachymetry in virgin corneas – always cuts less
deep than intended
 AK in corneal transplants is unpredictable – one
should always aim for significant
undercorrection
Lindstrom RL, Lindquist TD. Surgical correction of postoperative astigmatism. Cornea
1988; 7:138–148
Price FW, Grene RB, Marks RG, Gonzales JS. Astigmatism reduction clinical trial: a
multicenter prospective evaluation of the predictability of arcuate keratotomy;
evaluation of surgical nomogram predictability. Arch Ophthalmol 1995; 113:277–282;
correction, 577
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 22
Astigmatism (D) Incision Type Length (mm) Optical Zone
1.00 One LRI 6.0 At limbus
1.00 to 2.00 Two LRIs 6.0 At limbus
2.00 to 3.00 Two LRIs 8.0 At limbus
>3.00 Two LRIs 8.0 and CRIs as indicated at
3 months postop
LRI = limbal relaxing incision; CRIs = corneal relaxing incisions
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 23
 “Always cut on the red” (steep axis)
 Always plan your surgery before you get to the
operating room, and draw a diagram on the
patient’s topographic map for intraoperative
reference
 Mark the patient’s eye preop at the slit lamp with
the eye in the primary position
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 24
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 25
102° = steep
axis
Paired AK incisions
planned @ 7mm optical
zone. Blade set at 640
microns
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 26
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 27
 Excimer laser (PRK or LASIK) is effective,
particularly if there is a spherical refractive error
as well
 Most lasers can sculpt either plus or minus
cylinder, or a mixed correction, depending on the
starting refraction
 This flexibility allows planning for minimum tissue
removal with adequate refractive effect
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 28
 Most surgeons are happy treating 4 or 5
dioptres of regular cylinder, more in corneal
transplants
 Regression of effect may occur with astigmatic
corrections, just as with spherical corrections
 Epithelial hyperplasia and subepithelial haze are
the main causes of regression
 Many surgeons use Mitomycin C in PRK to
minimise regression
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 29
This is absolutely critical for optimum results
 Cornea or limbal conjunctiva can be marked at the
slit lamp with 25g needle and gentian violet ink
 Iris registration images (in some laser platforms)
enable the most accurate alignment
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 30
 Point spread
function
 Simulated
snellen letter
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 31
 Higher astigmatic corrections may be required
 Retreatments are more common
 Astigmatic keratotomy is unpredictable
 PRK seems to get better results than LASIK
(Lawless M, unpublished data 2008)
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 32
 Cytotoxic, crosslinks DNA
 Kills keratocytes, amongst other cells (which later
repopulate the stroma over 6-12 months)
 Prevents haze formation after PRK
 Common dose is 0.02% soaked on a sponge and
applied to the stroma for 10-20 seconds
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 33
 Intraocular option
◦ Insertion of toric intraocular lens, either phakic or
pseudophakic
 Use nomograms provided by lens manufacturers
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 34
Toric Visian phakic IOL for myopic astigmatism
 The Visian TICL* is available for patients with
myopia between -4.0 and -20.0 and astigmatism of
1D to 4D.
 Posterior chamber insertion, anterior to crystalline
lens
 3.0 mm ACD required (crystalline lens growth
throughout life)
 1-2% rate of anterior cortical cataract formation
 Eyes treated with LASIK on average have three
times more spherical aberration and two times more
coma than the Visian ICL eyes
*Sarver EJ, Sanders DR, Vukich, JA. Image quality in myopic eyes corrected with laser in situ
keratomileusis and phakic intraocular lens. J Refract Surg. 2003;19(4):397-404.
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 35
 Relevant because of the increasing use of clear
lens extraction (“refractive lens exchange”) for
treating high hyperopic refractive error
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 36
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 37
Steep axis of
postoperative
corneal
astigmatism
Alcon Toric IOL calculation
Sheet (online)
 Recommends power &
axis of placement
 Considers surgically-
induced astigmatism
 Again, place the IOL marks
on the steep (red) axis
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 38
 Ocular astigmatism of 0.75 D or more will
decrease VA.
 Most surgeons will treat the refractive
astigmatism rather than the corneal astigmatism
(unless lens extraction is part of the surgery).
 Patients often dislike having their astigmatism
over-corrected (axis reversal), or having a
significant axis change.
 Small amounts of astigmatism (<= 0.5D) may
improve depth of focus (and reading ability) in
presbyopes and pseudophakes.
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 39
 Any further questions can be directed to the email
address below
Dr Laurie Sullivan 2009
lsulliva@optusnet.com.au 40

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Principles and practice of corneal astigmatic surgery

  • 1. Dr Laurie Sullivan FRANZCO Melbourne, Australia Corneal Clinic, RVEEH, East Melbourne Bayside Eye Specialists Lasersight
  • 2.  To you, for your interest  To Gerard and the University of Sydney for asking me to contribute There is a commentary for this presentation so I hope you have your sound working Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 2
  • 3.  No financial interest, apart from the odd free travel to the B&L Technolas user group meeting  I use the B&L Technolas Z 100 excimer laser, and the Amadeus mechanical microkeratome, and Intralase femtosecond laser keratome Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 3
  • 4. I understand that by now, you have already covered:  Overview of Refractive Surgery:  History, classification, terminology  Anatomy, Physiology, Pharmacology, Pathology ,Corneal Wound Healing  Corneal Imaging: Topography, Orbscan, Pentacam, Aberrometry  Ocular and Systemic Disease relevant to Refractive Surgery  Patient Assessment and Evaluation  Principles of Laser Technology including Excimer, Femtosecond, Thermal and Conductive Keratoplasty  Principles and Practice of LASIK  Principles and Practice of PRK/LASEK So I am going to assume a fair bit or prior knowledge on your part.   Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 4
  • 5. = Differing refractive powers at differing axes (meridia)  Due to non-spherical (often “toric”) refractive surface(s)  Synonyms: “cylinder”, “toric” Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 5
  • 6.  Corneal astigmatism ◦ Regular or Irregular. Only regular astigmatism is remediable with refractive surgery. Irregular corneal astigmatism requires rigid contact lens or surgery to regularise the surface. ◦ Symmetrical or non-symmetrical  Intraocular (“lenticular”) astigmatism ◦ Refractive astigmatism without corresponding corneal curvatures Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 6
  • 7. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 7
  • 8. Cornea:  Manual or automated keratometry  Corneal topography (videokeratography) Refractive:  Subjective and objective refraction  Wavefront analysis Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 8
  • 9.  Computerised video-keratography  A means of describing, depicting (“mapping”), and quantifying corneal shape and/or power  Placido disc imaging the basis of many topographers.  Also slit scanning and Scheimpflug imaging in more recent machines.  These later technologies include posterior corneal shape and thickness maps Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 9
  • 10.  Warm (redred) colours indicate a relatively steepersteeper curvature or more anterioranterior elevation  Cool (blueblue) colours indicate a relatively flatterflatter curvature or more posteriorposterior elevation  Corneal curvatures are numerically described in dioptres (which are derived mathematically from the radii of curvature which are what is actually measured) Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 10
  • 11.  Keratoconus (KCN) and pellucid marginal corneal degeneration (PMCD) will often evidence astigmatism  Ectasia is a risk if these conditions are operated upon  Beware asymmetric corneas, drooping against-Beware asymmetric corneas, drooping against- the-rule astigmatism (“C sign” or “pinch sign”), andthe-rule astigmatism (“C sign” or “pinch sign”), and exaggerated posterior corneal surface elevationexaggerated posterior corneal surface elevation Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 11
  • 12. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 12
  • 13.  A means of obtaining a detailed refractive map of the entire optical system through the pupil  Can quantify higher order optical aberrations (especially coma and spherical) as well as sphere and cylinder  Most excimer lasers may use this information to drive the refractive correction, but it should be used only if it corresponds to the patient’s subjective refraction.  Iris registration (imaging) improves the accuracy of the alignment of the laser’s astigmatic correction Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 13
  • 14.  Toric (“cylindrical”) spectacle lens  Contact lenses ◦ Rigid: imposes a spherical surface over the cornea +/- toric surface of the contact lens itself ◦ Soft: toric contact lens surface(s)  Refractive surgery: mainly excimer laser, intraocular lenses, or corneal incisions. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 14
  • 15. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 15
  • 16.  Corneal options ◦ Steepen the flat axis (“remove tissue”; excimer laser, corneal shrinkage techniques E.g. thermal keratoplasty) ◦ Flatten the steep axis (“add tissue”; astigmatic keratotomy incisions, intracorneal ring segment insertion Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 16
  • 17.  Prior to the advent of the excimer laser AK was the main method of correcting astigmatism, often in association with Radial Keratotomy (RK) for correction of myopia  Early excimer lasers were only able to treat spherical error so AK was often used in conjunction Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 17
  • 18. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 18 AK incision RK incision
  • 19.  AK nomograms were developed to improve predictability.  Increased patient age, incision length, depth and number are important determinants of increased effect  Incisions closer to the corneal apex have more effect  Incisions near the limbus are called Limbal Relaxing Incisions (LRIs) and are used in cataract surgery  “Coupling” describes the observation that an incision will cause flattening in the axis of the incision and also steepening in the axis at 90° to the incision. This occurs because the cornea is a closed physical system, limited by the limbus Lindstrom RL, Lindquist TD. Surgical correction of postoperative astigmatism. Cornea 1988; 7:138–148 Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 19
  • 20. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 20
  • 21. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 21
  • 22.  A guarded micrometer diamond blade is generally set at 95-100% of thinnest local pachymetry in virgin corneas – always cuts less deep than intended  AK in corneal transplants is unpredictable – one should always aim for significant undercorrection Lindstrom RL, Lindquist TD. Surgical correction of postoperative astigmatism. Cornea 1988; 7:138–148 Price FW, Grene RB, Marks RG, Gonzales JS. Astigmatism reduction clinical trial: a multicenter prospective evaluation of the predictability of arcuate keratotomy; evaluation of surgical nomogram predictability. Arch Ophthalmol 1995; 113:277–282; correction, 577 Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 22
  • 23. Astigmatism (D) Incision Type Length (mm) Optical Zone 1.00 One LRI 6.0 At limbus 1.00 to 2.00 Two LRIs 6.0 At limbus 2.00 to 3.00 Two LRIs 8.0 At limbus >3.00 Two LRIs 8.0 and CRIs as indicated at 3 months postop LRI = limbal relaxing incision; CRIs = corneal relaxing incisions Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 23
  • 24.  “Always cut on the red” (steep axis)  Always plan your surgery before you get to the operating room, and draw a diagram on the patient’s topographic map for intraoperative reference  Mark the patient’s eye preop at the slit lamp with the eye in the primary position Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 24
  • 25. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 25 102° = steep axis Paired AK incisions planned @ 7mm optical zone. Blade set at 640 microns
  • 26. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 26
  • 27. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 27
  • 28.  Excimer laser (PRK or LASIK) is effective, particularly if there is a spherical refractive error as well  Most lasers can sculpt either plus or minus cylinder, or a mixed correction, depending on the starting refraction  This flexibility allows planning for minimum tissue removal with adequate refractive effect Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 28
  • 29.  Most surgeons are happy treating 4 or 5 dioptres of regular cylinder, more in corneal transplants  Regression of effect may occur with astigmatic corrections, just as with spherical corrections  Epithelial hyperplasia and subepithelial haze are the main causes of regression  Many surgeons use Mitomycin C in PRK to minimise regression Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 29
  • 30. This is absolutely critical for optimum results  Cornea or limbal conjunctiva can be marked at the slit lamp with 25g needle and gentian violet ink  Iris registration images (in some laser platforms) enable the most accurate alignment Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 30
  • 31.  Point spread function  Simulated snellen letter Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 31
  • 32.  Higher astigmatic corrections may be required  Retreatments are more common  Astigmatic keratotomy is unpredictable  PRK seems to get better results than LASIK (Lawless M, unpublished data 2008) Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 32
  • 33.  Cytotoxic, crosslinks DNA  Kills keratocytes, amongst other cells (which later repopulate the stroma over 6-12 months)  Prevents haze formation after PRK  Common dose is 0.02% soaked on a sponge and applied to the stroma for 10-20 seconds Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 33
  • 34.  Intraocular option ◦ Insertion of toric intraocular lens, either phakic or pseudophakic  Use nomograms provided by lens manufacturers Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 34 Toric Visian phakic IOL for myopic astigmatism
  • 35.  The Visian TICL* is available for patients with myopia between -4.0 and -20.0 and astigmatism of 1D to 4D.  Posterior chamber insertion, anterior to crystalline lens  3.0 mm ACD required (crystalline lens growth throughout life)  1-2% rate of anterior cortical cataract formation  Eyes treated with LASIK on average have three times more spherical aberration and two times more coma than the Visian ICL eyes *Sarver EJ, Sanders DR, Vukich, JA. Image quality in myopic eyes corrected with laser in situ keratomileusis and phakic intraocular lens. J Refract Surg. 2003;19(4):397-404. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 35
  • 36.  Relevant because of the increasing use of clear lens extraction (“refractive lens exchange”) for treating high hyperopic refractive error Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 36
  • 37. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 37 Steep axis of postoperative corneal astigmatism
  • 38. Alcon Toric IOL calculation Sheet (online)  Recommends power & axis of placement  Considers surgically- induced astigmatism  Again, place the IOL marks on the steep (red) axis Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 38
  • 39.  Ocular astigmatism of 0.75 D or more will decrease VA.  Most surgeons will treat the refractive astigmatism rather than the corneal astigmatism (unless lens extraction is part of the surgery).  Patients often dislike having their astigmatism over-corrected (axis reversal), or having a significant axis change.  Small amounts of astigmatism (<= 0.5D) may improve depth of focus (and reading ability) in presbyopes and pseudophakes. Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 39
  • 40.  Any further questions can be directed to the email address below Dr Laurie Sullivan 2009 lsulliva@optusnet.com.au 40