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FUNDING CHALLENGES:
EARLY STAGE INVESTIGATORS
                                 Jon Chung, Ph.D.

      Fight Colorectal Cancer Post Doctoral Fellow
      Johns Hopkins University School of Medicine
Career path for a cancer research
                scientist
    FELLOWSHIPS         4 YEARS      Undergraduate
         +
 PROFESSOR’S GRANT     6+ YEARS     Graduate student


                       6+ YEARS         Post Doc



INDEPENDENT RESEARCH
                       ~3+ YEARS New assistant Professor


                                       R01 GRANT
Funding for each career stage
          FUNDING                              Undergraduate

       PREDOCTORAL FELLOWSHIP
                                             Graduate student
 [AND/OR PAID FROM PROFESSOR’S GRANT]

       POSTDOCTORAL FELLOWSHIP                    Post Doc
[AND/OR PAID FROM PROFESSOR’S R01 GRANT]




           TRANSITION GRANT                New assistant Professor
       UNIVERSITY STARTUP PACKAGE

               R01 Grant                       First R01 Grant
My career path
          UNIVERSITY OF CAMBRIDGE UK             Undergraduate

  UNIVERSITY OF MANCHESTER/CANCER RESEARCH UK   Graduate student
UK GOVERNMENT/CANCER RESEARCH UK FELLOWSHIP

                 JOHNS HOPKINS                      Post Doc
                DR. BUNZ R01
     FIGHT COLORECTAL CANCER FELLOWSHIP
My career path
          UNIVERSITY OF CAMBRIDGE UK                Undergraduate

  UNIVERSITY OF MANCHESTER/CANCER RESEARCH UK     Graduate student
UK GOVERNMENT/CANCER RESEARCH UK FELLOWSHIP

                 JOHNS HOPKINS
                DR. BUNZ R01
                                                       Post Doc           ?
     FIGHT COLORECTAL CANCER FELLOWSHIP


             TRANSITION GRANT
                      or
         UNIVERSITY STARTUP PACKAGE
                                                New assistant Professor   ?
                                                    First R01 Grant
Typical costs for cancer research
                      LARGE EQUIPMENT
                -Microscope: $10,000-$100,000

                  -Ultra cold freezer: $5,000+

                    -Cell incubator: $5,000+

                        EVERYDAY COSTS
-Colorectal cancer cells: $300 per cell line (>50 colorectal lines)

        -Antibodies/enzymes/cancer drugs: $300 each

                   -“Consumables”: $20,000+
Career path for a cancer research
               scientist
20 years                        4 YEARS         Undergraduate

                               6+ YEARS       Graduate student


                               6+ YEARS            Post Doc




                               ~3-5 YEARS   New assistant Professor

~15% success rate (2011 NCI)                     R01 GRANT
Fight Colorectal Cancer Funded Project:
   Hedgehog inhibitors for colorectal
                cancer?
Fight Colorectal Cancer Funded Project:
   Hedgehog inhibitors for colorectal
                cancer?
     Medulloblastoma trial:




                              Rudin et al. 2009, NEJM
THANK YOU!

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Jon Chung CRC Funding for Research

  • 1. FUNDING CHALLENGES: EARLY STAGE INVESTIGATORS Jon Chung, Ph.D. Fight Colorectal Cancer Post Doctoral Fellow Johns Hopkins University School of Medicine
  • 2. Career path for a cancer research scientist FELLOWSHIPS 4 YEARS Undergraduate + PROFESSOR’S GRANT 6+ YEARS Graduate student 6+ YEARS Post Doc INDEPENDENT RESEARCH ~3+ YEARS New assistant Professor R01 GRANT
  • 3. Funding for each career stage FUNDING Undergraduate PREDOCTORAL FELLOWSHIP Graduate student [AND/OR PAID FROM PROFESSOR’S GRANT] POSTDOCTORAL FELLOWSHIP Post Doc [AND/OR PAID FROM PROFESSOR’S R01 GRANT] TRANSITION GRANT New assistant Professor UNIVERSITY STARTUP PACKAGE R01 Grant First R01 Grant
  • 4. My career path UNIVERSITY OF CAMBRIDGE UK Undergraduate UNIVERSITY OF MANCHESTER/CANCER RESEARCH UK Graduate student UK GOVERNMENT/CANCER RESEARCH UK FELLOWSHIP JOHNS HOPKINS Post Doc DR. BUNZ R01 FIGHT COLORECTAL CANCER FELLOWSHIP
  • 5. My career path UNIVERSITY OF CAMBRIDGE UK Undergraduate UNIVERSITY OF MANCHESTER/CANCER RESEARCH UK Graduate student UK GOVERNMENT/CANCER RESEARCH UK FELLOWSHIP JOHNS HOPKINS DR. BUNZ R01 Post Doc ? FIGHT COLORECTAL CANCER FELLOWSHIP TRANSITION GRANT or UNIVERSITY STARTUP PACKAGE New assistant Professor ? First R01 Grant
  • 6. Typical costs for cancer research LARGE EQUIPMENT -Microscope: $10,000-$100,000 -Ultra cold freezer: $5,000+ -Cell incubator: $5,000+ EVERYDAY COSTS -Colorectal cancer cells: $300 per cell line (>50 colorectal lines) -Antibodies/enzymes/cancer drugs: $300 each -“Consumables”: $20,000+
  • 7. Career path for a cancer research scientist 20 years 4 YEARS Undergraduate 6+ YEARS Graduate student 6+ YEARS Post Doc ~3-5 YEARS New assistant Professor ~15% success rate (2011 NCI) R01 GRANT
  • 8. Fight Colorectal Cancer Funded Project: Hedgehog inhibitors for colorectal cancer?
  • 9. Fight Colorectal Cancer Funded Project: Hedgehog inhibitors for colorectal cancer? Medulloblastoma trial: Rudin et al. 2009, NEJM