1. InTouch July 2016 1
InTouch
The newsletter of
North West Cancer Research
July 2016
in this
issue...
Meet our bladder cancer specialist | Students help progress new life-saving
medical research | Local fundraiser gallops 5K for mum

2. 2 InTouch July 2016 InTouch July 2016 3
Contact us
North West Cancer Research Centre,
200 London Road, Liverpool, L3 9TA
0151 709 2919
info@nwcr.org
www.nwcr.org
@NorthWestCancer
NorthWestCancer
Registered Charity Number 519357
COVER IMAGE: Desicription to go in here.
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2 InTouch July 2016
Welcome to the 2016 summer edition of InTouch.
Research into new bladder cancer treatments is saving
more lives than ever before (pg. 4 & 5). We heard from the
man himself, Dr. Syed Hussain, about his research that
has changed the way the UK, Europe and America treats
bladder cancer.
Kevin Wilson, one of Syed’s patients, shares his story
about his battle with bladder cancer (pg. 6 & 7).
Kevin was diagnosed with bladder cancer in 2013, but
thanks to Syed’s research and treatment Kevin’s future is
looking bright. Read more about his battle on pages
6 and 7.
The next generation of cancer researchers are
helping us to progress new, life-saving medical research
(pg. 8). Three students, who have embarked on summer
studentships at Lancaster University, are taking their
first steps towards careers in cancer research.
Whilst progressing world-class medical research.
Leaving a legacy in your will can help us to stop cancer
sooner. Find out how you can get free legal advice when
you leave a gift in your will to North West Cancer Research
on page 10.
You can help us create a cancer free future sooner by
donating today.
Thank you
To make a donation to help our vital research, simply fill in the
form on page 15. You can also make a donation by sending a
text message from your mobile phone. Just text GIFT37 plus
the amount you wish to donate (£1, £5, £10) to 70070. E.g.
Text GIFT37 £5 to 70070. Thank you.
Donate
InTouchJuly 2016
Welcome
Which University did you attend and
what did you study: PhD in MAP kinase
signaling from University of Dundee,
undergraduate BSc in Biochemistry
from Queen’s University Belfast.
Describe your job: As a young(ish!)
research lecturer a lot of my time is
spent in the lab working on developing
new projects and testing ideas. I also
spend a lot of time writing grants, and
starting in September I will be teaching
Molecular Biology and Biochemistry to
the undergraduates here at Bangor Uni.
What do you like best about your
job? It doesn’t get said enough, but
scientists should feel lucky to have the
opportunity to do the work that they do,
and I certainly feel this way personally.
Working on cancer biology is itself all
the motivation I will ever need. It is also
great that I have the freedom to direct
my own research and since I work on
a group of proteins that are previously
unstudied, every day can yield really
interesting findings and every finding is
completely novel.
What made you become a scientist?
As a young guy I was really into organic
chemistry and had a great teacher
at Ballymena Academy in Northern
Ireland where I did my A-levels. Perhaps
the most elegant organic chemical
reactions are seen in enzyme catalysis,
so I was obviously keen to study
Biochemistry at University.
Scientists under the microscope
In this issue we’re focusing on Dr. Chris Staples, who’s working on one of our funded research
projects at Bangor University.
03 Under the
microscope
04 Dr Syed Hussain
06 Kevin Wilson’s story
08 The next generation
of researchers
09 #sunscreenselfie
10 Your legacy
11 Donate in memory
of a loved one
12 Local fundraiser gallops
5k for mum
14 Current research projects
15 Donate Today
What made you go into cancer research
specifically? It is rare for anyone’s life
to be untouched by cancer in some
way, and like most people I have lost
loved ones to the disease. The search
for effective cancer treatments is a
major challenge for humanity, and any
contribution to the field is another little
step towards understanding how cancer
works and how to beat it.
What’s your favourite past time?
Spending time with my wife and three
kids.
What’s your favourite saying?
‘Everything you can imagine is real’ Pablo
Picasso
Tell us a fun fact about yourself:
I love to cook, and am also a big fan of
progressive metal!
Chris Staples

3. 4 InTouch July 2016 InTouch July 2016 5
Lack of awareness
of the symptoms
of bladder cancer
unfortunately means
that half of those
diagnosed die
The research has been
so successful that
many European and
American centres have
adopted this type of
treatment for bladder
cancer patients.
Nice to see you Syed. Your research specialises in the treatment of bladder
cancer – could you explain what bladder cancer is in layman’s terms?
“Bladder cancer is where the growth of abnormal tissue, known as a tumour,
advances into the muscular layer of the bladder. This is called muscle invasive
bladder cancer and can become life-limiting. If bladder cancer is left untreated for
a lengthy period of time, it can spread outside of the bladder.”
What are the treatment options for bladder cancer?
“There are two treatment options for muscle –invasive bladder cancer, the
first, and most life-changing, is to remove the bladder completely. The second
is to keep the bladder and treat with a combination of chemotherapy and
radiotherapy.”
How many people are diagnosed with bladder cancer in the UK?
“Approximately 10,000 people are diagnosed with bladder cancer every year, and
more than half of people diagnosed are over 70.”
Who is most likely to be diagnosed with bladder cancer?
“More men than women are diagnosed with bladder cancer. For every one woman
who’s diagnosed, there’s 4 men. This is due to historic smoking and working habits
related to men. Historically more men than women smoked. And a lot of men have
worked in chemical and industrial workplaces, which contributes to the growth of
cancerous tumours.”
Meet our bladder cancer specialist,
Dr. Syed Hussain, as we find out how he’s
revolutionising cancer treatments.
Syed Hussain is a Clinical Senior Lecturer and Medical Oncologist Consultant at the University
of Liverpool. With funding from North West Cancer Research (NWCR) he has revolutionised the
treatment of bladder cancer. His research breakthrough continues to save the lives of bladder
cancer patients around the world.
Dr. Syed Hussain at the North West Cancer Research Centre
What are the symptoms of bladder
cancer?
“The main symptom of bladder cancer
is blood in the urine. If you’re presented
with this symptom please see your
GP immediately, as, with all cancers,
the earlier bladder cancer is diagnosed
the more treatable it is. Other
symptoms include the reoccurrence
of urine infections. Most patients
are prescribed different types of
anti-biotics if they get more than one
urine infection. But if the infection is
occurring every few weeks, the patient
needs to be referred for further tests.”
Do many people survive after being
diagnosed with bladder cancer?
“Lack of awareness of the symptoms
of bladder cancer unfortunately
means that half of those diagnosed
die. Bladder cancer also has an 80%
reoccurrence rate. That’s higher than
any other cancer, and sometimes
reoccurrence happens in a different
organ in the body.”
What does your job include?
“As well as undertaking a senior
lectureship at the University of
Liverpool, which is funded by North
West Cancer Research. I’m also
involved in a number of ground-
breaking bladder cancer research
projects. These projects have changed
outcomes for bladder cancer sufferers
as more people than ever before are
surviving the cancer. Bladder cancer
treatments have significantly improved
over the last 10 years, thanks to the
work myself and my team are driving.”
Could you tell us what your
research discovered?
“One of our research projects
found that if you combine radiation
treatment with the chemotherapy
drug, Mitomycin-c and 5-Fluorouracil,
patients respond better than they
do with radiotherapy alone. The
chemotherapy drug is administered
during week 1, and week 4 of
radiotherapy. This type of treatment
often reduces the tumour significantly,
as the chemotherapy drug increases
the radiation sensitivity of the
tumour. Patients are responding over
30% better using the combination
treatment we discovered.
We’ve also found that this type
of treatment reduces the cancer
recurring by one-third.”
How successful has your
research been?
“The research has been so successful
that many European and American
centres have adopted this type
of treatment for bladder cancer
patients, who opt to keep their
bladders. However, as successful
as this treatment is, some patients
who are receiving cisplatin based
chemotherapy, sometimes develop
drug resistance and stop responding to
treatment.”
Can we stop patients becoming
resistant to bladder cancer
treatment drugs?
“Yes. Our second research project
looks into why some people may
become resistant to the cisplatin
chemotherapy drug. If we can find out
why some people stop responding
to the treatment, we can help more
patients than ever before to survive
bladder cancer.”
How has your research helped
bladder cancer sufferers?
“Our research has changed the way
bladder cancer is treated. Most
patients no longer have to make the
agonising decision to have their bladder
removed. By combining treatment
options we have given patients a
fighting chance against bladder cancer,
without them having to adjust to a life
without a bladder.”
To learn more about Syed’s research,
visit our website: http://nwcr.org/life-
stories/research-and-rescue

4. 6 InTouch July 2016 InTouch July 2016 7
Kevin Wilson with his wife, Jackie Wilson
Kevin Wilson before his bladder cancer diagnosis
Kevin Wilson with his son.
Kevin Wilson shares his story about his
battle with bladder cancer
Kevin Wilson is fighting his second cancerous tumour. But his prognosis is bright
thanks to the work of Dr. Syed Hussain.
After a tough few years Kevin’s future is looking bright. He
continues to see Dr. Syed at regular appointments, where his
treatment continues to fight his secondary bladder cancer.
Dr. Syed Hussain continues to treat patients from far and
wide. His research breakthrough has, and continues to,
benefit many patients diagnosed with bladder cancer.
If you’d like to help us continue to fund people like Dr. Syed
Hussain, please donate whatever you can by filling in the
donation form, or visiting www.nwcr.org.
After finding blood in his urine, Kevin was told he had a urine
infection and was given a course of anti-biotics. The anti-
biotics he was given had no effect on the symptoms he was
experiencing, so Kevin went back to his doctor. After further
tests Kevin was told he had muscle invasive bladder cancer.
Where the tumour has advanced into the muscular layer of
the bladder.
Kevin was given chemotherapy to stop the cancer from
spreading outside the bladder, before he underwent surgery
in December 2013.
“After meeting with my surgeons, Dr. Syed Hussain said
they’d have me home in time for my Christmas dinner. I
can’t thank him enough for all his support during this difficult
period of my life.”
At the age of 63, Kevin was looking forward to life beyond
retirement. After spending most of his working life around
chemicals, which experts believe have probably contributed
to Kevin’s cancer diagnosis, he was keen to enjoy his time
surrounded by family and friends.
“The diagnosis came as a complete shock for me. I thought
it was simply the case of a bladder infection that would
clear up after a course of anti-biotics. Little did I know I’d be
spending the next few years in and out of hospital.”
Unfortunately after Kevin’s successful bladder surgery, tests
revealed he has secondary bladder cancer in his lungs.
“The second diagnosis was like a slap in the face.
Dr. Syed told me the cancer in the lungs couldn’t be cured
by surgery, and I was beginning to wonder whether I’d ever be
rid of the disease.”
“That’s when he told me, in his words, I was young enough
and fit enough to be accepted onto his clinical trial.”
“In just two years my tumour has shrunk to twice the size it
was when we first found the cancer. All thanks to Dr. Hussain,
and his research into new cancer treatments. His work has
enabled me to overcome some of the obstacles I’ve faced
during my fight against cancer.”
In just two years my
tumour has shrunk to
twice the size it was
when we first found the
cancer. All thanks to
Dr. Hussain

5. 8 InTouch July 2016 InTouch July 2016 9
#suncreamselfie
is this year’s
summer hit.
We’ve gone and done it again.
Our #suncreamselfie campaign was this
year’s summer hit, as hundreds posted
their selfies online.
Skin cancer is the 5th most common cancer in the UK,
with over 1,000 people diagnosed in the North West
every year. Many other cancers such as lung, breast and
prostate will see their incidence rates plateau in the next
15-20 years. But skin cancer incident rates are expected
to rise due to the effects or historical sun worshiping, and
sun bed use.
The North West, also known as the skin cancer capital of
Europe, sees more skin cancer patients each year than
anywhere else. We want to reduce this number, so we
asked you to take part in our #suncreamselfie campaign;
and you didn’t disappoint. Even your pets got involved.
With the help of all your posts on Facebook and Twitter
we managed to tell over 80,000 about the dangers of
skin cancer. Thank you for all your help, and join us again
next May for another month of raising awareness of skin
cancer with your #suncreamselfies.
Funding the next generation of cancer
researchers.
Three students accepted onto our summer studentship programme at Lancaster University,
are helping to progress new, life-saving research.
Hope, Kate and Lily will spend 8 weeks with our researchers at Lancaster University;
developing their cancer research skills. The summer studentships programme we’ve funded
will allow the three young scientists to take their first steps towards a career in research.
Whilst also advancing our world-class medical research and developing new
cancer treatments.
Hope
Hope is 20 and is currently studying for an MSci in Biomedicine at
Lancaster University. She will be working on a skin cancer project which
looks at developing new and more effective treatments for the disease.
Over 100,000 people are diagnosed with skin cancer in the UK every
year, proving the need for such treatments.
Hope will be testing new chemicals that are made to see whether they
might have cancer-killing activity. With Hope’s help over the summer
months, the team will be able to identify new, promising treatments.
Kate
Kate is 19 and studying biomedical sciences at Lancaster University.
She will be researching how cancer develops, using small cell lung
cancer cells. She will be looking at how small cell lung cancers grow, and
whether we can reduce cell growth by removing particular genes. Genes
that can enable uncontrolled cell growth.
Kate will help to identify whether there are links between small cell lung
cancer and some previous research carried out by our scientists.
The project will provide further insight into cancer growth, and provide
new avenues of curable treatments.
Lily
Lily is a second-year MSci Biomedicine student at Lancaster University.
She will be conducting research into the process of chromosome
segregation. She will look at how chromosomes segregate, and how this
process changes in the development of cancers.
Lily will contribute to research that hopes to gain a better understanding
of the segregation process. By understanding this process scientists will
be able to identify new drugs that can kill certain tumour cells.

6. 10 InTouch July 2016 InTouch July 2016 11
Your legacy can help stop cancer sooner
Gifts in wills are very important to North West Cancer Research.
Donate in memory of a loved one
When a loved one passes away, donating to life-saving cancer research is a lasting way to
honour their memory. You can rest assured that any donation – large or small – will make the
world of difference in supporting our extraordinary researchers.
North West Cancer Research
are inspired by the kindness and
generosity of our donors. Their
support, even through difficult times,
strengthens vital, local research
into stopping cancer. Such support
enables our scientists to achieve real
breakthroughs, which are helping to
create a cancer-free future sooner.
Jennifer Higgs (In Memoriam Officer)
and Bobby Magee (Fundraising
Manager) recently visited the residents
at Catherine Court; a Riverside Housing
property in Litherland. The residents
gave a wonderful donation of £65.00
in memory of their friend and
neighbour, Freddie Sloan. Freddie
recently died of throat cancer, after a
courageous battle.
We are so grateful to receive their
support which really does make a
difference to our life-saving work
in the local area. Our researchers
are able to save more lives through
greater understanding of the disease.
Eventhough research can take years
to reach the bedside; without it we
can't save lives. This is why donations
are so vital to continuing our medical
research.
In memory giving is a fitting way to
celebrate the lives of those who were
special to you. Whilst ensuring their
legacy lives on in helping to ease the
impact of cancer for generations to
come.
If you’d like your will to play a part
in beating cancer, please contact
Jennifer Higgs. Call 0151 709 2919,
or email jennifer@nwcr.org for an
informal and confidential chat.
Residents of Catherine Court presenting Bobby and Jennifer with their amazing
donation, in memory of Freddie.
We are so grateful to
receive their support
which really does make
a difference to our
life-saving work in the
local area.
More than a third of funding for NWCR’s
carefully targeted medical research
comes from generous, caring people
who have made the battle to stop
cancer part of their life’s legacy.
It’s easy to do – especially with the
FREE legal support offered by our
trusted partners, McClure Solicitors.
Acting now means we can continue to
make advances in cancer medicine,
that will benefit local people for
generations to come.
Leaving a special gift in your will to
North West Cancer Research, after
you have looked after your family and
friends, will help more people to survive
cancer.
Any gift, large or small, makes a real
impact in easing the impact of cancer
on our communities, and the combined
kindness of the thousands of people
who have already remembered North
West Cancer Research in their will
adds up to something truly amazing.
Breakthroughs in cancer research
can and do happen. Our researchers
know more than ever about cancer
and we are able to save more lives
by discovering new ways to prevent,
diagnose and treat the disease.
But high-quality research takes time,
which is why we need to plan for the
future and ensure that – with your help
– our vital work can continue for many
years to come.
McClure Solicitors offer the following
FREE services.
Free will writing
McClure Solicitors will make your will
free of charge and we hope you’ll
consider helping North West Cancer
Research create a cancer-free future
sooner.
Free will review
Research shows that 1 in 4 wills are
defective or of poor quality. McClure
Solicitors will review your will free of
charge, and we hope you may consider
making a donation to NWCR.
McClure Solicitors also offer a 50%
discount on the cost of setting up a
Lasting Power of Attorney (LPA). An
LPA is a legal document which appoints
someone to act for you if you become
unable to make decisions. McClure
Solicitors will make your LPA at half
price (£180) which also includes a free
Welfare Power of Attorney.
Types Of Legacy
Residuary gift
A residuary gift is a percentage or share
of your estate. It is not affected by
variations in inflation so is one of the
most valuable ways to give. Suggested
wording may include: ‘I give to North
West Cancer Research. Charity
registered in England and Wales no
519357 of 200 London Road, Liverpool,
L3 9TA, (hereinafter called NWCR) the
residue (or % share of the residue) of
my estate absolutely and I direct that
the proceeds may be used for the
general and /or specific purposes of
NWCR as my executors see fit.’
Pecuniary gift
A pecuniary gift is a fixed amount of
money from your estate. Suggested
wording may include: ‘I give to North
West Cancer Research. Charity
registered in England and Wales no
519357 of 200 London Road, Liverpool,
L3 9TA, (hereinafter called NWCR) the
sum of £ and I direct that the proceeds
be used for the general and/ or specific
purposes of NWCR as my executors
see fit.’
You can choose who the Executors
of your will should be. Many people
choose friends, family or a solicitor
to act on their behalf. A will is one of
the most important documents you
will ever make, so it is important to
ensure the wording is correct and the
document is legally binding.
If you’d like your will to play a part
in beating cancer, please contact
Jennifer Higgs by calling 0151 709 2919
or emailing jennifer@nwcr.org for an
informal and confidential chat.

7. 12 InTouch July 2016 InTouch July 2016 13
Local fundraiser, Abby Harding, inspired
to gallop 5K by her mum’s brave battle
with cancer.
Sunday 6th March 2016, was an extra-special Mother’s Day
for fundraiser Abby Harding.
Inspired by the care and treatment
given to her mum during an arduous
battle with cancer, the 28-year-old
marketing manager proudly popped
on a hat in the shape of a horse’s head
and ran round Aintree Racecourse for
Canter for Cancer.
Canter for Cancer is our brand new
5K fun run launched in March 2016.
Participants were asked to run, walk
or gallop their way round the world-
famous Aintree racecourse, wearing
novelty horses heads. Even little ones
got involved as they took on our Only
Foals and Horses course.
Inspired by her mum’s strength and
bravery Abby said her mum Eileen had
almost reached the finishing line in her
recovery from cancer.
But she stressed: “Without the NHS
and the amazing doctors and nurses
– and without the continued research
funded by people like North West
Cancer Research – we may not have
even got to the starting line. We could
“You immediately think of all the worst outcomes. I was
getting married a few months later but this eclipsed
everything.”
Eileen’s family rallied to her side as she underwent
chemotherapy, and while she still faces more treatment,
Abby remains confident.
“We all know more operations will be tough but she’s braver
and stronger than anyone I know and I have complete belief
that the NHS will get her there. They’ve been outstanding,”
she added.
have lost that race before we even
began.”
Abby, who’s from Formby, was one of
thousands who took part in Canter for
Cancer. Supporting the cutting-edge
research funded by us and carried
out by scientists in the North West of
England and North Wales.
“The day that mum told me she had
cancer was the worst day of my life,”
said Abby.
Didyoucanterfor
cancer?Seeifyoucan
spotyourselfinour
Facebookalbum:LINK
...fundraisers like Abby
– whether they collect
thousands or just a
few pounds – make
a real impact on the
continuing fight for a
cancer-free future
Like Eileen, many mums, dads, sons and daughters
throughout the North West of England and North Wales are
bravely confronting cancer.
But fundraisers like Abby – whether they collect thousands
or just a few pounds – make a real impact on the continuing
fight for a cancer-free future.
“Cancer research is so important and Canter for Cancer is
a great way to unite everyone in a common cause to stop
cancer sooner.”
You can find out more about Abby’s story on our website:
http://nwcr.org/why-i-help/abbys-story-headline-tbc
Abby Harding with her mum on Abby’s wedding day

8. 14 InTouch July 2016 InTouch July 2016 15
1 in 2 of us will be touched by cancer at
some point in our lives.
Every year 350,000 new cases of cancer are diagnosed and more than 160,000 people die
from the disease. You are 25% more likely to be diagnosed with cancer in the North West than
anywhere else in the country.
These figures are pretty devastating,
but hope is not lost. More people than
ever before are surviving cancer. We’re
prepared to fight to create a healthier
future for the next generation.
This is why funding cancer research is
so important.
This isn’t a fight we take lightly, so we
only fund the best people and the
best research projects to stop cancer
sooner. Learn more about some of our
life-saving research projects below.
Dr. Jason Parsons- The radiobiology of
proton therapy
The research projects investigates
the DNA damaged induced by proton
therapy, and whether the cancer cells
repair this DNA damage. This work will
ultimately lead to improved proton
therapy procedures for more effective
treatment of cancer.
Dr. Jason Parsons- The molecular
mechanism of the cellular protein
levels in response to DNA damage
The DNA in our bodies is prone to
attack. This creates DNA damage
which can cause mutations and the
development of cancer. To prevent this
our cells contain a repair protein called
NTH1 that corrects the damage to DNA.
Some people with various cancers have
been found to have lower protein levels
of NTH1. The research will uncover
the function of NTH1 in the prevention
of cancer, as well as identifying new
treatment strategies.
Dr. Jason Parsons- The cellular
response to DNA damage
Lower protein levels of OGG1 are
found in patients with head and neck
cancer. But it is unknown how the
body regulates these protein levels,
and prevents cancer development.
This project will reveal the details of
this process and the prevention and
treatment of cancer.
Dr Janine Coombes- Successful
adaptive immunotherapy in cancer
Our immune systems produce ‘natural
killer’ cells which help to rid the body
of cancer and infections. But in some
cancer patients, these cells don’t work
as well. This research examines these
barriers at a molecular level- it’s looking
for a way to adapt these ‘natural killer’
cells so they can kill the cancer cells.
Hopefully offering better treatments
for a range of cancers.
Dr. Clive Price- Understanding tumour
formation
Most cancer cells fail to maintain a
stable genome structure, and this
failure is one of the main causes of
tumour formation. This research look
into the understanding of early events
in tumour formation.
Dr. Sylvie Urbe- How cell signals
control growth and division
The cells in our body continuously
receive signals from our neighbours.
Some signals instruct the cells to grow
and divide. Uncontrolled and excessive
growth leads to the formation of
tumours and cancer. Some of these
signals also cause cancer cells to
spread throughout the body. This
research analyses how these signals
control growth and division, and
whether this can be utilised during
cancer treatments.
Prof. Mark Pritchard- Why some
people with stomach bacterium,
Helicobacter Pylori, are immune from
stomach cancer
Infection of the stomach with a
bacterium called, Helicobacter pylori,
is extremely common, affecting a
third of the UK population. In a small
number of cases this infection can
lead to stomach cancer. This research
looks into why some people develop
stomach cancer, and why others are
resistant. Hopefully this research will
prevent more people from contracting
stomach cancer, as preventative
treatment will improve.
Dr. Barry J Campbell-
Our bowels harbour trillions of
commensal bacteria that are in
close proximity to a single layer of
cells in the lining of the bowel wall.
A critical question has always been
whether these microorganisms
participate in the process of bowel
cancer development. Our research
suggests that these bacteria also
possess the ability to activate cancer
proteins, including those known to
help the growth and spread of bowel
tumours. Further research will tell us
if specific bacteria can trigger early
cancer promoting signals. It is hoped
this research will lead to both new
information and prevention and/or
treatment of bowel cancer.
This is just a snippet of some of the
ground-breaking research projects
we drive. You can find out more on our
website:
http://nwcr.org/how-we%27re-
fighting/funding-research-locally
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9. 16 InTouch July 2016
Contact us
North West Cancer Research Centre,
200 London Road, Liverpool, L3 9TA
0151 709 2919t
Registered Charity
Number 519357
Did you know you can also text a donation?
Just text GIFT37 plus the amount you wish to donate (£1, £5, £10) to 70070.
E.g GIFT37 £5 to 70070. Thank you.
info@nwcr.orge www.nwcr.orgw @NorthWestCancer NorthWestCancer