Aesthefill is made of PLA which stimulates collagen synthesis. This presentation is about characteristics of Aesthefill and how to use it for Aesthetic Medicine. You can watch procedure video on YouTube (https://youtu.be/4MT5a6BWhxE)

1. Face Design with
Aesthefill
Dr. Yonghyun KWON

2. Classification of Filler

4. Biodegradable
synthetic Polymer

5. Conditions for
Biomaterial
생체재료
Biomaterials
생체적합성
Biocompatibility
생체기능성
Biofunctionality

6. Biofunctionality
• chemical stability
• proper mechanical strength
• proper fatigue strength
• plasticity
• possibility of sterilization
• reproducibility

7. Biocompatibility
• non-pyrogenic
• non-allergenic
• non-carcinogenic
• non-toxic
• not inducting thrombosis

8. Polymers Examples
Decomposition
Products
pKa
Poly(⍺-hydroxy
acids)
Poly Glycolic Acid Glycolic Acid 3.83
Poly Lactic Acid Lactic Acid 3.86
Poly(⍵-hydroxy
acids)
Poly-⍷-
caprolactione
5-
Hydroxyhexanoic
acid
4.88
Poly(ester-ether)
Poly(1,4-dioxane-
2-one)
(2-hydroxyethoxy)
acetic acid
3.2

9. Poly Lactic Acid

10. Properties
• PLLA
• crystallinity - 37%
• glass transition temperature - 60~65º
• melting temperature - 173~178º
• PDLA/PLLA
• increased crystallinity
• Higher glass transition temperature

11. Applications
• Medical
• anchors
• Packaging
• Fiber, film
• feedstock material in 3D printers

12. Carboxy
Methyl Cellulose

13. Properties
• sodium salt of carboxymethyl ether of cellulose
• Yield viscous colloidal solution with water
• pH 6.0~8.5
• Thickening agent, stabilizer, suspending agent

14. Aesthefill

15. Characteristics
Contents AestheFill® - REGEN Biotech
Main componen Poly Lactic Acid (PLA)
Required sessions 1~3 sessions, 4~8wks interval
onset time 4~8wks after treatment
duration 1.5 ~ 2 years
structure of particles
Multiporous globular shape
→ easy to inject
Suspension Time 15~30 Minutes, easily hydrated
Particle content
바이알(Vial) Package
※ Total 200mg/Vial (PLA 78%, CMC 22%)
PLA 156mg
CMC 44mg

16. Multi-porous

17. Biodegradation
Biostimulation

18. Biodegradation

19. Biostimulation
 After 2weeks - Cells are brought into the surface of PLA particle and space between particles.
 After 8weeks - Space between PLA particles is filled with cells.
 After 12wks, 20wks - Cells are migrated into PLA particles.

20. Biostimulation
 After 4weeks, new collagen is synthesized by cells settled between multiporous PLA
particle.
 After 12weeks, 20 weeks - Space between particles is filled by collagen. And collagen is
synthesized inside particles.(indicated with yellow arrow)

21. SMAS
• a continuous fibromuscular layer
• a conceptual framework
• consists of type I collagen

22. Volume
augmentation
Collagen synthesis
reinforcement of
fibrous tissue
Lifting
fibrosis
fibroblast
Aesthefill
stimulation
collagen capsule
surrounding

23. Face Design

24. Aging
Descent & Deflation
Holistic and systematic change

25. Lifting with Aesthefill?

26. Aesthefill HA filler1week later

27. 3D Volume lifting
• Gentle lift of facial feature
• Groove and fold
• Restoration of volume
• Younger look
• Friendlier smile
• Facial contouring

28. Combination

29. Dr.Kwon`s formula
• Volume
• Aesthefill diluted with 6cc
• Aesthefill + HA 2~4cc
• Lifting
• Aesthefill diluted with 10~12cc
• Aesthefill + dermotoxin
• Aesthefill + PDO thread

30. Thank you!