Pharmaceutical Inorganic Chemistry, B.Pharmacy I year I semester Subject

1. Dental Products
Mrs. Dipali M.Kulkarni,
Assistant Professor,
Yash Institute of Pharmacy,
Aurangabad.

2. Desensitizing agents, Calcium carbonate,
Sodium fluoride, and Zinc eugenol cement

3. Synonym
:Precipitated Chalk
Molecular Formula:
CaCO3
Molecular weight:
100.1
Standard: Calcium
Carbonate contains
not less than 98.0
per cent and not
more than 100.5
per cent of CaC03,
calculated on the
dried basis
Dose. 1 to 5 g.
It is an ex of
dentifrices
Description. A fine,
white,
microcrystalline
powder.
Assay:
Complexometric
titration
Titrant: 0.05 M
Disodium edetate
Indicator: Calcon
mixture
End point: Pink to
full blue colour
Calcium carbonate Monograph

4. Tests:
Substances
insoluble in acetic
acid: NMT 10 mg
Arsenic: NMT 4
ppm
Heavy metals:
NMT 20 ppm
( Method A)
Barium
Iron: NMT 200
ppm
Chloride: NMT
250 ppm
Sulphates: NMT
0.3 %
Loss on drying:
NMT 2 %
Calcium carbonate Monograph

5. Desensitizing agents
• Dentin Hypersensitivity is characterized by short sharp
pain arising from exposed dentin in response to stimuli—
typically thermal, evaporative, tactile, osmotic or
chemical—that cannot be ascribed to any other dental
defect or disease.
• it is sensation felt when the nerves inside the dentin
are exposed to the environment
• The sensation can range from irritation all the way to
intense, shooting pain.
• This sensitivity can be caused by several factors;
wear , decaying teeth or exposed tooth roots

6. Comparison between healthy and sensitive tooth

7. Broken tooth
Sometimes, it is
temporary
• Gastroesophageal reflux
disease (GERD)
• Conditions in
which person
frequently vomits.
I.e.
Gatrioparesis or
bulimia
• Gum recession
• Worn down fillings /crowns
• Tooth decay
Chipped tooth
• Injured tooth
treatments such as filling,
crowning and bleaching
Causes of sensitivity

8. Zinc oxide eugenol cement
• Zinc oxide eugenol (ZOE) is a material
Created by the combination of zinc oxide and eugenol contained in oil of cloves.
• An acid-base reaction takes place, formation of zinc eugenolate chelate
reaction is catalysed by water
accelerated by the presence of metal salts.
• It has anaesthetic, anti-bacterial properties.

9. Component Approximate w/w
%
Function
Solids
Zinc Oxide 69 % Principal ingredient
White Rosin 29.3% Reduce brittleness of set cement
and maintain homogeneity
Zinc acetate 1.0% Accelerator, improve strength
Zinc stearate 0.7 % Accelerator, plasticizer
Liquids
Eugenol 85% Reacts with ZnO, act as
anaesthetic
Olive Oil 15% Plasticizer
Composition of ZOE

10. • Type –I
ZOE: for
temporary
cementation
• Type –II ZOE:
for permanent
cémentation
• Type III ZOE:
for temporary
filling and
thermal base
• Type
IV ZOE:
cavity
liner
Classification of Zinc oxide Eugenol (ZOE)

11. can only be treated with the removal of the nerve (pulp) called root canal therapy.
This condition usually leads to severe chronic tooth sensitivity or actual toothach
severely inflamed and precipitates a condition called acute or chronic pulpitis.
reacts badly to the drilling stimulus (heat and vibration),
Because the tissue inside the tooth ,i.e. pulp,
when decay is very deep or very close to nerve or pulp chamber.
often used in dentistry
Uses
1. ZOE can be used as a dental filling material or dental cement in dentistry.

12. 2. The placement of a ZOE "temporary" for a few to
several days prior to the placement of the final
filling can help to sedate the pulp.
3. ZOE is used in mucostatic in a technique of taking
impressions of gum and teeth
4. It is used as pulp capping agent.
5. Commonly used as cavity liner under dental
amalgams or as temporary filling material.

13. Important Questions
• Discuss the role of fluoride in Dental caries
• Define Dentifrices, Anti-caries agents,
Desensitizing agents with examples.
• Monograph- Calcium carbonate,
Sodium Fluoride, Zinc Eugenol cement
• What are dental products? Discuss their
composition and role.
• What are anti caries agents? Discuss in detail.