Presentation for The International Congress of Young medical Scientist in Poznań.

1. Wojciech Francuzik
Aleksandra Skłodowska
Tutor: Prof. Zygmunt Adamski
Dermatology Interest Group,
Student Scientific Society of
Poznan University of Medical Sciences

2. EPIDEMIOLOGY
TIME
GEOGRAPHICAL
REGION
RESISTANCE TO
ANTIMYCOTICS

3. Examination of
medical
histories of ICU
patients with
fungal infections
Database
creation based
on mycological
diagnosis
Exclusion of
non-Candida
species

4. Divisionintogroups
C. albicans
C. glabrata
C. Tropicalis
C. krusei
Mixed group

5.  1) mycological diagnosis given by the
mycology lab based on samples acquired in
the medical ICU,
 2) patient age and gender,
 3) medical procedures that the patient
underwent,
 4) comorbid conditions that the patient
suffered from.

6.  1. What were the most common pathogenic
factors?
 2. Did the occurence differed in various age
groups?
 3. Did diferent species were related to
different comorbid conditions
 4. Did infection corellated with higher death
risk? And for what comorbid conditions.

7. 0
10
20
30
40
50
60
70
80
Our Study
1996-2000

8. Histogram of patients’ age
Age

9. 0
10
20
30
40
50
60
70
80
90
18 – 39 40 – 59 60 – 79 80 +
C. albicans [N (%)]
C. glabrata [N (%)]
C. tropicalis [N (%)]
C. krusei [N (%)]
Mixed

10. 0
10
20
30
40
50
60
70
80
90
Diabetes
mellitus
Renal
insufficiency
Cirrhosis Renal
replacement
therapy
C. albicans
C. glabrata
C. tropicalis
C. krusei
mixed group

11. Factor p value/
Age above 80 years 0.0011
Male gender 0.0070
Renal insufficiency 0.0120
Diabetes mellitus 0.0203
Hepatic insufficiency 0.0053
Renal replacement therapy 0.0388

13.  C. glabrata increases in numbers and is
linked to diabetes
 Emergence of previously uncommon species
 C. krusei and concomitant diseases
 Fatal therapy outcomes
 Drug susceptibility (AST)
 Fluconazole prophylaxis