Introduction to IntegenX--a company that is providing integrated systems for Genomic sciences

1. Advanced Systems for Rapid Human Identification
and Next Generation Sequencing
Stevan Jovanovich, Ph.D.
Proprietary and IntegenX Confidential | 6/27/2012

2. Overview
Who We Are
• Growth-stage life science company, with commercial
operations
• Next Generation Sequencing products on the market
• RapidHIT™ 200 Rapid Human ID System launching
in Q3
• 2011 revenues of $4.5M: expected to more than
triple in 2012
• All products covered by proprietary and/or >500
licensed patents
• $75M in private equity; $24M in grants and contracts:
DARPA, DTRA, DHS, NIH
2 | Proprietary and IntegenX Confidential | 6/27/2012

3. Experienced Executive Management Team
Stevan Jovanovich, Ph.D. – Co-Founder & CEO
• VP of Global Research at Amersham Biosciences
• ~$100 M funding at IntegenX with over 40 patents and publications
Dennis Harris, Ph.D. – Co-Founder & CSO
• CSO at Millipore and Serologicals Corporation
• VP R&D North America Amersham Pharmacia Biotech
David Smith – COO
• CFO at Thoratec, Chiron, and Anergen
• Leadership positions at Genentech, IBM and Syntex in North America, Asia and Europe
Howard Goldstein – EVP, Commercial Affairs
• 30+ years sales and marketing leadership building companies
• VP Molecular Devices, Amnis, Incyte, MDCC; CEO at Entigen and Arcxis
Ezra van Gelder – EVP, Research & Development
• 20+ years engineering management
• VP Development GE Healthcare, KLA Tencor
Debara Frost – VP, Operations
• VP Operations at Applied Biosystems
• VP Customer Services and Distribution at Applied Biosystems
3 | Proprietary and IntegenX Confidential | 6/27/2012

4. Product Solutions
Rapid Human Identification – RapidHIT™ 200
Need Rapid answers for DNA human identification for defense,
law enforcement, IQ, and DHS agencies
Solution Sample-to-answer in less than 90 min
Market DNA-based rapid identification $5B market in 2015
Next-Gen Sequencing Library Preparation – Apollo™ 324
Need Human error and lack of platform flexibility in DNA and RNA
sequencing prep
Solution Walk-away automation that serves multiple sequencing platforms
Market $2B total sequencing market
Room Temperature Stabilization and Storage – GenPlate™ and GenTegra™
Need Eliminate -80°C and cold chain
Solution Inorganic stabilization and protection
Market DNA-RNA based sample storage U.S. market $1B in 2015
4 | Proprietary and IntegenX Confidential | 6/27/2012

5. DNA Forensics and Rapid Human Identification
DNA is the ultimate biometric
• Personal, but shows identity and kinship
• Almost impossible to disguise or change
• DNA evidence is standard in many parts of the world
• CSI effect
Short Tandem Repeats (STR) of DNA
are used to identify people
In the US, 13 STRs are used in the
Combined DNA Index System (CODIS)
Rapid DNA identification opens up new horizons
• Screening of arrestees, detainees, immigrants, and evidence
• Actionable intelligence
5 | Proprietary and IntegenX Confidential | 6/27/2012

6. Rapid Human Identification: RapidHIT™ 200
The traditional HID process can take days to months:
In Out
Swabs DNA
Blood Identity
Semen
Etc.
Sample in, profile out
Results in <90 minutes
Minimal training required
Point-of-action solution
Produces CODIS data and can query
databases to give answers
6 | Proprietary and IntegenX Confidential | 6/27/2012

7. RapidHIT™ 200: The Complete Human ID Solution
Sample
3 Control
4 Swabs
1 Anode
2 Buffer
7 | Proprietary and IntegenX Confidential | 6/27/2012

8. RapidHIT™ 200 results data 02-29-2012
Sample 60M Buccal Swab
Capillaries 2 and 6
8 | Proprietary and IntegenX Confidential | 6/27/2012

9. RapidHIT ™ 200
Heterozygous peak balance is excellent
Sample Sample
Cap2: 60M Buccal Cap6: 60M Buccal
Alleles Pk Ht (rfu) Pk Ht (rfu) PHR(%) Alleles Pk Ht (rfu) Pk Ht (rfu) PHR(%)
D3S1358 17,17 100882 n/a n/a D3S1358 17,17 110501 n/a n/a
THO1 6,7 13284 15819 84.0% THO1 6,7 16201 21311 76.0%
D21S11 28,30 42017 37641 89.6% D21S11 28,30 44578 48880 91.2%
D18S51 13,14 59075 54996 93.1% D18S51 13,14 61880 61370 99.2%
PentaE 7,10 32751 32799 99.9% PentaE 7,10 34899 30145 86.4%
D5S818 12,12 137731 n/a n/a D5S818 12,12 144917 n/a n/a
87% 83%
D13S17 9,13 45463 40397 88.9% D13S17 9,13 53851 36820 68.4%
D7S820 10,11 56523 44707 79.1% D7S820 10,11 48710 46579 95.6%
D16S539 8,12 29209 23011 78.8% D16S539 8,12 18606 27570 67.5%
CSF1PO 10,12 30609 38897 78.7% CSF1PO 10,12 29716 29261 98.5%
PentaD 11,13 35174 30636 87.1% PentaD 11,13 46835 28881 61.7%
Amel X,Y 37292 33314 89.3% Amel X,Y 36597 40877 89.5%
vWA 15,18 19084 21006 90.9% vWA 15,18 27689 20669 74.6%
D8S1179 13,13 49611 n/a n/a D8S1179 13,13 54902 n/a n/a
TPOX 9,10 6724 5765 85.7% TPOX 9,10 6230 6932 89.9%
FGA 19,19 19350 n/a n/a FGA 19,19 15718 n/a n/a
9 | Proprietary and IntegenX Confidential | 6/27/2012

10. Rapid DNA-based Human Identification Markets
Law Enforcement
• Real-time screening of arrestees
• Property crimes and non-evidentiary samples
• Forensic identification and casework samples
• Terrorists and organized crime
12 | Proprietary and IntegenX Confidential | 6/27/2012

11. RapidHIT 200 Will Help Solve Property Crime
DNA is highly effective for property crime investigation
Backlogs in crime labs typically prevent use of DNA for property crimes
Deployment of RapidHIT 200 will allow police to quickly focus
investigations and clear cases
Start of DNA use for
high volume crimes
Effectiveness and Cost Efficiency of DNA Evidence in Volume Crime - Denver Colorado Site Summary
Simon Ashikhmin et al
15 | Proprietary and IntegenX Confidential | 6/27/2012

12. Rapid DNA-based Human Identification Markets
Defense
• Identifying the opposition in
asymmetric warfare
• Field-based antiterrorism
• Identifying suspects in raids
• Using DNA to unravel the
network
• Linking IEDs to bomb makers
• Finding captured soldiers
IntegenX is funded to develop
and deliver systems to DoD
16 | Proprietary and IntegenX Confidential | 6/27/2012

13. DoD Field Demonstration, May 2012
DoD Joint Forces Invite-Only Capabilities Demonstration
• Goal = Field forward capabilities for the war-fighter
(Actionable Intelligence)
• Format = Hands-on, tactical scenarios
Week 1 - Prove your technology
• Operational by non-expert personnel - 9 min training
• Enrolled additional 30 exercise participants in database
• Correctly identified all blind samples using the database
Week 2 - Stretch goals and collaboration
• Demonstrated RapidHIT 200 could be used in a mobile
environment
• Demonstrated ability to do additional sample types—contact
lens, eye, ear, and nose swabs, blood, cigarette butts, hat, etc.
• Trained others to train others
IntegenX was featured at the VIP day
17 | Proprietary and IntegenX Confidential | 6/27/2012

14. Additional Product Lines
Apollo 324™ Next Generation Sequencing
Library Preparation System
19 | Proprietary and IntegenX Confidential | 6/27/2012

15. Apollo 324™: The Complete Solution
Apollo 324
Supports • Fully automated
• Illumina • 1¼ - 7 hours per run
• Roche 454 • Up to 32 libraries
• Life Tech PGM • Platform agnostic
• Life Tech • Simple user interface
SOLiD • Ready-to-Use™
Reagents
• $79,500 List price
• $55/sample for reagents
Simplest and most versatile library preparation solution
20 | Proprietary and IntegenX Confidential | 6/27/2012

16. Apollo 324™ Kits
2011 Releases
• PrepX: 8 sample kit for Illumina DNA analysis
• PrepX 32: 32 sample kit for Illumina DNA analysis
• PrepX High: High cut for DNA samples such as ChIP-Seq
• PrepX SPIA RNA-Seq: NuGEN SPIA chemistry for RNA-Seq
2012 Q1 Releases
• PrepX 32 Indexed: 32 sample indexed DNA
• PrepX PGM DNA Library: Ion Torrent DNA kit
• PrepX 454 DNA Library: FLX kit for Roche/454
2012 Q2 Releases
• PrepX2: ~One hour 8 sample DNA Kit
• PrepX2 Exome DNA app note for DNA exome sequencing
2012 Q3 Releases
• PrepX Total RNA: High performance lower cost RNA 8 sample kit
• PrepX Small RNA: 8 sample kit for small RNAs
2012 Q4 Releases (anticipated)
• TissueX: Process raw tissue to DNA libraries
• PrepX2 48: 48 fast samples
21 | Proprietary and IntegenX Confidential | 6/27/2012

17. IntegenX Summary
IntegenX is a leader in sample preparation and sample-to-
answer solutions
IntegenX’s NGS platform is the simplest and most versatile
library preparation solution
Huge market opportunity in human identification
• Sample-to-answer rapid human ID is now a reality
• Rapid human identification will be a “killer app” that transcends life
sciences
This market crosses multiple disparate segments
• Law enforcement, defense, immigration
• Life science tools, molecular diagnostics, applied markets, and
consumer markets
IntegenX leads the Rapid Human Identification market
22 | Proprietary and IntegenX Confidential | 6/27/2012

18. www.integenx.com
Proprietary and IntegenX Confidential | 6/27/2012