Smart automation presentation 2011

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  • HigherworkloadMore ptn casesMore test per case, includingincreasingimportannce of MolecularDiagnosticsIncreasedqualityrequirements: reproducibility of results
  • Quote: By doing more of the same no new results can be expectedQuote: ‘’Your current safe boundries were once unknown frontiers.’’
  • There are four chambers in Xpress. 1 and 2 there are microwave and a agitation with airbobbles.2 and 3 heat and vacuum
  • Smart automation presentation 2011

    1. 1. SMART Automation Presentation
    2. 2. Agenda1 Introduction Sakura Finetek2 Workflow Management3 SMART Automation4 Customer & Patient Perspective 2
    3. 3. Dedicated to Histopathology We provide our customer in histopathology laboratories worldwide with reliable, high quality products and support, while pursuing continuous improvement, customer satisfaction, market leadership and a positive employee work environment. 3
    4. 4. Sakura Core Values Reliability High Quality Innovation Customer Added Value 5
    5. 5. Continuous innovationSetting the standard 1871 1914 1972 1979 1987 2004 2008 6
    6. 6. Serving the histopathology world Sakura Finetek Sakura Finetek Sakura Finetek USA., Inc. Europe B.V. Japan Co., Ltd. 7
    7. 7. A complete product lineGrossing & trimming Identification Tissue Processing Tissue Embedding Microtomy Staining Coverslipping Cryotomy Cytology Filing & Archiving 8
    8. 8. Challenges in histopathologyDoing more with less• Higher workload• Turnaround time An inefficient lab• Shortage of skilled staff Bottlenecks• Cost pressure Waiting time• Safety requirements No standardisation Multiple protocols• Increased quality requirements• Competitive working environment 9
    9. 9. Continue like this? 10
    10. 10. Or, be SMART! 11
    11. 11. A Rapid, Efficient & ConsistentQuality Lab Removing Bottlenecks & Standardisation Increase Same Day DiagnosisReducing waiting time and errors Create a continuous workflow Efficiency and Quality 12
    12. 12. Remove bottlenecks and waiting time:Increase same day diagnosis Conventional Process Waiting/ Batching 1x per day 10 - 12 hours SMART Automation Process Every 15 min 1 hour 13
    13. 13. Average processing turnaround times:Superior performance Xpress ® x Series Overnight processing 20 hours Multi-batch processing 8 hoursContinuous Processing 1,5 hours* Average processing turnaround times include waiting time (Source: SMART Analysis Tool) 14
    14. 14. Same Day Results:Superior performance Xpress® x Series 100% Before-Xpress 90% Xpress 80% 70% 60% 50% 40% 30% 20% 10% 0% Same day 2 days 3 days >3 days 80% same day results after using Xpress 11.) Rapid response, Molecular Friendly Surgical Pathology, Morales et al, Journal of American College of Surgeons, Vol. 207, September 2008 15
    15. 15. Creatinga Continuous Efficient WorkflowTuesday 15:00 14:30 14:00 13:30Monday Grossing Processing / Xpress Embedding / AutoTEC Microtomy Staining 08:30 11:30 Delivering / Microscopy 08:00 11:00 07:00 17:00 16
    16. 16. Increasing efficiency & productivity:Batch process vs Continuous process Batch process Continuous process Occupancy of shift Conventional Technicians (per 60 min) Occupancy of shift Automation Technicians (per 60 min) 8.0 8.0 Occupancy (number)Occupancy (number) 6.4 6.4 4.8 4.8 3.2 3.2 1.6 1.6 0 0 6 7 8 9 10 11 12 13 14 15 16 17 6 7 8 9 10 11 12 13 14 15 16 17 Time Time 17
    17. 17. SMART AutomationPowered by Sakura 18
    18. 18. Tissue-Tek® AutoWrite®Cassette & Slide Printers Efficiency • Continuous printing supporting a LEAN workflow • Ease of use with stacked cassettes • Full flexibility of all tissue carriers Speed • Rapid printing, up to 900 cassettes/ 800 slides per hour • Convenient & rapid loading and unloading Quality • High quality 1D, 2D bar coding, graphics for easy and reliable identification • Compliant with SIX Sigma principles • Connectable to LIMS & stand alone computer 19
    19. 19. Accu-Edge®Grossing Tool System Quality • Standardization of grossing leading to consistent quality • Successful LEAN and SIX Sigma implementation • Quality Management demands standardization • In-place Quality Management is required for laboratory accreditation Efficiency & speed • Error reduction • Less delays later in the process • Overall process improvement 20
    20. 20. SMART AutomationPowered by Sakura 21
    21. 21. Tissue-Tek ® Xpress® x Series Efficiency • Continuous efficient workflow/ Loading every 20 minutes: • Workload leveling & Increased productivity • Reduced levels of stress: Fewer human errors and rework  Reduced cost • Reagent volume reduction of more than 80% Speed • Standardized 1-hour processing/ Loading every 20 minutes • Throughput of 120 cassettes/ to 960 cassettes in an 8-hour shift • Unmatched same day diagnoses for all tissue types • Reduced patient waiting time Quality • Excellent morphology and sharp nuclear details due to gentle microwave technology • Standardized reproducible results: QC ready to use reagent kits • Future ready: All results on one block including molecular studies • Formalin- and xylene free processing 22
    22. 22. Tissue-Tek ® Xpress® x SeriesTissue-Tek® Xpress® x120 Tissue-Tek® Xpress® x50• Throughput of 120 cassettes per hour yielding to • Throughput of 50 cassettes per hour yielding to a continuous throughput of up to 960 cassettes a continuous throughput of up to 400 cassettes in an 8-hour shift in an 8-hour shift• Load up to 40 cassettes every 15 minutes • Load up to 40 cassettes every 40 minutes 23
    23. 23. How does it work?SMART Automation and Intelligent Design• Unique retort design with novel microwave technology and advanced robotics• Reduced reagent carryover• Intuitive menu screens and reporting tool• Compatible with the AutoTEC® and Paraform® 24
    24. 24. How does it work? 15 min 15 min 15 min 15 min MW MW Heat Heat Agitation agitation Vacuum Vacuum Acetone Acetone Isopropanol Isopropanol Paraffin Paraffin Others Others 1-40 Cassettes
    25. 25. How does it work?Complete Tissue Processing with only 2 reagents• Low power microwave and reliable vacuum technology• Circular microwave patterns• Eliminate hot and cold spots• Continuous throughput• All specimens processed in the same program 26
    26. 26. How does it work?Novel System of Reagents for Distinct Detail• Includes an exclusive paraffin formulation• Preserves DNA, RNA, and proteins• Eliminates the use of formalin and Xylene, minimizing waste management costs• Virtually eliminates chemical exposure due to closed system• Features easy-to-use processing reagent sets 27
    27. 27. SMART AutomationPowered by Sakura 28
    28. 28. Tissue-Tek® AutoTEC® & Paraform® Efficiency • Fully automated embedding • A continuous efficient workflow • Free up capacity for more value adding work Speed • Continuous loading and unloading • 120 cassettes per hour/ Loading every 15 minutes • Perfect fit with Tissue-Tek® Xpress® x Series® • Same throughput: 120 cassettes per hour Quality • Eliminating orientation mistakes, mix up and tissue loss • Usage of one magazine, identical paraffin wax 29
    29. 29. Tissue-Tek® AutoTEC® & Paraform®Twelve Paraform® outer frame colors Six Paraform® inner cassettes types 30
    30. 30. Tissue-Tek® AutoTEC® & Paraform®Six Paraform® inner cassettes types• Paraform® Standard Cassette• Paraform® Biopsy Cassette• Paraform® Orientation Cassette• Paraform® 13*13 Biopsy Cassette• Paraform® Core Biopsy Cassette• Paraform® Shaved Biopsy Cassette 31
    31. 31. Tissue-Tek® AutoTEC® & Paraform®Principles• Create a gentle workflow• Create a higher productivity. – 120 blocks an hour are embedded• Blocks will have a consistent quality• Orientation is preserved by the special design of the Paraform® Cassettes• Paraform Cassettes are compatible with all existing methods, like printing, processing and microtomy 32
    32. 32. Operation of the Paraform® Cassette Place the inner cassette 1 in the outer frame on a flat surface Position the cassette underneath the 4 tabs 2 Place the tissue sample in the center of the cassette 3 Close the lid 4 33
    33. 33. Operation of the AutoTEC® Cassettes are placed in magazine 1 Magazines are loaded 2 Each cassette is picked from magazine one by one 3 Cassette type is identified Cassettes are placed in pre-heated basemolds 4 34
    34. 34. Operation of the AutoTEC® Stager pushes down the cassette through the frame 1 A precise amount of paraffin is dispensed Basemold cools to form a solid block 2 Block is removed from basemold and presented to sensors Paraffin block is placed in one of the output doors 3 Consistent quality blocks ready for microtomy 4 35
    35. 35. SMART AutomationPowered by Sakura 36
    36. 36. Tissue-Tek® Prisma® & Film® Efficiency • True walk-away staining and coverslipping • Automated transfer from stainer to coverslipper • A continuous efficient workflow • Unmatched capacity, up to 11 runs of 60 slides simultaneously Speed • Unmatched speed, 660 slides per hour • Full flexibility in staining protocols and batch size with reagent reservoirs of 160 mL, 260 mL and 680 mL • Multiple programs at the same time (routine and specials) Quality • Long lasting protection with adhesive backed polymer film • Air bubble detector guarantees bubble free coverslipping 37
    37. 37. SMART AutomationClient Perspective 38
    38. 38. Hillerød hospital:Not only figures but real life resultsWe are now delivering a better service to more patients The workflow is steady and there are no batches to face each morning, staff are no longer so stressed. The increased automation, as well as other innovations resulting from LEAN, have lead to a greatly improvedHanne Bjørn, Senior Chief Biomedical workflow and processing time, and reduced standby time.Laboratory Scientist, HillerødHospital, Denmark Our improvements have had a knock-on effect on the cytology lab personnel who have also increased output and become more patient focused. Source: Clinical Lab Magazine 39
    39. 39. Maastricht University Medical Centre:Faster Diagnosis of CancerNow, diagnoses are made within two hours. Continuously. Malignant tumours can be diagnosed within a few hours without any concessions to quality. New cassettes can be loaded every fifteen minutes on the Xpress without unnecessary waiting.Professor Axel zur Hausen, Chair of thePathology Department at MaastrichtUniversity Medical Centre. It is an improvement that we no longer have big stacks of specimen to process. In addition, it decreases the chance of making mistakes “A quick and reliable diagnosis implies that treatment can be started sooner. Source: Clinical Lab Magazine 40
    40. 40. SMART AutomationPatient Perspective 41
    41. 41. 42
    42. 42. Be SMART A continuous efficient workflow Improved Unmatched same day results patient care A consistent high quality 43

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