Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Neuropsychiatric aspects of HIV

369 views

Published on

Neuropsychiatric aspects of HIV

Published in: Health & Medicine
  • Be the first to comment

Neuropsychiatric aspects of HIV

  1. 1. HIV/AIDS Fact sheet N°360. http://www.who.int/mediacentre/factsheets/fs360/en/ (accessed )
  2. 2. http://www.aidsdatahub.org/Country-Profiles/India
  3. 3. (i) Direct effects of HIV on brain. 1. Delirium 2. HIV-associated neurocognitive disorder (HAND) (ii) Vulnerability of Persons with severe mental illness to HIV infection. 1. Mood disorders 2. Schizophrenia 3. PTSD 4. Personality disorders
  4. 4. i) Chronic course of HIV infection and the associated stigma.
  5. 5. (HIV-associated neurocognitive disorder)
  6. 6. Serena Spudich. HIV and Neurocognitive Dysfunction. Curr HIV/AIDS Rep 2013; 10(3) 235-243
  7. 7. Cellular & molecular basis of HIV associated Nueropathogenesis, Indian J Med Res; 129:Jun 2009,637-51.
  8. 8. Cellular & molecular basis of HIV associated Nueropathogenesis, Indian J Med Res; 129:Jun 2009,637-51.
  9. 9. HAND HIV-associated neurocognitive disorders ANI HIV-associated asymptomatic neurocognitive impairment Cognitive impairment involving at least two cognitive domains (performance of at least 1 SD below the mean for norms on neuropsychological tests) The cognitive impairment does not interfere with everyday functioning. MND HIV-1-associated mild neurocognitive disorder Cognitive impairment involving at least two cognitive domains (performance of at least 1 SD below the mean for norms on neuropsychological tests) The cognitive impairment produces at least mild interference in daily functioning
  10. 10. HAD HIV-1-associated dementia (HAD) Marked cognitive impairment involving at least two cognitive domains (performance of at least 2 SD below the mean for norms on neuropsychological tests) The cognitive impairment produces marked interference with day-to-day functioning
  11. 11. HOST FACTORS VIRAL FACTORS GENETICS- Apoprotein Eo4 Allele AIDS Metabolic disorder Immune Activation levels Aging –phosphorylate tau proteins HIV Subtypes Vascular disease Drug resistance Anemia CD4 Count Malnutrition Co-infection Substance abuse  All of them lead to chronic inflammation
  12. 12. Neurocognitive Dysfn Pre HAART POST HAART HAND 35 % 44 % HAD 14 % 2 % MND 5 % 10 % ANI 10 % 32 % Justin C. McArthura and Bruce J. Brew,HIV-associated neurocognitive disorders: is there a hidden epidemic? AIDS 2010, 24:1367–1370
  13. 13. Diagnosis Implicated agents Depression Abacavir, Efavirenz(mc), Indinavir, Nevirapine, IFN-α, Steroids, INH. Mania Didanosine, Efavirenz, Zidovudine. Psychosis Abacavir, Efavirenz, Nevirapine, Acyclo/Ganciclovir, Prednisone. Anxiety Didanosine, Gancicylovir. Vivid dreams Abacavir, Nevirapine, Efavirenz. Suicidal ideation Abacavir, Efavirenz.

×