This document discusses various substances that can cause coma through exogenous intoxication, including their mechanisms of action, signs and symptoms, diagnosis, and treatment. It covers ethylene glycol, which is metabolized to toxic acids responsible for metabolic acidosis and tissue injury. It also discusses barbiturates as CNS depressants, methanol which is metabolized to the toxic compound formic acid, benzodiazepines which act as GABA agonists, and opioids which act through mu, kappa, and other receptors to cause respiratory depression, analgesia, and sedation. Signs of overdose include coma, seizures, and respiratory failure. Treatment focuses on supportive care, decontamination, and use of ant
2. a prolonged state of deep
unconsciousness, caused
especially by severe injury
or illness.
What is coma???
3. Ethylene glycol
Barbiturates
Methy alcohol
Benzdiazepine
opioids
Main subtances causing COMA
4. ETHYLENE GLYCOL:MECHANISM OF
POISONING.
Ethylene glycol is metabolized by alcohol dehydrogenase to
glycoaldehyde, which is then metabolized to glycolic, glyoxylic, and
oxalic acids. These acids, along with excess lactic acid, are
responsible for the anion gap metabolic acidosis. Oxalate readily
precipitates with calcium to form insoluble calcium oxalate crystals.
Tissue injury is caused by widespread deposition of oxalate crystals
and the toxic effects of glycolic and glyoxylic acids.
5.
6. SIGNS AND SYMPTOMS OF
POISONING
seizures
coma
cerebral edema (in some cases)
tachycardia
tachypnea, and
hypertension or hypotension
flank pain,
costovertebral angle tenderness, and
oliguric renal failure
7. DIAGNOSIS
Laboratory tests which include
complete blood count
serum electrolytes
alcohol toxicology panel with ethanol,
blood urea nitrogen
urinalysis
serum ethylene glycol level
calcium and magnesium levels
8. ANTIDOTE:ETHANOL AND
FOMEPIZOLE
Fomepizole
It is thought to act as an inhibitor of alcohol dehydrogenase and
therefore prevent the formation of acidic ethylene glycol metabolites.
It is adminstered in divided doses
-Loading dose, 15 mg / kg
-Maintance dose 10 mg / kg q4h
9. Administer fomepizole or ethanol to saturate the enzyme alcohol
dehydrogenase and prevent metabolism of ethylene glycol to its toxic
metabolites
Ethanol (ethyl alcohol) acts as a competitive substrate for the enzyme alcohol dehydrogenase, preventing the metabolic
formation of toxic metabolites from methanol or ethylene glycol
10. BARBITURATES:MECHANISM
OF ACTION
All barbiturates cause generalized depression of neuronal activity in
the brain. Interaction with a barbiturate receptor leads to enhanced
gammaaminobutyric acid (GABA)-mediated chloride currents and
results in synaptic inhibition. Hypotension that occurs with large
doses is caused by depression of central sympathetic tone as well as
by direct depression of cardiac contractility.
11. BARBITURATES:
Non-selective CNS depressants.
Derivatives of barbituric acid (2,4,6- trioxo
hexa hydro pyrimidine).
Popular sedative & hypnotics up to 1960’s.
Can produce effects ranging from sedation &
reduction of anxiety to unconsciousness &
death from respiratory & cardio vascular
failure.
USES:
Sedative & hypnotic.
Pre operative sedation.
Treatment of seizure disorders.
12. MECHANISM OF TOXIC
EFFECTS
Direct CNS depressants.
Bind to GABA receptors
Potent inducer of hepatic drug-
metabolising enzymes especially CYP450
system, so liable to cause drug interactions.
Precipitate attacks of acute porphyria.
Tolerance & dependence occur.
Prolong the opening of chloride
channel
Inhibiting excitable cells of the CNS
13. ACUTE BARBITURATE
POISONING
Leading cause of poisoning due to
their ready availability.
Most of the cases are suicidal but
some are due to error or ungraded
exploration in children.
Short acting barbiturates are more
dangerous than long acting.
Shock & anorexia occur quickly.
Coma is more severe with short acting
barbiturates.
20. SUPPORTIVE THERAPY
Administer activated charcoal, if available
Administer activated charcoal. Consider gastric lavage for massive ingestion
Enhanced elimination
1. Alkalinization of the urine (see p 55) increases the urinary elimination of
Phenobarbital but not other barbiturates. Its value in acute overdose is
unproved, and it may potentially contribute to fluid overload and pulmonary
edema.
2. Repeat-dose activated charcoal has been shown to decrease the half-life
of Phenobarbital, but it has not been shown to actually shorten the duration
of coma.
3. Hemoperfusion or hemodialysis may be necessary for severely intoxicated
patients not responding to supportive care (i.e., with intractable
hypotension).
22. MECHANISM OF ACTION
METHANOL FORMALDEHYDE FORMIC
ACID
ALDEHYDE DEHYDROGENASEALCOHOL DEHYDROGENASE
METHANOL ITSELF NOT TOXIC. FORMALDEHYDE VERY TOXIC, BUT VERY
RAPIDLY METABOLISED TO FORMIC ACID. FORMIC ACID RESPONSIBLE
FOR THE TOXICITY RELATED TO METHANOL INGESTIONS
23. MECHANISM OF ACTION
METHANOL
FORMALDEHYDE
FORMIC
ACID
ACIDOSIS
Early stage
of poisoning
ACIDOSIS
TISSUE
HYPOXIA
LACTIC ACID
PRODUCTION
CIRCULATORY
FAILURE
GENERAL TOXICITY
INCREASED FORMIC ACID TOXICITY
OCULAR
TOXICITY
INHIBITION OF MITOCHONDRIAL RESPIRATION
CIRCULUS
HYPOXICUS
24. SIGNS AND SYMPTOMS
In small doses Dizziness (vertigo)
Headache
Nausea & Vomitting
Abdominal pain
In Moderate doses Tachy cardia
Drowsiness
Mydriasis (dilation of the pupil)
In High doses Metabolic Acidosis
Convulsions
Retinal Oedema
COMA
Respiratory failure and death
25. SIGNS AND SYMPTOMS
CNS – CONVULSIONS, PROGRESSING TO COMA
RETINAL - BLURRED VISION, PHOTOPHOBIA, VISUAL
ACUITY LOSS, DILATED NON-REACTIVE PUPILS,
OPTIC NERVE BECOMES OEDEMATOUS
GIT - NAUSEA, VOMITING
CARDIAC - TACHYCARDIA, HYPERTENSION PROGRESSING
TO HYPOTENSION AND CARDIOGENIC SHOCK
RESPIRATORY - TACHYPNOEA
29. MODE OF
ACTION:
Benzodiazepines
Stimulating GABA b receptors
Opening up the chloride ion
channel in the receptor complex
↑se conductance of chloride ion
across the nerve cell membrane
Lowers the potential difference
btwn the interior & exterior of the
cell
Blocking the ability of the cell to
conduct nerve impulses
30. BENZODIAZEPINES
Anxiolytic & hypnotic agents.
Wide therapeutic index.
Safest of all sedative drugs.
USES:
Management of
Anxiety disorders
Seizure disorders
Insomnia
Movement disorders (adjunctive therapy)
Mania (adjunctive therapy)
31. MECHANISM OF
TOXICITY:Toxic symptoms-sedative action on the CNS.
Large doses-neuromuscular blockade .
Intravenous injection-peripheral vasodilation -fall
in BP, shock.
↓se alveolar ventilation (↓se PO2 , ↑se PCO2 ).
Induce CO2 narcosis in persons with COPD.
Respiratory depressant effect with sedative drugs-
concomitantly taken.
Death occurred in persons who concurrently
injected ethanol / CNS depressant.
IV dosing-hypotension & respiratory depression-
death.
32. ACUTE POISONING:
SIGNS AND SYMPTOMS:
MILD: Drowsiness , Ataxia , Weakness
MODERATE TO SEVERE :Vertigo , slurred
speech, nystagmus, partial ptosis, lethargy ,
hypotension, respiratory depression, coma
(stage 1 & 2 ).
COMA 1 (Stage 1): Responsive to painful
stimuli but not to verbal or tactile stimuli, no
disturbance in respiration or BP.
COMA 2 (Stage 2):Unconscious, not
responsive to painful stimuli, no disturbance
in respiration or BP.
34. IV FLUIDS:
CORRECTION OF HYPOTENSION WITH DOPAMINE
OR LEVARTERENOL:
ANTIDOTE TREATMENT: FLUMAZENIL
Flumazenil –reversing the coma induced by
benzodiazepines.
Mode of action – competitive antagonism.
Complete reversal of benzodiazepine effect with a
total slow iv dose of 1mg.
Administered in a series of smaller doses beginning
with 0.2 mg & progressively increasing by 0.1- 0.2
mg every minute until a cumulative total dose of
3.5 mg is reached.
Resedation occurs within ½ hr – 2 hrs.
35. Activation of opioid receptors results in inhibition of synaptic neurotransmission in
the central nervous system (CNS) and peripheral nervous system (PNS). Opioids
bind to and enhance neurotransmission at three major classes of opioid receptors.
It is also recognized that several poorly defined classes of opioid receptors exist
with relatively minor effects.
The physiological effects of opioids are mediated principally through mu and
kappa receptors in the CNS and periphery. Mu receptor effects include analgesia,
euphoria, respiratory depression, and miosis. Kappa receptor effects include
analgesia, miosis, respiratory depression, and sedation.
Two other opiate receptors that mediate the effects of certain opiates include
sigma and delta sites. Sigma receptors mediate dysphoria, hallucinations, and
psychosis; delta receptor agonism results in euphoria, analgesia, and seizures. The
opiate antagonists (eg, naloxone, nalmefene, naltrexone) antagonize the effects at
Mechanism of action:
Opioid poisoning
36. Signs and symptoms
• Opioids because of their effect on the part of the brain
that regulates breathing can when one overdoses on them
lead to the person not breathing anymore (respiratory
depression) and therefore death.
• Opiate overdose symptoms and signs can be referred to
as the "Opioid Overdose Triad": decreased level of
consciousness, pinpoint pupils and respiratory depression.
• Other symptoms include seizures and muscle spasms.
• Sometimes a person experiencing an opiate overdose can
lead to such a decreased level of consciousness that he or
she won't even wake up to their name being called or
being shaken by another person.
37. Treatment
• Death can be prevented in opioid overdoses if patients receive basic life support
and the administration of Naloxone soon after opioid overdose is suspected.
• Naloxone is effective at reversing the cause, rather than just the symptoms, of
an opioid overdose.
• A longer-acting variant is naltrexone. Naltrexone is primarily meant to treat
opioid and alcohol dependence.
• Programs to provide drug users and their caregivers with naloxone are
recommended.
• Airway control and adequate oxygenation remain the primary intervention if not
already established by EMS. Endotracheal intubation is indicated in patients who
cannot protect their airway.
38. REFERENCES:
TEXT BOOK OF FORENSIC MEDICINE AND TOXICOLOGY BY V.V PILLAY , 14TH
EDITION, PAGE NO:470-471.
PRINCIPLES OF CLINICAL TOXICOLOGY BY THOMAS . A . GOSSEL , 2ND EDITION,
PAGE NO:285-288.
PHARMACOLOGY BY H.P. RANG AND M.M. DALE , 5TH EDITION,PAGE NO:522.
ESSENTIALS OF MEDICAL PHARMACOLOGY BY K.D. TRIPATHI, 6TH EDITION, PAGE
NO:389.
WWW. GOOGLE.COM.