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Understanding ama 2018 09-01


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We look upon every Ancient creation is inferior to our own misguided intellect
Faith in Ayurveda leads to Worshiping
Knowledge of Ayurveda helps in Healthy living
Wisdom of Ayurveda brings Eternity

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Understanding ama 2018 09-01

  1. 1. Understanding AmaUnderstanding Ama Prof KSR Prasad @ 2nd National Symposium  on Autoimmunity – RA Ayuurveda P ti PUNE 01 09 2018 Dr. K. Shiva Rama Prasad, at Perspective, PUNE ‐ 01‐09‐2018
  2. 2. Introd ction Understanding Ama Introduction  • We look upon every Ancient creation is  inferior to our own misguided intellect   – Faith in Ayurveda leads to Worshiping y p g – Knowledge of Ayurveda helps in Healthy living  – Wisdom of Ayurveda brings Eternity y g y • we often refuse Knowledge and wisdom and  believe in Myth or Individual’s expressionsbelieve in Myth or Individual s expressions  • Most of the time we remain at DATA level of  DIKW format ( f / ll l d d )DIKW format (Data, Information/ Intellect, Knowledge, Wisdom) Dr. K. Shiva Rama Prasad, at
  3. 3. Ama & A ni Understanding Ama Ama & Agni • Ama is Anti Agni concept represents dark side of  di if idisease manifestation  • Even though the concept of Agni and its involvement  i th th i i ll t bli h d th tilit fin the pathogenesis is well established the utility of  Agni embedded in treatments are confusing • Thus the determination of these terms (Agni; Ushma;• Thus the determination of these terms (Agni; Ushma;  Ama) in present day is necessary • This concept took lots of inclusions such as – Auto• This concept took lots of inclusions such as – Auto  immunity, Free radical theory, etc  Dr. K. Shiva Rama Prasad, at
  4. 4. Ama ata Understanding Ama Amavata • Amavata at present we are correlating to  Rheumatoid Arthritis or Auto Immune  disorders needs to be validateddisorders needs to be validated • I remain here to evaluate Ama and its  d i ti di di t M dhderivative diseases according to Madhava Nidana and Madhava Chikitsa • Information of Agni  is much available  from Grahani Chapter of Charakafrom Grahani Chapter of Charaka Dr. K. Shiva Rama Prasad, at
  5. 5. Ama Genesis Understanding Ama Ama Genesis • Ama is developed – In Amashaya– In Amashaya – With Mandagni (lowered digestion / decreased pH) Nischala Gati (stasis peristalsis)– Nischala Gati (stasis peristalsis)  – Viruddha Ahara (Fish – Protein + Milk – Lactic Acid) S i dh bh k V (– Snigdha bhuktavato Vyayama (hyper hemodynamics inducted after fatty consumption)  • These conditions leads to develop Ammonia in• These conditions leads to develop Ammonia in  GI tract which is of Nitrogen waste Dr. K. Shiva Rama Prasad, at
  6. 6. Factor of Ammonia de elopment Understanding Ama Factor of Ammonia development • Ammonia (Ama) is constantly produced as a metabolic waste  from amino acid catabolism in mammalsfrom amino acid catabolism in mammals.  • Ammonia in the human body is produced mostly as a  byproduct of protein digestion and bacterial metabolism in  the GIT, kidney and muscle, When the glucose levels are  decreased by starvation or intense exercise, the skeletal  muscle can also generate ammonia through amino acidmuscle can also generate ammonia through amino acid  catabolism. • The flux that moves into the brain is most likely both by  diffusion of gaseous NH3 and by mediated transport of NH4+  by channels and transporters through plasma membrane  crossing which will have a direct effect on the pHcrossing, which will have a direct effect on the pH. Dr. K. Shiva Rama Prasad, at
  7. 7. De elopment Understanding Ama Development  Dr. K. Shiva Rama Prasad, at
  8. 8. Factor of Ammonia de elopment Understanding Ama Factor of Ammonia development • Free ammonia is very toxic (kodravebhyo vishasyeva),  ll ll bespecially to neurons, eventually cause subsequent  diseases, such as neurologic disorders, hepatic encephalopathies, Reye syndrome, and some toxic p p , y y , encephalopathies . • Ammonia, one of the principal products of nitrogen  metabolism, is normally converted to urea, in the liver,  by a series of enzymatic reactions. 1) J. Clin. Invest. C The American Society for Clinical Investigation, Inc., 0021‐9738/79/03/0449/12 1.00 449, Volume 63  March 1979 449‐460 2) Jing Liu et al, The Pharmabiotic Approach to Treat Hyperammonemia, Nutrients 2018, 10, 140;  doi:10.3390/nu10020140 Dr. K. Shiva Rama Prasad, at doi:10.3390/nu10020140
  9. 9. Ca ses of Ammonia de elopment Understanding Ama Causes of Ammonia development • Reduced pH ‐ protein fermentation  i d di t ll did H th h thincreased distally, as did pH, through the  transverse colon and into the distal colon • Decreased peristalsis ‐ The gut isDecreased peristalsis  The gut is  especially vulnerable to the presence of  chronic (and even acute) stress,  demonstrating stress‐induced changes in  gastric secretion, gut motility, mucosal  permeability and barrier function visceralpermeability and barrier function, visceral  sensitivity and mucosal blood flow. Ian Rowland et al, Gut microbiota functions: metabolism of nutrients and other food C O 0 00 / 0039 0 8 Dr. K. Shiva Rama Prasad, at Components, Eur J Nutr, DOI 10.1007/s00394‐017‐1445‐8
  10. 10. Ca ses of Ammonia de elopment Understanding Ama Causes of Ammonia development • Gut Bacteria ‐ The organisms involved include  several species of Bacteroides, Eubacterium hallii,  and Clostridium barlettii. proteolytic fermentation in  the distal colon ld d t i i ithe distal colon could produce toxic, carcinogenic  metabolites such as bacteriocins, ammonia, indoles,  and phenols by gut bacteriaand phenols by gut bacteria • In colon protein fermentation was associated with  increased concentrations of branched‐chain fattyincreased concentrations of branched chain fatty  acids, phenol, and indole derivatives of amino‐acid  fermentation and ammonia. Dr. K. Shiva Rama Prasad, at Chris kresser, Gut Health
  11. 11. Understanding Ama Dr. K. Shiva Rama Prasad, at
  12. 12. Ama Formation Understanding Ama Ama Formation • Ammonia ‐ NH3 is ionic and becomes stable NH4 in Liver  (Bhutagni) and after transportation (vayuna prerito hyam)(Bhutagni) and after transportation (vayuna prerito hyam)  reaches upper part of stomach (sleshma sthanam pradhavati) and again undergoes digestion (vidhagdhasou)  b ti h th bl d l (dh iabsorption reaches the blood vessels (dhamani pratipadyate). Interaction with Tridosha it makes the Vessels  oozing (abhishyandi). It is understood at Trika (Trimarma) as  heart heaviness and weakness, Brain (encephalopathy) and  Bladder (Bahumootrata). As the site of final Ammonia is in  Colon and Asrayashyayi Nyaya it impacts the local nervousColon and Asrayashyayi Nyaya it impacts the local nervous  system and causes Sacral stiffness and Pain. The NH4 exposed to Gastric acids are converted as Uric acid. The  components of Ammonia Urea and Uric acid are AMAcomponents of Ammonia, Urea and Uric acid are AMA.  Dr. K. Shiva Rama Prasad, at
  13. 13. Aleena Vs Leena Ama Understanding Ama Aleena Vs Leena Ama Urdhwa [Atisrushtam, Dravam, Vibaddham = Amlapitta] Mandagni ‐> Vidhatyannam‐> Adho Tryak [Leena] [Vibaddha Pureesha Grahani]Tryak [Leena]                      [Vibaddha Pureesha, Grahani] Dhatusta Dehasta [transports in to Mitochondriya]          [Liver, Brain, Lungs, Bladder, Heart] [Kayagni Amsha][Kayagni Amsha]  Dr. K. Shiva Rama Prasad, at
  14. 14. Leena Ama Vs Aleena Understanding Ama Leena Ama Vs Aleena Urdhwa [Atisrushtam, Dravam, Vibaddham = Amlapitta] Mandagni ‐> Vidhatyannam‐> Adho Tryak [Leena] [Vibaddha Pureesha Grahani]Tryak [Leena]                      [Vibaddha Pureesha, Grahani] Dhatusta Dehasta [transports in to Mitochondriya]          [Liver, Brain, Lungs, Bladder, Heart] [Kayagni Amsha][Kayagni Amsha]  Dr. K. Shiva Rama Prasad, at
  15. 15. Inter relation of Ammonia & Ama Understanding Ama Inter relation of Ammonia & Ama Ama Pitt K h V tPitta            Kapha          Vata  Amlapitta Prameha      Urustambha Peenasa Amavata Vataroga (Brain)Vataroga (Brain) Mutraroga (Bladder) Kukshi Roga (Pureesha) Ammonia = Urea = Uric Acid = Kukshi Roga (Pureesha) Dr. K. Shiva Rama Prasad, at Uric Acid =
  16. 16. Ama ata Lakshana Understanding Ama Amavata Lakshana • Digestion – Vairasya, Aruchi, Apaka, Agni dourbalya,  K hi K k hi K k hi h l Ch di A k jKathina Kukshi, Kukshi shoola, Chardi, Antrakooja,  Anaha Ud k T h• Udaka – Trushna • Mutra – Bahumootrata P h Vid ib dh• Pureesha – Vidwibandha • General – Alasya, Gourava, Jwara, Soonatanga,  Bh M h J dBhrama, Moorcha, Jadya • Trika – sthabda, Hrudroga,  id i• Nidra Viparyaya • Sandhi – Ruja, ShodhaDr. K. Shiva Rama Prasad, at
  17. 17. Le els of Ama Understanding Ama Levels of Ama 1. Routine = Regular Normal 2 Conversional = @ Liver (Bhutagni) as Urea2. Conversional = @ Liver (Bhutagni) as Urea 3. Excretion = @ KUB 4 Recycling = Urea converted to Uric Acid4. Recycling = Urea converted to Uric Acid  5. Deposition = deposited @ Mitochondria  6 Dispersion Neuro / Hepato / Immuno toxic6. Dispersion = Neuro / Hepato / Immuno toxic 7. Disease = Trika Roga (Mastishka /Hrudaya/ Vasti  (Prameha) Sandhi Roga(Prameha), Sandhi Roga 8. Pakwashaya in due course converts as Amashaya 9 Decreased or Increased Urea /Uric acid gives disease9. Decreased or Increased Urea /Uric acid gives disease  Dr. K. Shiva Rama Prasad, at
  18. 18. Ho Madha a Treated ? Understanding Ama How Madhava Treated ? • Chief principle adopted is –• Chief principle adopted is – – Agnivruddhi – Shad dharana, Panchakola,  Vaishwanara HingubhagottraVaishwanara, Hingubhagottra,  – Vatahara – Rasnasaptaka, Rasnapanchaka,  Mutrala Punarnava– Mutrala – Punarnava – Vedanahara – Alambusha, Shati Dr. K. Shiva Rama Prasad, at
  19. 19. Madha a Ama ika Pra o a Understanding Ama Madhava Amayika Prayoga 1 Shunti (analgesic) + Gokshura1. Shunti (analgesic) + Gokshura (diuretic) 2. Ernada taila (Vatahara) + Shunti (analgesic) + Vidanga (Krimihara) 3. Ernada taila (Vatahara) + [Go Ghruta +  Hingu (antispasmodic) or DhanyamlaHingu (antispasmodic) or Dhanyamla  /Kanji /Aranala Dr. K. Shiva Rama Prasad, at
  20. 20. Wh ? Understanding Ama Why ? • Ama and its derivative diseases are prevented withAma and its derivative diseases are prevented with  decreased usage of the following ‐ • Fertilizers (Urea) in Food( ) • Fermentation Industry (Alcohol / beverages) • Detergents / stain‐remover (Ammonia in daily use)Detergents / stain remover (Ammonia in daily use) • Moisturizers / Lotions (Urea used for skin /Foot care) • Preservative (on flesh)Preservative (on flesh) • Fuel (diesel) [Environmental] Dr. K. Shiva Rama Prasad, at
  21. 21. R h U d Understanding Ama Researches Under  My supervision y p • Alambushadi YogaAlambushadi Yoga • Dhanyamla Dhara • Hingwadi Gugglu Dr. K. Shiva Rama Prasad, at
  22. 22. Understanding Ama Second Innings ofSecond Innings of  Uric acid  • Just replace “Toxin” for the  word of “Ama” . . . . Neuro – Hepato – Cyto – etc.  Dr. K. Shiva Rama Prasad, at
  23. 23. E l U d t di t A id C li ti Understanding Ama Early Understanding to Avoid Complication  Th k Y• Thank You Prof KSR Prasad  th fauthor of … Technoayurveda’s Practical SOP Panchakarma Dr. K. Shiva Rama Prasad, at