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2/23/2017
1
Whose Life Is It Anyway?
Euthanasia, Assisted Suicide,
Suicide
Chapter 8
Learning Objectives
suicide.
what is
moral in end-of-life care.
suicide,
assisted suicide, and euthanasia.
Legalization
s may or may not do to end a
life
vary from state to state in the United States as well as from
country
to country.
euthanasia, allowing doctors to end the life of adult patients at
the
patient’s request.
consent for
doctors to kill infants who are terminally ill and in severe pain.
This
new measure, known as the Groningen Protocol, is the first to
allow
euthanasia for newborn babies.
2/23/2017
2
5 Different Types
Active
Euthanasia
Voluntary
Euthanasia
Active
Non-
voluntary
Active X
Passive
Euthanasia
Voluntary
Euthanasia
Passive
Non-
voluntary
Passive
Involuntary
Euthanasia
Passive
Active Euthanasia
Passive Euthanasia
ase patient’s
pain
is administered.
Turning off respirator, refusing chemotherapy.
2/23/2017
3
Voluntary Euthanasia
Non-Voluntary
cannot decide for themselves.
mentally
competent
Heath Care Surrogate
event you are mentally incapacitated.
are
unmarried, it is your parents or next of kin.
2/23/2017
4
Involuntary
ining treatment.
Assisted Suicide
the first
state to legalize Assisted Suicide.
History
- The earliest recorded reference to Euthanasia
comes
from Hippocrates, the father of medicine. He is quoted as
saying “I
will give no deadly medicine to any one if asked, nor suggest
any
such counsel”
– England prohibits suicide.
– the Providence Plantations (Rhode Island) declared
that if
an individual committed suicide his/her possessions would
become
the property of the King of England.
– Laws of Connecticut essentially states that any
person who
aids another individual in committing suicide is guilty of
murder if the
advisee actually goes through with suicide.
2/23/2017
5
History (continued)
– “The earliest American statute explicitly to outlaw
assisted
suicide was enacted in New York….Between 1857 and 1865, a
New
York commission drafted a criminal code that prohibited
‘aiding’
suicide and, specifically, ‘furnishing another person with any
deadly
weapon or poisonous drug, knowing that such person tends to
use
such weapon or drug in taking his own life.”
– “The California legislature adopted the English
common law,
under which assisting suicide was… a crime.”
History (continued)
– “The book "Permitting the Destruction of Life not
Worthy of
Life" was published.
psychiatry at the
University of Freiburg, and Karl Binding, a professor of law
from the
University of Leipzig, argued that patients who ask for "death
assistance"
should, under very carefully controlled conditions, be able to
obtain it
from a physician.
Germany.”
Nazi Germany
– In “Nazi Germany…Hitler ordered widespread ‘mercy
killing’ of the sick and disabled.”
– “The Euthanasia Society of England was formed to
promote euthanasia.”
2/23/2017
6
History (continued)
– Australia's Northern Territory approved the “Rights of
the
Terminally Ill Act . “ It went into effect in 1996 and was
overturned
by the Australian Parliament in 1997.”
Oregon Law
General
Janet Reno decided to permit the law to go into effect.
suicide is not
a "legitimate medical purpose" under federal drug-control law
and
that the Drug Enforcement Administration could strip the
prescribing
rights of any physician who authorized drugs to help someone
die.”
6–3 in
favor of Oregon, upholding the law.
Oregon’s Death with Dignity
According
to the Oregon Death With Dignity Act, “An adult who is
capable, is
a resident of Oregon, and has been determined by the attending
physician and consulting physician to be suffering from a
terminal
disease, and who has voluntarily expressed his or her wish to
die,
may make a written request for medication for the purpose of
ending his or her life in a humane and dignified manner “
2/23/2017
7
Supreme Court Said Up to States
Death
With Dignity Act. The people of Oregon turned down the
measure
by a vote of 60% to 40%
which
the U.S. Supreme Court ruled in assisted suicide was not a
Constitutional right.
that the issue would be best
addressed in the "laboratory of the states."
Ashcroft Directive
suicide is not
a "legitimate medical purpose" under federal drug-control law
and
that the Drug Enforcement Administration could strip the
prescribing
rights of any physician who authorized drugs to help someone
die.”
Oregon v. Ashcroft
a
Directive stating that a doctor could lose his or her federal
registration to prescribe controlled substances if the registration
is
used to prescribe federally controlled substances for assisted
suicide.
2/23/2017
8
Dr. Jack Kevorkian “Doctor Death”!
Kevorkian is born in Pontiac, Michigan, the son of Armenian
immigrants.
Graduates from University of Michigan medical school with a
specialty in pathology.
Publishes journal article, "The Fundus Oculi and the
Determination of
Death," discussing his efforts to photograph the eyes of dying
patients, a practice that earned him the nickname "Doctor
Death."
Kevorkian’s Definition of Death with
Dignity
was
that a dignified death? Do you think it's dignified to hang from
wood
with nails through your hands and feet bleeding, hang for three
or
four days slowly dying, with people jabbing spears into your
side,
and people jeering you? Do you think that's dignified? Not by a
long
shot. Had Christ died in my van with people around Him who
loved
Him, the way it was, it would be far more dignified. In my rusty
van.”
- Jack Kevorkian; National Press Club - July 29, 1996
First 5 Assisted Suicides
1. Janet Adkins 1990 F 54 Alzheimer's Disease
2. Sherry Miller 1991 F 43 MS
3. Marjorie Wantz 1991 F 58 Abdominal and Pelvic Pain
4. Susan William 1992 F 52 MS
5. Lois F. Hawes 1992 F 52 Lung cancer
2/23/2017
9
93 Known Deaths…
there
are many more where the person wished to remain anonymous.
CBS's "60 Minutes" airs a videotape showing Kevorkian giving
a lethal
injection to Thomas Youk, 52, who suffered from Lou Gehrig's
disease. The broadcast triggers an intense debate within
medical,
legal and media circles.
of patients
that were terminally ill.
Convicted in 1999
Convicted of second-degree murder and delivery of a controlled
substance in the death of Youk, a Michigan judge sentences
Kevorkian to 10-25 years in prison. He was eventually paroled
and
passed away in 2011.
Legalizing Death with Dignity:
Karen Ann Quinlan
-year-old woman named Karen Ann Quinlan
suffered a
respiratory arrest that resulted in severe and irreversible brain
damage and left her in a coma.
daughter's recovery was extremely unlikely, Quinlan's parents
requested that artificial means of life support be removed. The
hospital refused this request.
2/23/2017
10
Court Sided with Family
court
order allowing them to remove the artificial respirator that was
thought to be keeping their daughter alive.
disconnect the device so that the patient could "die with
dignity."
Turned off respirator
sion of the scope of
patients'
rights to control their death.
to
breathe on her own. She lived until 1985 without ever regaining
consciousness.
Terri Schiavo
o had a heart attack and collapsed
incurring massive brain damage and slipping into a coma.
persistent
vegetative state. (PVS)
2/23/2017
11
Terri’s Husband
sband began petitioning the
courts
to remove the feeding tube that kept her alive claiming that she
would not want to be kept on a machine with no hope for
recovery.
Catholic
who would not wish to violate the Church's teachings on
euthanasia by refusing nutrition and hydration .
Terri’s Never Had Treatment
still the
legal guardian of Terri.
- they had to go to court
to get
visitation.
second
opinion.
Terri’s Law
Six days
later Terri’s Law was passed and Gov. Bush sent armed men to
take
Schiavo to a hospital to have her feeding tube reinserted.
Gov.
Bush
the case and March 18,
2005 it
was ordered that the feeding tube be removed again…
2/23/2017
12
Dust in the Wind
March
31, 2005.
tend the
funeral!
location!
Baby “MB”
leaves him
almost totally paralysed.
tor to breathe and cannot cry, chew or
swallow.
Doctors - His life is not worth living!
child's interest in court argued that the burdens of his existence
outweighed the benefits.
2/23/2017
13
His Parents want to let him live
was
conscious.
Nemo,
but did not appear to like the news or the TV soap Eastenders.
Justice Holman said…
sounds
like any child of his age and gains pleasure from them," said
Justice
Holman. "No court has yet been asked to approve, against the
will
of parents, the withdrawal of life support with the inevitable
and
immediate death of a conscious child with sensory awareness
and
cognition, and no significant evidence of brain damage."
Do not resuscitate or medicate
would
not be required to resuscitate him or to give antibiotics if he
develops serious infections.
As reported by the BBC, Mar 15 2006
2/23/2017
1
Humans and Other Living
Creatures
Chapter 7
Learning Objectives
rights to
animals.
for product
testing and for scientific research.
animal
rights.
Overview of Animal Rights
mut from
“They
have none” to “They are equal in moral status to humans.” Most
reasonable views, as with many issues, fall somewhere between
these two extremes.
The analysis of the moral status of animals involves several
questions.
The first question is what, if any, rights they possess. The
question of
rights is complex, and there are still contentious debates as to
what
rights, if any, humans have, let alone other sentient nonhumans.
The second question involves the treatment and use of animals.
2/23/2017
2
Humans use animals in various ways
Main Philosophical Arguments
Rene Descartes
animals were nothing more
than unconscious machines.
clock that needed oiling.
2/23/2017
3
No Soul, No Rights
soul; if you
do not have a soul you do not feel pain or pleasure, therefore,
they
do not have any rights.
Animal Rights
1. If you do not have a soul,
Then you do not have rights.
2. Animals do not have souls.
3. Therefore, Animals do not have rights.
Kant- Animal Rights
1. If you do not have rationality;
Then you do not have Rights.
2. Animals do not have rationality.
3. Therefore, Animals do not have rights.
2/23/2017
4
Reductio Adsurdum
1. If you do not have rationality;
Then you do not have Rights.
2. Babies do not have rationality
3. Therefore, Babies do not have rights.
Rationality/ Moral Responsibility
1. If you do not have rationality; then you do
not have Moral Responsibility.
2. Animals do not have rationality
3. Therefore, Animals do not have Moral
Responsibility.
Utilitarianism: Animal rights
1. If you have the capacity to feel pain or pleasure, then you
have
rights.
2. Animals have the capacity to feel pain and pleasure.
3. Therefore: Animals have rights.
2/23/2017
5
People have Rights too
1. If you have the capacity to feel pain or pleasure, then you
have
rights.
2. People have the capacity to feel pain and pleasure.
3. Therefore: People have rights.
Crazy Utilitarian Argument
1. People have rights.
2. Animals have rights.
3. Therefore, people and animals have the same rights.
People are equal to Goats.
Equivocation in the term rights
e same “rights” too.
2/23/2017
6
What Rights do animals have?
- there is no
reason to
assume they have the same rights.
Babies = Animals
te or drive, and yet they have rights-
Babies = Goats
1. Babies have rights.
2. Animals have rights.
3. Therefore babies and animals have the same rights.
Babies are equal to Goats, cows, dogs cats….
2/23/2017
7
Immanuel Kant
-conscious and are there merely as a
means
to an end. That end is man. … Our duties towards animals are
merely indirect duties towards humanity.
Kantian Counter argument-
Potential rationality
1. If you have the potential for rationality, then you have rights.
2. Babies have the potential for rationality
3. Therefore, babies have rights.
Animal Potential Rationality
1. If you have the potential for rationality,
Then you have rights.
2. Animals do not have the potential for rationality.
3. Therefore, Animals do not have rights.
2/23/2017
8
The Notion Potential Rationality
Applied
people
with brain injuries, and people in comas or vegetative states all
lack
the potential for rationality - as such, on this view they lack
rights.
Food and Farming
USA.
ctory farms are vast warehouses which are used to raise
livestock.
DOWNED ANIMAL PROTECTION ACT
make it
unlawful for any stockyard owner, market agency, or dealer to
transfer or market nonambulatory livestock, and for other
purposes.
- It shall be unlawful for any
stockyard
owner, market agency, or dealer to buy, sell, give, receive,
transfer,
market, hold, or drag any nonambulatory livestock unless the
nonambulatory livestock has been humanely euthanized.'.
2/23/2017
9
Animal testing has led to human
deaths
suspected, based on clinical (human) studies: 1907
that animal studies indicated that there was nothing to fear
from asbestos: 1965
asbestos: 1986
Polio
prevention was long delayed by the erroneous
conception of the nature of the human disease based on
misleading experimental models of disease in monkeys.”
― Dr. Albert Sabin (scientist credited with development of
polio
vaccine, along with Dr. Jonas Salk)
Penicillin
1940s, for
penicillin would probably never been granted a license, and
possibly the whole field of antibiotics might never have been
realized.”
Sir Alexander Fleming (scientist credited with discovering
penicillin)
2/23/2017
10
FDA and Animal Testing
between 1976 to 1985, 52 percent were either withdrawn or
relabeled because of severe side effects not predicted through
animal studies.
Rats and Mice
chemicals found to be cancer-causing in rats were not cancer-
causing in mice.
caused cancer in mice.

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22320171Whose Life Is It Anyway Euthanasia, Ass.docx

  • 1. 2/23/2017 1 Whose Life Is It Anyway? Euthanasia, Assisted Suicide, Suicide Chapter 8 Learning Objectives suicide. what is moral in end-of-life care. suicide, assisted suicide, and euthanasia. Legalization s may or may not do to end a life
  • 2. vary from state to state in the United States as well as from country to country. euthanasia, allowing doctors to end the life of adult patients at the patient’s request. consent for doctors to kill infants who are terminally ill and in severe pain. This new measure, known as the Groningen Protocol, is the first to allow euthanasia for newborn babies. 2/23/2017 2 5 Different Types Active Euthanasia Voluntary
  • 4. Passive Euthanasia ase patient’s pain is administered. Turning off respirator, refusing chemotherapy. 2/23/2017 3 Voluntary Euthanasia Non-Voluntary cannot decide for themselves. mentally competent
  • 5. Heath Care Surrogate event you are mentally incapacitated. are unmarried, it is your parents or next of kin. 2/23/2017 4 Involuntary ining treatment. Assisted Suicide the first state to legalize Assisted Suicide. History
  • 6. - The earliest recorded reference to Euthanasia comes from Hippocrates, the father of medicine. He is quoted as saying “I will give no deadly medicine to any one if asked, nor suggest any such counsel” – England prohibits suicide. – the Providence Plantations (Rhode Island) declared that if an individual committed suicide his/her possessions would become the property of the King of England. – Laws of Connecticut essentially states that any person who aids another individual in committing suicide is guilty of murder if the advisee actually goes through with suicide. 2/23/2017 5 History (continued) – “The earliest American statute explicitly to outlaw assisted suicide was enacted in New York….Between 1857 and 1865, a New York commission drafted a criminal code that prohibited
  • 7. ‘aiding’ suicide and, specifically, ‘furnishing another person with any deadly weapon or poisonous drug, knowing that such person tends to use such weapon or drug in taking his own life.” – “The California legislature adopted the English common law, under which assisting suicide was… a crime.” History (continued) – “The book "Permitting the Destruction of Life not Worthy of Life" was published. psychiatry at the University of Freiburg, and Karl Binding, a professor of law from the University of Leipzig, argued that patients who ask for "death assistance" should, under very carefully controlled conditions, be able to obtain it from a physician. Germany.” Nazi Germany – In “Nazi Germany…Hitler ordered widespread ‘mercy killing’ of the sick and disabled.” – “The Euthanasia Society of England was formed to
  • 8. promote euthanasia.” 2/23/2017 6 History (continued) – Australia's Northern Territory approved the “Rights of the Terminally Ill Act . “ It went into effect in 1996 and was overturned by the Australian Parliament in 1997.” Oregon Law General Janet Reno decided to permit the law to go into effect. suicide is not a "legitimate medical purpose" under federal drug-control law and that the Drug Enforcement Administration could strip the prescribing rights of any physician who authorized drugs to help someone die.” 6–3 in
  • 9. favor of Oregon, upholding the law. Oregon’s Death with Dignity According to the Oregon Death With Dignity Act, “An adult who is capable, is a resident of Oregon, and has been determined by the attending physician and consulting physician to be suffering from a terminal disease, and who has voluntarily expressed his or her wish to die, may make a written request for medication for the purpose of ending his or her life in a humane and dignified manner “ 2/23/2017 7 Supreme Court Said Up to States Death With Dignity Act. The people of Oregon turned down the measure by a vote of 60% to 40%
  • 10. which the U.S. Supreme Court ruled in assisted suicide was not a Constitutional right. that the issue would be best addressed in the "laboratory of the states." Ashcroft Directive suicide is not a "legitimate medical purpose" under federal drug-control law and that the Drug Enforcement Administration could strip the prescribing rights of any physician who authorized drugs to help someone die.” Oregon v. Ashcroft a Directive stating that a doctor could lose his or her federal registration to prescribe controlled substances if the registration is used to prescribe federally controlled substances for assisted suicide. 2/23/2017
  • 11. 8 Dr. Jack Kevorkian “Doctor Death”! Kevorkian is born in Pontiac, Michigan, the son of Armenian immigrants. Graduates from University of Michigan medical school with a specialty in pathology. Publishes journal article, "The Fundus Oculi and the Determination of Death," discussing his efforts to photograph the eyes of dying patients, a practice that earned him the nickname "Doctor Death." Kevorkian’s Definition of Death with Dignity was that a dignified death? Do you think it's dignified to hang from wood with nails through your hands and feet bleeding, hang for three or four days slowly dying, with people jabbing spears into your side, and people jeering you? Do you think that's dignified? Not by a long shot. Had Christ died in my van with people around Him who loved Him, the way it was, it would be far more dignified. In my rusty
  • 12. van.” - Jack Kevorkian; National Press Club - July 29, 1996 First 5 Assisted Suicides 1. Janet Adkins 1990 F 54 Alzheimer's Disease 2. Sherry Miller 1991 F 43 MS 3. Marjorie Wantz 1991 F 58 Abdominal and Pelvic Pain 4. Susan William 1992 F 52 MS 5. Lois F. Hawes 1992 F 52 Lung cancer 2/23/2017 9 93 Known Deaths… there are many more where the person wished to remain anonymous. CBS's "60 Minutes" airs a videotape showing Kevorkian giving a lethal injection to Thomas Youk, 52, who suffered from Lou Gehrig's disease. The broadcast triggers an intense debate within
  • 13. medical, legal and media circles. of patients that were terminally ill. Convicted in 1999 Convicted of second-degree murder and delivery of a controlled substance in the death of Youk, a Michigan judge sentences Kevorkian to 10-25 years in prison. He was eventually paroled and passed away in 2011. Legalizing Death with Dignity: Karen Ann Quinlan -year-old woman named Karen Ann Quinlan suffered a respiratory arrest that resulted in severe and irreversible brain damage and left her in a coma. daughter's recovery was extremely unlikely, Quinlan's parents requested that artificial means of life support be removed. The hospital refused this request.
  • 14. 2/23/2017 10 Court Sided with Family court order allowing them to remove the artificial respirator that was thought to be keeping their daughter alive. disconnect the device so that the patient could "die with dignity." Turned off respirator sion of the scope of patients' rights to control their death. to breathe on her own. She lived until 1985 without ever regaining consciousness. Terri Schiavo
  • 15. o had a heart attack and collapsed incurring massive brain damage and slipping into a coma. persistent vegetative state. (PVS) 2/23/2017 11 Terri’s Husband sband began petitioning the courts to remove the feeding tube that kept her alive claiming that she would not want to be kept on a machine with no hope for recovery. Catholic who would not wish to violate the Church's teachings on euthanasia by refusing nutrition and hydration . Terri’s Never Had Treatment
  • 16. still the legal guardian of Terri. - they had to go to court to get visitation. second opinion. Terri’s Law Six days later Terri’s Law was passed and Gov. Bush sent armed men to take Schiavo to a hospital to have her feeding tube reinserted. Gov. Bush the case and March 18, 2005 it was ordered that the feeding tube be removed again… 2/23/2017
  • 17. 12 Dust in the Wind March 31, 2005. tend the funeral! location! Baby “MB” leaves him almost totally paralysed. tor to breathe and cannot cry, chew or swallow. Doctors - His life is not worth living! child's interest in court argued that the burdens of his existence outweighed the benefits.
  • 18. 2/23/2017 13 His Parents want to let him live was conscious. Nemo, but did not appear to like the news or the TV soap Eastenders. Justice Holman said… sounds like any child of his age and gains pleasure from them," said Justice Holman. "No court has yet been asked to approve, against the will of parents, the withdrawal of life support with the inevitable and immediate death of a conscious child with sensory awareness and cognition, and no significant evidence of brain damage." Do not resuscitate or medicate
  • 19. would not be required to resuscitate him or to give antibiotics if he develops serious infections. As reported by the BBC, Mar 15 2006 2/23/2017 1 Humans and Other Living Creatures Chapter 7 Learning Objectives rights to animals. for product testing and for scientific research. animal
  • 20. rights. Overview of Animal Rights mut from “They have none” to “They are equal in moral status to humans.” Most reasonable views, as with many issues, fall somewhere between these two extremes. The analysis of the moral status of animals involves several questions. The first question is what, if any, rights they possess. The question of rights is complex, and there are still contentious debates as to what rights, if any, humans have, let alone other sentient nonhumans. The second question involves the treatment and use of animals. 2/23/2017 2 Humans use animals in various ways
  • 21. Main Philosophical Arguments Rene Descartes animals were nothing more than unconscious machines. clock that needed oiling. 2/23/2017 3
  • 22. No Soul, No Rights soul; if you do not have a soul you do not feel pain or pleasure, therefore, they do not have any rights. Animal Rights 1. If you do not have a soul, Then you do not have rights. 2. Animals do not have souls. 3. Therefore, Animals do not have rights. Kant- Animal Rights 1. If you do not have rationality; Then you do not have Rights. 2. Animals do not have rationality. 3. Therefore, Animals do not have rights. 2/23/2017
  • 23. 4 Reductio Adsurdum 1. If you do not have rationality; Then you do not have Rights. 2. Babies do not have rationality 3. Therefore, Babies do not have rights. Rationality/ Moral Responsibility 1. If you do not have rationality; then you do not have Moral Responsibility. 2. Animals do not have rationality 3. Therefore, Animals do not have Moral Responsibility. Utilitarianism: Animal rights 1. If you have the capacity to feel pain or pleasure, then you have rights. 2. Animals have the capacity to feel pain and pleasure. 3. Therefore: Animals have rights.
  • 24. 2/23/2017 5 People have Rights too 1. If you have the capacity to feel pain or pleasure, then you have rights. 2. People have the capacity to feel pain and pleasure. 3. Therefore: People have rights. Crazy Utilitarian Argument 1. People have rights. 2. Animals have rights. 3. Therefore, people and animals have the same rights. People are equal to Goats. Equivocation in the term rights e same “rights” too.
  • 25. 2/23/2017 6 What Rights do animals have? - there is no reason to assume they have the same rights. Babies = Animals te or drive, and yet they have rights- Babies = Goats 1. Babies have rights. 2. Animals have rights. 3. Therefore babies and animals have the same rights. Babies are equal to Goats, cows, dogs cats…. 2/23/2017 7
  • 26. Immanuel Kant -conscious and are there merely as a means to an end. That end is man. … Our duties towards animals are merely indirect duties towards humanity. Kantian Counter argument- Potential rationality 1. If you have the potential for rationality, then you have rights. 2. Babies have the potential for rationality 3. Therefore, babies have rights. Animal Potential Rationality 1. If you have the potential for rationality, Then you have rights. 2. Animals do not have the potential for rationality. 3. Therefore, Animals do not have rights. 2/23/2017 8 The Notion Potential Rationality
  • 27. Applied people with brain injuries, and people in comas or vegetative states all lack the potential for rationality - as such, on this view they lack rights. Food and Farming USA. ctory farms are vast warehouses which are used to raise livestock. DOWNED ANIMAL PROTECTION ACT make it unlawful for any stockyard owner, market agency, or dealer to transfer or market nonambulatory livestock, and for other purposes. - It shall be unlawful for any stockyard owner, market agency, or dealer to buy, sell, give, receive, transfer,
  • 28. market, hold, or drag any nonambulatory livestock unless the nonambulatory livestock has been humanely euthanized.'. 2/23/2017 9 Animal testing has led to human deaths suspected, based on clinical (human) studies: 1907 that animal studies indicated that there was nothing to fear from asbestos: 1965 asbestos: 1986 Polio prevention was long delayed by the erroneous conception of the nature of the human disease based on misleading experimental models of disease in monkeys.” ― Dr. Albert Sabin (scientist credited with development of polio vaccine, along with Dr. Jonas Salk)
  • 29. Penicillin 1940s, for penicillin would probably never been granted a license, and possibly the whole field of antibiotics might never have been realized.” Sir Alexander Fleming (scientist credited with discovering penicillin) 2/23/2017 10 FDA and Animal Testing between 1976 to 1985, 52 percent were either withdrawn or relabeled because of severe side effects not predicted through animal studies. Rats and Mice chemicals found to be cancer-causing in rats were not cancer- causing in mice.