Hair loss treatment with anti androgens (find out

1. Hair Loss Treatment with Anti-
Androgens (Find Out Which Works
for You)
http://www.1300hairloss.com.au

2.  Hair loss, in many cases, is believed to be androgen-
dependent.
 Considered as the common baldness, the condition
called androgenetic alopecia or pattern baldness is
triggered by the build-up of the androgen
dihydrotestosterone (DHT) in the hair follicles in the
scalp.
 DHT is the chemical derivative of testosterone
through the enzyme type II 5-alpha reductase (5-AR).
Because of this androgenic nature, several anti-
androgen therapies are devised to manage AGA in
both men and women.
 Anti-androgens block the biological effects of
androgens on responsive tissues. Anti-androgens
work by (1) blocking the hormone receptors, (2)
restricting androgen production, or (3) competing for
binding sites on the cell’s surface. Anti-androgens

3. Finasteride
 The following anti-androgen therapies are mostly
helpful in the treatment of AGA:
Finasteride
 Only prescribed to men and postmenopausal women,
finasteride is a popular anti-androgen therapy for hair
loss which is FDA-approved. Finasteride is an orally-
administered corrective hair loss treatment that works at a
molecular level.
 Finasteride is a selective inhibitor of type II 5-alpha
reductase, the enzyme responsible for the conversion of
testosterone into DHT. Because it can cause birth defects
to a male fetus, finasteride is contraindicated in women.
 The side effects of finasteride include loss of libido and
erectile dysfunction. It is also reported that it increases the
risk of men developing high-grade prostate cancer.

4. Dutasteride and
Spironolactone
Dutasteride
 Dutasteride is the other drug that works more or less like
finasteride. The main difference between the two is that
dutasteride is not a selective inhibitor. It blocks type I and
type II of the 5-AR enzyme.
 It is also not approved by the FDA as a pattern hair loss
treatment. Dutasteride produces the same side effects as
finasteride does.
Spironolactone
 Considered as the “king of anti-androgens,” spironolactone
is a diuretic pill that has very strong anti-androgenic
properties. It prevents DHT from binding with the androgen
receptors on the hair follicles.
 It also obstructs the production of testosterone which is
why it is rarely prescribed in men. Reducing testosterone
levels reduces DHT levels simultaneously. When used in
men, it can cause impotence and breast enlargement.

5. Cyproterone Acetate
Cyproterone Acetate
 Cyproterone acetate also contains anti-
androgenic properties that work best in women
with hirsutism and hair loss. It blocks the
androgen receptors in the follicles from binding
with DHT. Administering estrogen therapy may be
necessary in conjunction with cyproterone
acetate.
 It may produce the same side effects as
spironolactone does when used in men. Liver
toxicity is one of the serious side effects of this
hair loss treatment.