ppt

1. RESPON IMUN ADAPTIF
HUMORAL
Heri Wibowo
DEP. PARASITOLOGI FKUI
This Photo by Unknown Author is licensed under CC BY-NC
Modul imuno inffeksi S1 FKUI - 2023

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KLASIFIKASI SISTIM
IMUN

3. B-CELL
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✓ B cells, also known as B lymphocytes, are a type of white
blood cell of the lympyhoctes subtype.
✓ Function : the humoral immunity component of
the adaptive immune system
✓ B cells produce antibody molecules.
✓ Antibody products:
1. Released in plasma
2. Attaches to the B cell membrane and functions as a
receptor

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DEVELOPMENT OFB CELL

5. Jaringan dan organ dalam
sistim imun
Primary Lymphoid Organs:
• Bone marrow & Thymus (child & adult)
Fungsi : Hematopoiesis &
Lymphopoiesis
Secondary (peripheral) Lymphoid
Organs:
• Lymph Nodes & Spleen
Fungsi : Menangkap dan
mempresentasikan antigen ke sel
limfosit → Stimulasi imun adaptif
• BALT (Bronchus Associated Lymphoid Tissue)
• GALT (Gut Associated Lymphoid Tissue)
• MALT (Mucosal Associated Lymphoid Tissue)
• SALT ( Skin Associated Lymphoid Tissue)

6. Respon Imun Spesifik (Adaptif)
Inisiasi Respon Imun adaptif dalam kelenjar
Getah Bening (KGB) / Lymph Node

7. SECONDARY
LYMPHOID ORGAN
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8. B DEPENDENT T
CELL
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In T cell-dependent activation of B cells, the B cell recognizes and internalizes an antigen and presents it to a
helper T cell that is specific to the same antigen. The helper T cell interacts with the antigen presented by the
B cell, which activates the T cell and stimulates the release of cytokines that then activate the B cell.
Activation of the B cell triggers proliferation and differentiation into B cells and plasma cells.

9. IMMUNOGLOBULIN PRODUCTION BY B CELL
1.Dependent T Cell
• Develop of clone Memory & Plasma B Cell
• Mostly Imunoglobulin G (IgG)
2.Independent T Cell
• Plasma B Cell and No B Cell Memory
• Mostly Imunoglobulin M (IgM)

10. T Cell-Dependent Activation of B cells
In T cell-dependent activation of B cells, the B cell
recognizes and internalizes an antigen and
presents it to a helper T cell that is specific to the
same antigen. The helper T cell interacts with the
antigen presented by the B cell, which activates
the T cell and stimulates the release of cytokines
that then activate the B cell. Activation of the B
cell triggers proliferation and differentiation into B
cells and plasma cells.
B Dependent T Cell, Product :
- B. Memory
- Mostly Immunoglobulin G ( IgG)
IgG

11. T Cell-Independent Activation of B cells
The T cell-independent response is
short-lived and does not result in the
production of memory B cells. Thus it
will not result in a secondary
response to subsequent exposures to
T-independent antigens.
B Independent T Cell, Product :
- No B cell Memory
- Mostly Immunoglobulin M ( IgM)

12. Compared to the primary response, the secondary antibody response occurs more rapidly and produces
higher and more sustained antibody levels (because it already involves memory B cells that were
already formed during the primary response). The secondary response mostly involves IgG

13. STRUCTUR OF
ANTOBODY
✓ An antibody (  immunoglobulin ) is a
Y-shaped structure which consists of
four polypeptides — two heavy chains
and two light chains.
✓ This structure allows antibody
molecules to carry out their dual
functions:
1. antigen binding and
2. Biological activity mediation.
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14. • Ag dapat berikatan pada binding site Ab pada bagian epitope

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16. CLASS IMMUNOGLOBULIN AND STRUCTUR
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17. CLASS OF
IMMUNOGLOBULIN
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Mechanism of
action of
antibodies in the
body's defense

19. Antibody-dependent cellular cytotoxicity ( ADCC )
 antibody-dependent cell-mediated cytotoxicity
Mechanism of cell-mediated immune
defense whereby an effector cell of
the immune system actively lyses a
target cell, whose membrane-surface
antigens have been bound by
specific antibodies

20. The binding of antibody and
complement receptors at
the Phagocytes surface
activates the phagocytic
process
Kerjasama imun bawaan & Adaptif
Kerjasama imun bawaan
ADCC : Phagocytosis of unicellular pathogens

22. Eosinophil
one of the immune system components
responsible for combating multicellular
parasites. Eosinophils kill a variety of
helminth parasites and some protozoan
parasites by antibody- or complement-
dependent mechanisms
These cells are eosinophilic or "acid-loving" due to their
large acidophilic cytoplasmic granules. The small granules
within the cellular cytoplasm, which contain many chemical
mediators, such as eosinophil peroxidase, ribonuclease
(RNase), deoxyribonucleases (DNase), lipase, plasminogen,
and major basic protein. These mediators are released by a
process called degranulation following activation of the
eosinophil.
ADCC on Multicellular Pathogen Defense
Kerjasama imun bawaan & Adaptif

23. MONOCLONAL ANTIBODI :
Diagnostic & Terapeutic
Monoclonal antibodies (mAbs) are
produced by B cells and specifically
target antigens. The hybridoma
technique introduced by Köhler and
Milstein in 1975 [1] has made it possible
to obtain pure mAbs in large amounts,
greatly enhancing the basic research and
potential for their clinical use.

24. Antibody for
Diagnostics.
Antibodies have become a critical
component of many diagnostic assays.
Uses included but are not limited to
the detection of infections, recognition
of allergies and the measurement of
hormones and other biological markers
in blood. Applied for antibody based
diagnostic tests is “immunoassay

25. Antibody for Teurapeutic

26. TERIMAKASIH