highlights of anatomy

1.  Name : Dr. Prakash Tiwari
 ID No. (PhD Enrolment No): 10BB12J22009
 Ph.D Thesis Title: “Study of epigenetic, apoptotic and cell
survival pathways during the development of 7, 12-
dimethylbenz [a] anthracene induced mouse skin tumors and
their response towards the antitumor agents alone or in
combination as a function of time.”
 Department : Environmental Carcinogenesis Division, CSIR-
IITR, Lucknow
 Subject of registration: Biological Science
 University: AcSIR - Academy of Scientific & Innovative
Research, CSIR-IITR, Lucknow
 Date of completion of Ph.D. : 09-NOVEMBER-2016
Anatomy_Prakash Tiwari_2001000237

2. Highlights of Ph.D research work
 Identification of miR-203 aberration and promoter methylation of
cell cycle regulatory genes (p16, p21) during the skin
tumorigenesis via modulation of micro RNA biogenesis (Dicer-1,
Ago-2) and epigenetic regulators (DNMT-1, HDAC-1).
 Observation of K-Ras-PI3K-AKT pathway hyper activation
during skin tumorigenesis in association with aberration of
micro RNA like of miR-21, miR-20a, miR-211 and let-7a.
 Identification of chemo-preventive potential of butyric acid,
nicotinamide and calcium glucarate against tumorigenesis via
modulation of epigenetic apoptotic and cell survival pathways.

3. Highlights of Post-doctoral research work
 Field surveillance and identification of SNPs associated with
antifolate drug resistance in Plasmodium falciparum under
Mararia control program.
 Sero-epidimological and molecular characterization of zoonotic
diseases like Scrub tyhus, Leptospirosis, CCHF and other
zoonotic diseases.
 Genetic and health monitoring of small laboratory animals (Mice
and Rat), animal experimentation, and maintenance of records as
per CPCSEA norms, testing and validation of lab protocols and
other routine molecular.
 Diagnosis and epidemiological characterization of Dengue,
Chikungunya, ZIKA and COVID-19, in this pandemic.

4. Research Publications
 Tiwari, P., Sahay, S., Pandey, M., Qadri, S.S. and Gupta, K.P., 2016. Preventive effects of butyric
acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a)
anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and
associated micro RNAs. Biochimie, 121, pp.112-122.
 Tiwari, P., Sahay, S., Pandey, M., Qadri, S.S. and Gupta, K.P., 2015. Combinatorial
chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7, 12-
dimethylbenz (a) anthracene induced mouse skin tumorigenesis attained by enhancing the
induction of intrinsic apoptotic events. Chemico-biological interactions, 226, pp.1-11.
 Tiwari, P. and Gupta, K.P., 2014. Modulation of miR-203 and its regulators as a function of time
during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in
presence or absence of the antitumor agents. Toxicology and applied pharmacology, 278(2),
pp.148-158.
 Krishna, S., Mishra, S., Tiwari, P., Vishwakarma, A.K., Khandai, S., Shrivastava, S., Verma, A.K.,
Tiwari, S., Barman, H., Jhariya, S. and Tiwari, P., 2021. Therapeutic efficacy of artemether-
lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria
endemic states of India. Malaria Journal, 20(1), pp.1-10.
 Manjunathachar, H.V., Barde, P.V., Raut, C.G., Tiwari, P., Chouksey, V., Gowda, K., Kumar, R.
and Das, A., 2021. Determination of cut-off of diagnostic ELISA for Scrub typhus in endemic
setup: Central India. Journal of Vector Borne Diseases, 58(1), p.90.
 Pandey, M., Sahay, S., Tiwari, P., Upadhyay, D.S., Sultana, S. and Gupta, K.P., 2014.
Involvement of EZH2, SUV39H1, G9a and associated molecules in pathogenesis of urethane
induced mouse lung tumors: potential targets for cancer control. Toxicology and applied
pharmacology, 280(2), pp.296-304.

5. Significant academic/research achievements and experience
 Experiences in the area of molecular biology, epigenetics, health
research and molecular techniques are congruent with the required
experiences.
 Expert skill on techniques: Nucleic acid / protein extraction, Gel
electrophoresis, Western blotting, Immuno-histo chemistry (IHC), MS-
PCR, Diagnostic PCR, qRT PCR, DNA sequencing, Bacterial and
mammalian cell culture, Gene cloning, ELISA, Microscopy and Bio-
informatics tools for DNA and protein sequence analysis. I have also
attained expertise in handling and restraining of small laboratory
animals (rodents) for research.
Research work experience fit with job profile asked in advertisement
Significant academic achievements
 CSIR-UGC Junior Research Fellowship (CSIR-UGC-NET, Dec- 2009.)
 CSIR-UGC Lectureship Award (CSIR-UGC-NET, June- 2009.).