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Which of the following statements is true?
A.
mutations occur less frequently at non-synonymous sites than at synonymous sites
B.
the substitution rate tends to be much lower at synonymous sites than at non-synonymous sites
C.
the neutral theory proposes that most genetic variation results from strong balancing selection
D.
across mammalian genomes, most genes are under strong purifying selection, with a relatively
small portion of genes subject to positive selection
E.
all of the above are true

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