Which of the following statements is true? A. mutations occur less frequently at non-synonymous sites than at synonymous sites B. the substitution rate tends to be much lower at synonymous sites than at non-synonymous sites C. the neutral theory proposes that most genetic variation results from strong balancing selection D. across mammalian genomes, most genes are under strong purifying selection, with a relatively small portion of genes subject to positive selection E. all of the above are true.