There were 53 reported cases of Zika virus in South Carolina as of November 9, 2016, all related to travel. A single case of sexual transmission was reported. Pharmacists can play a key role in educating the public about Zika virus prevention and recommending effective insect repellents. The ideal timeline for FDA approval of an accelerated Zika virus vaccine is December 2017. A clinical trial is currently studying the safety and effectiveness of a Zika virus DNA vaccine.