LGBT college students in Pennsylvania experience significantly higher rates of mental health conditions, self-harm, and suicidality compared to heterosexual and cisgender peers and the general college population. Over half of LGBT students surveyed had been diagnosed with a mental health condition. Barriers to accessing mental health care included cost, lack of time, and health insurance issues. Minority stress from discrimination, family rejection, and internalized homophobia/transphobia likely contribute to poorer mental health outcomes for LGBT students.