This document discusses challenges in B2B e-commerce and strategies to address them. It highlights three main challenges that companies face: 1) optimizing distribution channels in the changing landscape, 2) reducing costs through empowering customers with self-service online, and 3) improving sales of complex products. The document then elaborates on each challenge and provides examples of companies that have successfully addressed them, such as how Dermalogica established cooperation across its distribution channels and empowered customers with an online store.