What is ediblocked for cannabis edibles, read this https://cannabis.net/blog/opinion/are-you-ediblocked-do-you-not-get-high-after-eating-edibles

1. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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CAN'T GET HIGH ON EDIBLES
Are You Ediblocked? Do You Not Get
High After Eating Edibles?
New reports are coming in from people who can't get high off edibles!
Posted by:
Reginald Reefer, today at 12:00am
Are you Ediblocked?
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2. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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I remember the rst time I ate too many brownies (https://cannabis.net/blog/opinion/what-can-
you-do-if-you-eat-too-many-cannabis-edibles), which sent me into a world of intense visuals, deep
body highs and cottonmouth like never before.
Most people who eat edibles feel the e ects of it, but there is a class of human that seems to be
immune to edibles – and scientists aren’t quite sure why this happens.
There are theories. Theories we’ll discuss in this article.
However, the implications of this discovery reaches much further than the inability of an individual
to get high from 11-hydroxy-THC, and could impact things like our standardized drug tests of
impairment, cannabis medicine, and much more.
Throughout the rest of this article, we’ll also be taking a closer look at these issues.
Are you Ediblocked?

3. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
https://cannabis.net/blog/opinion/are-you-ediblocked-do-you-not-get-high-after-eating-edibles 4/12
The term “Ediblocked” comes from the Boston Globe Article
(https://www.bostonglobe.com/2021/05/12/marijuana/ediblocked-some-people-cant-get-high-
eating-marijuana-scientists-arent-sure-why/), which was the inspiration to writing this article. I
rather enjoy the term and also can see that this can be extended to other substances.
For example, I once took LSD with a group of psychonauts where one person in particular said, “I
don’t get it, this to me feels like I do when I’m smoking weed!”
I looked at the man with my pupils dilated, seeing all sorts of shitfuckery swirl about while the walls
breathed and thought to myself, “This dude is a caveman!” Of course, he wasn’t and in all likeliness
he experienced something similar to an “ediblock”.
But what makes the discovery so important is that it illustrates that “standardized tests of
impairment” fail to take into consideration that people process drugs di erently.
Of course, making a test that can adapt to the individual’s biochemical makeup is still only science
ction at this point – but it also shows us that many people who might have been “deemed
impaired” by law enforcement could have been more sober than the o cer putting the cu s on.
Here’s a snippet from one of the guys in the Boston Globe Article;
“They couldn’t stop laughing — they were all having a great time,” recalled McDonald, a 55-year-old
cannabis cultivator from Ontario, Canada. “And I got absolutely nothing from them. I was sitting there
with my arms crossed, like, ‘aw man … everybody’s Hoverboard works except for mine.’ ”
This is a guy named Al who rst discovered that he was immune to edibles when his friends ate a
bunch of high potency cannabis cookies. Al says he starts “feeling” the e ects of THC by the 700-
milligram marker which would send most people into a deep bodied charged trip.
It could also be the reason why Joey Diaz seemingly can consume ungodly amounts of THC while
being “okay-ish”.
For some of you, the idea of being immune to edibles does not seem like a big deal – but for
people who are undergoing surgery or some patients who tried cannabis for pain relief – may have
not been able to tap into the therapeutic value of the plant due to this inhibition to process THC
like the “norm”.
But why does this happen? How does one become “Ediblocked”?
Right now researchers aren’t 100% about the reason but they hypothesize that it could be
something to do with a particular liver enzyme responsible for processing THC. As opposed to
“inhibiting THC”, they argue that these people simply have more e cient processing capabilities in
the liver.

4. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
https://cannabis.net/blog/opinion/are-you-ediblocked-do-you-not-get-high-after-eating-edibles 5/12
“While no studies have directly examined those with ultra-high tolerances to marijuana edibles, Gruber
and other researchers have a compelling hypothesis: People with an unusual variation of a key liver
enzyme could essentially be too e cient at processing ingested THC, turning the compound into its
“active” high-causing metabolite and then its inactive waste product before the active form can enter the
bloodstream or brain. It’s also possible other people’s enzymes make them unusually ine cient at
performing this process, with little THC getting metabolized in the rst place.
“It’s almost as if they’re skipping the intermediate step,” Gruber said of people with uncommon subtypes
of the CPY2C9 gene, which encodes the enzyme that shepherds THC through its three-step metabolic
transformation. “You’re breaking it down so fast it doesn’t have an opportunity to create the
psychoactive e ect.” - Source (https://www.bostonglobe.com/2021/05/12/marijuana/ediblocked-
some-people-cant-get-high-eating-marijuana-scientists-arent-sure-why/)
Why this becomes a problem for the individual cannabis consumer comes down to how we test
“impairment” in society. Most of the modern tests do not account for liver enzymes and the ability
to process THC better.
People like Al, can eat 500 mg and be stone-cold sober. Yet if he was pulled over by a cop, tested
for THC in the saliva or blood – he’s be deemed “impaired”.
“The research casts doubt on biological marijuana tests widely used by researchers, doctors, police, and
employers, which look for those same metabolites but don’t account for the apparently vast and hard-
wired variations in metabolic rate between individuals. (In Massachusetts, most suspected stoned drivers
are evaluated by o cers with so-called “drug recognition expert” certi cations, a process that typically
includes a saliva or blood test for THC.)”
The issue from a medical perspective
This is not just about getting high either. For people who use cannabis as a medicine, it could mean
that if you have a higher presence of the CPY2C9 Gene – you may need heavier doses of cannabis
to take e ect.
The problem, as Doctor Lester Grinspoon points out – “Taking too much could send you into an 8-
hour trip!” or 18-hours in my case.
I guess my CYPY2C9 gene likes to take his time – but then again, I had close to 20 brownies in a
span of 2 hours, so my THC levels were probably far exceeding 1gram.
“Grinspoon said the phenomenon illustrates how little we understand the body’s cannabinoid system,
thanks in part to longstanding federal restrictions on studying marijuana. “This is something that, with
appropriate research and smart people working on it, we could understand and maybe even x,” he
said.”
And he’s right!

5. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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The federal government with their anti-freedom policies have hindered cannabinoid research for
decades in the name of “safety” and now science has to play catch-up.
It once more illustrates how government’s approach to drugs is not only outdated, but potentially
dangerous to individuals who consume cannabis both medically and recreationally.
I wonder where we could have been in terms of cannabis medicine if the government didn’t decide
to sti e research and information?
WEED TOLERANCE ISSUES, READ MORE...
(https://cannabis.net/blog/opinion/how-to-properly-
take-a-tbreak-resetting-your-thc-tolerance-levels)
WHEN IS IT TIME TO TAKE A WEED BREAK TO LOWER YOUR TOLERANCE?
(https://cannabis.net/blog/opinion/how-to-properly-take-a-tbreak-resetting-your-thc-tolerance-
levels)
OR..
(https://cannabis.net/blog/how-to/what-do-you-do-
if-you-cant-get-high-anymore)
WHAT CAN YOU DO IF YOU CAN'T GET HIGH ANYMORE? CLICK HERE!
(https://cannabis.net/blog/how-to/what-do-you-do-if-you-cant-get-high-anymore)

6. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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7. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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8. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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9. 5/21/2021 Are You Ediblocked? Do You Not Get High After Eating Edibles?
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Why isn't the Cannabis Industry More Women-Friendly?
An effective way of dealing with this issue would be to implement laws, such as those in certain communities which reserve some
cannabis licenses for women, as well as minority-owned businesses. Another way to help would be for organizations to conduct
skills training, such as helping women (and other minorities) learn how to write business plans particularly if they want to make th…