The keynote discusses the growth and momentum of .NET and C# as popular technologies. .NET Core 2.0 and ASP.NET Core 2.0 have been improved with better performance, smaller file sizes, and additional features. Visual Studio 2017 and Visual Studio for Mac provide better tooling for developing with .NET and C#. The speaker demonstrates new capabilities in .NET Core 2.0 and ASP.NET Core 2.0.