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![Molluscum contagiosum
ï” Pox virus [molluscum contagiosum
virus genotype 1(most
common),2(common in hiv patients),3
and 4]
ï” Affects children, adults with sexually
transmitted disease and
immunocompromised patients
ï” Skin to skin transmission, contact with
fomites, sexual transmission or auto
inoculation
ï” Incubation period â 14 to 50 days](https://image.slidesharecdn.com/viralinfectionsderm-230912170739-7653a30a/85/viralinfectionsderm-pptx-22-320.jpg)
![1.1.2. viral infections of skin [compatibility mode]](https://cdn.slidesharecdn.com/ss_thumbnails/1-1-2-viralinfectionsofskincompatibilitymode-120714004456-phpapp02-thumbnail.jpg?width=640&height=640&fit=bounds)
viralinfectionsderm.pptx
- 1. Common Viral infectionsof skin Raj Sharani Final yr MBBS student
- 3. Synopsis ï” Herpes simplexvirus ï” Varicella zoster virus ï” Herpes zoster ï” Verrucae vulgaris ï” Genital warts ï” Molluscum contagiosum ï” Hand foot mouth disease ï” Viral exanthem ï” Measles
- 4. âą Herpes simplexvirus type 1 and type 2 causes grouped painful vesicles âą HSV-1 causes Herpes labialis (cold sores) âą HSV-2 causes Herpes genitalis Herps simplex infection
- 5. PATHOGENESIS Mucosa or Abradedskin sensory nerve endings Retrograde spread to Dorsal root ganglion Latency Trigger, Reactivation Anterograde spread, Recurrence
- 7. Herpetic whitlow ï” Traumainduced Herpetic whitlow over fingers most common health care professionals
- 8. Microscopic features Tzanck smearâpresence of multinucleated gaint cells with Giemsa stain
- 9. ï Ballooning degeneration, intraepithelialblisters HISTOPATHOLOGY
- 10. TREATMENT Antiviral Primary (10 days) Recurrence (5days) Suppressive 6months-1yr Acyclovir 200mg 5times/day 400mg tid 400 mg bd Valaciclovir 1gm bd 500mg bd 500-1000 mg bd Famciclovir 250mg tid 125mg bd 250mg bd
- 11. Varicella zoster virusinfection ï” Varicella (chicken pox) is the primary exogenous infection ï” Herpes zoster is caused by reactivating of endogenous infection from dormant virus in nerves or gangilion ï” Incubation period 14-17 days ï” Varicella is transmitted by aerosols
- 12. Varicella ï” Initially rashbegins on face, scalp rapidly spreads to trunk ï” Dew drop on a rose petal appearance of vesicles ï” Vesicles become umbilicated and pustular , rupture to form crust ï” Centripetal pattern of lesions
- 13. Herpes zoster orshingles ï” Vesicles are unilateral with initial symptoms of pain and paraesthesia in the involved dermatome ï” Grouped vesicles on an erythematous base ï” Secondary bacterial infection, Hypopigmention or hyperpigmentation and scars ï” Post herpetic neuralgia â chronic segmental pain for 3 months after resolution of herpes zoster lesions
- 14. ï” Common inOphthalmic division of trigeminal nerve, Thoracic nerves ï” Hutchinsons sign - lesions in the tip of the nose then there will be involvement of eye (cornea)
- 15. ï” Acyclovir 800mg 5 times a day ï” Famciclovir 500 mg tds ï” Valacyclovir 1000 mg tds ï” PEP : Within 96 hrs/ VZV Ig After 96 hrs / Acyclovir 40-80mg/kg/day x 7 days Cold compress, analgesic ï” Topical capsaicin ï” Carbamezepine, Phenytoin, Gabapentin TREATMENT
- 16. Warts or verrucae ï”Human papillomavirus ï” Transmission â spread by direct or indirect contact via fomites ï” Incubation period - few weeks upto an year ï” About 120 types are identified in human
- 17. Verruca vulgaris ï” Humanpapilloma virus type 2 ï” Painless, firm papules with horny surface 1mm to 1cm ï” Mostly seen over back of hands and fingers
- 18. Condyloma accuminata orgenital warts Fleshy exuberant pink papules may evolve into cauliflower like lesion
- 19.
- 20. Treatment Salicyclic acid 10%-20% Electrodesiccation Cryotherapy Curettagefor warts unresponsive to topical treatment
- 21. Cryotherapy ï” Uses liquidnitrogen at -196°C Electrodesiccation âą Scraping or burning off of skin growth with local anesthetic
- 22. Molluscum contagiosum ï” Poxvirus [molluscum contagiosum virus genotype 1(most common),2(common in hiv patients),3 and 4] ï” Affects children, adults with sexually transmitted disease and immunocompromised patients ï” Skin to skin transmission, contact with fomites, sexual transmission or auto inoculation ï” Incubation period â 14 to 50 days
- 23. Clinical features âą Lesionsare smooth surfaced, firm, dome shaped pearly papules with a central umbilication âą Seen in face, trunk, extremities in children and in genital areas for adults
- 24. Microscopic examination ï” Hendersonpaterson bodies â intracytoplasmic eosinophilic inclusion bodies Treatment ï” Resolve spontaneously ï” Cryosurgery ï” Electrodesiccation ï” 10% KOH application
- 25. Hand foot mouthdisease ï” Enterovirus genus, most commonly the coxsackievirus ï” By skin-to-skin contact ï” By airborne respiratory droplets , saliva ï” Oral lesions ï” Vesicular eruptions over hand , foot and mouth ï” Generally resolves by itself
- 26. macular/ maculopapular rash ViralExanthems
- 27. Viral exanthems ï” Rubella ï”Coxsackie ï” EBV ï” Parvovirus B19 ï” Mumps ï” Measles ï” Hepatitis B & C ï” ECHO virus ï” HIV ï” HPV ï” Molluscum ï” Orf ï” Kaposis sarcoma ï” HIV Macular/ Maculopapular Papular
- 29. Measles ï” Cough ï” Coryza-runny nose ï” Conjunctivitis ï” Koplikâs spots inside the mouth ï” Maculopapular rash
- 30.