ALCohoL ReSeARCh C u r r e n t R e v i e w s506 Alcohol .docxADDY50
ALCohoL ReSeARCh: C u r r e n t R e v i e w s
506 Alcohol Research: C u r r e n t R e v i e w s
Resilience to Meet the
Challenge of Addiction
Psychobiology and Clinical Considerations
Tanja N. Alim, M.D.; William B. Lawson, M.D.; Adriana Feder, M.D.; Brian M.
Iacoviello, Ph.D.; Shireen Saxena, M.S.; Christopher R. Bailey; Allison M.
Greene, M.S.; and Alexander Neumeister, M.D.
Tanja N. Alim, M.D., is an assis-
tant professor and William B.
Lawson, M.D., is a professor
and chair of the Department
of Psychiatry, both at the
Department of Psychiatry and
Behavioral Sciences, Howard
University, Washington, DC.
Adriana Feder, M.D., is an assistant
professor; Brian M. Iacoviello,
Ph.D., is a postdoctoral fellow;
and Shireen Saxena, M.S.,
Christopher R. Bailey, and
Allison M. Greene, M.S., are
research associates; all at the
Mood and Anxiety Disorders
Program, Department of Psychiatry,
Mount Sinai School of Medicine,
New York, New York.
Alexander Neumeister, M.D., is
a professor in the Department of
Psychiatry and Radiology, New
York University Langone Medical
Center, New York, New York.
Acute and chronic stress–related mechanisms play an important role in the
development of addiction and its chronic, relapsing nature. Multisystem adaptations in
brain, body, behavioral, and social function may contribute to a dysregulated
physiological state that is maintained beyond the homeostatic range. In addition,
chronic abuse of substances leads to an altered set point across multiple systems.
Resilience can be defined as the absence of psychopathology despite exposure to
high stress and reflects a person’s ability to cope successfully in the face of adversity,
demonstrating adaptive psychological and physiological stress responses. The study of
resilience can be approached by examining interindividual stress responsibility at
multiple phenotypic levels, ranging from psychological differences in the way people
cope with stress to differences in neurochemical or neural circuitry function. The
ultimate goal of such research is the development of strategies and interventions to
enhance resilience and coping in the face of stress and prevent the onset of addiction
problems or relapse. Key WoRDS: Addiction; substance abuse; stress; acute stress
reaction; chronic stress reaction; biological adaptation to stress; psychological
response to stress; physiological response to stress; resilience; relapse; coping
skills; psychobiology
evidence from different disciplinessuggests that acute and chronicstress–related mechanisms play
an important role in both the develop-
ment and the chronic, relapsing nature
of addiction (Baumeister 2003; Baumeister
et al. 1994; Brady and Sinha 2005).
Stress is defined as the physiological
and psychological process resulting from
a challenge to homeostasis by any real
or perceived demand on the body
(Lazarus and Fokman 1984; McEwen
2000; Selye 1976). Stress often induces
multisystem adaptations that occur in
the brain and .
ALCohoL ReSeARCh C u r r e n t R e v i e w s506 Alcohol .docxSHIVA101531
ALCohoL ReSeARCh: C u r r e n t R e v i e w s
506 Alcohol Research: C u r r e n t R e v i e w s
Resilience to Meet the
Challenge of Addiction
Psychobiology and Clinical Considerations
Tanja N. Alim, M.D.; William B. Lawson, M.D.; Adriana Feder, M.D.; Brian M.
Iacoviello, Ph.D.; Shireen Saxena, M.S.; Christopher R. Bailey; Allison M.
Greene, M.S.; and Alexander Neumeister, M.D.
Tanja N. Alim, M.D., is an assis-
tant professor and William B.
Lawson, M.D., is a professor
and chair of the Department
of Psychiatry, both at the
Department of Psychiatry and
Behavioral Sciences, Howard
University, Washington, DC.
Adriana Feder, M.D., is an assistant
professor; Brian M. Iacoviello,
Ph.D., is a postdoctoral fellow;
and Shireen Saxena, M.S.,
Christopher R. Bailey, and
Allison M. Greene, M.S., are
research associates; all at the
Mood and Anxiety Disorders
Program, Department of Psychiatry,
Mount Sinai School of Medicine,
New York, New York.
Alexander Neumeister, M.D., is
a professor in the Department of
Psychiatry and Radiology, New
York University Langone Medical
Center, New York, New York.
Acute and chronic stress–related mechanisms play an important role in the
development of addiction and its chronic, relapsing nature. Multisystem adaptations in
brain, body, behavioral, and social function may contribute to a dysregulated
physiological state that is maintained beyond the homeostatic range. In addition,
chronic abuse of substances leads to an altered set point across multiple systems.
Resilience can be defined as the absence of psychopathology despite exposure to
high stress and reflects a person’s ability to cope successfully in the face of adversity,
demonstrating adaptive psychological and physiological stress responses. The study of
resilience can be approached by examining interindividual stress responsibility at
multiple phenotypic levels, ranging from psychological differences in the way people
cope with stress to differences in neurochemical or neural circuitry function. The
ultimate goal of such research is the development of strategies and interventions to
enhance resilience and coping in the face of stress and prevent the onset of addiction
problems or relapse. Key WoRDS: Addiction; substance abuse; stress; acute stress
reaction; chronic stress reaction; biological adaptation to stress; psychological
response to stress; physiological response to stress; resilience; relapse; coping
skills; psychobiology
evidence from different disciplinessuggests that acute and chronicstress–related mechanisms play
an important role in both the develop-
ment and the chronic, relapsing nature
of addiction (Baumeister 2003; Baumeister
et al. 1994; Brady and Sinha 2005).
Stress is defined as the physiological
and psychological process resulting from
a challenge to homeostasis by any real
or perceived demand on the body
(Lazarus and Fokman 1984; McEwen
2000; Selye 1976). Stress often induces
multisystem adaptations that occur in
the brain and .
ALCohoL ReSeARCh C u r r e n t R e v i e w s506 Alcohol .docxADDY50
ALCohoL ReSeARCh: C u r r e n t R e v i e w s
506 Alcohol Research: C u r r e n t R e v i e w s
Resilience to Meet the
Challenge of Addiction
Psychobiology and Clinical Considerations
Tanja N. Alim, M.D.; William B. Lawson, M.D.; Adriana Feder, M.D.; Brian M.
Iacoviello, Ph.D.; Shireen Saxena, M.S.; Christopher R. Bailey; Allison M.
Greene, M.S.; and Alexander Neumeister, M.D.
Tanja N. Alim, M.D., is an assis-
tant professor and William B.
Lawson, M.D., is a professor
and chair of the Department
of Psychiatry, both at the
Department of Psychiatry and
Behavioral Sciences, Howard
University, Washington, DC.
Adriana Feder, M.D., is an assistant
professor; Brian M. Iacoviello,
Ph.D., is a postdoctoral fellow;
and Shireen Saxena, M.S.,
Christopher R. Bailey, and
Allison M. Greene, M.S., are
research associates; all at the
Mood and Anxiety Disorders
Program, Department of Psychiatry,
Mount Sinai School of Medicine,
New York, New York.
Alexander Neumeister, M.D., is
a professor in the Department of
Psychiatry and Radiology, New
York University Langone Medical
Center, New York, New York.
Acute and chronic stress–related mechanisms play an important role in the
development of addiction and its chronic, relapsing nature. Multisystem adaptations in
brain, body, behavioral, and social function may contribute to a dysregulated
physiological state that is maintained beyond the homeostatic range. In addition,
chronic abuse of substances leads to an altered set point across multiple systems.
Resilience can be defined as the absence of psychopathology despite exposure to
high stress and reflects a person’s ability to cope successfully in the face of adversity,
demonstrating adaptive psychological and physiological stress responses. The study of
resilience can be approached by examining interindividual stress responsibility at
multiple phenotypic levels, ranging from psychological differences in the way people
cope with stress to differences in neurochemical or neural circuitry function. The
ultimate goal of such research is the development of strategies and interventions to
enhance resilience and coping in the face of stress and prevent the onset of addiction
problems or relapse. Key WoRDS: Addiction; substance abuse; stress; acute stress
reaction; chronic stress reaction; biological adaptation to stress; psychological
response to stress; physiological response to stress; resilience; relapse; coping
skills; psychobiology
evidence from different disciplinessuggests that acute and chronicstress–related mechanisms play
an important role in both the develop-
ment and the chronic, relapsing nature
of addiction (Baumeister 2003; Baumeister
et al. 1994; Brady and Sinha 2005).
Stress is defined as the physiological
and psychological process resulting from
a challenge to homeostasis by any real
or perceived demand on the body
(Lazarus and Fokman 1984; McEwen
2000; Selye 1976). Stress often induces
multisystem adaptations that occur in
the brain and .
ALCohoL ReSeARCh C u r r e n t R e v i e w s506 Alcohol .docxSHIVA101531
ALCohoL ReSeARCh: C u r r e n t R e v i e w s
506 Alcohol Research: C u r r e n t R e v i e w s
Resilience to Meet the
Challenge of Addiction
Psychobiology and Clinical Considerations
Tanja N. Alim, M.D.; William B. Lawson, M.D.; Adriana Feder, M.D.; Brian M.
Iacoviello, Ph.D.; Shireen Saxena, M.S.; Christopher R. Bailey; Allison M.
Greene, M.S.; and Alexander Neumeister, M.D.
Tanja N. Alim, M.D., is an assis-
tant professor and William B.
Lawson, M.D., is a professor
and chair of the Department
of Psychiatry, both at the
Department of Psychiatry and
Behavioral Sciences, Howard
University, Washington, DC.
Adriana Feder, M.D., is an assistant
professor; Brian M. Iacoviello,
Ph.D., is a postdoctoral fellow;
and Shireen Saxena, M.S.,
Christopher R. Bailey, and
Allison M. Greene, M.S., are
research associates; all at the
Mood and Anxiety Disorders
Program, Department of Psychiatry,
Mount Sinai School of Medicine,
New York, New York.
Alexander Neumeister, M.D., is
a professor in the Department of
Psychiatry and Radiology, New
York University Langone Medical
Center, New York, New York.
Acute and chronic stress–related mechanisms play an important role in the
development of addiction and its chronic, relapsing nature. Multisystem adaptations in
brain, body, behavioral, and social function may contribute to a dysregulated
physiological state that is maintained beyond the homeostatic range. In addition,
chronic abuse of substances leads to an altered set point across multiple systems.
Resilience can be defined as the absence of psychopathology despite exposure to
high stress and reflects a person’s ability to cope successfully in the face of adversity,
demonstrating adaptive psychological and physiological stress responses. The study of
resilience can be approached by examining interindividual stress responsibility at
multiple phenotypic levels, ranging from psychological differences in the way people
cope with stress to differences in neurochemical or neural circuitry function. The
ultimate goal of such research is the development of strategies and interventions to
enhance resilience and coping in the face of stress and prevent the onset of addiction
problems or relapse. Key WoRDS: Addiction; substance abuse; stress; acute stress
reaction; chronic stress reaction; biological adaptation to stress; psychological
response to stress; physiological response to stress; resilience; relapse; coping
skills; psychobiology
evidence from different disciplinessuggests that acute and chronicstress–related mechanisms play
an important role in both the develop-
ment and the chronic, relapsing nature
of addiction (Baumeister 2003; Baumeister
et al. 1994; Brady and Sinha 2005).
Stress is defined as the physiological
and psychological process resulting from
a challenge to homeostasis by any real
or perceived demand on the body
(Lazarus and Fokman 1984; McEwen
2000; Selye 1976). Stress often induces
multisystem adaptations that occur in
the brain and .
Metabolic depression in hibernation and major depression: an explanatory theo...Loki Stormbringer
Metabolic depression, an adaptive biological process for energy preservation, is responsible for torpor, hibernation and estivation. We propose that a form of metabolic depression, and not mitochondrial dysfunction, is the process underlying the observed hypometabolism, state-dependent neurobiological changes and vegetative symptoms of major depression in humans. The process of metabolic depression is reactivated via differential gene expression in response to perceived adverse stimuli in predisposed persons. Behavior inhibition by temperament, anxiety disorders, genetic vulnerabilities, and early traumatic experiences predispose persons to depression. The proposed theory is supported by similarities in the presentation and neurobiology of hibernation in bears and major depression and explains the yet unexplained neurobiological changes of depression. Although, gene expression is suppressed in other hibernators by deep hypothermia, bears were chosen because they hibernate with mild hypothermia. Pre-hibernation in bears and major depression with atypical features are both characterized by fat storage through overeating, oversleeping, and decreased mobility. Hibernation in bears and major depression with melancholic features are characterized by withdrawal from the environment, lack of energy, loss of weight from not eating and burning stored fat, changes in sleep pattern, and the following similar neurobiological findings: reversible subclinical hypothyroidism; increased concentration of serum cortisol; acute phase protein response; low respiratory quotient; oxidative stress response; decreased neurotransmitter levels; and changes in cyclic-adenosine monophosphate-binding activity. Signaling systems associated with protein phosphorylation, transcription factors, and gene expression are responsible for the metabolic depression process during pre-hibernation and hibernation. Antidepressants and mood stabilizers interfere with the hibernation process and produce their therapeutic effects by normalizing the fluctuation of activities in the different signaling systems, which are down-regulated during hibernation and depression and up-regulated during exodus from hibernation and the hypomanic or manic phase of mood disorders. The ways individuals cognitively perceive, understand, communicate, and react to the vegetative symptoms of depression, from downregulation in energy production, and in the absence of known medical causes, produce the other characteristics of depression including guilt, helplessness, hopelessness, suicidal phenomena, agitation, panic attacks, psychotic symptoms, and sudden switch to hypomanic or manic episodes. The presence of one or more of these characteristics depends on the person's neuropsychological function, its social status between the others, and the other's response to the person. Neurobiological changes associated with metabolic depression during entrance, maintenance, and exodus from hibernation in bears is suggested a
Stress is defined as a state of physiological or psychological strain caused by an adverse stimuli , physical, mental, or emotional, internal or external that tend to disturb the functioning of an organism and which the organism naturally desires to avoid.
GERO 508 Spring 2021
Week 2
The Mind & Body Connection
Timothy Lu Office Hours: By Appointment Email: [email protected]
Dr Paul Nash CPsychol, AFBPsS, FHEA
Office: GERO 231E
Office Hours: Thurs 09.00-12.00
(OR AGREED APPOINTMENT)
Email: [email protected]
Gillian Fennell
Email: [email protected]
Questions about assessments?
2
The session in brief
Biological – What is stress?
Biological consequences of stress
Biological models of stress
Measuring biological stress
What does stress look like?
The meaning of sex
Psychological approaches to stress
Environmental approaches to stress
Specific models of stress
Bio-Psycho-Social models of stress
Measuring psychological components of stress
3
What forms can stress take?
4
Stress – The overview
Actual Stress
- See a predator / See a car coming towards you
5
Perceived Stress
- In a situation where something may or may not happen
Which do you think happens with humans? Why?
Humans exhibit the anticipatory stress response, well done us!! Turn on stress response for psychological reasons
- memory, emotions, thoughts
NOT what stress was designed for which leads to potential for chronic stress
Essentially the aim of the stress response is to return us to the homeostatic equilibrium we are in.
Acute or Chronic?
6
The meaning of sex
7
Fight or Flight
Tend and Befriend
Evolutionary
Protection of self and offspring
Nurturing offspring under stressful situation
Protect from harm (tend)
Create / join social groups to maximize resource and protection (befriend)
Evolutionary
Protection of self
Fight a stressor
Escape a stressor
Short lived
Few mins – Alive or dead
Most research based on males until the tend / befriend hypothesis produced. Mainly due to different cyclical variation in hormones and endocrine responses making research with women less predictable.
Not the whole story and we have biological and psychological differences later in the course!
Stress – The psychological approach
8
Stress as a response
The ways in which we respond to a stressor
Storm and stress approach
Coping & resilience
Effects of prolonged stress
Stress as a stimulus
Views stress as a significant life event or change that demands response, adjustment, or adaptation
Sees change as inherently stressful
Stress is dealt with uniformly across populations
Illness outcome thresholds are uniform
Stress as a transaction
Stress is a product of the human – environment transaction
Hardiness, resilience, locus of control and self-efficacy are important constructs
Duration of transaction (Episodic, Acute, Chronic)
Environmental stressors
9
Suboptimal environmental conditions pose demands that may exceed an individuals ability to cope
The imbalance between environmental demands and response capabilities is called…..?
…Stress
Environmental stressors include:
Chronic
Noise when living by a freeway
Acute
Noise when in a tunnel
Which is more ...
Metabolic depression in hibernation and major depression: an explanatory theo...Loki Stormbringer
Metabolic depression, an adaptive biological process for energy preservation, is responsible for torpor, hibernation and estivation. We propose that a form of metabolic depression, and not mitochondrial dysfunction, is the process underlying the observed hypometabolism, state-dependent neurobiological changes and vegetative symptoms of major depression in humans. The process of metabolic depression is reactivated via differential gene expression in response to perceived adverse stimuli in predisposed persons. Behavior inhibition by temperament, anxiety disorders, genetic vulnerabilities, and early traumatic experiences predispose persons to depression. The proposed theory is supported by similarities in the presentation and neurobiology of hibernation in bears and major depression and explains the yet unexplained neurobiological changes of depression. Although, gene expression is suppressed in other hibernators by deep hypothermia, bears were chosen because they hibernate with mild hypothermia. Pre-hibernation in bears and major depression with atypical features are both characterized by fat storage through overeating, oversleeping, and decreased mobility. Hibernation in bears and major depression with melancholic features are characterized by withdrawal from the environment, lack of energy, loss of weight from not eating and burning stored fat, changes in sleep pattern, and the following similar neurobiological findings: reversible subclinical hypothyroidism; increased concentration of serum cortisol; acute phase protein response; low respiratory quotient; oxidative stress response; decreased neurotransmitter levels; and changes in cyclic-adenosine monophosphate-binding activity. Signaling systems associated with protein phosphorylation, transcription factors, and gene expression are responsible for the metabolic depression process during pre-hibernation and hibernation. Antidepressants and mood stabilizers interfere with the hibernation process and produce their therapeutic effects by normalizing the fluctuation of activities in the different signaling systems, which are down-regulated during hibernation and depression and up-regulated during exodus from hibernation and the hypomanic or manic phase of mood disorders. The ways individuals cognitively perceive, understand, communicate, and react to the vegetative symptoms of depression, from downregulation in energy production, and in the absence of known medical causes, produce the other characteristics of depression including guilt, helplessness, hopelessness, suicidal phenomena, agitation, panic attacks, psychotic symptoms, and sudden switch to hypomanic or manic episodes. The presence of one or more of these characteristics depends on the person's neuropsychological function, its social status between the others, and the other's response to the person. Neurobiological changes associated with metabolic depression during entrance, maintenance, and exodus from hibernation in bears is suggested a
Stress is defined as a state of physiological or psychological strain caused by an adverse stimuli , physical, mental, or emotional, internal or external that tend to disturb the functioning of an organism and which the organism naturally desires to avoid.
GERO 508 Spring 2021
Week 2
The Mind & Body Connection
Timothy Lu Office Hours: By Appointment Email: [email protected]
Dr Paul Nash CPsychol, AFBPsS, FHEA
Office: GERO 231E
Office Hours: Thurs 09.00-12.00
(OR AGREED APPOINTMENT)
Email: [email protected]
Gillian Fennell
Email: [email protected]
Questions about assessments?
2
The session in brief
Biological – What is stress?
Biological consequences of stress
Biological models of stress
Measuring biological stress
What does stress look like?
The meaning of sex
Psychological approaches to stress
Environmental approaches to stress
Specific models of stress
Bio-Psycho-Social models of stress
Measuring psychological components of stress
3
What forms can stress take?
4
Stress – The overview
Actual Stress
- See a predator / See a car coming towards you
5
Perceived Stress
- In a situation where something may or may not happen
Which do you think happens with humans? Why?
Humans exhibit the anticipatory stress response, well done us!! Turn on stress response for psychological reasons
- memory, emotions, thoughts
NOT what stress was designed for which leads to potential for chronic stress
Essentially the aim of the stress response is to return us to the homeostatic equilibrium we are in.
Acute or Chronic?
6
The meaning of sex
7
Fight or Flight
Tend and Befriend
Evolutionary
Protection of self and offspring
Nurturing offspring under stressful situation
Protect from harm (tend)
Create / join social groups to maximize resource and protection (befriend)
Evolutionary
Protection of self
Fight a stressor
Escape a stressor
Short lived
Few mins – Alive or dead
Most research based on males until the tend / befriend hypothesis produced. Mainly due to different cyclical variation in hormones and endocrine responses making research with women less predictable.
Not the whole story and we have biological and psychological differences later in the course!
Stress – The psychological approach
8
Stress as a response
The ways in which we respond to a stressor
Storm and stress approach
Coping & resilience
Effects of prolonged stress
Stress as a stimulus
Views stress as a significant life event or change that demands response, adjustment, or adaptation
Sees change as inherently stressful
Stress is dealt with uniformly across populations
Illness outcome thresholds are uniform
Stress as a transaction
Stress is a product of the human – environment transaction
Hardiness, resilience, locus of control and self-efficacy are important constructs
Duration of transaction (Episodic, Acute, Chronic)
Environmental stressors
9
Suboptimal environmental conditions pose demands that may exceed an individuals ability to cope
The imbalance between environmental demands and response capabilities is called…..?
…Stress
Environmental stressors include:
Chronic
Noise when living by a freeway
Acute
Noise when in a tunnel
Which is more ...
Aula 2: Um pouco de filosofia da ciênciaCaio Maximino
Slides da segunda vídeo-aula do curso online "Inferência estatística para ciências experimentais", ministrada pelo prof. Caio Maximino (FAPSI/Unifesspa)
Vídeo: https://tubedu.org/videos/watch/08d116ca-5aa0-41ce-ab59-9dcbbf921c34
Quiz: https://kahoot.it/challenge/06864533?challenge-id=92ac686d-79d5-4d28-aea1-4f96bc87f702_1607463389214
Journal club: "Contextual fear learning and memory differ between stress copi...Caio Maximino
Apresentação para o JC do LaNeC.
Referência: Baker MR, Wong RY (2019). Contextual fear learning and memory differ between stress coping styles in zebrafish. Sci Rep 9, 9935. doi: 10.1038/s41598-019-46319-0
https://www.nature.com/articles/s41598-019-46319-0
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
3. “Stress” is a polysemic concept
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Selye (1950); non-specific response of the body to any noxious stimulus
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Stressor X stress response
– Chrousos (2009): A stressor is any stimulus that threatens homeostasis → circular definition
– Armario (2006): many studies interpret the presence of a stress response as an indicator of stress exposure,
without an independent definition of either the stressor or the stress response
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Levine and Ursin (1991): stress should be considered as a process that includes the stimulus, the
perceptual processing of this input, and the behavioral and physiological outputs
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Adaptive X maldaptive
– Selye (1976): eustress X distress
4. Koolhaas JM, de Boer SF, Ruiter AJH, Meerlo P,
Sgoifo A (1997). Social stress in rats and mice. Acta
Physiologica Scandinavica 161: 9-72
5. Characteristics of stressors
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Controllability and predictability
– Weiss (1972): it is not the physical nature of an aversive stimulus that induces
stress, but rather the degree in which the stimulus can be predicted and controlled
– Salvador (2005): perceived, not actual, control
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Frequency (e.g., acute vs. repeated vs. chronic) – can be related to
predictability
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Intensity
6. Characteristics of stressors
Koolhaas et al. (2011). Stress revisited: A critical evaluation of the stress
concept. Neuroscience & Biobehavioral Reviews 35: 1291-1301
7. Allostasis and regulatory range
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McEwen and Wingfield (2009): allostasis is defined as the process of achieving
stability through change in anticipation of physiological requirements
– involves mechanisms that change the controlled physiological variable by predicting what
level will be needed to meet anticipated demand
– Homeostasis refers to the controlled values, and allostasis refers to the mediators
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When environmental changes and/or life-history changes demand more from
behavior and physiology, we have an allostatic load
– Allostatic overload Type I: occurs when the animal's energy demand for maintaining
homeostasis exceeds the energy the animal can obtain from its environment
– Allostatic overload Type II: occurs when allostatic load is too high for too long
8. The reactive scope model
Romero LM, Dickens MJ & Cyr NE (2009). The reactive scope model — A
new model integrating homeostasis, allostasis, and stress. Horm. Behav. 55:
375–389
9.
10. HP(A/I) axis
Steenbergen PJ, Richardson MK, Champagne DL (2011). The use of the
zebrafish model in stress research. Prog. Neuro-Psychopharmacol. Biol.
Psychiatry 35: 1432-1451
11. Comparative issues
Bouyoucos IA, Schoen AN, Wahl RC, Anderson G (2021). Ancient fishes
and the functional evolution of the corticosteroid stress response in
vertebrates. Comp. Biochem. Physiol A 260: 111024
12. Despite differences, function is conserved
Bouyoucos IA, Schoen AN, Wahl RC, Anderson G (2021). Ancient fishes and the functional
evolution of the corticosteroid stress response in vertebrates. Comp. Biochem. Physiol A 260:
111024
14. GCs act by genomic and nongenomic mechanisms
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Glucocorticoid receptor-dependent gene regulatory networks. PLoS
Genet 1(2): e16.
15. Borski RJ (2000). Nongenomic Membrane Actions of
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Maximino, C. (2021). Decynium-22 affects behavior in the
zebrafish light/dark test. Neuroanatomy and Behaviour, 3, e21
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17.
18. Actions of GCs
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Permissive: exerted by GCs present before the stressor; prime the defense
mechanisms by which an organism responds to stress
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Suppressive: inhibitory effects attributable to the stress-induced rise in GC
concentrations; prevent overshoot
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Stimulating: excitatory effects attributable to stress-induced rise in GC concentrations
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Preparative: do not affect the immediate response to a stressor, but modulate the
organism’s response to a subsequent stressor.
19.
20. Impacts of the capitalocene on stress axes
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Musa et al. (2017): Tilapias acclimated to high water temperatures for 14 d showed higher cortisol levels at 1, 7,
and 14 d; and much higher 11-ß-hydroxylase activity at 14 d
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Leishman et al. (2022): Higher fecal cortisol metabolite concentration in adult polar bears in the wild or in zoos
with temperatures above 20 ºC
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Petochi et al. (2011): CO2 exposure (“ocean acidification”) can increase plasma cortisol levels on acute
exposures, but not chronic exposure
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Bisson & Hontela (2002): Agrichemicals inhibit cortisol secretion in steroidogenic cells of rainbow trout (in vitro)
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Cericato et al. (2008): Jundiás exposed to sub-lethal concentrations of agrichemicals show blunted GC
secretion after acute stress