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Diabetic Nephropathy
Diabetic Retinopathy
Hypercholesterolemia
Oral Mucositis
Gout
Acute Lymphocytic Leukemia
Bone Metastasis
Brain Cancer
Breast Cancer
Cervical Cancer
Chronic Lymphocytic Leukemia
Endometrial Cancer
Ewing Sarcoma
Gastric Cancer
Gastrointestinal Stromal Tumors
Head And Neck Cancer
Hodgkin Lymphoma
Kidney Cancer
Liver Cancer
Malignant Mesothelioma
Medullary Thyroid Cancer
Melanoma
Multiple Myeloma
Non-Hodgkin Lymphoma
Non-Small Cell Lung Cancer
Ovarian Cancer
Pancreatic Cancer
Testicular Cancer
Thyroid Cancer
Age Related Macular Degeneration
Keratoconjunctivitis sicca (Dry Eye)
Retinal Vein Occlusion
Acute Respiratory Distress
Syndrome
Sepsis
Staphylococcal Infections
Acute Coronary Syndrome
Angina Pectoris
Atrial Fibrillation
Coronary Artery Disease (CAD)
Critical Limb Ischemia
Hypertension
Pulmonary Arterial Hypertension
Acute Pain
Anxiety Disorders
Chronic Pain
Dementia
Diabetic Neuropathy
Obsessive-Compulsive Disorder
Osteoarthritis Pain
Parkinson's Disease
Post-Traumatic Stress Disorder
Restless Legs Syndrome
Schizophrenia
Traumatic Brain Injury
Liver Cirrhosis
Childhood Enuresis
Growth Hormone Disorders
Hyperparathyroidism
Hyperthyroidism
Guillain-Barre Syndrome
Cytomegalovirus
Fungal Infections
Gram-Negative Bacterial Infections
H1N1 Infection
Herpes Zoster
HIV-1 Infection
Human Papillomavirus Infections
Staphylococcus Aureus (MRSA)
Cardiovascular Devices
Prosthetic Heart Valve
Peripheral Vascular Devices
Cardiovascular Monitoring & Diagnostic Devices
Cardiovascular Surgery
Cardiac Rhythm Management
Cardiovascular Prosthetic Devices
Interventional Cardiology
Cardiac Assist Devices
Wound Care Management
Hospital Supplies
Syringes and Needles
Disposable Hospital & Surgical Supplies
Drug Delivery Devices
Inhalation Systems
Needle Free Injections
Infusion Systems
Diabetes Care Devices
Insulin Delivery & Glucose Monitoring
Ophthalmic Devices
Cataract Surgery Devices
Ophthalmic Diagnostic Equipment
Refractive Surgery Devices
ENT Devices
Hearing Implants
Diagnostic Devices
Electrosurgical Devices
Dental Equipment & Accessories
Diagnostic Imaging & MRI Systems
C/T Systems & Mammography Equipment
X-Ray & Ultrasound Systems
Nuclear Imaging Equipment
Contrast Media Injectors
Bone Densitometry
Anesthesia and Respiratory Devices
Anesthesia Machines & Disposables
Respiratory Devices & Disposables
Sleep Apnea Diagnostic Systems
Healthcare IT
Medical Imaging Information Systems
Nephrology and Urology Devices
Renal Dialysis Equipment
Orthopedic Devices
Orthobiologics & Arthroscopy
Joint Reconstruction
Trauma Fixation
Orthopedic Prosthetics
Cranium Maxillofacial Fixation (CMF)
Spinal Surgery
Endoscopy Devices & instruments
Rigid & Flexible Endoscope
In Vitro Diagnostics
Genetic Testing
Clinical Chemistry
Hematology
Immuno Chemistry
Infectious Immunology
Histology And Cytology
Patient Monitoring
Multiparameter Patient Monitoring
Micro-Electromechanical Systems
Non-invasive Blood Pressure Monitors
Neurology Devices
Neurostimulation Devices
Interventional Neurology
CSF Management
Neurosurgical Products
Radiosurgery
Value to the
Lead Investor
Healthcare’s Investment Marketplace
Discovery
Develop-
ment I
N
D
PhaseI
PhaseII
PhaseIII
N
D
A
Approval
Launch
Growth
Mature
Healthcare Development & Financing Cycle
IPO / Public MarketsVenture CapitalAngels / Founders Private Equity / M&A
SEED
EXIT
… E M E R G I N G G R O W T H C O M PA N I E S
… ‘ L E A D ’ I N V E S T O R S
… D I R E C T I N V E S T O R S
… S T R AT E G I C PA RT N E R S & B U Y E R S
T R A N S F O R M I N G H E A LT H C A R E C A P I TA L M A R K E T S
on behalf of…
Healthcare’s Investment Bank
HealthiosXchange
12,000 Investors
Across (10)
Asset Classes
in (37) Countries &
2,000 Strategics in
(46) Market sectors
“Seed-to-Exit”
Direct
Investment
NO
Adverse
Selection
Messaging
&
Notifications
Ratings &
Reviews
Rules-Based
Deal Flow
Prediction &
Sentiment Data
Proprietary
Events
(6,000)+
Growth
Companies
NO Fee
NO Carry
Shorter “Exit”
Horizons
Real-Time
Valuations &
Research
Less
Correlation
Reporting &
Communications
Zero
Un-Invested
Capital
SHOWCASING THE PORTFOLIO
REDUCED FINANCING RISK
ADDITIONAL CARRIED INTEREST
GREATER FINANCING & “EXIT”
CERTAINTY
SUPERIOR RETURNS
Healthcare’s Investment Bank
Showcasing the Portfolio
Healthcare’s Investment Bank
Reduced Financing Risk
Australia
North America
UAE & India
AsiaEurope & Middle East
Healthcare’s Investment Marketplace 6
Additional Carried Interest
Trading Lower Fees for Greater Carry
Source: Coller Capital, “Global Private Equity & Venture Barometer: Summer 2014”
26%
22% 22%
15% 15%
11%
3%
2%
15%
0%
5%
10%
15%
20%
25%
30%
Performance
Fees
Economic
Environment
Transparency
Regulation
Liquidity
Volatility
Consolidation
Other
ProportionofRespondents
Healthcare’s Investment Bank
Greater Transaction Certainty & “Exit” Path
Healthcare’s Investment Bank
Greater Transaction Certainty & “Exit” Path
The actual
number of
months before
the next
transaction is 4.
We predicted 3.
The actual value of the next
transaction is $150 million
and we predicted $150
million.
Healthcare’s Investment Bank
Superior Returns
12,000 Investors
Across (10)
Asset Classes
in (37) Countries &
2,000 Strategics in
(46) Market sectors
“Seed-to-Exit”
Direct
Investment
NO
Adverse
Selection
Messaging
&
Notifications
Ratings &
Reviews
Rules-Based
Deal Flow
Prediction &
Sentiment Data
Proprietary
Events
(6,000)+
Growth
Companies
NO Fee
NO Carry
Shorter “Exit”
Horizons
Real-Time
Valuations &
Research
Less
Correlation
Reporting &
Communications
Zero
Un-Invested
Capital
SUPERIOR RETURNS

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Value to lead investor

  • 1. Diabetic Nephropathy Diabetic Retinopathy Hypercholesterolemia Oral Mucositis Gout Acute Lymphocytic Leukemia Bone Metastasis Brain Cancer Breast Cancer Cervical Cancer Chronic Lymphocytic Leukemia Endometrial Cancer Ewing Sarcoma Gastric Cancer Gastrointestinal Stromal Tumors Head And Neck Cancer Hodgkin Lymphoma Kidney Cancer Liver Cancer Malignant Mesothelioma Medullary Thyroid Cancer Melanoma Multiple Myeloma Non-Hodgkin Lymphoma Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Testicular Cancer Thyroid Cancer Age Related Macular Degeneration Keratoconjunctivitis sicca (Dry Eye) Retinal Vein Occlusion Acute Respiratory Distress Syndrome Sepsis Staphylococcal Infections Acute Coronary Syndrome Angina Pectoris Atrial Fibrillation Coronary Artery Disease (CAD) Critical Limb Ischemia Hypertension Pulmonary Arterial Hypertension Acute Pain Anxiety Disorders Chronic Pain Dementia Diabetic Neuropathy Obsessive-Compulsive Disorder Osteoarthritis Pain Parkinson's Disease Post-Traumatic Stress Disorder Restless Legs Syndrome Schizophrenia Traumatic Brain Injury Liver Cirrhosis Childhood Enuresis Growth Hormone Disorders Hyperparathyroidism Hyperthyroidism Guillain-Barre Syndrome Cytomegalovirus Fungal Infections Gram-Negative Bacterial Infections H1N1 Infection Herpes Zoster HIV-1 Infection Human Papillomavirus Infections Staphylococcus Aureus (MRSA) Cardiovascular Devices Prosthetic Heart Valve Peripheral Vascular Devices Cardiovascular Monitoring & Diagnostic Devices Cardiovascular Surgery Cardiac Rhythm Management Cardiovascular Prosthetic Devices Interventional Cardiology Cardiac Assist Devices Wound Care Management Hospital Supplies Syringes and Needles Disposable Hospital & Surgical Supplies Drug Delivery Devices Inhalation Systems Needle Free Injections Infusion Systems Diabetes Care Devices Insulin Delivery & Glucose Monitoring Ophthalmic Devices Cataract Surgery Devices Ophthalmic Diagnostic Equipment Refractive Surgery Devices ENT Devices Hearing Implants Diagnostic Devices Electrosurgical Devices Dental Equipment & Accessories Diagnostic Imaging & MRI Systems C/T Systems & Mammography Equipment X-Ray & Ultrasound Systems Nuclear Imaging Equipment Contrast Media Injectors Bone Densitometry Anesthesia and Respiratory Devices Anesthesia Machines & Disposables Respiratory Devices & Disposables Sleep Apnea Diagnostic Systems Healthcare IT Medical Imaging Information Systems Nephrology and Urology Devices Renal Dialysis Equipment Orthopedic Devices Orthobiologics & Arthroscopy Joint Reconstruction Trauma Fixation Orthopedic Prosthetics Cranium Maxillofacial Fixation (CMF) Spinal Surgery Endoscopy Devices & instruments Rigid & Flexible Endoscope In Vitro Diagnostics Genetic Testing Clinical Chemistry Hematology Immuno Chemistry Infectious Immunology Histology And Cytology Patient Monitoring Multiparameter Patient Monitoring Micro-Electromechanical Systems Non-invasive Blood Pressure Monitors Neurology Devices Neurostimulation Devices Interventional Neurology CSF Management Neurosurgical Products Radiosurgery Value to the Lead Investor
  • 2. Healthcare’s Investment Marketplace Discovery Develop- ment I N D PhaseI PhaseII PhaseIII N D A Approval Launch Growth Mature Healthcare Development & Financing Cycle IPO / Public MarketsVenture CapitalAngels / Founders Private Equity / M&A SEED EXIT … E M E R G I N G G R O W T H C O M PA N I E S … ‘ L E A D ’ I N V E S T O R S … D I R E C T I N V E S T O R S … S T R AT E G I C PA RT N E R S & B U Y E R S T R A N S F O R M I N G H E A LT H C A R E C A P I TA L M A R K E T S on behalf of…
  • 3. Healthcare’s Investment Bank HealthiosXchange 12,000 Investors Across (10) Asset Classes in (37) Countries & 2,000 Strategics in (46) Market sectors “Seed-to-Exit” Direct Investment NO Adverse Selection Messaging & Notifications Ratings & Reviews Rules-Based Deal Flow Prediction & Sentiment Data Proprietary Events (6,000)+ Growth Companies NO Fee NO Carry Shorter “Exit” Horizons Real-Time Valuations & Research Less Correlation Reporting & Communications Zero Un-Invested Capital SHOWCASING THE PORTFOLIO REDUCED FINANCING RISK ADDITIONAL CARRIED INTEREST GREATER FINANCING & “EXIT” CERTAINTY SUPERIOR RETURNS
  • 5. Healthcare’s Investment Bank Reduced Financing Risk Australia North America UAE & India AsiaEurope & Middle East
  • 6. Healthcare’s Investment Marketplace 6 Additional Carried Interest Trading Lower Fees for Greater Carry Source: Coller Capital, “Global Private Equity & Venture Barometer: Summer 2014” 26% 22% 22% 15% 15% 11% 3% 2% 15% 0% 5% 10% 15% 20% 25% 30% Performance Fees Economic Environment Transparency Regulation Liquidity Volatility Consolidation Other ProportionofRespondents
  • 7. Healthcare’s Investment Bank Greater Transaction Certainty & “Exit” Path
  • 8. Healthcare’s Investment Bank Greater Transaction Certainty & “Exit” Path The actual number of months before the next transaction is 4. We predicted 3. The actual value of the next transaction is $150 million and we predicted $150 million.
  • 9. Healthcare’s Investment Bank Superior Returns 12,000 Investors Across (10) Asset Classes in (37) Countries & 2,000 Strategics in (46) Market sectors “Seed-to-Exit” Direct Investment NO Adverse Selection Messaging & Notifications Ratings & Reviews Rules-Based Deal Flow Prediction & Sentiment Data Proprietary Events (6,000)+ Growth Companies NO Fee NO Carry Shorter “Exit” Horizons Real-Time Valuations & Research Less Correlation Reporting & Communications Zero Un-Invested Capital SUPERIOR RETURNS

Editor's Notes

  1. All-at-once, the global healthcare industry is the most complex, chaotic, compelling and dynamic market in the world. A $3 trillion global industry, growing 16% annually, capitalizing itself $13.8 million at a time through more than 9,000 negotiated transactions in 6,000 companies into which, on average, $49 million of capital is deployed over 6.2 years, yielding a “Cash-on-Cash” returns of 4.1x and IRR’s of 22.1% while generating 81% liquidity on invested capital through 892 “Exit” events, of which 87% are M&A. HealthiosXchange is the premier capital marketplace dedicated exclusively to the global healthcare industry. By aggregating 6,000 Emerging Growth healthcare companies in (37) countries together with 30,000 investors in (10) asset classes and 2,000 strategic partners representing (46) market sectors IN A SINGLE MARKET ENVIRONMENT, HealthiosXchange represents a universal capital markets experience perfectly reflective of the industry it serves. We intend to transform the manner in which capital is invested – and value is realized – throughout the global healthcare industry, by serving the needs of: The most successful Lead Investors
  2. HealthiosXchange believes that the cornerstone of the global healthcare capital markets is the “Lead” institutional investor: Venture Capital, Growth Equity and Private Equity firms. In the healthcare capital markets, the “Lead” investor plays a critically important role: Screening deal flow Selecting the opportunity Performing due diligence Pricing the investment Negotiating the transaction Overseeing management Providing governance Performance measurement & reporting Managing financing and liquidity pathway HealthiosXchange seeks to be the premier healthcare capital market in the world, by transforming the manner in which capital is invested – and value is realized – throughout the global healthcare industry. We intend to achieve this goal by assisting “Lead” investors to: Showcase their portfolio Reduce financing risk in their portfolio Achieve superior investment returns Extend the relationship of Lead investors with their own Limited Partners Create greater financing and “Exit” certainty
  3. HealthiosXchange provides every emerging growth healthcare company with its own customized profile to: Perfect the Company’s positioning within their target market sector Maximize awareness among its Peers within its target market 360-degree social and industry media exposure Engage with prospective investors and strategic partners Provide notifications and alerts to key relationships based on news flow Benchmark success with exclusive valuation, capital flows and investment research Report progress to “Friends”, “Followers”, investors, partners and buyers For Lead investors, these capabilities permit them to manage their portfolio in the most consistent, transparent and efficient manner.
  4. Listed on HealthiosXchange are more than 30,000 healthcare investors in (37 countries, segregated in (10) discrete asset classes, along with more than 2,000 strategic buyers in (46) market categories. Among the listed investors are: 3,700 Family Offices 2,100 Alternative Direct Investors 1,300 “Cross-Over” Investors 18,000 Registered Investment Advisors 137 Private Banks 212 Foreign Trusts 29 Sovereign Wealth Organizations Through this global footprint, HealthiosXchange is building the most comprehensive universe of active healthcare investors in the world. This capital markets footprint represents and important resource for “Lead” investors to ensure continuous, efficient and cost effective access to capital for their entire healthcare portfolio.
  5. 55% of Limited Partners with fund investments in healthcare identified management fees as the principal motivation for a shift in investment strategies. In addition, investors cited better control of investments, greater transparency, and an opportunity to gain direct exposure to new industries. 60% of North American investors (and more than 40% of foreign investors) would pay higher carried interest in return for lower fund management fees. HealthiosXchange is pioneering unique capital markets strategies and syndication techniques which permit Lead investors to deepen their relationships with the Limited Partner community. In certain transactions, it will be possible for “Lead” investors to earn carried interest on capital deployed directly alongside of their own in support of the financing needs of designated portfolio companies.
  6. 100% of investment returns in the global healthcare industry is generated by 23.7% of portfolio companies There have been (4,393) M&A transactions completed in the global healthcare industry between 2003 and 2012. Of those transactions, 80% (or 3,514 deals) have been consummated by 56% (or 1,107) of the strategic buyers The ratio of portfolio companies which attracted a minimum of $15 million in invested capital since 2009 to strategic buyer which has consummated a minimum of one M&A transaction during the same period = 20.3 to 1 Exits represent the culmination of the investment cycle:  a time when buyers consolidate value, when investors realize return, and when entrepreneurs consummate their success. Yet, throughout the emerging growth healthcare community, liquidity has become exceedingly difficult to achieve. HealthiosXchange provides Lead investors with the resources to ensure greater transaction certainty and “Exit” pathways by: Hosting exclusive online events, investment conferences, road shows and “Shark Tanks” Trending & Activity Reports Benchmarking the achievement of milestones and inflection points (v.s. Peers) Exploiting proprietary capital markets tools, such as Matching, Targeting and Geo-Location
  7. 100% of investment returns in the global healthcare industry is generated by 23.7% of portfolio companies There have been (4,393) M&A transactions completed in the global healthcare industry between 2003 and 2012. Of those transactions, 80% (or 3,514 deals) have been consummated by 56% (or 1,107) of the strategic buyers The ratio of portfolio companies which attracted a minimum of $15 million in invested capital since 2009 to strategic buyer which has consummated a minimum of one M&A transaction during the same period = 20.3 to 1 Exits represent the culmination of the investment cycle:  a time when buyers consolidate value, when investors realize return, and when entrepreneurs consummate their success. Yet, throughout the emerging growth healthcare community, liquidity has become exceedingly difficult to achieve. HealthiosXchange provides Lead investors with the resources to ensure greater transaction certainty and “Exit” pathways by: Hosting exclusive online events, investment conferences, road shows and “Shark Tanks” Trending & Activity Reports Benchmarking the achievement of milestones and inflection points (v.s. Peers) Exploiting proprietary capital markets tools, such as Matching, Targeting and Geo-Location
  8. HealthiosXchange believes that the cornerstone of the global healthcare capital markets is the “Lead” institutional investor: Venture Capital, Growth Equity and Private Equity firms. In this capacity, the “Lead” investor plays a critically important role. By providing Lead investors with extensive resources in support of the needs of their portfolio, while reducing financing risk, enhancing investment returns and extending the relationship of Lead investors with their own Limited Partners, HealthiosXchange seeks to make a indelible contribution to the culture of innovation, growth and value creation around the world