QuickBooks error H101 indicates issues with multi-user mode, typically arising when the company file cannot be accessed by QuickBooks desktop due to various causes such as incorrect hosting settings, firewall blocks, or corrupted files. Symptoms include failure to switch to multi-user mode, error messages, and application crashes. The document outlines several effective solutions to address the error, including verifying hosting settings, creating a new .nd file, configuring firewall settings, using QuickBooks database server manager, repairing corrupted files, and reinstalling QuickBooks if necessary.