This document provides guidance on tuberculosis (TB) treatment initiation and follow up. It outlines key actions including counseling patients, initiating appropriate treatment regimens based on drug sensitivity and testing for HIV/diabetes, assessing socioeconomic status, opening treatment cards, ensuring treatment adherence, arranging drug and supply availability, and maintaining patient follow up and records. It also describes the Nikshay Mitra program which aims to improve TB treatment outcomes through community support such as nutritional assistance. Health staff are tasked with enrolling donors to this program.