This document discusses several metabolic and regulatory disorders of the musculoskeletal system, including gout, pseudogout, and muscular dystrophy. It provides details on the epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and controversies regarding treatment for each condition. Gout is caused by deposition of urate crystals in the joints due to hyperuricemia. Pseudogout involves deposition of calcium pyrophosphate dihydrate crystals in joints and can mimic gout. Muscular dystrophies like Duchenne involve a genetic defect of the dystrophin gene leading to progressive muscle weakness.
This document summarizes several degenerative disorders of the musculoskeletal system. It discusses osteoarthritis, describing it as the breakdown of cartilage in the joints. It also covers degenerative diseases of the spine like degenerative disc disease, spinal stenosis, and spondylolisthesis. Additional topics include osteoporosis, scoliosis, fibromyalgia, and cervical spondylosis. For each condition, it provides information on causes, symptoms, diagnosis, and treatment options. The overall document provides an overview of common degenerative disorders that affect the bones, joints, and spine.
Preserved blood cells undergo progressive functional and structural changes that reduce oxygen delivery to tissues
The release of extracellular vesicles and cell-free DNA during storage may cause a hypercoagulable state
STORAGE LESION : amalgamation of reversible and irreversible changes that begin after 2 to 3 weeks of storage, progress with duration of storage and reduce red-cell function and viability after transfusion
The document discusses various adverse effects that can occur from blood transfusions, including:
- Acute hemolytic reactions, which can be life-threatening if not treated promptly by stopping the transfusion and providing supportive care.
- Febrile non-hemolytic reactions, which are usually mild and self-limiting but can recur with subsequent transfusions.
- Anaphylactic reactions, which are potentially fatal allergic reactions that require immediate epinephrine treatment.
- Transfusion-related lung injury, a pulmonary syndrome caused by donor antibodies reacting with recipient lung cells that requires supportive care and notification of the blood bank.
It emphasizes the importance of proper screening and identification procedures to prevent errors
This document discusses several metabolic and regulatory disorders of the musculoskeletal system, including gout, pseudogout, and muscular dystrophy. It provides details on the epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and controversies regarding treatment for each condition. Gout is caused by deposition of urate crystals in the joints due to hyperuricemia. Pseudogout involves deposition of calcium pyrophosphate dihydrate crystals in joints and can mimic gout. Muscular dystrophies like Duchenne involve a genetic defect of the dystrophin gene leading to progressive muscle weakness.
This document summarizes several degenerative disorders of the musculoskeletal system. It discusses osteoarthritis, describing it as the breakdown of cartilage in the joints. It also covers degenerative diseases of the spine like degenerative disc disease, spinal stenosis, and spondylolisthesis. Additional topics include osteoporosis, scoliosis, fibromyalgia, and cervical spondylosis. For each condition, it provides information on causes, symptoms, diagnosis, and treatment options. The overall document provides an overview of common degenerative disorders that affect the bones, joints, and spine.
Preserved blood cells undergo progressive functional and structural changes that reduce oxygen delivery to tissues
The release of extracellular vesicles and cell-free DNA during storage may cause a hypercoagulable state
STORAGE LESION : amalgamation of reversible and irreversible changes that begin after 2 to 3 weeks of storage, progress with duration of storage and reduce red-cell function and viability after transfusion
The document discusses various adverse effects that can occur from blood transfusions, including:
- Acute hemolytic reactions, which can be life-threatening if not treated promptly by stopping the transfusion and providing supportive care.
- Febrile non-hemolytic reactions, which are usually mild and self-limiting but can recur with subsequent transfusions.
- Anaphylactic reactions, which are potentially fatal allergic reactions that require immediate epinephrine treatment.
- Transfusion-related lung injury, a pulmonary syndrome caused by donor antibodies reacting with recipient lung cells that requires supportive care and notification of the blood bank.
It emphasizes the importance of proper screening and identification procedures to prevent errors
1. Determining an isolate's nutritional and metabolic capabilities through a combination of enzyme and inhibitor tests is commonly used to identify its genus and species.
2. Tests establish enzymatic capabilities and ability to grow under stressors like salts, surfactants, toxins and antibiotics. Enzyme tests measure single enzymes or full pathways, while inhibitor tests examine susceptibility.
3. Common tests include catalase, oxidase, urease, and carbohydrate fermentation, along with assays for metabolic pathways and stressor susceptibility. Together these provide a biochemical profile for identification.
- Mandibular fractures are common injuries that may be encountered by dental surgeons. They can be classified based on type, site, and cause of the fracture.
- Signs and symptoms depend on the specific site of the fracture and may include pain, swelling, limitation of mouth opening, and malocclusion. Radiographs are important for diagnosis.
- Management involves addressing the airway, hemorrhage, and pain. Definitive treatment consists of reduction to realign fragments followed by immobilization to allow bone healing, which depends on the stability and mobility at the fracture site. Teeth in the line of fracture may require extraction.
The document discusses identification of pathogenic bacteria in a clinical microbiology laboratory. It provides guidance on identifying common gram positive and gram negative bacteria through microscopic morphology, biochemical tests, and growth characteristics. Key tests discussed include gram stain, catalase, coagulase, optochin sensitivity, bile solubility, and indole for differentiating between staphylococci, streptococci, pneumococci, enterococci, and neisseria.
An effort to put light on the common health hazards caused by improper ergonomics and a glance over the proper ergonomic practises to be followed in daily dental practise to increase the ease and efficiency of your practise..
14 Principles of HENRI FAYOL project on KFC Class-XIIAtif Khan
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
An immersive workshop at General Assembly, SF. I typically teach this workshop at General Assembly, San Francisco. To see a list of my upcoming classes, visit https://generalassemb.ly/instructors/seth-familian/4813
I also teach this workshop as a private lunch-and-learn or half-day immersive session for corporate clients. To learn more about pricing and availability, please contact me at http://familian1.com
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
SlideShare is a global platform for sharing presentations, infographics, videos and documents. It has over 18 million pieces of professional content uploaded by experts like Eric Schmidt and Guy Kawasaki. The document provides tips for setting up an account on SlideShare, uploading content, optimizing it for searchability, and sharing it on social media to build an audience and reputation as a subject matter expert.
1. Determining an isolate's nutritional and metabolic capabilities through a combination of enzyme and inhibitor tests is commonly used to identify its genus and species.
2. Tests establish enzymatic capabilities and ability to grow under stressors like salts, surfactants, toxins and antibiotics. Enzyme tests measure single enzymes or full pathways, while inhibitor tests examine susceptibility.
3. Common tests include catalase, oxidase, urease, and carbohydrate fermentation, along with assays for metabolic pathways and stressor susceptibility. Together these provide a biochemical profile for identification.
- Mandibular fractures are common injuries that may be encountered by dental surgeons. They can be classified based on type, site, and cause of the fracture.
- Signs and symptoms depend on the specific site of the fracture and may include pain, swelling, limitation of mouth opening, and malocclusion. Radiographs are important for diagnosis.
- Management involves addressing the airway, hemorrhage, and pain. Definitive treatment consists of reduction to realign fragments followed by immobilization to allow bone healing, which depends on the stability and mobility at the fracture site. Teeth in the line of fracture may require extraction.
The document discusses identification of pathogenic bacteria in a clinical microbiology laboratory. It provides guidance on identifying common gram positive and gram negative bacteria through microscopic morphology, biochemical tests, and growth characteristics. Key tests discussed include gram stain, catalase, coagulase, optochin sensitivity, bile solubility, and indole for differentiating between staphylococci, streptococci, pneumococci, enterococci, and neisseria.
An effort to put light on the common health hazards caused by improper ergonomics and a glance over the proper ergonomic practises to be followed in daily dental practise to increase the ease and efficiency of your practise..
14 Principles of HENRI FAYOL project on KFC Class-XIIAtif Khan
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
An immersive workshop at General Assembly, SF. I typically teach this workshop at General Assembly, San Francisco. To see a list of my upcoming classes, visit https://generalassemb.ly/instructors/seth-familian/4813
I also teach this workshop as a private lunch-and-learn or half-day immersive session for corporate clients. To learn more about pricing and availability, please contact me at http://familian1.com
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
SlideShare is a global platform for sharing presentations, infographics, videos and documents. It has over 18 million pieces of professional content uploaded by experts like Eric Schmidt and Guy Kawasaki. The document provides tips for setting up an account on SlideShare, uploading content, optimizing it for searchability, and sharing it on social media to build an audience and reputation as a subject matter expert.
18. Natural history
• Ligament injury : Knee instability
• Meniscus injury : pain, range of motion
• Cartilage injury
• Osteoarthritis
19. Physical examination
• Swelling
• Point of tenderness
• Limitation of range of motion
• Special tests ***
20. Special tests
Stability test
• Anterior drawer test
• Posterior drawer test
• Varus stress test
• Valgus stress test
• Prone external rotation test
• Lachman test
• Lateral pivot shift test
42. Investigation or Imaging
• Plain film radiograph : AP ,lateral, mortise
view
• For exclude bone fracture
• Able to exclude ligament sprain grade by
measuring parameter
61. BONE AND JOINT INJURIES
• Fracture = Disruptions of bone tissue
• Osteochondral or intraarticular fractures =
Visible disruptions of articular cartilage or
fractures involved both the articular cartilage
and subchondral bone
• Chondral fractures = involved only the
cartilage
63. Bone Tissue
• Its tensile strength nearly equals that of
cast iron
• 3 times lighter
• 10 times more flexible
• Consists of mesenchymal cells embeded
within abundant extracellular matrix
• Constantly changing in response to
mechanical and hormonal signals
64.
65. Bone Tissue
The matrix contains :
1. Mineral great strength and stiffness
in compression and bending
2. Collagen type 1 strength and
plasticity
3. Cytokine , Growth factors
66. Periosteum
• Outer layer more fibrous layer
• Inner layer more cellular and vascular
cambium layer
• Participates in healing of many types of
fractures
• In children , Thicker periosteum than
Adults
67. Types of Bone
Woven bone (immature bone)
• Embryonic skeleton
• More rapid rate of
deposition and resorption
• Initial fracture repair
• Irregular pattern of matrix
fibrils
• relatively high cell content
and water concentration
• 4 times the number of
osteocytes per unit volume
• Less stiffness
• More easily deformed
Lamellar bone (mature bone)
• Replaces woven bone
during growth and
development
• Replaces woven bone in
remodeling phase under
mechanical load
• More stiffness
• Difficultly deformed
68.
69. Bone formation
1. Cutting cone
2. Intramembranous formation
3. Endochondral bone formation
70. Cutting cone
• Primarily a mechanism to remodel bone
• Osteoclasts at the front
• Trailing osteoblasts lay down new bone
71. Intramembranous formation
• Long bone grows in width
• Osteoblasts differentiate directly from
preosteoblasts and lay down seams of
osteoid
• Do not involve cartilage anlage
72. Endochondral bone formation
• Long bone grows in length
• The chondrocytes hypertrophy, degenerate
and calcify
• Vascular invasion of cartilage occurs followed
by ossification
74. Inflammatory phase
• Require high energy until remodeling
• Inflammatory mediators released from
platelets, dead cells
• Vasodilatation and exudate plasma
edema in the region
• Macrophages and Lymphocyte migration
• The inflammatory response subsides,
necrotic tissue and exudate are resorbed
75.
76. Repair phase
• Fibroblasts and chondrocytes start
producing a new matrix, the fracture
callus
• Follows inflammatory phase rapidly
• Unstable Vs Stable fracture ???
77.
78. Repair and Remodeling of
Unstable Fractures (Secondary
bone healing
• Organization of hematoma first step
in fracture repair
• Initiate fracture healing
• The intact fracture hematoma provides a
fibrin scaffold that facilitates migration
of repair cells
79. • Platelets and cells in hematoma release
GFs and other proteins cell
migration, proliferation, matrix
synthesis
• Blood supply, medullary system and
periosteum are important for fracture
healing
• The mesenchymal cells proliferate,
differentiate, and produce the fracture
callus consisting of fibrous tissue,
cartilage, and woven bone
80. Osteoclast
• Derived from circulating monocytes in
the blood and monocytic precursor cells
from the bone marrow
• Do not appear to form repair tissue
81. Osteoblast
• Develop from the
undifferentiated
mesenchymal cells
that migrate into
the fracture site
• Participate in bone
formation
82. • Hard (bony) callus
“The bone formed initially at the
periphery of the callus by
intramembranous bone formation”
• Soft (fibrous and cartilaginous) callus
“forms in the central regions with low
oxygen tension and consists primarily of
cartilage and fibrous tissue”
• Endochondral ossification
enlarging the hard callus and increasing
the stability of the fracture fragments
87. • At these stages, the healing is not
complete
• The immature fracture callus is weaker
than normal bone
• Gaining full strength during remodeling
phase
• During final stage of Repair, Remodeling
of the repair tissue begins with
replacement of woven bone by lamellar
bone and resorption of unneeded callus
88. • By radioisotope studies, the remodeling
process continues for year after clinical
and radiographic union
• Decrease bone density and remains
changes for years
89.
90. Repair and Remodeling of Stabilized
Fractures (Primary Bone Healing)
The fracture surfaces are rigidly held in
contact
Fracture healing can occur without
grossly visible callus in either cancellous
or cortical bone
Called “ Primary bone healing”
Small bone gaps Vs bone contact??
91. • Lamellar bone can form directly across
the fracture line by extension of osteons
• A cluster of osteoclasts cuts across the
fracture line, osteoblasts following the
osteoclasts deposit new bone, and blood
vessels follow the osteoblasts
• The new bone matrix, enclosed
osteocytes, and blood vessels form new
haversian systems.
104. Articular cartilage
• Sparsely distributed chondrocytes
• Surrounded by an elaborate, highly organized
macromolecular framework filled with water
• Collagens, Proteoglycans and Non-collagenous
proteins form the
macromolecular framework
105.
106.
107. Physical examination
• Pain
• Swelling
• Tenderness
• Limitation of Range of motion
• Neurological status
• Vascular status
111. Treatment
• Non-operative
• Operative
Decision making depend on
• Site of injury,
• Severity of injury
• Fracture configuration
• Surrounding structures injury
• Other organ system injury
• Patient’s underlying disease
122. “Clinical union”
• Stability of the fracture fragments
progressively increases because of the
internal and external callus formation
• The fracture site becomes stable and
pain-free
123. “Radiographic union”
• Plain radiographs show bone trabeculae
or cortical bone crossing the fracture site
• Often occurs later than clinical union
126. Delay union
• Fracture line remains clearly visible
radiographically
• There is no undue separation of the
fragments, no cavitation of the surfaces, no
calcification, and no sclerosis
• Related to the severity of the injury, poor
blood supply, the age and nutritional status
of the patient, or other factors
127. Nonunion
• An arrest of the healing process
• With a large volume of callus called
“Hypertrophic nonunion”
• With some callus but less than normal
“Oligotrophic nonunion”
• Without callus or less called “Atrophic
nonunion”
• With cartilagenous tissue and clear fluid filled in
cavity called “Pseudarthrosis”
• “A Fibrous Union”
134. Common direction
• Shoulder : anterior
• Elbow : posterior
• Wrist : Lunate volar dislocation
• Finger : Posterior
• Hip : posterior
• Knee : all direction
• Ankle : all direction
135.
136.
137.
138.
139.
140.
141.
142. Physical examination
• Mark swelling
• Mark deformity
• Limitation of motion
• Neurological status
• Vascular status