This lecture by Dr. Faiza, FCPS Physiology, covers the comprehensive topic of transport across the cell membrane. Beginning with an overview of passive and active transport mechanisms, Dr. Faiza delves into the intricacies of simple diffusion, facilitated diffusion, osmosis, primary active transport, and secondary active transport. She elucidates the physiological principles underlying each transport mechanism, including the role of energy in active transport processes such as the sodium-potassium pump. The lecture further explores the diverse functions of transport proteins, discussing examples like the sodium-glucose cotransporter and the sodium-calcium counter transporter. Dr. Faiza also explains the significance of lipid and water-soluble channels in cellular transport, comparing and contrasting the characteristics of channel proteins and carrier proteins. The lecture culminates in a comprehensive examination of vesicular transport, including endocytosis and exocytosis, highlighting their roles in cellular uptake and secretion processes. With detailed explanations and illustrative examples, this lecture equips learners with a thorough understanding of the mechanisms governing transport across the cell membrane.