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TONIX Quick Facts 
                                                               




                                                              Trading Symbol:                     TNXP:OTCQB 
                                                              Stock Price (4/30/12):              $1.60 
                                                              Shares Outstanding:                 34.3 Million 
                                                              Market Capitalization:              $54.9 Million 
                                                              Fiscal Year End:                    December 31 
                                                              Stock Transfer Agent:               vStock Transfer 
                                                              SEC Counsel:                        Sichenzia Ross Friedman  
FACT SHEET – May 1, 2012                                                                          Ference LLP             
                                                              Auditors:                           EisnerAmper LLP  
                                                              IR Contact:                         Benjamin Selzer 
                                                                                                  (212) 980‐9155 x106 
                                                              Website:                            www.tonixpharma.com  
Corporate Overview 
TONIX Pharmaceuticals is developing new therapies for challenging disorders of the central nervous system (CNS).  The 
company  targets  conditions  characterized  by  significant  unmet  medical  need,  inadequate  existing  treatment  options, 
and high dissatisfaction among both patients and physicians. TONIX reformulates and repurposes known pharmaceutical 
agents to develop products with optimal safety, efficacy and predictability.  TONIX also intends to commercialize generic 
products through its wholly‐owned subsidiary, Krele LLC. 

Focus on Fibromyalgia and Post‐Traumatic Stress Disorder – Large Markets with Unmet Need  
TONIX  is  focusing  its  initial  product  development  efforts  on  fibromyalgia  syndrome  (FM)  and  post‐traumatic  stress 
disorder  (PTSD),  two  CNS  conditions  with  related,  often  debilitating  symptoms  that  can  affect  daily  living.  FM,  which 
affects about 5 million Americans, is characterized by chronic widespread pain and concurrent symptoms including sleep 
disturbance,  fatigue  and  decrease  in  physical  and  cognitive  function.  PTSD  is  a  psychiatric  disorder  that  can  appear 
following  a  traumatic  experience,  and  has  both  combat  and  civilian  forms.    Approximately  3.5%  of  the  U.S.  adult 
population  will  have  suffered  from  PTSD  within  the  past  12  months.    Sleep  disturbances  including  nightmares  and 
insomnia  are  core  features  of  FM  and  PTSD.    FM  and  PTSD  share  several  common  symptoms,  and  some  patients  are 
believed to suffer from both.   

Novel Formulation Technology Applied to Known Ingredients = Better Drugs 
The company’s lead product candidates for these indications, TNX‐102 for FM and TNX‐105 for PTSD, are novel dosage 
oral  formulations  of  cyclobenzaprine,  the  active  ingredient  in  two  U.S.  FDA‐  approved  muscle  relaxants.  TONIX  is 
applying  its  patent‐protected  formulation  technology  to  improve  absorption,  drug  clearance  and  peak  blood  levels 
relative  to  currently  marketed  cyclobenzaprine  products.    In  a  Phase  2a  study,  very  low  dose  cyclobenzaprine  (VLDC) 
administered at bedtime has been demonstrated to improve core FM symptoms, such as pain, tenderness, fatigue and 
depression.  

Strategy to Reduce Development Risk and Streamline Regulatory Path   

A significant body of data on cyclobenzaprine, the active ingredient in the company’s drugs, is already in the public 
domain and as the result of previously approved NDAs for marketed products. TONIX anticipate seeking approval of 
TNX‐102 and TNX‐105 through the NDA process under Section 505(b)(2) of the U.S. Federal Food, Drug and Cosmetic Act 
(FFDCA).  This approach would allow TONIX to reference existing data for its NDA filings, and may enable its product 
candidates to advance through development and the regulatory  process on a less costly, shorter pathway than is typical 
for pharmaceutical products based on novel active ingredients.                                    


TONIX PHARMACEUTICALS, INC.                       509 MADISON AVENUE, SUITE 306                             NEW YORK, NY 10022
PHONE:  (212) 980‐9155                                 FAX:  (212) 923‐5700                                www.tonixpharma.com
 
Robust Product Pipeline with Near‐term Milestones 
 
    Product             Indication                   Status 

    TNX‐102             Fibromyalgia                 •   Very low dose cyclobenzaprine in novel formulation 
                                                     •   Phase 2a successfully completed 
                                                     •   Completing formulation development 
                                                     •   First of two pivotal trials expected to begin Q1 2013 

    TNX‐105             Post‐Traumatic Stress        •   Low dose cyclobenzaprine in novel formulation 
                        Disorder                     •   Will leverage data from TNX‐102 PK trial 
                                                     •   Pivotal trials anticipated to start 2013 
                                                     •   Applying for Department of Defense funding 
    TNX‐201             Headache                     •   NDA to be filed for existing DESI product 
                                                     •   Potentially shortened process for FDA approval 
                                                     •   DESI to NDA switch products enjoy mandated exclusivity 
    TNX‐301             Alcoholism                   •   US patent allowed 
                                                     •   Potential for government funding 
 
Experienced Leadership 
 
                                         Title                    Experience 

    Seth Lederman, MD                    CEO & Chairman           •    Co‐founder, Vela, Targent, Validus & Fontus  
    Benjamin A. Selzer                   COO                      •    Aton, Reliant, investment banking 
    Leland J. Gershell, MD, PhD          CFO                      •    Cowen, Apothecary Capital, Favus Research, Madison 
                                                                       Williams 
    Bruce L. Daugherty, PhD, MBA         Senior Director of       •    Merck, Roche Institute 
                                         Drug Development 
    Stuart Davidson                      Director                 •    Managing Partner, Labrador Ventures 
                                                                  •    Former CEO, Alkermes & Combion 
    Patrick P. Grace                     Director                 •    Managing Partner, Apollo Philanthropy Partners, LLC 
    Donald W. Landry, MD, PhD            Director                 •    Columbia University, Chair of Medicine 
    Ernest Mario, PhD                    Director                 •    Former CEO, Glaxo, Alza & Reliant 
    Charles Mather                       Director                 •    Managing Director, Janney Capital Markets 
    John Rhodea                          Director                 •    Former Partner, Booz Allen & Hamilton 
 
Recent News Events 
 
http://ir.stockpr.com/tonixpharma/press‐releases 
 
 
TONIX PHARMACEUTICALS, INC.                       509 MADISON AVENUE, SUITE 306                           NEW YORK, NY 10022
PHONE:  (212) 980‐9155                                 FAX:  (212) 923‐5700                              www.tonixpharma.com
 

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TNXP Fact Sheet May 2012

  • 1. TONIX Quick Facts    Trading Symbol:    TNXP:OTCQB  Stock Price (4/30/12):    $1.60  Shares Outstanding:     34.3 Million    Market Capitalization:     $54.9 Million      Fiscal Year End:      December 31  Stock Transfer Agent:      vStock Transfer  SEC Counsel:         Sichenzia Ross Friedman   FACT SHEET – May 1, 2012             Ference LLP      Auditors:       EisnerAmper LLP   IR Contact:      Benjamin Selzer            (212) 980‐9155 x106  Website:      www.tonixpharma.com   Corporate Overview  TONIX Pharmaceuticals is developing new therapies for challenging disorders of the central nervous system (CNS).  The  company  targets  conditions  characterized  by  significant  unmet  medical  need,  inadequate  existing  treatment  options,  and high dissatisfaction among both patients and physicians. TONIX reformulates and repurposes known pharmaceutical  agents to develop products with optimal safety, efficacy and predictability.  TONIX also intends to commercialize generic  products through its wholly‐owned subsidiary, Krele LLC.  Focus on Fibromyalgia and Post‐Traumatic Stress Disorder – Large Markets with Unmet Need   TONIX  is  focusing  its  initial  product  development  efforts  on  fibromyalgia  syndrome  (FM)  and  post‐traumatic  stress  disorder  (PTSD),  two  CNS  conditions  with  related,  often  debilitating  symptoms  that  can  affect  daily  living.  FM,  which  affects about 5 million Americans, is characterized by chronic widespread pain and concurrent symptoms including sleep  disturbance,  fatigue  and  decrease  in  physical  and  cognitive  function.  PTSD  is  a  psychiatric  disorder  that  can  appear  following  a  traumatic  experience,  and  has  both  combat  and  civilian  forms.    Approximately  3.5%  of  the  U.S.  adult  population  will  have  suffered  from  PTSD  within  the  past  12  months.    Sleep  disturbances  including  nightmares  and  insomnia  are  core  features  of  FM  and  PTSD.    FM  and  PTSD  share  several  common  symptoms,  and  some  patients  are  believed to suffer from both.    Novel Formulation Technology Applied to Known Ingredients = Better Drugs  The company’s lead product candidates for these indications, TNX‐102 for FM and TNX‐105 for PTSD, are novel dosage  oral  formulations  of  cyclobenzaprine,  the  active  ingredient  in  two  U.S.  FDA‐  approved  muscle  relaxants.  TONIX  is  applying  its  patent‐protected  formulation  technology  to  improve  absorption,  drug  clearance  and  peak  blood  levels  relative  to  currently  marketed  cyclobenzaprine  products.    In  a  Phase  2a  study,  very  low  dose  cyclobenzaprine  (VLDC)  administered at bedtime has been demonstrated to improve core FM symptoms, such as pain, tenderness, fatigue and  depression.   Strategy to Reduce Development Risk and Streamline Regulatory Path    A significant body of data on cyclobenzaprine, the active ingredient in the company’s drugs, is already in the public  domain and as the result of previously approved NDAs for marketed products. TONIX anticipate seeking approval of  TNX‐102 and TNX‐105 through the NDA process under Section 505(b)(2) of the U.S. Federal Food, Drug and Cosmetic Act  (FFDCA).  This approach would allow TONIX to reference existing data for its NDA filings, and may enable its product  candidates to advance through development and the regulatory  process on a less costly, shorter pathway than is typical  for pharmaceutical products based on novel active ingredients.    TONIX PHARMACEUTICALS, INC.  509 MADISON AVENUE, SUITE 306  NEW YORK, NY 10022 PHONE:  (212) 980‐9155  FAX:  (212) 923‐5700  www.tonixpharma.com  
  • 2. Robust Product Pipeline with Near‐term Milestones    Product  Indication  Status  TNX‐102  Fibromyalgia  • Very low dose cyclobenzaprine in novel formulation  • Phase 2a successfully completed  • Completing formulation development  • First of two pivotal trials expected to begin Q1 2013  TNX‐105  Post‐Traumatic Stress  • Low dose cyclobenzaprine in novel formulation  Disorder  • Will leverage data from TNX‐102 PK trial  • Pivotal trials anticipated to start 2013  • Applying for Department of Defense funding  TNX‐201  Headache  • NDA to be filed for existing DESI product  • Potentially shortened process for FDA approval  • DESI to NDA switch products enjoy mandated exclusivity  TNX‐301  Alcoholism  • US patent allowed  • Potential for government funding    Experienced Leadership      Title  Experience  Seth Lederman, MD  CEO & Chairman  • Co‐founder, Vela, Targent, Validus & Fontus   Benjamin A. Selzer  COO  • Aton, Reliant, investment banking  Leland J. Gershell, MD, PhD  CFO  • Cowen, Apothecary Capital, Favus Research, Madison  Williams  Bruce L. Daugherty, PhD, MBA  Senior Director of  • Merck, Roche Institute  Drug Development  Stuart Davidson  Director  • Managing Partner, Labrador Ventures  • Former CEO, Alkermes & Combion  Patrick P. Grace  Director  • Managing Partner, Apollo Philanthropy Partners, LLC  Donald W. Landry, MD, PhD  Director  • Columbia University, Chair of Medicine  Ernest Mario, PhD  Director  • Former CEO, Glaxo, Alza & Reliant  Charles Mather  Director  • Managing Director, Janney Capital Markets  John Rhodea  Director  • Former Partner, Booz Allen & Hamilton    Recent News Events    http://ir.stockpr.com/tonixpharma/press‐releases      TONIX PHARMACEUTICALS, INC.  509 MADISON AVENUE, SUITE 306  NEW YORK, NY 10022 PHONE:  (212) 980‐9155  FAX:  (212) 923‐5700  www.tonixpharma.com