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The tumor suppressor gene p53 is the most frequently mutated gene in human cancers. P53 is a
transcription factor that promotes apoptosis, so the protein must be maintained in an inactive
state. Propose a mechanism to account for how DNA damage could trigger apoptosis through p53
(can draw it instead if choose to). You can upload either a written explanation or a drawing of the
pathway. Your answer should include:
a signal, a "receptor" or sensor for the signal, a transduction event, and output
how p53 is converted from inactive/active states
An explanation for how p53 could trigger apoptosis via transcriptional regulation

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The tumor suppressor gene p53 is the most frequently mutated.pdf

  • 1. The tumor suppressor gene p53 is the most frequently mutated gene in human cancers. P53 is a transcription factor that promotes apoptosis, so the protein must be maintained in an inactive state. Propose a mechanism to account for how DNA damage could trigger apoptosis through p53 (can draw it instead if choose to). You can upload either a written explanation or a drawing of the pathway. Your answer should include: a signal, a "receptor" or sensor for the signal, a transduction event, and output how p53 is converted from inactive/active states An explanation for how p53 could trigger apoptosis via transcriptional regulation