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Harris Integrative Health & Nutrition
Harris Integrative Health & Nutrition

This presentation discusses why weight loss is not just about calories. Hormones, Environment, Stress are just a few reasons weight management is so challenging

Healthcare
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• Integrative Health Version 20.17 Presented By: Dr Don E. Harris The Skinny on Weight Management in 2017 Why Poor Nutrition, Environmental Toxins, Hormones and Lifestyles are Responsible for the Weight Epidemic
Dr. Don E. Harris Memberships and Associations: • American Academy of Anti Aging Medicine (A4M) • American Academy of Environmental Medicine(AAEM) • American College for Advancement in Medicine (ACAM) • American College of Sports Medicine (ACSM) • American Nutraceutical Association (ANA) • American Nutrition Association (ANA) • American Society for Nutrition (ASN) • American Society of Clinical Oncologists (ASCO) • IDEA Health and Fitness Association • Institute for Functional Medicine (IFM) • International and American Society of Clinical Nutritionists ( IAACN) • Society for Nutrition Education (SNE) Post Doctoral Education: • Post Doc Fellowship: Integrative Cancer Therapy (Current) • Certified Clinical Nutritionist • Certified Health Trainer • Certified Cancer Exercise Trainer Employment: • Harris Integrative Health & Nutrition, President • University of Illinois at Chicago, Department of Oral Biology 25 Years in Practice Specializing in Clinical Nutrition with Emphasis on Integrative Cancer Therapies Education: •Bridgewater State College 1986 BS Biology BS Psychology •National University of Health Science 1991 BS Human Biology Doctor of Chiropractic •University of South Florida MS Integrative Cancer Therapy 2016
An Integrative Health Care/Clinical Nutrition practice dedicated to assisting clients learn how each individual can alter their Lifestyle to live a life.Longer/Healthier Harris Integrative Health & Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
1) Understand the principles behind health issues facing our lives today and our future . 2) How these principles can positively affect our health and well being. 3) Prepare you to make informed decisions concerning your health The Goal of Today's Workshop 4) Not to put you to sleep. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
TreatmentSymptom Symptom Symptom Cause Treatment Treatment Cause and Effect Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Symptom Linear Approach to Healthcare Treatment We must begin to approach health care as a web-like environment, and not just a single cause mentality. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
- The age of a person expressed in terms of the period elapsed from the time of birth. - The age of a person expressed in terms of the physiological maturity of organs and systems. Chronological Age Biological Age Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
More people have multiple sclerosis, lupus, chron’s, RA , IBS, colitis, (auto-immune), than ever before More people have acid reflux ulcers, and stomach problems than ever before More women have menopause problems than ever before More women have more frequent PMS and more severe PMS than ever before More people suffer from allergies, asthmas, arthritis, migraine headaches than ever before More people have diabetes than ever before More people have pre-diabetic conditions than ever before More people have heart disease than ever before More people have chronic fatigue and fibromyalgia than ever before More kids have attention deficit disorder and hyperactivity than ever before More people have skin problems than ever before More people have insomnia than ever before More men and women suffer from sexual dysfunction and infertility than ever before More people suffer from depression, anxiety, and stress than ever before More People get Colds and flues than ever before More men suffer from prostate problems and more women get yeast infections than ever before
• More People are Going to Doctors Than Ever Before • More people are taking prescription and nonprescription drugs than ever before • More surgeries are being performed than ever before • More people are getting X-rays, diagnostic testing than ever before Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
General Information Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Common Conditions 2017 Neurococognitive Disorders Alzheimer's Attention Deficient Disorder Attention Deficient Hyperactivity Disorder Parkinson’s ALS Dementia Stroke Endocrine Disorders Diabetes Insulin Resistance Thyroid Hormone Replacement Adrenal Dysfunction Hormone Dysfunction Infertility Cardiovascular Arteriosclerosis Heart Attack Stroke Gastro-Intestinal Disorders Crohn’s Colitis IBS Leaky Gut Dysbiosis Esophageal Reflux Disease Ulcers/Ulcerative Colitis Systemic Disease Chronic Fatigue Fibromyalgia Autoimmune Obesity Arthritis Inflammation Sexual Dysfunction Metabolic Syndrome Cancer Infectious Disorders Viral Bacterial Fungal Parasitic General Information Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Psychological Depression/Anxiety ADHD Anger Divorce
Etiology for Most Diseases •Infections •Inflammation •Oxidative Stress •Hyperglycemia •Allergies •Immune Dysfunction •Acidosis •Maldigestion •Hormone Imbalances •Dysbiosis •Hypercoagulation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
10 Biomarkers of Aging Tufts University Strength Muscle Mass Basal Metabolic Rate (BMR/REE) Fat Percentage Aerobic Capacity Blood Sugar Tolerance Cholesterol/HDL Ratio Blood Pressure Bone Density Temperature Regulation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Over 65 % of Deaths are Related to Poor Nutrition/Environment/Lifestyle Accidents 3.6% Pulmonary Disease 4.6% Pneumonia/Flu 1.8% Diabetes 2.8% Suicide/Alzheimer’s 1.5% Kidney Disease 1.1% Liver Disease 1.0% Cardiovascular Disease (stroke) 7.1% Cancer 22.3% Heart Disease 36.4% 65.8%
“The United States spends 2X more per person on health care than any other country, yet in DALE its care ranks in the world.” World Health Organization Disability-Adjusted Life Years 24th •WHO scientists have developed a new way of calculating the number of years that a person can be expected to live in full health. •It is known as the DALE (Disability-Adjusted Life Years) system, and gives a truer picture of the health of a country than simply studying death rates. •To calculate DALE, the years of ill-health are weighted according to severity and subtracted from the expected overall life expectancy to give the equivalent years of healthy life. "Basically, you die earlier and spend more time disabled if you're an American rather than a member of most other advanced countries." Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Obesity $192 Billion United States spends 2.1 TRILLION on health care annually United States spends $7,900/person on health care annually 78%, or $1.6 trillion annually – are for the treatment of preventable, lifestyle related conditions such as type II diabetes, obesity, and heart disease. 11 United States spends 16% of GDP on health care annually Australia spends 8.8% of GDP on health care annually France spends 11.2% of GDP on health care annually Sweden spends 9.2% of GDP on health care annually Japan spends 8.2% of GDP on health care annually Spain spends 8.2% of GDP on health care annually GDP of the United States 14.3 Trillion Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Sarcopenia Muscle Loss “ No decline with age is as dramatic or potentially more significant than the decline in In fact, there may be no single feature of age-related decline more striking than the decline in in affecting ambulation, mobility, energy intake, intestinal function, overall nutrient intake and status, immune function, inflammatory control.” Lean Body Mass Lean Body Mass Influences of Hunger Hormones
Most Expensive Drugs (Billions) Chronic Disorders • Lipitor $7.20 Cholesterol • Nexium $6.3 Heartburn • Plavix $6.1 Blood Clots • Advair $4.7 Asthma • Abilify $4.6 Antipsychotic • Seroquel $4.4 Antipsychotic • Singulair $4.1 Asthma • Crestor $3.8 Cholesterol • Actos $3.5 Diabetes • Epogen $3.3 Anemia 48 Billion 250 Billion Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Most Prescribed Drugs (Millions) Chronic Disorders • Hydrocodone (with acetaminophen) 131.2 Pain • Zocor 94.1 Cholesterol • Lisinopril (BP) 87.4 BP • Synthroid 70.5 Thyroid • Norvasc (BP) 57.2 BP • Prilosec (not OTC) 53.4 Antacid • Z-Pak/Zithromax 52.6 Antibiotic • Amoxicillin 52.3 Antibiotic • Glucophage (metformin) 48.3 Diabetes • Hydrochlorothiazide (BP) 47.8 BP 694 Million Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Inflammation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation
Causes of Inflammation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation • Food allergies or food sensitivities that may cause few symptoms. • An imbalance of bacteria and fungi in your gastrointestinal tract, also known as dysbiosis. This causes your immune system to overreact to bacteria in your gut and can be without notable symptoms. • Stress constant psychological, emotional or physical stress raises the level of cortisol, creating inflammation. • Environmental toxicity from our air, water, food pollutants and toxic metals like mercury and lead all contribute to inflammation and have been linked to diseases as varied as endometriosis and cancer. • Diet and lifestyle too much fat, sugar, and protein in your diet, and exercisecan all increase inflammation in your body
Inflammation•Cancer •Chronic Lower Respiratory •Cerebrovascular Disease (Stroke) •Diabetes •Autoimmune Disease •Arthritis •Alzheimer’s Disease•Fatigue •Skin problems •Heart Disease Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation •Psychological Disorders
Inflammation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
• Acute Short duration (minutes-days) with emigration of fluid, plasma proteins, and into tissue. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation • Chronic Longer duration (days-months) with tissue accumulation of lymphocytes, plasma cells, & macrophages plus variable proliferation of
27 • Immune dysregulation • Chronic inflammation • Auto-immune arthritis (antigenic cross-reactivity) – ankylosing spondylitis ~ Klebsiella spp – rheumatoid arthritis ~ Proteus spp • Colon Cancer & Breast Cancer • Psoriasis, cystic acne, eczema • Chronic fatigue & Fibromyalgia • Behavioral disorders – organic acids from bacteria & fungi Behavioral disorders– Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Dysbiosis Implicated in Inflammation/Dysbiosis
• Acid Reflux (GERD) • Bowel Obstruction • Celiac Disease • Constipation • Crohn’s Disease • Diarrhea • Diverticulitis • Gallstones • Gastritis • Irritable Bowel Syndrome • Pancreatitis • Peptic Ulcer • Ulcerative Colitis Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation/Dysbiosis/Common GI Disorders
50 Heredity accounts for one - quarter of the variation in human life expectancy. The other three quarters of this variation are based on the fact that, after the age of , genetic expression is influenced by Diet Lifestyle and Environmental Toxins Heredity Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Altered Terrain Two individuals are exposed to the exact same stimulus; bacteria, virus, toxin One individual may develop an adverse response Infection Disease Inflammation One individual may not be affected at all Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
• The heritability of life span is relatively minor. Our genes alter how our metabolism functions in response to Diet, Lifestyle and Environmental Toxins which control our disease patterns and and our life expectancy. We Inherit Genetic Tendencies, Not Genetic Certainties. Heredity General Information Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Free Radicals (ROS) Demonstrate Apple • Free radicals are atoms with an odd (unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these Highly reactive radicals can start a chain reaction, like dominoes. Their chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To prevent free radical damage the body has a defense system of antioxidents Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
• Even though some free radical production is normal, things like stress, smoking, exercise, and aging contribute to the production of harmful free radicals. • No one can avoid free radicals. It is even thought that free radicals play a part in disease processes like cancer. Free Radicals (ROS) Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
37 If the organs of your body are not defended by sufficient antioxidants against oxidative stress, they lose function over time, and their ability to produce hormones or control immune function is lost. After several years , free radical-induced organ damage can result in the appearance of “twisted molecules”. These unnatural twisted molecules can activate the body’s immune system to combat misidentified foreign invaders, resulting in damage to organs like the thyroid. Free Radicals (ROS) White blood cells specialize in producing free radicals which are used in host defense to kill invading pathogens Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
Diet Lifestyle Environment and Chronic Disease Diet
•Vitamin/Mineral Deficiencies •Caloric Intake • High Glycemic Foods •Alkalinity VS. Acidity •Allergic Reactions •Gluten Sensitivities •Essential Fatty Acids •Saturated Fats/Hydrogenated/Partially Hydrogenated •Pesticides/Herbicides •Hormones Diet Lifestyle Environment and Chronic Disease Diet/Nutrition Common Nutritional Issues
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Vitamin/Mineral Deficiencies (Partial List) • Vitamin A: The nutritional deficiency of vitamin A causes diseases like night blindness, growth impairment, immune impairment, xerophthalmia, keratomalacia, hyperkeratosis, acne, dry hair and blindness. it is common in underdeveloped countries affecting one third of the children under the age of five around the world. • Thiamine (B1): Beriberi is caused by dearth of thiamine (vit-B1). Beriberi disease involves nervous system. Thiamine is found in the bran of rice. In populations, where the staple food is polished rice, as in South Asia, this nutritional disease was prevalent. Beriberi is rare in developed nations and in regions where the food habits include other cereals. • Iron: Iron deficiency anemia, which is due to deficiency of hemoglobin in the red blood cells, is characterized by severe fatigue and breathlessness. Hemoglobin is a protein containing iron. • Calcium: Calcium deficiency leads to weakening and stoppage calcium replacement in the bones and results in osteoporosis. Diet/Nutrition • Calcium • Magnesium • Vitamin D` • Folic Acid • Iron • B6/12
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Vitamin/Mineral Deficiencies (Partial List) • Vitamin C (ascorbic acid): Ascorbic acid deficiency causes Scurvy Disease or subclinical scurvy. The symptoms of scurvy include malaise, lethargy, shortness of breath, bone pain, myalgia's, gum bleeding, loosening of teeth, jaundice, edema, oliguria, neuropathy, suppurating wounds and mental disability. • Vitamin D: Rickets (rachitis) in children and osteomalacia in adults cause weak, malformed brittle bones. Its deficiency in the food and non exposure to sun brings on rickets or osteomalacia. • Riboflavin (B2): Riboflavin (vit-B2) nutritional deficiency is medically known as ariboflavinosis. The symptoms include photophobia, bloodshot eyes, angular cheilitis, angular stomatitis, inflammation of the lining of mouth and tongue, mouth ulcers, iron-deficiency anemia, scrotal dermatitis and dry and scaling skin. It is mostly caused by inadequacy in food, impaired liver function and alcoholism. • Folic acid: Birth defects and neural tube defects in fetus occur when the mother suffers deficiency of folic acid (vit-B9). Diet/Nutrition
Diet Lifestyle Environment and Chronic Disease Calories Diet/Nutrition
Definitions: • Obesity: Having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher. •Body Mass Index (BMI): A measure of an adult’s weight in relation to his or her height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters. •In 1990, among states participating in the Behavioral Risk Factor Surveillance System, 10 states had a prevalence of obesity less than 10% and no states had prevalence equal to or greater than 15%. •By 1998, no state had prevalence less than 10%, seven states had a prevalence of obesity between 20-24%, and no state had prevalence equal to or greater than 25%. •In 2007, only one state (Colorado) had a prevalence of obesity less than 20%. Thirty states had a prevalence equal to or greater than 25%; three of these states (Alabama, Mississippi and Tennessee) had a prevalence of obesity equal to or greater than 30%. By 2012 44 states had a prevalence of greater than 25%, 19 states were =/>30%. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
• It’s never about the total weight loss • It’s always about the type of weight that is lost Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
Obesity: Having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher. •Body Mass Index (BMI): A measure of an adult’s weight in relation to his or her height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters. •In 1990, among states participating in the Behavioral Risk Factor Surveillance System, 10 states had a prevalence of obesity less than 10% and no states had prevalence equal to or greater than 15%. •By 1998, no state had prevalence less than 10%, seven states had a prevalence of obesity between 20-24%, and no state had prevalence equal to or greater than 25%. •In 2007, only one state (Colorado) had a prevalence of obesity less than 20%. Thirty states had a prevalence equal to or greater than 25%; three of these states (Alabama, Mississippi and Tennessee) had a prevalence of obesity equal to or greater than 30%. By the Numbers Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
1998 (*BMI 30, or about 30 lbs. overweight for 5’4” person) 2007 1990 No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 Diet/Nutrition
(*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 Before1990
(*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 1991 - 1998 Diet/Nutrition
(*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 1999 - 2007 Diet/Nutrition
(*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Refined CHO Ingestion Plasma Glucose Insulin Secretion Insulin Receptor Down Regulation Insulin Resistance Hypoglycemia Hyperinsulinemia Syndrome X Diabetes Mellitus Kidney Failure Limb Amputation Blindness MI Early Death Insulin Resistance PPAR gamma “thrifty gene Arthritis Serotonin/ Endorphin Receptors Weight Gain Kidney Na Retention Stress CHO Hunger Inflammation Fatigue Depression Hypertension AGE CV Risk Pain Blood Lipids Cancer Dysbiosis Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Refined CHO Ingestion Plasma Glucose Insulin Secretion Insulin Receptor Down Regulation Insulin Resistance Hypoglycemia Hyperinsulinemia Syndrome X Diabetes Mellitus Kidney Failure Limb Amputation Blindness MI Early Death Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Refined CHO Ingestion Weight Gain Fatigue Depression Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Refined CHO Ingestion Insulin Resistance PPAR gamma “thrifty gene Arthritis Inflammation Pain Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Refined CHO Ingestion Insulin Resistance PPAR gamma “thrifty gene Arthritis Inflammation Pain Cancer Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Refined CHO Ingestion Insulin Resistance PPAR gamma “thrifty gene Arthritis Inflammation Pain Cancer Early Death Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Diet Lifestyle Environment and Chronic Disease Sugar Intake Insulin Resistance Diet/Nutrition
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • It is never the amount of weight you lose that is important, but the type of weight you lose and the amount of muscle tissue that remains. • The term Sarcopenic obesity is a condition afflicting many as a result of diets. Sarco (muscle), Penia (loss of) refers to the loss of muscle tissue. • “No decline with age is as dramatic or potentially more significant than the decline in Lean Body Mass. In fact, there may be no single feature of age-related decline more striking than the decline in Lean Body Mass in affecting ambulation, mobility, energy intake, intestinal function, overall nutrient intake and status, immune function, and inflammatory control,” as stated by the NIH. • The last thing a person trying to lose weight wants is muscle tissue that is damaged, degraded, or has disappeared. Remember, excess fat is inflammatory. You now have a situation where excess inflammatory tissue exists and healthy anti-inflammatory tissue has been damaged and / or disappeared. Hormones that Affect Weight Loss • Insulin • Cortisol • Leptin • Ghrelin • Estrogen • Testosterone Improper Weight Loss
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • Digestive Disorders • Osteoarthritis • Dyslipidemia • Type 2 Diabetes • Increased Morbidity/mortality following surgery • Hypertension Improper Weight Loss • Congestive Heart Failure • PAD • Cardiovascular Disease Stroke/MI • Metabolic Syndrome
61 According to the United States Department of Agriculture, 1988-1989 •365 servings of soda pop or 638 can/year for people 12-29 •90 pounds of fats and oils •6o pounds of cakes and cookies •23 gallons of ice cream •22 pounds of candy •8 pounds of corn chips, popcorn, and pretzels •7 pounds of potato chips Diet/Nutrition Diet Lifestyle Environment and Chronic Disease
Insulin Resistance and Weight Loss Metabolic Syndrome • Over 80 million Americans suffer from insulin resistance, and it appears to sit at the center of a web of related health problems. Women who are insulin resistant are at much greater risk of obesity, diabetes, hypertension (high blood pressure), heart disease, high cholesterol, breast cancer and polycystic ovarian syndrome (PCOS). There is some evidence that insulin resistance may contribute to endometrial cancer. It has also been implicated in Alzheimer’s disease. • Experts estimate that 25% of all Americans suffer from insulin resistance. We believe the percentage is much higher among perimenopausal women Diet Lifestyle Environment and Chronic Disease Diet/Nutrition
Diet Lifestyle Environment and Chronic Disease Insulin Resistance Diet/Nutrition
• Insulin resistance occurs when cells become insensitive to the insulin message. When cells don’t respond effectively to insulin, blood sugar is not properly managed, and the pancreas is required to secrete more insulin. When insulin levels in the blood become very high, they influence gene expression, altering cellular effects and promoting accelerated aging. Insulin Resistance and Inflammation • The connection between life span and the hormone insulin is extraordinary. • Control of blood sugar and its companion hormone insulin is a major point of investigation because insulin plays a principal role in communicating with the genes and altering their expression Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
Characteristics that Identify Insulin Resistance • A family history of type II diabetes. • Tendency to gain fat in the upper body • Menstrual irregularities and polycystic ovaries. • Marginally elevated LDL cholesterol. • Marginally elevated blood fats (triglycerides). • Marginally elevated blood pressure • A “sweet tooth.” • Symptoms that resemble hypoglycemia. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
Summary of the Effects of Improper Control of Insulin Metabolism • Generalized Cardiovascular Disease HEART • Increases Blood Sugar and Fat Deposition/Obesity • Decreases Reproductive Hormones Estrogen, Testosterone (Pregnancy/ED) Reproduction • Decreases Overall Function of the Immune System Immunity Mental Health • Damages Eyes, Nerves, Kidneys, also known as Diabetes I and II • Increases Fatigue • Increases Chances of Hyperglycemia/Hypoglycemia • Marginally elevated LDL cholesterol. • Marginally elevated blood fats (triglycerides). • Marginally elevated blood pressure • Increases Chances of Developing Poly Cystic Ovary Disease (PCOD)
69 Sugar is a Drug An external substance acting throughout the brain and body on cellular receptors designed for an internal chemical called “glucose” Sugar increases circulating levels of beta endorphin and serotonin Candice Pert PhD Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
Diet Lifestyle Environment and Chronic Disease Alkalinity Diet/Nutrition
• Aging also decreases the amount of Hydrochloric acid in the stomach • By the age of 35 most people produce 1/3 the amount of hydrochloric acid • Improperly digested food exists the stomach in an unusable form and can cause bowel dysfunction and dysbiosis DYS ALTERED BIO LIFE Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition pH of Foods/Alkaline or Acidic
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • Weight Gain, Obesity and Diabetes pH of Foods/Alkaline or Acidic • For the most part food in its natural state is balanced in terms of ph. • There exist numerous foods that are either acidic, (low pH or less than 7), or alkaline, (high pH greater than 7). • Nutrients, Fiber, are removed and preservatives, dyes, fillers are added back in. The food is not even close to being in balanced with the pH it was meant to have. • have. • pH is important because our bodies require certain pH for all biological functions. When a situation exists that throws the balance of pH off, even a little, the biochemical processes do not function at 100 percent. • Joint Inflammation, Arthritis • Bladder Conditions, Kidney Stones, Obesity and Diabetes • Cardiovascular Disease • Weight Gain, Obesity and Diabetes • Immune Deficiency • Cancer, Chronic Illness • Osteoporosis • Hormone Concerns • Premature Aging • Increase in Free Radicals
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition pH of Foods/Alkaline or Acidic • Intense physical exercise What Makes Us Acidic? • The first line of defense against disease is a proper pH Balance. Disease can only grow in an acidic body, which makes a condition favorable for the growth of bacteria, yeast, fungus, mold, viruses, and other unwanted organisms. • What we eat including meat, fish, poultry, dairy, grains, refined/processed foods • Cancer always strikes those with an over-acidic body • An acidic state causes a lack of oxygenation at the cellular level. When the pH level falls below 7.4, there is less than the maximum oxygen in the blood. Blood carries the the maximum oxygen at pH 7.4 (Alkaline). Without proper oxygenation, unfriendly bacteria, mold and viruses will develop. • What we drink including coffee, soft drinks, alcohol, many types of water • Pollutions and Toxins • Dehydration
Diet Lifestyle Environment and Chronic Disease Allergies Diet/Nutrition
75 Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
76 Conditions linked to Food Allergy • Irritable bowel syndrome • Migraines • Auto-immune diseases • ADHD and behavior disorders • Enuresis and incontinence • Joint pains Diet/Nutrition
77 Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
78 Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
79 AntibodySerum proteins which are induced following contact with antigen. They bind specifically to the antigen which induced the formation. Antigen Are any molecules which are recognized by the immune system and induce an immune response. In a healthy immune system antibodies are produced in response to antigens entering the body via lungs, digestive tract and skin, or are produced by contact with internal invaders such as cancer cells. In an unhealthy immune system antigens are not fought off and are free to cause damage and cancer cells are not destroyed and could lead to cancer. Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
Conditions linked to Food Allergy • Irritable bowel syndrome • Migraines • Auto-immune diseases • ADHD and behavior disorders • Enuresis and incontinence • Joint pains Every receptor found in the CNS is also found on immune cells Every thought and every chemical that effects the CNS will effect the immune system
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Food Allergies • The most severe allergic reaction is anaphylaxis — a life-threatening whole-body allergic reaction that can impair your breathing, cause a dramatic drop in your blood pressure and affect your heart rate. Anaphylaxis can come on within minutes of exposure to the trigger food. • Most food-related symptoms occur within two hours of ingestion; often they start within minutes. In some very rare cases, the reaction may be delayed by four to six hours or even longer. • Everybody living today is allergic to one or more foods, more likely several, and, don’t even know it. • The body’s immune system keeps you healthy by fighting off infections and other dangers to good health. A food allergy reaction occurs when your immune system overreacts to a food or a substance in a food, identifying it as a danger and triggering a protective response. • Symptoms of a food allergy can range from mild to severe. Just because an initial reaction causes few problems doesn’t mean that all reactions will be similar; a food that triggered only mild symptoms on one occasion may cause more severe symptoms at another time.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Food Allergies • Eggs • Milk • Peanuts • Tree Nuts • Fish • Shell Fish • Wheat • Soy • Vomiting and/or Stomach Cramps • Hives • Shortness of Breath • Wheezing • Repetitive Cough • Swelling of the Tongue • Shock or Circulatory Collapse • Tight Hoarse Throat, Trouble Swallowing • Weak Pulse • Pale Skin • Dizziness
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Diet Lifestyle Environment and Chronic Disease Grains
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Food Allergies/Gluten Gluten is the protein aspect of certain grains, including wheat, barley, rye and spelt. When you eat these grains, or foods containing them, you are eating gluten. The most common foods containing gluten are bread, pasta, pizza crust, bagels, cookies, and pastries. So you can see, it is quite easy to be exposed to gluten everyday and even every meal. In addition to the common places we find gluten, it can also be found hidden in many other foods because it helps to thicken liquids and allows things to stick together. It can also create a chewy and/or fluffy texture. Gluten also hides in products you wouldn’t think of based on their chewiness. Soy sauce, for example, contains gluten – so be sure to choose the gluten-free alternative called tamari sauce (it says gluten-free on the label). Sometimes, other condiments, like mustard, ketchup, and BBQ sauce, may also contain gluten. Then there are flavored chips and crackers. Even corn chips, if they are spicy or flavored in any way, may well include flour and/or wheat in their ingredients lists. The same goes for anything seasoned such as spice mixes (taco mix, for example) or anything containing modified food starch (even chewing gum). The simple truth is that humans cannot digest gluten. We can consume foods that we can’t digest – we also cannot digest fiber and beans, for example. In small quantities, it is usually not an issue. The dangers of gluten come into play when we consume large amounts of it (at every meal, for example) and especially if we have a genetic tendency to react to gluten. undigested proteins from gluten (also known as gliadin) get noticed by the immune system in our gut, triggering an inflammatory response that can spread throughout the body. Gluten then causes leaky gut, an immune system/digestive issue in which the cells lining the intestines, and the space between them, is damaged, allowing food to leak through (gluten and as well as other food) and to trigger inflammatory responses while decreasing absorption of nutrients. Leaky gut has been associated with such chronic health issues as obesity, diabetes, heart disease, liver disease, neurological issues (like Parkinson’s and Alzheimer’s), and cancer. Then, there’s celiac disease, which is an autoimmune disease in which further damage to the intestines due to immune responses to gluten can cause severe and life threatening health issues. It is estimated that 1 in 133 people have developed celiac disease already – that’s over 2 million people in the U.S – and most of them have no idea. Even if you don’t have celiac disease, it is thought that at least 1 in 4 people develop what is now known as non-celiac gluten sensitivity (NCGS). NCGS is associated with a number of health issues varying from fatigue and bloating to migraines and PMS. The effective treatment for both celiac disease and NCGS is the avoidance of gluten. The dangers of gluten don’t stop there. Once the immune system in the intestines starts reacting to gluten, it is exponentially more likely that the immune system will start reacting to other foods – most often dairy proteins (casein and whey), eggs, potato, soy, and other grains (rice, millet, and corn). At this point, a person is often hit by digestive symptoms, no matter what they eat, and potentially also experiences fatigue, sleep issues, mood changes, skin rashes, frequent infections, thyroid issues, and in some cases, autoimmunity. As mentioned before, 1 in 4 people have a gluten intolerance—so it’s quite possible, if not likely, that you have one. Some indications include tiredness, anxiety, depressed mood, insomnia, bloating, IBS, eczema, allergies, sinusitis, and low thyroid function. Even hormone imbalances—such as PMS, PCOS, and unexplained infertility—have been tied to gluten intolerance. Currently research indicates that the best way to determine whether you have gluten sensitivity is to remove gluten from your diet for at least three weeks (however, in some cases, it could require six months of elimination) and then reintroduce gluten to determine whether symptoms occur or return. Another option is to test for IgG antibodies to gluten, which can be done with as little as a finger prick, although most practitioners are not offering this panel or may not be familiar with the relevance of the results. Feel free to contact my office for assistance.
Diet Lifestyle Environment and Chronic Disease Omega 3’S
Arthritis Inflammatory bowel disease Auto-immune diseases Eczema Asthma Atherosclerosis Cardiovascular disease EFA Imbalances & Inflammation
• Structural components of all membranes – Increased fluidity & permeability – Optimal organelle function • Precursors for eicosanoid synthesis – “Local” hormones – Regulate inflammation • Structural components of all membranes – Increased fluidity & permeability – Optimal organelle function • Precursors for eicosanoid synthesis – “Local” hormones – Regulate inflammation Major roles of EFAs
90 The fluidity and permeability of membranes is largely determined by the degree of unsaturation of the fats in the membrane phospholipids. Cell Membranes
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Essential Fatty Acids Polyunsaturated Fatty Acids (PUFA) • Lowers Total Cholesterol • Lowers Risk of Heart Disease • Helps with Diabetes • Increases HDL • Benefits People with Rheumatoid Arthritis, SLE, Osteoporosis • Essential fatty acids are, as they sound, fats that are necessary within the human body. • Essential fatty acids are also not usually produced naturally within the body. This means that you have to obtain essential fatty acids by adding them to your diet. Omega-3 Essential Fatty Acids • Omega-3 essential fatty acids are necessary within the human body, but they can also be produced modestly within the body • A lack of Omega-3 essential fatty acids could lead to blood clots, problems with memory, a decreased sense of vision, irregular heartbeat and a decrease in the functioning of your immune system. I Benefits of a diet rich in Omega-3 Fatty Acids (REDUCES INFLAMMATION) • Depression, Bipolar Schizophrenia, ADHD, Cognitive Decline • Flaxseed Oil Walnuts • Walnut, Sesame Seeds • Spinach • Salmon, Tuna, Sardines Sources of Omega-3 Fatty Acids
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Essential Fatty Acids Omega-6 Essential Fatty Acids • Supports Bone Health • Omega-6 fatty acids, like omega -3s, are essential fatty acids that can only be provided to us through food and supplements. man body. • Medical research on humans found a correlation (correlation does not imply causation) between the high intake of omega-6 fatty acids from vegetable oils and disease in humans. • Omega 6 Fatty Acids are pro-inflammatory and anti-inflammatory PUFAs Benefits of a diet rich in Omega-3 Fatty Acids (REDUCES INFLAMMATION) • Safflower, Grapeseed, Sunflower, Corn Walnut, Cotton, Soy Oils Sources of Omega-6 Fatty Acids • Helps with Diabetes Neuropathy • Rheumatoid Arthritis, • ADHD
Injury Agent, Physical or Chemical Injury to Cell Cell Membrane Damage Arachidonic Acid, Phopholipase A2 EPA PG2, Cyclooxygenase TXA 2 Platelet AggregationPDGF PG3 TXA3 No Platelet Aggregation Aspirin Binds Cox EPA Competes for Cox
Essential Fatty Acids Linoleic Acid Oils of corn, safflower, sunflower, sesame Alpha-linolenic Acid Flax, pumpkin, chia, walnut GLA Arachidonic Acid Animal meat, milk EPA/DHA PGE2 PGE3 IL-1, Il-6 IL-2, PGE 3, PGE 6
Essential Fatty Acids Linoleic Acid Omega 6’s Oils of corn, safflower, sunflower, sesame Alpha-linolenic Acid Omega 3’s Flax, pumpkin, chia, walnut GLA PGE1 Arachidonic Acid Animal meat, milk EPA DHA PGE2 PGE3 Leukotrienes Thromboxanes Eicosonoids Omega 3 Fatty Acids Anti-Inflammatory Pro-Inflammatory
Ratio Omega 6 Fatty Acid to Omega 3 Fatty Acid 1:1 4:1 45:1
Diet Lifestyle Environment and Chronic Disease Trans Fats
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils • Most of the trans fat in the foods we eat is formed through a manufacturing process that adds hydrogen to vegetable oil, which converts the liquid into a solid fat at room temperature. This process is called hydrogenation • Trans fat is considered by many doctors to be the worst type of fat you can eat. Unlike other dietary fats, trans fat — also called trans-fatty acids — both raises your LDL ("bad") cholesterol and lowers your HDL ("good") cholesterol. • Trans fat is formed through an industrial process that adds hydrogen to vegetable oil, which causes the oil to become solid at room temperature. • This partially hydrogenated oil is less likely to spoil, so foods made with it have a longer shelf life. • To make partially hydrogenated oils (those that are partially solidified), hydrogen atoms are added to liquid fats like soybean oil, rendering a fat that’s partially solidified, partially filled with hydrogen atoms, and partially kinked. That last point is very important; it’s what makes partially hydrogenated oil so dangerous. • These kinked, partially hydrogenated oils literally build up inside the body, sticking to each other, forming longer, unbranched chains that continue to grow and kink, linking up sticky end to sticky end, and they grow so large inside the body They bioaccumulate inside our bodies, the same way mercury and heavy metals bioaccumulate inside a tuna
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • Digestive Disorders • Osteoarthritis • Dyslipidemia • Type 2 Diabetes • Increased Morbidity/mortality following surgery • Hypertension • Congestive Heart Failure • PAD • Cardiovascular Disease Stroke/MI • Metabolic Syndrome Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils • These kinked, partially hydrogenated oils literally build up inside the body, sticking to each other, forming longer, unbranched chains that continue to grow and kink, linking up sticky end to sticky end, and they grow so large inside the body They bioaccumulate inside our bodies, the same way mercury and heavy metals bioaccumulate inside a tuna in the ocean. Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils Found • Fast Foods • Fried Chicken • Biscuits • Fried Fish Sandwiches • French Fries • Donuts/Muffins • Crackers • Most Cookes • Cakes/Icing/Pies • Chips • Microwave Popcorn • Artificial Thickeners
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Artificial Additives • Food additives are chemicals that keep foods fresh or enhance their color, flavor or texture. • To Make Food Convenient and Easy to Prepare • To Increase Nutritional Value • To Improve Flavor of Foods • To Improve Shelf Life or Storage Time • To Enhance Attractiveness of Food Products and Improve Consumer Acceptance • The food industry has continually created new chemical to manipulate, preserve and transform our food. • Scientists are now able to mimic natural flavors,color foods to make them look more “natural” or “fresh”, preserve foods for longer and longer periods of time, and create altered versions of breads, crackers, fruits, vegetables, meats, dairyproducts and many more commonly used foods. Five Main Reasons for Why Chemicals Must be Added to Our Foods
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Artificial Additives • Anti-caking agents – stop ingredients from becoming lumpy • Emulsifiers – Stop Fats from Clotting Together • Food Acids – Maintain the Right Acid Level • Colors – Enhance or Adds Color • Artificial Sweeteners – Increase the Sweetness • Flovors – Adds Flavor • Antioxidants – Prevent foods from oxidizing or going rancid Five Main Reasons for Why Chemicals Must be Added to Our Foods • Foaming Agents – Maintains uniform Aeration of Gases in Foods • Thickeners and Vegetable Gums – Enhances Texture and Consistency • Preservatives – Stops Microbes from Multiplying and Spoiling the Food • Humectants – Keeps Food Moist • Flavor Enhancers – Increases the Power of a Flavor • Stabilisers and Firming Agents – Maintains Even Food Dispersion • Gelling Agents – Alters the Texture of Foods Through Gel Formation
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Artificial Additives • Hydrogenated Fats – Cardiovascular Disease, Obesity • Nitrites/Nitrates – Can Develop into Nitrosamines in the body, which can be carcinogenic • Sugar/Sweeteners – Obesity, Dental Cavities, Diabetes, and Hypoglycemia, Increased Triglycerides • Monosodium Glutamate (MSG) – Common Allergic and Behavioral Reactions • Artificial Food Colors – Allergies, Asthma, Hyperactivity, Possible Carcinogen • Preservatives (BHA, BHT, EDTA, etc.) – Allergic Reactions, Hyperactivity, Possibly Cancer, May be Toxic to Nervous System and the Liver Key Additives to Avoid • Artificial Flavors – Allergic or Behavioral Reactions • Refined Flour – Low-Nutrient Calories, Carbohydrate Imbalances, Altered Insulin Production • Salt (Excessive) – Fluid Retention and Blood Pressure Increase • Olestra (An Artificial Fat) – Diarrhea and Digestive Disturbances
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How to Protect Against Leptin Resistance Influences of Hunger Hormones • Avoid bad fats • Partially hydrogenated and hydrogenated fats • Trans fat • Eat good fats • Vegetable oils (polyunsaturated fats oxidize) Fat Attracts Fat • Clean saturated fat • Cholesterol • Poly/monounsaturated fats (not vegetable) • Eliminate Grains and Sugar until resistance is repaired • Avoid Toxins 1/3 is toxin related Diet/Nutrition
Faulty Methylation Diet/Nutrition
Recently, it has been suggested that specific food intolerances may not be true allergies but, rather, may be related to metabolic toxicity resulting from an intestinal disorder.13 Hunter proposes that symptoms from apparent food intolerances may result from reduced enzyme concen 2 3 Figure 1: Metabolism of Benzene to Phenyl Sulfate trations, either inherited or acquired, and from intestinal bacterial endotoxins. According to Hunter, “Specific food residues are broken down by the colonic microflora with the production of chemicals, which, in susceptible individuals with low concentrations of relevant hepatic enzymes, pass into the systemic circulation to produce distant symptoms.” Diet/Nutrition
Conditions linked to Food Allergy • Irritable bowel syndrome • Migraines • Auto-immune diseases • ADHD and behavior disorders • Enuresis and incontinence • Joint pains Every receptor found in the CNS is also found on immune cells Every thought and every chemical that effects the CNS will effect the immune system
Chronic Inflammation, Allergies, and Leptin • . As we gain weight, our bodies do not add more fat cells. The fat cells we already have become larger and are filled with more fat instead. They may leak as they are stretched more and more. Then immune cells called macrophages come in to clean up the mess. The macrophages release inflammatory chemicals in the fatty tissues as they are cleaning up. • Your body counteracts this silent inflammation by producing anti-inflammatory chemicals. Some of these interfere with the function of the hormone leptin. • Excess fat leads to inflammation and the chemicals that counteract inflammation (which are necessary to keep silent inflammation from causing symptoms) make it impossible for the body’s weight-control hormone, leptin, to function properly. Influences of Hunger Hormones Diet/Nutrition
Diet Lifestyle Environment and Chronic Disease Food Toxins Diet/Nutrition
113 Leaky Gut The leakage of toxic substances through the lining into the bloodstream. The intestinal tract is an immune organ, the site of nearly two - thirds of the body’s defense system, GALT (Gut-Associated Lymphoid Tissue). Inflammation Via the Intestinal Tract GALT is responsible for producing the antibody proteins. GALT activating organisms: yeast, waterborne organisms.
114 Dysbiosis Implicated in: • Immune dysregulation • Chronic inflammation • Auto-immune arthritis (antigenic cross-reactivity) – ankylosing spondylitis ~ Klebsiella spp – rheumatoid arthritis ~ Proteus spp • Colon Cancer & Breast Cancer • Psoriasis, cystic acne, eczema • Chronic fatigue & Fibromyalgia • Behavioral disorders – organic acids from bacteria & fungi Behavioral disorders–
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116 Inflammation and Heart Disease Cardiologist Attilio Maseri, M.D. suggests the new research linking inflammation and heart disease suggests that the current approach to heart disease prevention that focuses entirely on lowering cholesterol may be ill- advised. Many types of infection, toxic exposure or trauma could result in increased production of inflammatory alarm substances. These alarm substances, in turn, could interact with the genes in genetically susceptible individuals to produce heart inflammation and subsequent heart disease. Markers for inflammation may be better predictors of heart disease than elevated blood cholesterol itself.
Diet Lifestyle Environment and Chronic Disease Hormones Diet/Nutrition
Diet Lifestyle Environment and Chronic Disease Diet/Nutrition • Leptin, the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores. • Estrogen balance is essential for achieving and maintaining fat loss. In men and premenopausal women, too much estrogen – a condition called estrogen dominance causes toxic fat gain, water retention, bloating, and a host of other health and wellness issues. There are only two ways to accumulate excess estrogen in the body: We either produce too much of it on our own, or acquire it from our environment or diet. • Testosterone levels isn’t just a question for the 40 and over but usually decreases with age. If you’re a human being (male or female) who wants to lose fat (or keep it off) then testosterone is a very important hormone
Diet Lifestyle Environment and Chronic Disease Diet/Nutrition • Ghrelin Produced in your stomach, ghrelin is a hormone. If you skip a meal, your ghrelin makes you ravenous, Making it nearly impossible for you to resist the next food item you see. Shaving calories off during the day is a big mistake if your on a weight loss train. Ghrelin increases if you fast you need to fuel yourself during first thing. • Insulin is a hormone made by one of the body's organs called the pancreas. Insulin helps your body turn blood sugar (glucose) into energy. It also helps your body store it in your muscles, fat cells, and liver to use later, when your body needs it. After you eat, your blood sugar (glucose) rises. • Cortisol under stressful conditions, provides the body with protein for energy production through gluconeogenesis, the process of converting amino acids into useable carbohydrate (glucose) in the liver.
Diet Lifestyle Environment and Chronic Disease Lifestyle
Diet Lifestyle Environment and Chronic Disease This area of your life is probably the one you have the most control over but possibly is the most difficult to change. I’m sure you are aware of the importance of exercise. We all know the effects of lack of physical conditioning; weak muscles, weak bones, weak heart, etc. It is crucial to maintain some level of physical activity and conditioning. One of the most important aspects of working with chronic inflammatory and weight loss patients is to keep them moving. Walking, stretching, and swimming are activities I strongly encourage all my patients to do. I recommend doing your exercise program where you feel the most comfortable. If a gym is your choice, then join one. Many of my patients can get their exercise in and around their own home. Some prefer a personal trainer to come to their home, or work with them at a fitness facility. The best exercise for you is the one that you will do with regularity. A significant part of maintaining health and reducing your risk for developing disease is to exercise. However, people with inflammation often overdue what they are capable of. Personal trainers are a great resource if this is the case, and if they are well acquainted with your condition and all of its nuances. Massage Therapy is a wonderful adjunct to your therapy but again, only if the therapist is well versed in what you suffer from. Be careful when choosing your lifestyle programs. It is important to move but only within within the confines of your abilities and with properlyined support people you trust.
Diet Lifestyle Environment and Chronic Disease Exercise
Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity • There are two principal factors in the onset of chronic inflammatory conditions: genetic predisposition, which you can’t control: and your lifestyle, exercise patterns, which you can control. • There are different forms of exercise and to receive the maximum benefit from your time you need to perform all types. You need to build strength in your muscles, keep your muscles flexible, and condition them to perform tasks for an extended period of time. • strength • flexibility • endurance • Muscle Mass; If you are the average middle-aged person, your problem usually isn’t excess weight. It is more than likely excess body fat. Remember we have already discussed how dangerous excess body fat can be. Too much fat is inflammatory and can lead to chronic inflammatory conditions. As a consequence of aging we tend to lose muscle tissue only to be replaced by fat tissue. The typical person loses about 6.6 pounds of lean-body mass each decade of life, this rate accelerates after the age of 45. Some of my patients will insist they weigh the same as they were in high school. I don’t disagree with them, they probably do. But what has happened is they have loss muscle and gained fat.
Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity Muscle Strength Strong muscle tissue is as important as having muscle tissue. It can be divided into skeletal muscle and cardiac muscle. The two are just what they imply, skeletal muscle attaches to ligaments and bones and cardiac muscle is your heart. A brief lesson on how muscle tissue works will serve you well. Motor nerves connect your skeletal muscle to your central nervous system. These nerves carry messages back and forth from your central nervous system and your skeletal muscles. These nerves and muscles are known as a motor unit. The age old problem is as we age and fall prey to Chronic Inflammatory Diseases you lose these motor units. It is estimated that you lose 20% of these motor units between the ages of 30 and 70. Another aspect of your muscles losing strength is that your muscles consist of two types of fibers, fast twitch and slow twitch. Slow twitch are responsible for posture and low intensity movements. The fast twitch fibers are responsible for heavy lifting and running at a fast pace. As the aging process continues, the fibers that are responsible for developing strength decline. When you add a variety of illness it compounds the loss. The good news is; A DECLINE in MUSCLE STRENGTH and SIZE IS NOT INEVITABLE! The secret is that slow twitch fibers must be worked at 80% of their One Repetition Maximum (1RM). This is defined as the most weight a person can lift with one try. The bottom line with all the research is that a weight lifting program must be incorporated into your exercise program to maintain muscle strength that will lead to less inflammation and help decrease the
Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity Lean Body Mass consists of muscle, bone, and vital organs. can lead to loss of these tissues. Muscle, to a far greater extent than most people realize is responsible for the vitality of your whole physiological structure. Muscle is biologically active. It burns calories and increases your metabolism. It is not inflammatory. The more muscle one has the less strain it puts on other organs to perform their functions. A high ratio of muscle to fat on the body… Causes your metabolism to increase, meaning you can burn more inflammatory causing fat. Increases your aerobic capacity, which we will talk about soon, and the health of your whole cardiovascular system because you have more tissue consuming oxygen Triggers muscle tissue to consume increased insulin which decreases your chances of developing chronic inflammatory diseases. Assists developing increased levels of the beneficial HDL cholesterol Two things are responsible for how much muscle you have: •The more you use and stress your muscles, the more muscle tissue you will develop and maintain. •The levels of anabolic ones understand. ones circulating in your blood will determine how much muscle mass you have. This is true even for women. Yes, women have anabolic hormones that stimulate muscle growth. I know because I have dated some women that had more than me. I’m much too insecure to date a woman who was stronger than me.
Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity • Body Fat Percentage Chronic Inflammatory Diseases can be attributed to increased body fat. Inflammation is a result of excess fat, thus the higher percentage of fat that one has, the higher percentage that your inflammatory illness is in part due to. Body fat distribution may be as important as the percentage itself. The most distinguishing factor may be that people who carry their fat above their hips, (central obesity), have a higher risk of developing heart disease, stroke, and diabetes, Chronic Inflammatory Diseases. The typical beer belly may be a direct relationship to these illnesses. Thus as I have stated before, losing weight that leaves a higher fat percentage which lays above the hips can be inflammatory and lead to further inflammation.
Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity • Aerobic Capacity Aerobic capacity is your body’s ability to process oxygen within a given time. That is: 1) to rapidly breathe in air into the lungs to aerate the blood: 2) to deliver the right amount of blood at given times via the heart: 3) to deliver oxygen to all parts of the body through the bloodstream. As we age and develop Chronic Inflammatory Diseases our aerobic capacity begins to diminish after age 20 by about 5% every decade. Why is it important to maintain healthy aerobic capacity? All tissue needs oxygen. The better our tissues receive oxygen and nutrients the healthier it is. When the transport of these vital nutrients diminishes it can lead to cells dying. When a cell dies it releases its contents which can cause inflammation. If too many cells begin to die (as in heart tissue) the muscle becomes less efficient and the heart itself can become diseased. Aerobic Capacity is best developed by stimulating your cardiovascular system and lungs to work at higher levels. Running, aerobics, and cycling are ways people use to develop aerobic capacity. It has been shown that working out longer at a less intense rate helps to develop aerobic capacity.
Diet Lifestyle Environment and Chronic Disease Stress
Diet Lifestyle Environment and Chronic Disease • The body treats physical and emotional stress in the same manner. Stress is one of the most significant reasons chronic inflammatory diseases are escalating. Too much stress in our lives produces destructive hormones that alter many functions. It can alter thyroid function. It can decrease your resistance to disease, attack organs such as your heart and brain. It can alter your responses to insulin and ultimately, alter the way your body handles sugar. Stress causes your adrenal gland to hyper secrete a hormone called Cortisol. This hormone is sometimes referred to as the stress hormone. Other hormones are produced in response to stress and in combination with Cortisol can wreak havoc throughout the body. The internal damage done to organs, such as the liver, thyroid gland, adrenal gland, gastrointestinal tract, and cardiovascular system is extensive. • We all are under too much stress. We can’t get away from it. Stress is a normal part of today’s life. However, the amount and severity of the stress we suffer in today’s society, is not normal. Below is a small list of the more common stressors in our lives. Physical Activity/Stress • Marital Issues/Divorce • Financial Pressures • Job or Lack of a Job • Death of a Loved One • Lack of Relaxation • Children/Elderly Parents The Stress Response
The Stress Response• Rapid Pulse • General Irritability • Dryness of the Throat & Mouth • Inability to Concentrate • Sleep Disturbances • Headaches • Decreased Immune Response • Fatigue of Unknown Origin • Anxiety/Depression • Weakness/Dizziness • Diarrhea/Indigestion • Decreased Testosterone/Estrogen • Trembling/Nervous Ticks • Sexual Response/Reproduction • Increase Cholesterol Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress
• Breaks down muscle tissue, amino acids, proteins, and fatty acids Blood Sugar • Resting Energy Expenditure • Obesity • Visceral Fat • Inflammation • Bone Loss Osteoporosis • Cravings/Appetite • Immune response secretory IgA (Intestinal) • Leaky gut • Insulin Insulin Resistance • Frontal Lobe Activity Depression Memory Loss • Hypocampus and Pituitary Gland • Cancer TH2 ??? Physical Activity/Stress Diet Lifestyle Environment and Chronic Disease The Stress Response
The Stress Response. • Whenever we're angry, scared, anxious, or tense, the brain produces cortisol and adrenaline: hormones specifically designed to incite the fight-or-flight response that was once crucial to our survival. • Adrenaline's main role is to make you alert and focused, with exceptional concentration and memory. • Cortisol helps increase heart and respiratory rates and getting your muscles tensed and ready. • Since, physiologically speaking, your body thinks you've run a mile or two or done something active in response to the 'threat', the hormone sends signals to refuel the body as soon as possible. It's a biological green light to indulge in foods loaded with carbs and fat that leads to weight gain in the chronically stressed. It's a vicious cycle of stress, followed by elevated cortisol, followed by that foods you don't need. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress • Excess acid is produced systemically from too much stress (cortisol) leading to acidosis which can lead to numerous degenerative diseases.
• While those physiological processes worked well for our prehistoric ancestors, they're not as useful in a world where physical dangers are seldom. Physical Activity/Stress Diet Lifestyle Environment and Chronic Disease The Stress Response
134 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
135 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
136 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
137 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
The Skinny on Weight Management; 2015 The Skinny on Obesity (Ep. 1): An Epidemic for Every Body Robert H. Lustig, M.D. Professor of Pediatrics, Division of Endocrinology
139 Injury Agent, Physical or Chemical Injury to Cell Cell Membrane Damage Arachidonic Acid, Phopholipase A2 EPA PG2, Cyclooxygenase TXA 2 Platelet AggregationPDGF PG3 TXA3 No Platelet Aggregation Vitamin E Inhibits Phospholipase A2 Aspirin Binds Cox EPA Competes for Cox
140 Leaky Gut The leakage of toxic substances through the lining into the bloodstream. The intestinal tract is an immune organ, the site of nearly two - thirds of the body’s defense system, GALT (Gut-Associated Lymphoid Tissue). Inflammation Via the Intestinal Tract GALT is responsible for producing the antibody proteins. GALT activating organisms: yeast, waterborne organisms.
Environmental Toxins
• For the first time in the history of the world, every human being is now subjected to contact with dangerous chemicals, from the moment of conception until death. In the less than two decades of their use, the synthetic pesticides have been so thoroughly distributed throughout the animate and inanimate world that they occur virtually everywhere. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Sadly, scientists have found disturbing levels of modern man-made chemical in the wildlife , plants, seaweeds, fish and waters in all bodies of water • Inuit Indian mothers reveal some of the highest levels of modern chemical poisons . If they brought their milk to to the US for disposal, it would legally have to go to a toxic waste dump. Approximately 200 million people are suffering damage to body and brain, often irreparable, by the exposure to lead, mercury, chromium, obsolete pesticides and radionuclides in thousands of polluted places.
Amount of Toxic Chemicals Released into the Environment Through 1994 •On-Site Land 4 Million Pounds •Surface Water 25 Million Pounds •Air 42 Million Pounds •On-site Deep -well 40 Million Pounds •Total Reported Release 111Million Pounds •Total Estimated Release 2.2Billion Pounds
• 60,000 different chemicals since WWII • Over 188,000,000 pounds of chemicals are discharged into surface water such as lakes and rivers • More than 2,400, 000,000 pounds of chemical emissions are pumped into the air we breathe. • A grand total of 5,705,670,380 pounds of chemical pollutants are released into our environment • 551,034,696 pounds of industrial chemicals were dumped into public sewage storage. • 1,180,831,181 pounds of chemicals were released into the ground, threatening our natural aquifers. • 188,953,884 pounds of chemicals were discharged into surface waters. • 2,427,061,906 pounds of air emissions were pumped into the atmosphere.
Environmental Toxins •Environmental Pollutants •Herbicides/Pesticides •Heavy Metals •Chemical Exposure •Air, Water, and Food Pollutants •Endotoxins •Candidiasis •Plastics Wrapped around fruits, vegetables and meats Bottles for water, soda milk, ketchup, fruit juices, infant bottle Styrofoam Trays Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
•Environmental •Chemicals •Exhaust Fumes •Cigarette Smoke •Perfumes •Cleaners •Pesticides/Herbacides/Fungicides •Molds •Pollens •Dust Mites Sources of Toxicity Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Air Food Water Beverages Medicines Legal Illegal The EPA also estimates that fine-particle pollution causes an estimated 20,000 premature deaths in the U.S. each year
• Diseases and Conditions Linked to Environmental Toxicity • Certain cancers (especially breast cancer and various childhood cancers) • Immune deficiency and Auto-immune diseases • Neurological disorders such as Parkinson’s Disease • Hormonal imbalances • Chemical imbalances in the brain • Alterations of systemic enzymes • Changes in metabolism • Sleep disturbances • Thyroid problems • Fertility problems • Arthritis • Asthma • Eczema • Depression • Chronic Fatigue
• Tap water. A sample of average city water contains more than 500 chemicals. • Today’s fertilizers often contain excessive amounts of toxic heavy metals which are then absorbed into what ever grows in that fertilized soil. • The preservatives and hormones added to our food as well as the packaging and plastic wrapping of food for storage. • Household cleaning products such as some dish washing liquids, and surface cleaners • Personal care products such as antiperspirants, hair sprays, lotions and nail polish removers (which can be absorbed through the nails) • Some household products release unhealthy chemicals into the air, such as styrene from plastics, benzene from solvents, and formaldehyde from manufactured wood products such as kitchen cabinets and pressed furniture. • Permanent-press clothes, dry-cleaned clothes, carpeting, and synthetic materials emit traces of toxic vapors. • Smoke from cigarettes, cigars, or pipes affect the toxic levels of both the smoker as well as those exposed to the secondhand smoke. • Pesticides and insect sprays
Environmental toxins can affect every organ and system of the body and contribute to a number of symptoms including: • General Symptoms • fatigue, weakness and malaise • insomnia and sleep disturbances • sensory abnormalities including hearing loss, ringing in the ears, vision concerns, alterations in taste and touch • skin conditions such as eczema, psoriasis, rosacea, dermatitis, alopecia, itchy skin, etc. • Immune System • food allergies and food sensitivities • environmental allergies and increased chemical sensitivity • chronic viral or fungal infections • autoimmune conditions of various kinds; weakened immunity • cancers, particularly of the blood • Nervous System • chronic or progressive neurological problems such as numbness and tingling • alteration in cognitive abilities – “brain fog” (often you may indicate a specific spot on your head that feels abnormal) or neuro-cognitive difficulties (speech, reasoning, focus) • ADD, ADHD, concentration, focus and/or memory concerns • Autism, ADD, mental retardation, and cerebral palsy have been linked to environmental toxins such as lead, arsenic, toluene, PCBs and methylmercury.[2] • dementia and delayed reaction and mental processing • psychological problems and mood alterations (depression, anger, nervousness, emotional instability, etc) • Endocrine System • fibroids, cysts on reproductive organs • changes in temperature perception, sweating or flushing • hormone changes such as PMS, menopausal symptoms, alternations in hormone levels • Reproductive concerns, premature births and birth defects • Gastro-Intestinal and Renal System • nausea, vomiting, diarrhea or other bowel concerns • intestinal dysbiosis and alterations in appetite, weight • increase in food intolerances • abdominal pain, stomach cramps, burning of the throat or mouth • irritable bowel syndrome, Crohn’s disease, etc. • liver or kidney disease or dysfunction • cancers including (colon, pancreatic, stomach, rectal, liver, kidney or bladder) • Musculoskeletal System impaired motor function, loss of balance or coordination abnormal gait, posture, or movements • muscle and joint pain • osteoporosis and other bone disorders • Cardiovascular and Respiratory Systems • hypotension or hypertension • cardiovascular disease, peripheral vascular disease and alterations in heart rate • anemia, alterations in blood counts and blood vessel damage • respiratory infections – laryngitis, pharyngitis, bronchitis, pneumonia • difficulty breathing, asthma, restrictive airway disorders, pulmonary fibrosis • cancers (lung, respiratory tract or blood)
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Environmental chemicals get into the body, but once there ,we do not have the metabolism to get rid of them, so they silently stockpile • These stealth toxins, that are in all our bodies, are the underlying cause of many diseases • Getting rid of these toxins can influence the most hopeless and baffling diseases Styrene
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Phthalates are a group (family) of chemicals used in hundreds of products, such as toys, vinyl flooring and wall covering, detergents, toys lubricating oils, food packaging, pharmaceuticals, blood bags and tubing, and personal care products, such as nail polish, hair sprays, aftershave lotions, soaps, shampoos, perfumes and other fragrance preparations. o Possible reproductive concerns • Once inside our bodies, phthalates hook onto our cell parts where they gum up the works: damage hormone receptors, damage brain chemistry. Since it’d the receptors that are damaged taking hormones to compensate is often ineffective. • Phthalates outgas from plastics and products leaching into our foods o Damages brain chemistry o Cancer o Damage hormone receptors Environmental Toxins • Phthalates are potent Environmental Endocrine Disruptors, (EEDs); Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife.
Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Dioxins are a group (family) environmental pollutants. They belong to the so-called “dirty dozen” - a group of dangerous chemicals known as persistent organic pollutants (POPs). Dioxins are of concern because of their highly toxic potential. Experiments have shown they affect a number of organs and systems. • Once dioxins enter the body, they last a long time because of their chemical stability and their ability to be absorbed by fat tissue Their half-life in the body is estimated to be 7 to 11 years. In the environment, dioxins tend to accumulate in the food chain. The higher an animal is in the food chain, the higher the concentration of dioxins. • Dioxins are mainly by-products of industrial processes but can also result from natural processes, such as volcanic eruptions and forest fires. Dioxins are unwanted by-products of a wide range of manufacturing processes including smelting, chlorine bleaching of paper pulp and the manufacturing of some herbicides and pesticides. In terms of dioxin release into the environment, uncontrolled waste incinerators (solid waste and hospital waste) are often the worst culprits, due to incomplete burning. • Chronic exposure of animals to dioxins has resulted in several types of cancer. • Due to the omnipresence of dioxins, all people have background exposure and a certain level of dioxins in the body, leading to the so-called body burden.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • PCB’s Polychlorinated Biphenyls (PCBs) are a group (family) of manufactured organic chemicals that contain 209 individual chlorinated chemicals. • The incineration of municipal waste may lead to PCB pollution and produce dangerous by-products, such as hydrogen chloride (HCl) and dioxins (PCDDs and PCDFs). • Landfills containing transformers and capacitors • PCBs are probable human carcinogens and can also cause non-cancer health effects, such as reduced ability to fight infections, low birth weights, and learning problems. • Thyroid hormone-level alterations • Body weight loss • Carcinogenesis • Dermal Toxicity • Fatty Liver • Genotoxicity • Hepatomegaly • Immunosuppressive Effects • Neurotoxicity • Reproductive and Developmental Toxicity • Acute Lethality • Found in farm raised salmon
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Bisphenol-A (BPA) is an estrogen mimicker or xenoestrogen. BPA imitates the sex hormone estrogen in your body. This synthetic hormone can trick the body into thinking it’s the real thing. BPA has been linked to everything from breast and others cancers to reproductive problems, obesity, early puberty and heart disease, and according to government tests, 93 percent of Americans have BPA in their bodies! Some endocrine disruptors mimic testosterone or block other hormone activity. • Environmental Endocrine Disruptors, (EEDs); Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. Major components of the endocrine system include: • Female Ovaries • Male Testes • Pituitary Gland • Thyroid Gland • Adrenal Glands • Products that contain BPA include water bottles, baby bottles, dental fillings and sealants, dental devices, medical devices, eyeglass lenses, DVDs and CDs, household electronic items, and sports equipment.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Volatile Organic Compounds VOCs are emitted as gases from certain solids or liquids. VOCs include a variety of chemicals, some of which may have short- and long-term adverse health effects. Concentrations of many VOCs are consistently higher indoors (up to ten times higher) than outdoors. VOCs are emitted by a wide array of products numbering in the thousands. • Organic chemicals are widely used as ingredients in household products. Paints, varnishes; and wax all contain organic solvents, as do many cleaning, disinfecting, cosmetic, degreasing and hobby products. Fuels are made up of organic chemicals. All of these products can release organic compounds while you are using them, and, to some degree, when they are stored. • Eye, nose and throat irritation • headaches, loss of coordination and nausea • damage to liver, kidney and central nervous system • Some organics can cause cancer in animals, some are suspected or known to cause cancer in humans • Paints, paint strippers and other solvents, wood preservatives, aerosol sprays, cleansers and disinfectants, moth repellents and air fresheners, stored fuels and automotive, products ,hobby supplies, dry-cleaned clothing, pesticides
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Lead; As a result of human activities, such as fossil fuel burning, mining, and manufacturing, lead and lead compounds can be found in all parts of our environment. This includes air, soil, and water. Lead is used in many different ways. It is used to produce batteries, ammunition, metal products like solder and pipes, and X-ray shielding devices. Lead is a highly toxic metal and, as a result of related health concerns, its use in several products like gasoline, paints, and pipe solder, has been drastically reduced in recent years. Today, the most common sources of lead exposure in the United States are lead-based paint and possibly water pipes in older homes, contaminated soil, household dust, drinking water, lead crystal, lead in certain cosmetics and toys, and lead-glazed pottery. Health effects EPA has determined that lead is a probable human carcinogen. • Lead can affect every organ and system in the body. Long-term exposure of adults can result in decreased performance in some tests that measure functions of the nervous system; weakness in fingers, wrists, or ankles; small increases in blood pressure; and anemia. Exposure to high lead levels can severely damage the brain and kidneys and ultimately cause death. In pregnant women, high levels of exposure to lead may cause miscarriage. High level exposure in men can damage the organs responsible for sperm production.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Mercury; Mercury combines with other elements to form organic and inorganic mercury compounds. Metallic mercury is used to produce chlorine gas and caustic soda, and is also used in thermometers, dental fillings, switches, light bulbs, and batteries. Coal-burning power plants are the largest human-caused source of mercury emissions to the air in the United States. Mercury in soil and water is converted by microorganisms to methylmercury, a bioaccumulating toxin. Health effects The EPA has determined that mercuric chloride and methylmercury are possible human carcinogens. ● The nervous system is very sensitive to all forms of mercury. Exposure to high levels can permanently damage the brain, kidneys, and developing fetuses. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. ● Short-term exposure to high levels of metallic mercury vapors may cause lung damage, nausea, vomiting, diarrhea, increases in blood pressure or heart rate, skin rashes, and eye irritation. • Mercury exposure in high levels can permanently damage the brain, kidneys, and developing fetuses. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. ● Short-term exposure to high levels of metallic mercury vapors may cause lung damage, nausea, vomiting, diarrhea, increases in blood pressure or heart rate, skin rashes, and eye irritation.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Arsenic; Aside from occurring naturally in the environment, arsenic can be released in larger quantities through volcanic activity, erosion of rocks, forest fires, and human activity. The wood preserving industry uses about 90% of the industrial arsenic in the U.S. Arsenic is also found in paints, dyes, metals, drugs, soaps and semi- conductors. Animal feeding operations and certain fertilizers and pesticides can release high amounts of arsenic to the environment as can industry practices such as copper or lead smelting, mining, and coal burning. Health effects Arsenic is odorless and tasteless. Inorganic arsenic is a known carcinogen and can cause cancer of the skin, lungs, liver and bladder. ● Lower level exposure can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of “pins and needles” in hands and feet. • Arsenic ingestion of very high levels can possibly result in death. Long-term low level exposure can cause a darkening of the skin and the appearance of small “corns” or “warts” on the palms, soles, and torso.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Cadmium; Cadmium is a very toxic metal. All soils and rocks, including coal and mineral fertilizers, contain some cadmium. Cadmium has many uses, including batteries, pigments, metal coatings, and plastics. It is used extensively in electroplating. Health effects Cadmium and cadmium compounds are known human carcinogens. Smokers get exposed to significantly higher cadmium levels than non-smokers. Severe damage to the lungs may occur through breathing high levels of cadmium. • Cadmium ingestion at high levels severely irritates the stomach, leading to vomiting and diarrhea. Long-term exposure to lower levels leads to a buildup in the kidneys and possible kidney disease, lung damage, and fragile bones.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins
Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Flouride is a highly toxic substance. Consider, for example, the poison warning that the FDA now requires on all fluoride toothpastes sold in the U.S. or the tens of millions of people throughout China and India who now suffer serious crippling bone diseases from drinking water with elevated levels of fluoride. • In terms of acute toxicity (i.e., the dose that can cause immediate toxic consequences), fluoride is more toxic than lead, but slightly less toxic than arsenic. This is why fluoride has long been used in rodenticides and pesticides to kill pests like rats and insects. It is also why accidents involving over-ingestion of fluoridated dental products–including fluoride gels, fluoride supplements, and fluoridated water can cause serious poisoning incidents, including death. • Chairman of the National Research Council’s (NRC) comprehensive fluoride review, Dr. John Doull, recently stated that: “when we looked at the studies that have been done, we found that many of these questions are unsettled and we have much less information than we should • Fluoride Neurotoxicity • Hormonal Disruption • Fluoride Link to Bone Cancer
Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Chlorine It's a very dangerous toxin that has many uses, from disinfecting to bleaching. In small quantities, liquid and gas forms can be poisonous. • up to 2/3s of our harmful exposure to chlorine is due to inhalation of steam and skin absorption while showering. • Inhalation is a much more harmful means of exposure since the chlorine gas (chloroform) we inhale goes directly into our blood stream. When we drink contaminated water the toxins are partially filtered out by our kidneys and digestive system. • Cancer • Heart Disease
Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Pesticides There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders, autism, asthma, birth defects. • While agriculture has traditionally been tied to pesticide-related illnesses, of the 40 most commonly used pesticides in schools, • 28 can cause cancer • 14 are linked to endocrine disruption • 26 can adversely affect reproduction• 26 are nervous system poisons • 13 can cause birth defects • Of of the 30 most commonly used lawn pesticides, • 19 can cause cancer • 13 are linked to birth defects • 21 can affect reproduction• 15 are nervous system toxicants
Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Pesticides There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders, autism, asthma, birth defects. • While agriculture has traditionally been tied to pesticide-related illnesses, of the 40 most commonly used pesticides in schools, • Oxybenzone • Decabromodiphenyl Ether (DECA) • Asbestos• Parabens • Perchlorate • Butylated Hydroxyanisole (BHA) • Formaldehyde, e.g. cigarette smoke Antibiotics Anti-depressants • Benzene• Perfluorooctanoic Acid (PFOA) Aluminum Chloroform Brominated Fire Retartants (PBDEs
Reduction of the toxic properties of a substance by chemical changes induced in the body, producing a compound which is less poisonous or is more readily eliminated. Nearly every organ of the body contains specific enzymes that participate in the detoxification process and help protect that organ against toxins that originate in the outside world or are produced inside the body. Depending on their inheritance factors, individuals have very different detoxification abilities. Factors can vary as much as 5 fold.
•The liver is responsible for removing all impurities from the bloodstream. •If these impurities are not removed they are attacked by the immune system •The result is a over/under active immune response resulting in many inflammatory conditions and the production of free radicals
Symptom Picture of General Toxicity General Symptoms • Malaise - Chronic Fatigue - Headache - Joint & Muscle Pain • Chronic Mucous Production • Poor Exercise Tolerance
Research has shown that our ability to DETOXIFY our internal environments bears a direct relationship to our susceptibility to disease and ultimately our aging process. Many health problems have been definitively linked in a cause- and –effect relationship with exposure to specific toxins , including those we willingly expose ourselves to by our lifestyle choices. If organ reserve is depleted the liver and other detoxifying organs can’t remove these toxins from our bodies which will lead to a multitude of illnesses.
Organ Reserve and Aging
If we consider that the body has a fourfold to tenfold organ reserve for each organ, then we can suggest that, in times of stress, the body may need 4 to 10 times the normal nutrient intake just to keep even with the stress. Walter Schmitt, Jr., DC; Dig. Of Chiro Econ; May/June 1987; p.15
Organ Reserve: At a younger age organ reserve provides a margin of defense to people exposed to various stress related factors As individuals age they lose organ reserve. A stress related factor can now exceed the ability of the organ to maintain homeostasis. This loss of organ reserve can develop into a pathological process. Organ Reserve Biological Aging
Contributing Factors that can Modify Organ Reserve 1 Diet: A) Most RDA’s for vitamins and minerals (cofactors), are inadequate for maintaining organ reserve in today’s environment. B) Proper glucose regulation is a key factor in determining enhanced organ reserve. C) Antioxidants are crucial in preventing free radical oxidative damage especially to mitochondrial DNA. 2 Environment: A) Stress increases production of hormones which can lead to altered cell physiology. B) Anxiety is physiologically similar to stress in it’s response. 3 Daily Activities: A) Increases in muscle mass and aerobic respiration are the two most important controllable biomarkers related to organ reserve. 1) Increase in bone density 2) Decrease in blood pressure 3) Better control of glucose and cholesterol 4) Increase in strength and REE
Organ Reserve: At a younger age organ reserve provides a margin of defense to people exposed to various stress related factors As individuals age they lose organ reserve. A stress related factor can now exceed the ability of the organ to maintain homeostasis. This loss of organ reserve can develop into a pathological process. Organ Reserve Biological Aging
Contributing Factors that can Modify Organ Reserve 1 Diet: A) Most RDA’s for vitamins and minerals are inadequate for maintaining organ reserve in today’s environment. B) Proper glucose regulation is a key factor in determining enhanced organ reserve. C) Antioxidants are crucial in preventing free radical oxidative damage especially to mitochondrial DNA. 2 Environment: A) Stress increases production of hormones which can lead to altered cell physiology. B) Anxiety is physiologically similar to stress in it’s response. 3 Daily Activities: A) Increases in muscle mass and aerobic respiration are the two most important controllable biomarkers related to organ reserve. 1) Increase in bone density 2) Decrease in blood pressure 3) Better control of glucose and cholesterol 4) Increase in strength and REE
178 Reduction of the toxic properties of a substance by chemical changes induced in the body, producing a compound which is less poisonous or is more readily eliminated. Nearly every organ of the body contains specific enzymes that participate in the detoxification process and help protect that organ against toxins that originate in the outside world or are produced inside the body. Depending on their inheritance factors, individuals have very different detoxification abilities. Factors can vary as much as 5 fold.
179 Total Load A single exposure or a single substance may not overburden the body and induce damage. It is the total exposure to the toxin and how effectively they can be detoxified that determines relative health risk.
Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins Pesticides Asbestos Chloroform Non-metallic inorganics Synthetic organic chemicals (SOCs) Radioactive materials 1. Heavy Metals Found in drinking water, fish, vaccines, pesticides, preserved wood, Can cause cancer, neurological disorders, Alzheimer’s disease, fatig 2. PCBs (Polychlorinated biphenyls) Molds, benzene styrene
Phases of Treatment 2) Elimination Diet 1) Detoxification/Chelation Calorie Restriction Diet/Nutraceaticals OPTIMAL FUNCTIONAL HEALTH for WEIGHT MANAGEMENT 3) Low Glycemic, pH, Inflammatory, Organic Diet Digestion/Absorption Detoxification/Elimination Endocrine Imbalances Immune/Inflammatory Imbalance Lifestyle Reintroduction Environment
Foods for Detox Influences of Hunger Hormones
Elimination Diet Influences of Hunger Hormones
Low Glycemic Diet Influences of Hunger Hormones
Alkaline Diet Influences of Hunger Hormones
Anti-Inflammatory Diet DIET Influences of Hunger Hormones
• Water (pure) with Lemon 60 oz/Daily • Diet • 40 % Carbohydrates • 60% Complex Carbohydrates • 20% Fiber • 20 % Sugar (Low Glycemic Index) • 30% Protein • Consider Protein Powder Drink with Full Compliment of Amino Acids • 30% Fat • 80% Unsaturated Fatty Acids • 20% Saturated Fatty Acids •High Alkaline Foods •Juicing? •Lower Daily Caloric Intake DIET •Eat Organic Foods/Wash Fruits and Vegetables Daily Healthy-Aging Diet Recommendations (SUGGESTED)
Daily Healthy-Aging Diet Recommendations •Reduce Intake Of Soft Drinks/Refined Sugars/Harmful Fats (Saturated, Hydrogenated Partially Hydrogenated) •Minimize use of Artificial Sweeteners DIET •Eat High Quality Breakfast ½ Hour after Awakening •Eat 6 Small Meals/Day Foods High in ORAC Scale (Oxygen Radical Absorbance Capacity) 3,000/Daily •Wolfberry 25,300 (3.5 oz) •Blueberries 2,400 (3.5 oz) •Garlic 1,939 (3.5 oz) •Spinach 1,260 (3.5 oz) • Thyme Oil 159,590 (3.5 oz.) •Bioflavonoids (Proanthocyanidins, Quercitin, Citrus flavonoids, and green tea polyphenols) • Carotenoids (beta-carotene, lycopene, lutein, and zeaxanthin) •Fiber Soluble >30g •Fiber Insoluble 10g •Eliminate Allergy Potential Foods
The skinny on weight loss top notch
The skinny on weight loss top notch
The skinny on weight loss top notch
The skinny on weight loss top notch
The skinny on weight loss top notch
The skinny on weight loss top notch
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The skinny on weight loss top notch

  • 1. • Integrative Health Version 20.17 Presented By: Dr Don E. Harris The Skinny on Weight Management in 2017 Why Poor Nutrition, Environmental Toxins, Hormones and Lifestyles are Responsible for the Weight Epidemic
  • 2. Dr. Don E. Harris Memberships and Associations: • American Academy of Anti Aging Medicine (A4M) • American Academy of Environmental Medicine(AAEM) • American College for Advancement in Medicine (ACAM) • American College of Sports Medicine (ACSM) • American Nutraceutical Association (ANA) • American Nutrition Association (ANA) • American Society for Nutrition (ASN) • American Society of Clinical Oncologists (ASCO) • IDEA Health and Fitness Association • Institute for Functional Medicine (IFM) • International and American Society of Clinical Nutritionists ( IAACN) • Society for Nutrition Education (SNE) Post Doctoral Education: • Post Doc Fellowship: Integrative Cancer Therapy (Current) • Certified Clinical Nutritionist • Certified Health Trainer • Certified Cancer Exercise Trainer Employment: • Harris Integrative Health & Nutrition, President • University of Illinois at Chicago, Department of Oral Biology 25 Years in Practice Specializing in Clinical Nutrition with Emphasis on Integrative Cancer Therapies Education: •Bridgewater State College 1986 BS Biology BS Psychology •National University of Health Science 1991 BS Human Biology Doctor of Chiropractic •University of South Florida MS Integrative Cancer Therapy 2016
  • 3. An Integrative Health Care/Clinical Nutrition practice dedicated to assisting clients learn how each individual can alter their Lifestyle to live a life.Longer/Healthier Harris Integrative Health & Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 4. 1) Understand the principles behind health issues facing our lives today and our future . 2) How these principles can positively affect our health and well being. 3) Prepare you to make informed decisions concerning your health The Goal of Today's Workshop 4) Not to put you to sleep. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 5.
  • 6. TreatmentSymptom Symptom Symptom Cause Treatment Treatment Cause and Effect Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 7. Symptom Linear Approach to Healthcare Treatment We must begin to approach health care as a web-like environment, and not just a single cause mentality. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 8. - The age of a person expressed in terms of the period elapsed from the time of birth. - The age of a person expressed in terms of the physiological maturity of organs and systems. Chronological Age Biological Age Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 9. More people have multiple sclerosis, lupus, chron’s, RA , IBS, colitis, (auto-immune), than ever before More people have acid reflux ulcers, and stomach problems than ever before More women have menopause problems than ever before More women have more frequent PMS and more severe PMS than ever before More people suffer from allergies, asthmas, arthritis, migraine headaches than ever before More people have diabetes than ever before More people have pre-diabetic conditions than ever before More people have heart disease than ever before More people have chronic fatigue and fibromyalgia than ever before More kids have attention deficit disorder and hyperactivity than ever before More people have skin problems than ever before More people have insomnia than ever before More men and women suffer from sexual dysfunction and infertility than ever before More people suffer from depression, anxiety, and stress than ever before More People get Colds and flues than ever before More men suffer from prostate problems and more women get yeast infections than ever before
  • 10. • More People are Going to Doctors Than Ever Before • More people are taking prescription and nonprescription drugs than ever before • More surgeries are being performed than ever before • More people are getting X-rays, diagnostic testing than ever before Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 11. General Information Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 12. Common Conditions 2017 Neurococognitive Disorders Alzheimer's Attention Deficient Disorder Attention Deficient Hyperactivity Disorder Parkinson’s ALS Dementia Stroke Endocrine Disorders Diabetes Insulin Resistance Thyroid Hormone Replacement Adrenal Dysfunction Hormone Dysfunction Infertility Cardiovascular Arteriosclerosis Heart Attack Stroke Gastro-Intestinal Disorders Crohn’s Colitis IBS Leaky Gut Dysbiosis Esophageal Reflux Disease Ulcers/Ulcerative Colitis Systemic Disease Chronic Fatigue Fibromyalgia Autoimmune Obesity Arthritis Inflammation Sexual Dysfunction Metabolic Syndrome Cancer Infectious Disorders Viral Bacterial Fungal Parasitic General Information Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Psychological Depression/Anxiety ADHD Anger Divorce
  • 13. Etiology for Most Diseases •Infections •Inflammation •Oxidative Stress •Hyperglycemia •Allergies •Immune Dysfunction •Acidosis •Maldigestion •Hormone Imbalances •Dysbiosis •Hypercoagulation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 14. 10 Biomarkers of Aging Tufts University Strength Muscle Mass Basal Metabolic Rate (BMR/REE) Fat Percentage Aerobic Capacity Blood Sugar Tolerance Cholesterol/HDL Ratio Blood Pressure Bone Density Temperature Regulation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 15. Over 65 % of Deaths are Related to Poor Nutrition/Environment/Lifestyle Accidents 3.6% Pulmonary Disease 4.6% Pneumonia/Flu 1.8% Diabetes 2.8% Suicide/Alzheimer’s 1.5% Kidney Disease 1.1% Liver Disease 1.0% Cardiovascular Disease (stroke) 7.1% Cancer 22.3% Heart Disease 36.4% 65.8%
  • 16. “The United States spends 2X more per person on health care than any other country, yet in DALE its care ranks in the world.” World Health Organization Disability-Adjusted Life Years 24th •WHO scientists have developed a new way of calculating the number of years that a person can be expected to live in full health. •It is known as the DALE (Disability-Adjusted Life Years) system, and gives a truer picture of the health of a country than simply studying death rates. •To calculate DALE, the years of ill-health are weighted according to severity and subtracted from the expected overall life expectancy to give the equivalent years of healthy life. "Basically, you die earlier and spend more time disabled if you're an American rather than a member of most other advanced countries." Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 17. Obesity $192 Billion United States spends 2.1 TRILLION on health care annually United States spends $7,900/person on health care annually 78%, or $1.6 trillion annually – are for the treatment of preventable, lifestyle related conditions such as type II diabetes, obesity, and heart disease. 11 United States spends 16% of GDP on health care annually Australia spends 8.8% of GDP on health care annually France spends 11.2% of GDP on health care annually Sweden spends 9.2% of GDP on health care annually Japan spends 8.2% of GDP on health care annually Spain spends 8.2% of GDP on health care annually GDP of the United States 14.3 Trillion Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 18. Sarcopenia Muscle Loss “ No decline with age is as dramatic or potentially more significant than the decline in In fact, there may be no single feature of age-related decline more striking than the decline in in affecting ambulation, mobility, energy intake, intestinal function, overall nutrient intake and status, immune function, inflammatory control.” Lean Body Mass Lean Body Mass Influences of Hunger Hormones
  • 19. Most Expensive Drugs (Billions) Chronic Disorders • Lipitor $7.20 Cholesterol • Nexium $6.3 Heartburn • Plavix $6.1 Blood Clots • Advair $4.7 Asthma • Abilify $4.6 Antipsychotic • Seroquel $4.4 Antipsychotic • Singulair $4.1 Asthma • Crestor $3.8 Cholesterol • Actos $3.5 Diabetes • Epogen $3.3 Anemia 48 Billion 250 Billion Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 20. Most Prescribed Drugs (Millions) Chronic Disorders • Hydrocodone (with acetaminophen) 131.2 Pain • Zocor 94.1 Cholesterol • Lisinopril (BP) 87.4 BP • Synthroid 70.5 Thyroid • Norvasc (BP) 57.2 BP • Prilosec (not OTC) 53.4 Antacid • Z-Pak/Zithromax 52.6 Antibiotic • Amoxicillin 52.3 Antibiotic • Glucophage (metformin) 48.3 Diabetes • Hydrochlorothiazide (BP) 47.8 BP 694 Million Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 21. Inflammation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation
  • 22. Causes of Inflammation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation • Food allergies or food sensitivities that may cause few symptoms. • An imbalance of bacteria and fungi in your gastrointestinal tract, also known as dysbiosis. This causes your immune system to overreact to bacteria in your gut and can be without notable symptoms. • Stress constant psychological, emotional or physical stress raises the level of cortisol, creating inflammation. • Environmental toxicity from our air, water, food pollutants and toxic metals like mercury and lead all contribute to inflammation and have been linked to diseases as varied as endometriosis and cancer. • Diet and lifestyle too much fat, sugar, and protein in your diet, and exercisecan all increase inflammation in your body
  • 23. Inflammation•Cancer •Chronic Lower Respiratory •Cerebrovascular Disease (Stroke) •Diabetes •Autoimmune Disease •Arthritis •Alzheimer’s Disease•Fatigue •Skin problems •Heart Disease Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation •Psychological Disorders
  • 24. Inflammation Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 25. • Acute Short duration (minutes-days) with emigration of fluid, plasma proteins, and into tissue. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation • Chronic Longer duration (days-months) with tissue accumulation of lymphocytes, plasma cells, & macrophages plus variable proliferation of
  • 26.
  • 27. 27 • Immune dysregulation • Chronic inflammation • Auto-immune arthritis (antigenic cross-reactivity) – ankylosing spondylitis ~ Klebsiella spp – rheumatoid arthritis ~ Proteus spp • Colon Cancer & Breast Cancer • Psoriasis, cystic acne, eczema • Chronic fatigue & Fibromyalgia • Behavioral disorders – organic acids from bacteria & fungi Behavioral disorders– Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Dysbiosis Implicated in Inflammation/Dysbiosis
  • 28. • Acid Reflux (GERD) • Bowel Obstruction • Celiac Disease • Constipation • Crohn’s Disease • Diarrhea • Diverticulitis • Gallstones • Gastritis • Irritable Bowel Syndrome • Pancreatitis • Peptic Ulcer • Ulcerative Colitis Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Inflammation/Dysbiosis/Common GI Disorders
  • 29.
  • 30.
  • 31. 50 Heredity accounts for one - quarter of the variation in human life expectancy. The other three quarters of this variation are based on the fact that, after the age of , genetic expression is influenced by Diet Lifestyle and Environmental Toxins Heredity Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 32.
  • 33. Altered Terrain Two individuals are exposed to the exact same stimulus; bacteria, virus, toxin One individual may develop an adverse response Infection Disease Inflammation One individual may not be affected at all Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 34. • The heritability of life span is relatively minor. Our genes alter how our metabolism functions in response to Diet, Lifestyle and Environmental Toxins which control our disease patterns and and our life expectancy. We Inherit Genetic Tendencies, Not Genetic Certainties. Heredity General Information Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 35. Free Radicals (ROS) Demonstrate Apple • Free radicals are atoms with an odd (unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these Highly reactive radicals can start a chain reaction, like dominoes. Their chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To prevent free radical damage the body has a defense system of antioxidents Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 36. • Even though some free radical production is normal, things like stress, smoking, exercise, and aging contribute to the production of harmful free radicals. • No one can avoid free radicals. It is even thought that free radicals play a part in disease processes like cancer. Free Radicals (ROS) Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 37. 37 If the organs of your body are not defended by sufficient antioxidants against oxidative stress, they lose function over time, and their ability to produce hormones or control immune function is lost. After several years , free radical-induced organ damage can result in the appearance of “twisted molecules”. These unnatural twisted molecules can activate the body’s immune system to combat misidentified foreign invaders, resulting in damage to organs like the thyroid. Free Radicals (ROS) White blood cells specialize in producing free radicals which are used in host defense to kill invading pathogens Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases General Information
  • 38. Diet Lifestyle Environment and Chronic Disease Diet
  • 39. •Vitamin/Mineral Deficiencies •Caloric Intake • High Glycemic Foods •Alkalinity VS. Acidity •Allergic Reactions •Gluten Sensitivities •Essential Fatty Acids •Saturated Fats/Hydrogenated/Partially Hydrogenated •Pesticides/Herbicides •Hormones Diet Lifestyle Environment and Chronic Disease Diet/Nutrition Common Nutritional Issues
  • 40. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Vitamin/Mineral Deficiencies (Partial List) • Vitamin A: The nutritional deficiency of vitamin A causes diseases like night blindness, growth impairment, immune impairment, xerophthalmia, keratomalacia, hyperkeratosis, acne, dry hair and blindness. it is common in underdeveloped countries affecting one third of the children under the age of five around the world. • Thiamine (B1): Beriberi is caused by dearth of thiamine (vit-B1). Beriberi disease involves nervous system. Thiamine is found in the bran of rice. In populations, where the staple food is polished rice, as in South Asia, this nutritional disease was prevalent. Beriberi is rare in developed nations and in regions where the food habits include other cereals. • Iron: Iron deficiency anemia, which is due to deficiency of hemoglobin in the red blood cells, is characterized by severe fatigue and breathlessness. Hemoglobin is a protein containing iron. • Calcium: Calcium deficiency leads to weakening and stoppage calcium replacement in the bones and results in osteoporosis. Diet/Nutrition • Calcium • Magnesium • Vitamin D` • Folic Acid • Iron • B6/12
  • 41. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Vitamin/Mineral Deficiencies (Partial List) • Vitamin C (ascorbic acid): Ascorbic acid deficiency causes Scurvy Disease or subclinical scurvy. The symptoms of scurvy include malaise, lethargy, shortness of breath, bone pain, myalgia's, gum bleeding, loosening of teeth, jaundice, edema, oliguria, neuropathy, suppurating wounds and mental disability. • Vitamin D: Rickets (rachitis) in children and osteomalacia in adults cause weak, malformed brittle bones. Its deficiency in the food and non exposure to sun brings on rickets or osteomalacia. • Riboflavin (B2): Riboflavin (vit-B2) nutritional deficiency is medically known as ariboflavinosis. The symptoms include photophobia, bloodshot eyes, angular cheilitis, angular stomatitis, inflammation of the lining of mouth and tongue, mouth ulcers, iron-deficiency anemia, scrotal dermatitis and dry and scaling skin. It is mostly caused by inadequacy in food, impaired liver function and alcoholism. • Folic acid: Birth defects and neural tube defects in fetus occur when the mother suffers deficiency of folic acid (vit-B9). Diet/Nutrition
  • 42. Diet Lifestyle Environment and Chronic Disease Calories Diet/Nutrition
  • 43.
  • 44. Definitions: • Obesity: Having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher. •Body Mass Index (BMI): A measure of an adult’s weight in relation to his or her height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters. •In 1990, among states participating in the Behavioral Risk Factor Surveillance System, 10 states had a prevalence of obesity less than 10% and no states had prevalence equal to or greater than 15%. •By 1998, no state had prevalence less than 10%, seven states had a prevalence of obesity between 20-24%, and no state had prevalence equal to or greater than 25%. •In 2007, only one state (Colorado) had a prevalence of obesity less than 20%. Thirty states had a prevalence equal to or greater than 25%; three of these states (Alabama, Mississippi and Tennessee) had a prevalence of obesity equal to or greater than 30%. By 2012 44 states had a prevalence of greater than 25%, 19 states were =/>30%. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
  • 45. • It’s never about the total weight loss • It’s always about the type of weight that is lost Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
  • 46. Obesity: Having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher. •Body Mass Index (BMI): A measure of an adult’s weight in relation to his or her height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters. •In 1990, among states participating in the Behavioral Risk Factor Surveillance System, 10 states had a prevalence of obesity less than 10% and no states had prevalence equal to or greater than 15%. •By 1998, no state had prevalence less than 10%, seven states had a prevalence of obesity between 20-24%, and no state had prevalence equal to or greater than 25%. •In 2007, only one state (Colorado) had a prevalence of obesity less than 20%. Thirty states had a prevalence equal to or greater than 25%; three of these states (Alabama, Mississippi and Tennessee) had a prevalence of obesity equal to or greater than 30%. By the Numbers Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
  • 47. 1998 (*BMI 30, or about 30 lbs. overweight for 5’4” person) 2007 1990 No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 Diet/Nutrition
  • 48. (*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 Before1990
  • 49. (*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 1991 - 1998 Diet/Nutrition
  • 50. (*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity Trends Among U.S. Adults BRFSS 1990, 1998, 2007 1999 - 2007 Diet/Nutrition
  • 51. (*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person) Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 52. Refined CHO Ingestion Plasma Glucose Insulin Secretion Insulin Receptor Down Regulation Insulin Resistance Hypoglycemia Hyperinsulinemia Syndrome X Diabetes Mellitus Kidney Failure Limb Amputation Blindness MI Early Death Insulin Resistance PPAR gamma “thrifty gene Arthritis Serotonin/ Endorphin Receptors Weight Gain Kidney Na Retention Stress CHO Hunger Inflammation Fatigue Depression Hypertension AGE CV Risk Pain Blood Lipids Cancer Dysbiosis Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 53. Refined CHO Ingestion Plasma Glucose Insulin Secretion Insulin Receptor Down Regulation Insulin Resistance Hypoglycemia Hyperinsulinemia Syndrome X Diabetes Mellitus Kidney Failure Limb Amputation Blindness MI Early Death Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 55. Refined CHO Ingestion Insulin Resistance PPAR gamma “thrifty gene Arthritis Inflammation Pain Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 56. Refined CHO Ingestion Insulin Resistance PPAR gamma “thrifty gene Arthritis Inflammation Pain Cancer Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 57. Refined CHO Ingestion Insulin Resistance PPAR gamma “thrifty gene Arthritis Inflammation Pain Cancer Early Death Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 58. Diet Lifestyle Environment and Chronic Disease Sugar Intake Insulin Resistance Diet/Nutrition
  • 59. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • It is never the amount of weight you lose that is important, but the type of weight you lose and the amount of muscle tissue that remains. • The term Sarcopenic obesity is a condition afflicting many as a result of diets. Sarco (muscle), Penia (loss of) refers to the loss of muscle tissue. • “No decline with age is as dramatic or potentially more significant than the decline in Lean Body Mass. In fact, there may be no single feature of age-related decline more striking than the decline in Lean Body Mass in affecting ambulation, mobility, energy intake, intestinal function, overall nutrient intake and status, immune function, and inflammatory control,” as stated by the NIH. • The last thing a person trying to lose weight wants is muscle tissue that is damaged, degraded, or has disappeared. Remember, excess fat is inflammatory. You now have a situation where excess inflammatory tissue exists and healthy anti-inflammatory tissue has been damaged and / or disappeared. Hormones that Affect Weight Loss • Insulin • Cortisol • Leptin • Ghrelin • Estrogen • Testosterone Improper Weight Loss
  • 60. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • Digestive Disorders • Osteoarthritis • Dyslipidemia • Type 2 Diabetes • Increased Morbidity/mortality following surgery • Hypertension Improper Weight Loss • Congestive Heart Failure • PAD • Cardiovascular Disease Stroke/MI • Metabolic Syndrome
  • 61. 61 According to the United States Department of Agriculture, 1988-1989 •365 servings of soda pop or 638 can/year for people 12-29 •90 pounds of fats and oils •6o pounds of cakes and cookies •23 gallons of ice cream •22 pounds of candy •8 pounds of corn chips, popcorn, and pretzels •7 pounds of potato chips Diet/Nutrition Diet Lifestyle Environment and Chronic Disease
  • 62. Insulin Resistance and Weight Loss Metabolic Syndrome • Over 80 million Americans suffer from insulin resistance, and it appears to sit at the center of a web of related health problems. Women who are insulin resistant are at much greater risk of obesity, diabetes, hypertension (high blood pressure), heart disease, high cholesterol, breast cancer and polycystic ovarian syndrome (PCOS). There is some evidence that insulin resistance may contribute to endometrial cancer. It has also been implicated in Alzheimer’s disease. • Experts estimate that 25% of all Americans suffer from insulin resistance. We believe the percentage is much higher among perimenopausal women Diet Lifestyle Environment and Chronic Disease Diet/Nutrition
  • 63. Diet Lifestyle Environment and Chronic Disease Insulin Resistance Diet/Nutrition
  • 64.
  • 65.
  • 66. • Insulin resistance occurs when cells become insensitive to the insulin message. When cells don’t respond effectively to insulin, blood sugar is not properly managed, and the pancreas is required to secrete more insulin. When insulin levels in the blood become very high, they influence gene expression, altering cellular effects and promoting accelerated aging. Insulin Resistance and Inflammation • The connection between life span and the hormone insulin is extraordinary. • Control of blood sugar and its companion hormone insulin is a major point of investigation because insulin plays a principal role in communicating with the genes and altering their expression Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
  • 67. Characteristics that Identify Insulin Resistance • A family history of type II diabetes. • Tendency to gain fat in the upper body • Menstrual irregularities and polycystic ovaries. • Marginally elevated LDL cholesterol. • Marginally elevated blood fats (triglycerides). • Marginally elevated blood pressure • A “sweet tooth.” • Symptoms that resemble hypoglycemia. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
  • 68. Summary of the Effects of Improper Control of Insulin Metabolism • Generalized Cardiovascular Disease HEART • Increases Blood Sugar and Fat Deposition/Obesity • Decreases Reproductive Hormones Estrogen, Testosterone (Pregnancy/ED) Reproduction • Decreases Overall Function of the Immune System Immunity Mental Health • Damages Eyes, Nerves, Kidneys, also known as Diabetes I and II • Increases Fatigue • Increases Chances of Hyperglycemia/Hypoglycemia • Marginally elevated LDL cholesterol. • Marginally elevated blood fats (triglycerides). • Marginally elevated blood pressure • Increases Chances of Developing Poly Cystic Ovary Disease (PCOD)
  • 69. 69 Sugar is a Drug An external substance acting throughout the brain and body on cellular receptors designed for an internal chemical called “glucose” Sugar increases circulating levels of beta endorphin and serotonin Candice Pert PhD Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition
  • 70. Diet Lifestyle Environment and Chronic Disease Alkalinity Diet/Nutrition
  • 71. • Aging also decreases the amount of Hydrochloric acid in the stomach • By the age of 35 most people produce 1/3 the amount of hydrochloric acid • Improperly digested food exists the stomach in an unusable form and can cause bowel dysfunction and dysbiosis DYS ALTERED BIO LIFE Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition pH of Foods/Alkaline or Acidic
  • 72. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • Weight Gain, Obesity and Diabetes pH of Foods/Alkaline or Acidic • For the most part food in its natural state is balanced in terms of ph. • There exist numerous foods that are either acidic, (low pH or less than 7), or alkaline, (high pH greater than 7). • Nutrients, Fiber, are removed and preservatives, dyes, fillers are added back in. The food is not even close to being in balanced with the pH it was meant to have. • have. • pH is important because our bodies require certain pH for all biological functions. When a situation exists that throws the balance of pH off, even a little, the biochemical processes do not function at 100 percent. • Joint Inflammation, Arthritis • Bladder Conditions, Kidney Stones, Obesity and Diabetes • Cardiovascular Disease • Weight Gain, Obesity and Diabetes • Immune Deficiency • Cancer, Chronic Illness • Osteoporosis • Hormone Concerns • Premature Aging • Increase in Free Radicals
  • 73. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition pH of Foods/Alkaline or Acidic • Intense physical exercise What Makes Us Acidic? • The first line of defense against disease is a proper pH Balance. Disease can only grow in an acidic body, which makes a condition favorable for the growth of bacteria, yeast, fungus, mold, viruses, and other unwanted organisms. • What we eat including meat, fish, poultry, dairy, grains, refined/processed foods • Cancer always strikes those with an over-acidic body • An acidic state causes a lack of oxygenation at the cellular level. When the pH level falls below 7.4, there is less than the maximum oxygen in the blood. Blood carries the the maximum oxygen at pH 7.4 (Alkaline). Without proper oxygenation, unfriendly bacteria, mold and viruses will develop. • What we drink including coffee, soft drinks, alcohol, many types of water • Pollutions and Toxins • Dehydration
  • 74. Diet Lifestyle Environment and Chronic Disease Allergies Diet/Nutrition
  • 75. 75 Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 76. 76 Conditions linked to Food Allergy • Irritable bowel syndrome • Migraines • Auto-immune diseases • ADHD and behavior disorders • Enuresis and incontinence • Joint pains Diet/Nutrition
  • 77. 77 Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 78. 78 Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 79. 79 AntibodySerum proteins which are induced following contact with antigen. They bind specifically to the antigen which induced the formation. Antigen Are any molecules which are recognized by the immune system and induce an immune response. In a healthy immune system antibodies are produced in response to antigens entering the body via lungs, digestive tract and skin, or are produced by contact with internal invaders such as cancer cells. In an unhealthy immune system antigens are not fought off and are free to cause damage and cancer cells are not destroyed and could lead to cancer. Diet/Nutrition Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 80. Conditions linked to Food Allergy • Irritable bowel syndrome • Migraines • Auto-immune diseases • ADHD and behavior disorders • Enuresis and incontinence • Joint pains Every receptor found in the CNS is also found on immune cells Every thought and every chemical that effects the CNS will effect the immune system
  • 81. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Food Allergies • The most severe allergic reaction is anaphylaxis — a life-threatening whole-body allergic reaction that can impair your breathing, cause a dramatic drop in your blood pressure and affect your heart rate. Anaphylaxis can come on within minutes of exposure to the trigger food. • Most food-related symptoms occur within two hours of ingestion; often they start within minutes. In some very rare cases, the reaction may be delayed by four to six hours or even longer. • Everybody living today is allergic to one or more foods, more likely several, and, don’t even know it. • The body’s immune system keeps you healthy by fighting off infections and other dangers to good health. A food allergy reaction occurs when your immune system overreacts to a food or a substance in a food, identifying it as a danger and triggering a protective response. • Symptoms of a food allergy can range from mild to severe. Just because an initial reaction causes few problems doesn’t mean that all reactions will be similar; a food that triggered only mild symptoms on one occasion may cause more severe symptoms at another time.
  • 82. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Food Allergies • Eggs • Milk • Peanuts • Tree Nuts • Fish • Shell Fish • Wheat • Soy • Vomiting and/or Stomach Cramps • Hives • Shortness of Breath • Wheezing • Repetitive Cough • Swelling of the Tongue • Shock or Circulatory Collapse • Tight Hoarse Throat, Trouble Swallowing • Weak Pulse • Pale Skin • Dizziness
  • 83. 83
  • 84. Diet Lifestyle Environment and Chronic Disease Grains
  • 85. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Food Allergies/Gluten Gluten is the protein aspect of certain grains, including wheat, barley, rye and spelt. When you eat these grains, or foods containing them, you are eating gluten. The most common foods containing gluten are bread, pasta, pizza crust, bagels, cookies, and pastries. So you can see, it is quite easy to be exposed to gluten everyday and even every meal. In addition to the common places we find gluten, it can also be found hidden in many other foods because it helps to thicken liquids and allows things to stick together. It can also create a chewy and/or fluffy texture. Gluten also hides in products you wouldn’t think of based on their chewiness. Soy sauce, for example, contains gluten – so be sure to choose the gluten-free alternative called tamari sauce (it says gluten-free on the label). Sometimes, other condiments, like mustard, ketchup, and BBQ sauce, may also contain gluten. Then there are flavored chips and crackers. Even corn chips, if they are spicy or flavored in any way, may well include flour and/or wheat in their ingredients lists. The same goes for anything seasoned such as spice mixes (taco mix, for example) or anything containing modified food starch (even chewing gum). The simple truth is that humans cannot digest gluten. We can consume foods that we can’t digest – we also cannot digest fiber and beans, for example. In small quantities, it is usually not an issue. The dangers of gluten come into play when we consume large amounts of it (at every meal, for example) and especially if we have a genetic tendency to react to gluten. undigested proteins from gluten (also known as gliadin) get noticed by the immune system in our gut, triggering an inflammatory response that can spread throughout the body. Gluten then causes leaky gut, an immune system/digestive issue in which the cells lining the intestines, and the space between them, is damaged, allowing food to leak through (gluten and as well as other food) and to trigger inflammatory responses while decreasing absorption of nutrients. Leaky gut has been associated with such chronic health issues as obesity, diabetes, heart disease, liver disease, neurological issues (like Parkinson’s and Alzheimer’s), and cancer. Then, there’s celiac disease, which is an autoimmune disease in which further damage to the intestines due to immune responses to gluten can cause severe and life threatening health issues. It is estimated that 1 in 133 people have developed celiac disease already – that’s over 2 million people in the U.S – and most of them have no idea. Even if you don’t have celiac disease, it is thought that at least 1 in 4 people develop what is now known as non-celiac gluten sensitivity (NCGS). NCGS is associated with a number of health issues varying from fatigue and bloating to migraines and PMS. The effective treatment for both celiac disease and NCGS is the avoidance of gluten. The dangers of gluten don’t stop there. Once the immune system in the intestines starts reacting to gluten, it is exponentially more likely that the immune system will start reacting to other foods – most often dairy proteins (casein and whey), eggs, potato, soy, and other grains (rice, millet, and corn). At this point, a person is often hit by digestive symptoms, no matter what they eat, and potentially also experiences fatigue, sleep issues, mood changes, skin rashes, frequent infections, thyroid issues, and in some cases, autoimmunity. As mentioned before, 1 in 4 people have a gluten intolerance—so it’s quite possible, if not likely, that you have one. Some indications include tiredness, anxiety, depressed mood, insomnia, bloating, IBS, eczema, allergies, sinusitis, and low thyroid function. Even hormone imbalances—such as PMS, PCOS, and unexplained infertility—have been tied to gluten intolerance. Currently research indicates that the best way to determine whether you have gluten sensitivity is to remove gluten from your diet for at least three weeks (however, in some cases, it could require six months of elimination) and then reintroduce gluten to determine whether symptoms occur or return. Another option is to test for IgG antibodies to gluten, which can be done with as little as a finger prick, although most practitioners are not offering this panel or may not be familiar with the relevance of the results. Feel free to contact my office for assistance.
  • 86. Diet Lifestyle Environment and Chronic Disease Omega 3’S
  • 87. Arthritis Inflammatory bowel disease Auto-immune diseases Eczema Asthma Atherosclerosis Cardiovascular disease EFA Imbalances & Inflammation
  • 88.
  • 89. • Structural components of all membranes – Increased fluidity & permeability – Optimal organelle function • Precursors for eicosanoid synthesis – “Local” hormones – Regulate inflammation • Structural components of all membranes – Increased fluidity & permeability – Optimal organelle function • Precursors for eicosanoid synthesis – “Local” hormones – Regulate inflammation Major roles of EFAs
  • 90. 90 The fluidity and permeability of membranes is largely determined by the degree of unsaturation of the fats in the membrane phospholipids. Cell Membranes
  • 91.
  • 92. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Essential Fatty Acids Polyunsaturated Fatty Acids (PUFA) • Lowers Total Cholesterol • Lowers Risk of Heart Disease • Helps with Diabetes • Increases HDL • Benefits People with Rheumatoid Arthritis, SLE, Osteoporosis • Essential fatty acids are, as they sound, fats that are necessary within the human body. • Essential fatty acids are also not usually produced naturally within the body. This means that you have to obtain essential fatty acids by adding them to your diet. Omega-3 Essential Fatty Acids • Omega-3 essential fatty acids are necessary within the human body, but they can also be produced modestly within the body • A lack of Omega-3 essential fatty acids could lead to blood clots, problems with memory, a decreased sense of vision, irregular heartbeat and a decrease in the functioning of your immune system. I Benefits of a diet rich in Omega-3 Fatty Acids (REDUCES INFLAMMATION) • Depression, Bipolar Schizophrenia, ADHD, Cognitive Decline • Flaxseed Oil Walnuts • Walnut, Sesame Seeds • Spinach • Salmon, Tuna, Sardines Sources of Omega-3 Fatty Acids
  • 93. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Essential Fatty Acids Omega-6 Essential Fatty Acids • Supports Bone Health • Omega-6 fatty acids, like omega -3s, are essential fatty acids that can only be provided to us through food and supplements. man body. • Medical research on humans found a correlation (correlation does not imply causation) between the high intake of omega-6 fatty acids from vegetable oils and disease in humans. • Omega 6 Fatty Acids are pro-inflammatory and anti-inflammatory PUFAs Benefits of a diet rich in Omega-3 Fatty Acids (REDUCES INFLAMMATION) • Safflower, Grapeseed, Sunflower, Corn Walnut, Cotton, Soy Oils Sources of Omega-6 Fatty Acids • Helps with Diabetes Neuropathy • Rheumatoid Arthritis, • ADHD
  • 94.
  • 95. Injury Agent, Physical or Chemical Injury to Cell Cell Membrane Damage Arachidonic Acid, Phopholipase A2 EPA PG2, Cyclooxygenase TXA 2 Platelet AggregationPDGF PG3 TXA3 No Platelet Aggregation Aspirin Binds Cox EPA Competes for Cox
  • 96. Essential Fatty Acids Linoleic Acid Oils of corn, safflower, sunflower, sesame Alpha-linolenic Acid Flax, pumpkin, chia, walnut GLA Arachidonic Acid Animal meat, milk EPA/DHA PGE2 PGE3 IL-1, Il-6 IL-2, PGE 3, PGE 6
  • 97. Essential Fatty Acids Linoleic Acid Omega 6’s Oils of corn, safflower, sunflower, sesame Alpha-linolenic Acid Omega 3’s Flax, pumpkin, chia, walnut GLA PGE1 Arachidonic Acid Animal meat, milk EPA DHA PGE2 PGE3 Leukotrienes Thromboxanes Eicosonoids Omega 3 Fatty Acids Anti-Inflammatory Pro-Inflammatory
  • 98. Ratio Omega 6 Fatty Acid to Omega 3 Fatty Acid 1:1 4:1 45:1
  • 99. Diet Lifestyle Environment and Chronic Disease Trans Fats
  • 100. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils • Most of the trans fat in the foods we eat is formed through a manufacturing process that adds hydrogen to vegetable oil, which converts the liquid into a solid fat at room temperature. This process is called hydrogenation • Trans fat is considered by many doctors to be the worst type of fat you can eat. Unlike other dietary fats, trans fat — also called trans-fatty acids — both raises your LDL ("bad") cholesterol and lowers your HDL ("good") cholesterol. • Trans fat is formed through an industrial process that adds hydrogen to vegetable oil, which causes the oil to become solid at room temperature. • This partially hydrogenated oil is less likely to spoil, so foods made with it have a longer shelf life. • To make partially hydrogenated oils (those that are partially solidified), hydrogen atoms are added to liquid fats like soybean oil, rendering a fat that’s partially solidified, partially filled with hydrogen atoms, and partially kinked. That last point is very important; it’s what makes partially hydrogenated oil so dangerous. • These kinked, partially hydrogenated oils literally build up inside the body, sticking to each other, forming longer, unbranched chains that continue to grow and kink, linking up sticky end to sticky end, and they grow so large inside the body They bioaccumulate inside our bodies, the same way mercury and heavy metals bioaccumulate inside a tuna
  • 101. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition • Digestive Disorders • Osteoarthritis • Dyslipidemia • Type 2 Diabetes • Increased Morbidity/mortality following surgery • Hypertension • Congestive Heart Failure • PAD • Cardiovascular Disease Stroke/MI • Metabolic Syndrome Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils
  • 102. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils • These kinked, partially hydrogenated oils literally build up inside the body, sticking to each other, forming longer, unbranched chains that continue to grow and kink, linking up sticky end to sticky end, and they grow so large inside the body They bioaccumulate inside our bodies, the same way mercury and heavy metals bioaccumulate inside a tuna in the ocean. Trans Fatty Acids Hydrogenated and Partially Hydrogenated Oils Found • Fast Foods • Fried Chicken • Biscuits • Fried Fish Sandwiches • French Fries • Donuts/Muffins • Crackers • Most Cookes • Cakes/Icing/Pies • Chips • Microwave Popcorn • Artificial Thickeners
  • 103. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Artificial Additives • Food additives are chemicals that keep foods fresh or enhance their color, flavor or texture. • To Make Food Convenient and Easy to Prepare • To Increase Nutritional Value • To Improve Flavor of Foods • To Improve Shelf Life or Storage Time • To Enhance Attractiveness of Food Products and Improve Consumer Acceptance • The food industry has continually created new chemical to manipulate, preserve and transform our food. • Scientists are now able to mimic natural flavors,color foods to make them look more “natural” or “fresh”, preserve foods for longer and longer periods of time, and create altered versions of breads, crackers, fruits, vegetables, meats, dairyproducts and many more commonly used foods. Five Main Reasons for Why Chemicals Must be Added to Our Foods
  • 104. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Artificial Additives • Anti-caking agents – stop ingredients from becoming lumpy • Emulsifiers – Stop Fats from Clotting Together • Food Acids – Maintain the Right Acid Level • Colors – Enhance or Adds Color • Artificial Sweeteners – Increase the Sweetness • Flovors – Adds Flavor • Antioxidants – Prevent foods from oxidizing or going rancid Five Main Reasons for Why Chemicals Must be Added to Our Foods • Foaming Agents – Maintains uniform Aeration of Gases in Foods • Thickeners and Vegetable Gums – Enhances Texture and Consistency • Preservatives – Stops Microbes from Multiplying and Spoiling the Food • Humectants – Keeps Food Moist • Flavor Enhancers – Increases the Power of a Flavor • Stabilisers and Firming Agents – Maintains Even Food Dispersion • Gelling Agents – Alters the Texture of Foods Through Gel Formation
  • 105. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Diet/Nutrition Artificial Additives • Hydrogenated Fats – Cardiovascular Disease, Obesity • Nitrites/Nitrates – Can Develop into Nitrosamines in the body, which can be carcinogenic • Sugar/Sweeteners – Obesity, Dental Cavities, Diabetes, and Hypoglycemia, Increased Triglycerides • Monosodium Glutamate (MSG) – Common Allergic and Behavioral Reactions • Artificial Food Colors – Allergies, Asthma, Hyperactivity, Possible Carcinogen • Preservatives (BHA, BHT, EDTA, etc.) – Allergic Reactions, Hyperactivity, Possibly Cancer, May be Toxic to Nervous System and the Liver Key Additives to Avoid • Artificial Flavors – Allergic or Behavioral Reactions • Refined Flour – Low-Nutrient Calories, Carbohydrate Imbalances, Altered Insulin Production • Salt (Excessive) – Fluid Retention and Blood Pressure Increase • Olestra (An Artificial Fat) – Diarrhea and Digestive Disturbances
  • 106. 106
  • 107. How to Protect Against Leptin Resistance Influences of Hunger Hormones • Avoid bad fats • Partially hydrogenated and hydrogenated fats • Trans fat • Eat good fats • Vegetable oils (polyunsaturated fats oxidize) Fat Attracts Fat • Clean saturated fat • Cholesterol • Poly/monounsaturated fats (not vegetable) • Eliminate Grains and Sugar until resistance is repaired • Avoid Toxins 1/3 is toxin related Diet/Nutrition
  • 109. Recently, it has been suggested that specific food intolerances may not be true allergies but, rather, may be related to metabolic toxicity resulting from an intestinal disorder.13 Hunter proposes that symptoms from apparent food intolerances may result from reduced enzyme concen 2 3 Figure 1: Metabolism of Benzene to Phenyl Sulfate trations, either inherited or acquired, and from intestinal bacterial endotoxins. According to Hunter, “Specific food residues are broken down by the colonic microflora with the production of chemicals, which, in susceptible individuals with low concentrations of relevant hepatic enzymes, pass into the systemic circulation to produce distant symptoms.” Diet/Nutrition
  • 110. Conditions linked to Food Allergy • Irritable bowel syndrome • Migraines • Auto-immune diseases • ADHD and behavior disorders • Enuresis and incontinence • Joint pains Every receptor found in the CNS is also found on immune cells Every thought and every chemical that effects the CNS will effect the immune system
  • 111. Chronic Inflammation, Allergies, and Leptin • . As we gain weight, our bodies do not add more fat cells. The fat cells we already have become larger and are filled with more fat instead. They may leak as they are stretched more and more. Then immune cells called macrophages come in to clean up the mess. The macrophages release inflammatory chemicals in the fatty tissues as they are cleaning up. • Your body counteracts this silent inflammation by producing anti-inflammatory chemicals. Some of these interfere with the function of the hormone leptin. • Excess fat leads to inflammation and the chemicals that counteract inflammation (which are necessary to keep silent inflammation from causing symptoms) make it impossible for the body’s weight-control hormone, leptin, to function properly. Influences of Hunger Hormones Diet/Nutrition
  • 112. Diet Lifestyle Environment and Chronic Disease Food Toxins Diet/Nutrition
  • 113. 113 Leaky Gut The leakage of toxic substances through the lining into the bloodstream. The intestinal tract is an immune organ, the site of nearly two - thirds of the body’s defense system, GALT (Gut-Associated Lymphoid Tissue). Inflammation Via the Intestinal Tract GALT is responsible for producing the antibody proteins. GALT activating organisms: yeast, waterborne organisms.
  • 114. 114 Dysbiosis Implicated in: • Immune dysregulation • Chronic inflammation • Auto-immune arthritis (antigenic cross-reactivity) – ankylosing spondylitis ~ Klebsiella spp – rheumatoid arthritis ~ Proteus spp • Colon Cancer & Breast Cancer • Psoriasis, cystic acne, eczema • Chronic fatigue & Fibromyalgia • Behavioral disorders – organic acids from bacteria & fungi Behavioral disorders–
  • 115. 115
  • 116. 116 Inflammation and Heart Disease Cardiologist Attilio Maseri, M.D. suggests the new research linking inflammation and heart disease suggests that the current approach to heart disease prevention that focuses entirely on lowering cholesterol may be ill- advised. Many types of infection, toxic exposure or trauma could result in increased production of inflammatory alarm substances. These alarm substances, in turn, could interact with the genes in genetically susceptible individuals to produce heart inflammation and subsequent heart disease. Markers for inflammation may be better predictors of heart disease than elevated blood cholesterol itself.
  • 117. Diet Lifestyle Environment and Chronic Disease Hormones Diet/Nutrition
  • 118. Diet Lifestyle Environment and Chronic Disease Diet/Nutrition • Leptin, the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores. • Estrogen balance is essential for achieving and maintaining fat loss. In men and premenopausal women, too much estrogen – a condition called estrogen dominance causes toxic fat gain, water retention, bloating, and a host of other health and wellness issues. There are only two ways to accumulate excess estrogen in the body: We either produce too much of it on our own, or acquire it from our environment or diet. • Testosterone levels isn’t just a question for the 40 and over but usually decreases with age. If you’re a human being (male or female) who wants to lose fat (or keep it off) then testosterone is a very important hormone
  • 119. Diet Lifestyle Environment and Chronic Disease Diet/Nutrition • Ghrelin Produced in your stomach, ghrelin is a hormone. If you skip a meal, your ghrelin makes you ravenous, Making it nearly impossible for you to resist the next food item you see. Shaving calories off during the day is a big mistake if your on a weight loss train. Ghrelin increases if you fast you need to fuel yourself during first thing. • Insulin is a hormone made by one of the body's organs called the pancreas. Insulin helps your body turn blood sugar (glucose) into energy. It also helps your body store it in your muscles, fat cells, and liver to use later, when your body needs it. After you eat, your blood sugar (glucose) rises. • Cortisol under stressful conditions, provides the body with protein for energy production through gluconeogenesis, the process of converting amino acids into useable carbohydrate (glucose) in the liver.
  • 120. Diet Lifestyle Environment and Chronic Disease Lifestyle
  • 121. Diet Lifestyle Environment and Chronic Disease This area of your life is probably the one you have the most control over but possibly is the most difficult to change. I’m sure you are aware of the importance of exercise. We all know the effects of lack of physical conditioning; weak muscles, weak bones, weak heart, etc. It is crucial to maintain some level of physical activity and conditioning. One of the most important aspects of working with chronic inflammatory and weight loss patients is to keep them moving. Walking, stretching, and swimming are activities I strongly encourage all my patients to do. I recommend doing your exercise program where you feel the most comfortable. If a gym is your choice, then join one. Many of my patients can get their exercise in and around their own home. Some prefer a personal trainer to come to their home, or work with them at a fitness facility. The best exercise for you is the one that you will do with regularity. A significant part of maintaining health and reducing your risk for developing disease is to exercise. However, people with inflammation often overdue what they are capable of. Personal trainers are a great resource if this is the case, and if they are well acquainted with your condition and all of its nuances. Massage Therapy is a wonderful adjunct to your therapy but again, only if the therapist is well versed in what you suffer from. Be careful when choosing your lifestyle programs. It is important to move but only within within the confines of your abilities and with properlyined support people you trust.
  • 122. Diet Lifestyle Environment and Chronic Disease Exercise
  • 123. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity • There are two principal factors in the onset of chronic inflammatory conditions: genetic predisposition, which you can’t control: and your lifestyle, exercise patterns, which you can control. • There are different forms of exercise and to receive the maximum benefit from your time you need to perform all types. You need to build strength in your muscles, keep your muscles flexible, and condition them to perform tasks for an extended period of time. • strength • flexibility • endurance • Muscle Mass; If you are the average middle-aged person, your problem usually isn’t excess weight. It is more than likely excess body fat. Remember we have already discussed how dangerous excess body fat can be. Too much fat is inflammatory and can lead to chronic inflammatory conditions. As a consequence of aging we tend to lose muscle tissue only to be replaced by fat tissue. The typical person loses about 6.6 pounds of lean-body mass each decade of life, this rate accelerates after the age of 45. Some of my patients will insist they weigh the same as they were in high school. I don’t disagree with them, they probably do. But what has happened is they have loss muscle and gained fat.
  • 124. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity Muscle Strength Strong muscle tissue is as important as having muscle tissue. It can be divided into skeletal muscle and cardiac muscle. The two are just what they imply, skeletal muscle attaches to ligaments and bones and cardiac muscle is your heart. A brief lesson on how muscle tissue works will serve you well. Motor nerves connect your skeletal muscle to your central nervous system. These nerves carry messages back and forth from your central nervous system and your skeletal muscles. These nerves and muscles are known as a motor unit. The age old problem is as we age and fall prey to Chronic Inflammatory Diseases you lose these motor units. It is estimated that you lose 20% of these motor units between the ages of 30 and 70. Another aspect of your muscles losing strength is that your muscles consist of two types of fibers, fast twitch and slow twitch. Slow twitch are responsible for posture and low intensity movements. The fast twitch fibers are responsible for heavy lifting and running at a fast pace. As the aging process continues, the fibers that are responsible for developing strength decline. When you add a variety of illness it compounds the loss. The good news is; A DECLINE in MUSCLE STRENGTH and SIZE IS NOT INEVITABLE! The secret is that slow twitch fibers must be worked at 80% of their One Repetition Maximum (1RM). This is defined as the most weight a person can lift with one try. The bottom line with all the research is that a weight lifting program must be incorporated into your exercise program to maintain muscle strength that will lead to less inflammation and help decrease the
  • 125. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity Lean Body Mass consists of muscle, bone, and vital organs. can lead to loss of these tissues. Muscle, to a far greater extent than most people realize is responsible for the vitality of your whole physiological structure. Muscle is biologically active. It burns calories and increases your metabolism. It is not inflammatory. The more muscle one has the less strain it puts on other organs to perform their functions. A high ratio of muscle to fat on the body… Causes your metabolism to increase, meaning you can burn more inflammatory causing fat. Increases your aerobic capacity, which we will talk about soon, and the health of your whole cardiovascular system because you have more tissue consuming oxygen Triggers muscle tissue to consume increased insulin which decreases your chances of developing chronic inflammatory diseases. Assists developing increased levels of the beneficial HDL cholesterol Two things are responsible for how much muscle you have: •The more you use and stress your muscles, the more muscle tissue you will develop and maintain. •The levels of anabolic ones understand. ones circulating in your blood will determine how much muscle mass you have. This is true even for women. Yes, women have anabolic hormones that stimulate muscle growth. I know because I have dated some women that had more than me. I’m much too insecure to date a woman who was stronger than me.
  • 126. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity • Body Fat Percentage Chronic Inflammatory Diseases can be attributed to increased body fat. Inflammation is a result of excess fat, thus the higher percentage of fat that one has, the higher percentage that your inflammatory illness is in part due to. Body fat distribution may be as important as the percentage itself. The most distinguishing factor may be that people who carry their fat above their hips, (central obesity), have a higher risk of developing heart disease, stroke, and diabetes, Chronic Inflammatory Diseases. The typical beer belly may be a direct relationship to these illnesses. Thus as I have stated before, losing weight that leaves a higher fat percentage which lays above the hips can be inflammatory and lead to further inflammation.
  • 127. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress Physical Activity • Aerobic Capacity Aerobic capacity is your body’s ability to process oxygen within a given time. That is: 1) to rapidly breathe in air into the lungs to aerate the blood: 2) to deliver the right amount of blood at given times via the heart: 3) to deliver oxygen to all parts of the body through the bloodstream. As we age and develop Chronic Inflammatory Diseases our aerobic capacity begins to diminish after age 20 by about 5% every decade. Why is it important to maintain healthy aerobic capacity? All tissue needs oxygen. The better our tissues receive oxygen and nutrients the healthier it is. When the transport of these vital nutrients diminishes it can lead to cells dying. When a cell dies it releases its contents which can cause inflammation. If too many cells begin to die (as in heart tissue) the muscle becomes less efficient and the heart itself can become diseased. Aerobic Capacity is best developed by stimulating your cardiovascular system and lungs to work at higher levels. Running, aerobics, and cycling are ways people use to develop aerobic capacity. It has been shown that working out longer at a less intense rate helps to develop aerobic capacity.
  • 128. Diet Lifestyle Environment and Chronic Disease Stress
  • 129. Diet Lifestyle Environment and Chronic Disease • The body treats physical and emotional stress in the same manner. Stress is one of the most significant reasons chronic inflammatory diseases are escalating. Too much stress in our lives produces destructive hormones that alter many functions. It can alter thyroid function. It can decrease your resistance to disease, attack organs such as your heart and brain. It can alter your responses to insulin and ultimately, alter the way your body handles sugar. Stress causes your adrenal gland to hyper secrete a hormone called Cortisol. This hormone is sometimes referred to as the stress hormone. Other hormones are produced in response to stress and in combination with Cortisol can wreak havoc throughout the body. The internal damage done to organs, such as the liver, thyroid gland, adrenal gland, gastrointestinal tract, and cardiovascular system is extensive. • We all are under too much stress. We can’t get away from it. Stress is a normal part of today’s life. However, the amount and severity of the stress we suffer in today’s society, is not normal. Below is a small list of the more common stressors in our lives. Physical Activity/Stress • Marital Issues/Divorce • Financial Pressures • Job or Lack of a Job • Death of a Loved One • Lack of Relaxation • Children/Elderly Parents The Stress Response
  • 130. The Stress Response• Rapid Pulse • General Irritability • Dryness of the Throat & Mouth • Inability to Concentrate • Sleep Disturbances • Headaches • Decreased Immune Response • Fatigue of Unknown Origin • Anxiety/Depression • Weakness/Dizziness • Diarrhea/Indigestion • Decreased Testosterone/Estrogen • Trembling/Nervous Ticks • Sexual Response/Reproduction • Increase Cholesterol Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress
  • 131. • Breaks down muscle tissue, amino acids, proteins, and fatty acids Blood Sugar • Resting Energy Expenditure • Obesity • Visceral Fat • Inflammation • Bone Loss Osteoporosis • Cravings/Appetite • Immune response secretory IgA (Intestinal) • Leaky gut • Insulin Insulin Resistance • Frontal Lobe Activity Depression Memory Loss • Hypocampus and Pituitary Gland • Cancer TH2 ??? Physical Activity/Stress Diet Lifestyle Environment and Chronic Disease The Stress Response
  • 132. The Stress Response. • Whenever we're angry, scared, anxious, or tense, the brain produces cortisol and adrenaline: hormones specifically designed to incite the fight-or-flight response that was once crucial to our survival. • Adrenaline's main role is to make you alert and focused, with exceptional concentration and memory. • Cortisol helps increase heart and respiratory rates and getting your muscles tensed and ready. • Since, physiologically speaking, your body thinks you've run a mile or two or done something active in response to the 'threat', the hormone sends signals to refuel the body as soon as possible. It's a biological green light to indulge in foods loaded with carbs and fat that leads to weight gain in the chronically stressed. It's a vicious cycle of stress, followed by elevated cortisol, followed by that foods you don't need. Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress • Excess acid is produced systemically from too much stress (cortisol) leading to acidosis which can lead to numerous degenerative diseases.
  • 133. • While those physiological processes worked well for our prehistoric ancestors, they're not as useful in a world where physical dangers are seldom. Physical Activity/Stress Diet Lifestyle Environment and Chronic Disease The Stress Response
  • 134. 134 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
  • 135. 135 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
  • 136. 136 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
  • 137. 137 Diet Lifestyle Environment and Chronic Disease Physical Activity/Stress The Stress Response
  • 138. The Skinny on Weight Management; 2015 The Skinny on Obesity (Ep. 1): An Epidemic for Every Body Robert H. Lustig, M.D. Professor of Pediatrics, Division of Endocrinology
  • 139. 139 Injury Agent, Physical or Chemical Injury to Cell Cell Membrane Damage Arachidonic Acid, Phopholipase A2 EPA PG2, Cyclooxygenase TXA 2 Platelet AggregationPDGF PG3 TXA3 No Platelet Aggregation Vitamin E Inhibits Phospholipase A2 Aspirin Binds Cox EPA Competes for Cox
  • 140. 140 Leaky Gut The leakage of toxic substances through the lining into the bloodstream. The intestinal tract is an immune organ, the site of nearly two - thirds of the body’s defense system, GALT (Gut-Associated Lymphoid Tissue). Inflammation Via the Intestinal Tract GALT is responsible for producing the antibody proteins. GALT activating organisms: yeast, waterborne organisms.
  • 141.
  • 143. • For the first time in the history of the world, every human being is now subjected to contact with dangerous chemicals, from the moment of conception until death. In the less than two decades of their use, the synthetic pesticides have been so thoroughly distributed throughout the animate and inanimate world that they occur virtually everywhere. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Sadly, scientists have found disturbing levels of modern man-made chemical in the wildlife , plants, seaweeds, fish and waters in all bodies of water • Inuit Indian mothers reveal some of the highest levels of modern chemical poisons . If they brought their milk to to the US for disposal, it would legally have to go to a toxic waste dump. Approximately 200 million people are suffering damage to body and brain, often irreparable, by the exposure to lead, mercury, chromium, obsolete pesticides and radionuclides in thousands of polluted places.
  • 144. Amount of Toxic Chemicals Released into the Environment Through 1994 •On-Site Land 4 Million Pounds •Surface Water 25 Million Pounds •Air 42 Million Pounds •On-site Deep -well 40 Million Pounds •Total Reported Release 111Million Pounds •Total Estimated Release 2.2Billion Pounds
  • 145. • 60,000 different chemicals since WWII • Over 188,000,000 pounds of chemicals are discharged into surface water such as lakes and rivers • More than 2,400, 000,000 pounds of chemical emissions are pumped into the air we breathe. • A grand total of 5,705,670,380 pounds of chemical pollutants are released into our environment • 551,034,696 pounds of industrial chemicals were dumped into public sewage storage. • 1,180,831,181 pounds of chemicals were released into the ground, threatening our natural aquifers. • 188,953,884 pounds of chemicals were discharged into surface waters. • 2,427,061,906 pounds of air emissions were pumped into the atmosphere.
  • 146. Environmental Toxins •Environmental Pollutants •Herbicides/Pesticides •Heavy Metals •Chemical Exposure •Air, Water, and Food Pollutants •Endotoxins •Candidiasis •Plastics Wrapped around fruits, vegetables and meats Bottles for water, soda milk, ketchup, fruit juices, infant bottle Styrofoam Trays Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases
  • 147. •Environmental •Chemicals •Exhaust Fumes •Cigarette Smoke •Perfumes •Cleaners •Pesticides/Herbacides/Fungicides •Molds •Pollens •Dust Mites Sources of Toxicity Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Air Food Water Beverages Medicines Legal Illegal The EPA also estimates that fine-particle pollution causes an estimated 20,000 premature deaths in the U.S. each year
  • 148. • Diseases and Conditions Linked to Environmental Toxicity • Certain cancers (especially breast cancer and various childhood cancers) • Immune deficiency and Auto-immune diseases • Neurological disorders such as Parkinson’s Disease • Hormonal imbalances • Chemical imbalances in the brain • Alterations of systemic enzymes • Changes in metabolism • Sleep disturbances • Thyroid problems • Fertility problems • Arthritis • Asthma • Eczema • Depression • Chronic Fatigue
  • 149. • Tap water. A sample of average city water contains more than 500 chemicals. • Today’s fertilizers often contain excessive amounts of toxic heavy metals which are then absorbed into what ever grows in that fertilized soil. • The preservatives and hormones added to our food as well as the packaging and plastic wrapping of food for storage. • Household cleaning products such as some dish washing liquids, and surface cleaners • Personal care products such as antiperspirants, hair sprays, lotions and nail polish removers (which can be absorbed through the nails) • Some household products release unhealthy chemicals into the air, such as styrene from plastics, benzene from solvents, and formaldehyde from manufactured wood products such as kitchen cabinets and pressed furniture. • Permanent-press clothes, dry-cleaned clothes, carpeting, and synthetic materials emit traces of toxic vapors. • Smoke from cigarettes, cigars, or pipes affect the toxic levels of both the smoker as well as those exposed to the secondhand smoke. • Pesticides and insect sprays
  • 150. Environmental toxins can affect every organ and system of the body and contribute to a number of symptoms including: • General Symptoms • fatigue, weakness and malaise • insomnia and sleep disturbances • sensory abnormalities including hearing loss, ringing in the ears, vision concerns, alterations in taste and touch • skin conditions such as eczema, psoriasis, rosacea, dermatitis, alopecia, itchy skin, etc. • Immune System • food allergies and food sensitivities • environmental allergies and increased chemical sensitivity • chronic viral or fungal infections • autoimmune conditions of various kinds; weakened immunity • cancers, particularly of the blood • Nervous System • chronic or progressive neurological problems such as numbness and tingling • alteration in cognitive abilities – “brain fog” (often you may indicate a specific spot on your head that feels abnormal) or neuro-cognitive difficulties (speech, reasoning, focus) • ADD, ADHD, concentration, focus and/or memory concerns • Autism, ADD, mental retardation, and cerebral palsy have been linked to environmental toxins such as lead, arsenic, toluene, PCBs and methylmercury.[2] • dementia and delayed reaction and mental processing • psychological problems and mood alterations (depression, anger, nervousness, emotional instability, etc) • Endocrine System • fibroids, cysts on reproductive organs • changes in temperature perception, sweating or flushing • hormone changes such as PMS, menopausal symptoms, alternations in hormone levels • Reproductive concerns, premature births and birth defects • Gastro-Intestinal and Renal System • nausea, vomiting, diarrhea or other bowel concerns • intestinal dysbiosis and alterations in appetite, weight • increase in food intolerances • abdominal pain, stomach cramps, burning of the throat or mouth • irritable bowel syndrome, Crohn’s disease, etc. • liver or kidney disease or dysfunction • cancers including (colon, pancreatic, stomach, rectal, liver, kidney or bladder) • Musculoskeletal System impaired motor function, loss of balance or coordination abnormal gait, posture, or movements • muscle and joint pain • osteoporosis and other bone disorders • Cardiovascular and Respiratory Systems • hypotension or hypertension • cardiovascular disease, peripheral vascular disease and alterations in heart rate • anemia, alterations in blood counts and blood vessel damage • respiratory infections – laryngitis, pharyngitis, bronchitis, pneumonia • difficulty breathing, asthma, restrictive airway disorders, pulmonary fibrosis • cancers (lung, respiratory tract or blood)
  • 151. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Environmental chemicals get into the body, but once there ,we do not have the metabolism to get rid of them, so they silently stockpile • These stealth toxins, that are in all our bodies, are the underlying cause of many diseases • Getting rid of these toxins can influence the most hopeless and baffling diseases Styrene
  • 152. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Phthalates are a group (family) of chemicals used in hundreds of products, such as toys, vinyl flooring and wall covering, detergents, toys lubricating oils, food packaging, pharmaceuticals, blood bags and tubing, and personal care products, such as nail polish, hair sprays, aftershave lotions, soaps, shampoos, perfumes and other fragrance preparations. o Possible reproductive concerns • Once inside our bodies, phthalates hook onto our cell parts where they gum up the works: damage hormone receptors, damage brain chemistry. Since it’d the receptors that are damaged taking hormones to compensate is often ineffective. • Phthalates outgas from plastics and products leaching into our foods o Damages brain chemistry o Cancer o Damage hormone receptors Environmental Toxins • Phthalates are potent Environmental Endocrine Disruptors, (EEDs); Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife.
  • 153. Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Dioxins are a group (family) environmental pollutants. They belong to the so-called “dirty dozen” - a group of dangerous chemicals known as persistent organic pollutants (POPs). Dioxins are of concern because of their highly toxic potential. Experiments have shown they affect a number of organs and systems. • Once dioxins enter the body, they last a long time because of their chemical stability and their ability to be absorbed by fat tissue Their half-life in the body is estimated to be 7 to 11 years. In the environment, dioxins tend to accumulate in the food chain. The higher an animal is in the food chain, the higher the concentration of dioxins. • Dioxins are mainly by-products of industrial processes but can also result from natural processes, such as volcanic eruptions and forest fires. Dioxins are unwanted by-products of a wide range of manufacturing processes including smelting, chlorine bleaching of paper pulp and the manufacturing of some herbicides and pesticides. In terms of dioxin release into the environment, uncontrolled waste incinerators (solid waste and hospital waste) are often the worst culprits, due to incomplete burning. • Chronic exposure of animals to dioxins has resulted in several types of cancer. • Due to the omnipresence of dioxins, all people have background exposure and a certain level of dioxins in the body, leading to the so-called body burden.
  • 154. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • PCB’s Polychlorinated Biphenyls (PCBs) are a group (family) of manufactured organic chemicals that contain 209 individual chlorinated chemicals. • The incineration of municipal waste may lead to PCB pollution and produce dangerous by-products, such as hydrogen chloride (HCl) and dioxins (PCDDs and PCDFs). • Landfills containing transformers and capacitors • PCBs are probable human carcinogens and can also cause non-cancer health effects, such as reduced ability to fight infections, low birth weights, and learning problems. • Thyroid hormone-level alterations • Body weight loss • Carcinogenesis • Dermal Toxicity • Fatty Liver • Genotoxicity • Hepatomegaly • Immunosuppressive Effects • Neurotoxicity • Reproductive and Developmental Toxicity • Acute Lethality • Found in farm raised salmon
  • 155. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Bisphenol-A (BPA) is an estrogen mimicker or xenoestrogen. BPA imitates the sex hormone estrogen in your body. This synthetic hormone can trick the body into thinking it’s the real thing. BPA has been linked to everything from breast and others cancers to reproductive problems, obesity, early puberty and heart disease, and according to government tests, 93 percent of Americans have BPA in their bodies! Some endocrine disruptors mimic testosterone or block other hormone activity. • Environmental Endocrine Disruptors, (EEDs); Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. Major components of the endocrine system include: • Female Ovaries • Male Testes • Pituitary Gland • Thyroid Gland • Adrenal Glands • Products that contain BPA include water bottles, baby bottles, dental fillings and sealants, dental devices, medical devices, eyeglass lenses, DVDs and CDs, household electronic items, and sports equipment.
  • 156. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Volatile Organic Compounds VOCs are emitted as gases from certain solids or liquids. VOCs include a variety of chemicals, some of which may have short- and long-term adverse health effects. Concentrations of many VOCs are consistently higher indoors (up to ten times higher) than outdoors. VOCs are emitted by a wide array of products numbering in the thousands. • Organic chemicals are widely used as ingredients in household products. Paints, varnishes; and wax all contain organic solvents, as do many cleaning, disinfecting, cosmetic, degreasing and hobby products. Fuels are made up of organic chemicals. All of these products can release organic compounds while you are using them, and, to some degree, when they are stored. • Eye, nose and throat irritation • headaches, loss of coordination and nausea • damage to liver, kidney and central nervous system • Some organics can cause cancer in animals, some are suspected or known to cause cancer in humans • Paints, paint strippers and other solvents, wood preservatives, aerosol sprays, cleansers and disinfectants, moth repellents and air fresheners, stored fuels and automotive, products ,hobby supplies, dry-cleaned clothing, pesticides
  • 157. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Lead; As a result of human activities, such as fossil fuel burning, mining, and manufacturing, lead and lead compounds can be found in all parts of our environment. This includes air, soil, and water. Lead is used in many different ways. It is used to produce batteries, ammunition, metal products like solder and pipes, and X-ray shielding devices. Lead is a highly toxic metal and, as a result of related health concerns, its use in several products like gasoline, paints, and pipe solder, has been drastically reduced in recent years. Today, the most common sources of lead exposure in the United States are lead-based paint and possibly water pipes in older homes, contaminated soil, household dust, drinking water, lead crystal, lead in certain cosmetics and toys, and lead-glazed pottery. Health effects EPA has determined that lead is a probable human carcinogen. • Lead can affect every organ and system in the body. Long-term exposure of adults can result in decreased performance in some tests that measure functions of the nervous system; weakness in fingers, wrists, or ankles; small increases in blood pressure; and anemia. Exposure to high lead levels can severely damage the brain and kidneys and ultimately cause death. In pregnant women, high levels of exposure to lead may cause miscarriage. High level exposure in men can damage the organs responsible for sperm production.
  • 158. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Mercury; Mercury combines with other elements to form organic and inorganic mercury compounds. Metallic mercury is used to produce chlorine gas and caustic soda, and is also used in thermometers, dental fillings, switches, light bulbs, and batteries. Coal-burning power plants are the largest human-caused source of mercury emissions to the air in the United States. Mercury in soil and water is converted by microorganisms to methylmercury, a bioaccumulating toxin. Health effects The EPA has determined that mercuric chloride and methylmercury are possible human carcinogens. ● The nervous system is very sensitive to all forms of mercury. Exposure to high levels can permanently damage the brain, kidneys, and developing fetuses. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. ● Short-term exposure to high levels of metallic mercury vapors may cause lung damage, nausea, vomiting, diarrhea, increases in blood pressure or heart rate, skin rashes, and eye irritation. • Mercury exposure in high levels can permanently damage the brain, kidneys, and developing fetuses. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. ● Short-term exposure to high levels of metallic mercury vapors may cause lung damage, nausea, vomiting, diarrhea, increases in blood pressure or heart rate, skin rashes, and eye irritation.
  • 159. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Arsenic; Aside from occurring naturally in the environment, arsenic can be released in larger quantities through volcanic activity, erosion of rocks, forest fires, and human activity. The wood preserving industry uses about 90% of the industrial arsenic in the U.S. Arsenic is also found in paints, dyes, metals, drugs, soaps and semi- conductors. Animal feeding operations and certain fertilizers and pesticides can release high amounts of arsenic to the environment as can industry practices such as copper or lead smelting, mining, and coal burning. Health effects Arsenic is odorless and tasteless. Inorganic arsenic is a known carcinogen and can cause cancer of the skin, lungs, liver and bladder. ● Lower level exposure can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of “pins and needles” in hands and feet. • Arsenic ingestion of very high levels can possibly result in death. Long-term low level exposure can cause a darkening of the skin and the appearance of small “corns” or “warts” on the palms, soles, and torso.
  • 160. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins • Heavy Metals The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. • Cadmium; Cadmium is a very toxic metal. All soils and rocks, including coal and mineral fertilizers, contain some cadmium. Cadmium has many uses, including batteries, pigments, metal coatings, and plastics. It is used extensively in electroplating. Health effects Cadmium and cadmium compounds are known human carcinogens. Smokers get exposed to significantly higher cadmium levels than non-smokers. Severe damage to the lungs may occur through breathing high levels of cadmium. • Cadmium ingestion at high levels severely irritates the stomach, leading to vomiting and diarrhea. Long-term exposure to lower levels leads to a buildup in the kidneys and possible kidney disease, lung damage, and fragile bones.
  • 161. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins
  • 162. Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Flouride is a highly toxic substance. Consider, for example, the poison warning that the FDA now requires on all fluoride toothpastes sold in the U.S. or the tens of millions of people throughout China and India who now suffer serious crippling bone diseases from drinking water with elevated levels of fluoride. • In terms of acute toxicity (i.e., the dose that can cause immediate toxic consequences), fluoride is more toxic than lead, but slightly less toxic than arsenic. This is why fluoride has long been used in rodenticides and pesticides to kill pests like rats and insects. It is also why accidents involving over-ingestion of fluoridated dental products–including fluoride gels, fluoride supplements, and fluoridated water can cause serious poisoning incidents, including death. • Chairman of the National Research Council’s (NRC) comprehensive fluoride review, Dr. John Doull, recently stated that: “when we looked at the studies that have been done, we found that many of these questions are unsettled and we have much less information than we should • Fluoride Neurotoxicity • Hormonal Disruption • Fluoride Link to Bone Cancer
  • 163. Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Chlorine It's a very dangerous toxin that has many uses, from disinfecting to bleaching. In small quantities, liquid and gas forms can be poisonous. • up to 2/3s of our harmful exposure to chlorine is due to inhalation of steam and skin absorption while showering. • Inhalation is a much more harmful means of exposure since the chlorine gas (chloroform) we inhale goes directly into our blood stream. When we drink contaminated water the toxins are partially filtered out by our kidneys and digestive system. • Cancer • Heart Disease
  • 164. Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Pesticides There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders, autism, asthma, birth defects. • While agriculture has traditionally been tied to pesticide-related illnesses, of the 40 most commonly used pesticides in schools, • 28 can cause cancer • 14 are linked to endocrine disruption • 26 can adversely affect reproduction• 26 are nervous system poisons • 13 can cause birth defects • Of of the 30 most commonly used lawn pesticides, • 19 can cause cancer • 13 are linked to birth defects • 21 can affect reproduction• 15 are nervous system toxicants
  • 165. Environmental Toxins Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases • Pesticides There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders, autism, asthma, birth defects. • While agriculture has traditionally been tied to pesticide-related illnesses, of the 40 most commonly used pesticides in schools, • Oxybenzone • Decabromodiphenyl Ether (DECA) • Asbestos• Parabens • Perchlorate • Butylated Hydroxyanisole (BHA) • Formaldehyde, e.g. cigarette smoke Antibiotics Anti-depressants • Benzene• Perfluorooctanoic Acid (PFOA) Aluminum Chloroform Brominated Fire Retartants (PBDEs
  • 166. Reduction of the toxic properties of a substance by chemical changes induced in the body, producing a compound which is less poisonous or is more readily eliminated. Nearly every organ of the body contains specific enzymes that participate in the detoxification process and help protect that organ against toxins that originate in the outside world or are produced inside the body. Depending on their inheritance factors, individuals have very different detoxification abilities. Factors can vary as much as 5 fold.
  • 167. •The liver is responsible for removing all impurities from the bloodstream. •If these impurities are not removed they are attacked by the immune system •The result is a over/under active immune response resulting in many inflammatory conditions and the production of free radicals
  • 168. Symptom Picture of General Toxicity General Symptoms • Malaise - Chronic Fatigue - Headache - Joint & Muscle Pain • Chronic Mucous Production • Poor Exercise Tolerance
  • 169.
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  • 171. Research has shown that our ability to DETOXIFY our internal environments bears a direct relationship to our susceptibility to disease and ultimately our aging process. Many health problems have been definitively linked in a cause- and –effect relationship with exposure to specific toxins , including those we willingly expose ourselves to by our lifestyle choices. If organ reserve is depleted the liver and other detoxifying organs can’t remove these toxins from our bodies which will lead to a multitude of illnesses.
  • 173. If we consider that the body has a fourfold to tenfold organ reserve for each organ, then we can suggest that, in times of stress, the body may need 4 to 10 times the normal nutrient intake just to keep even with the stress. Walter Schmitt, Jr., DC; Dig. Of Chiro Econ; May/June 1987; p.15
  • 174. Organ Reserve: At a younger age organ reserve provides a margin of defense to people exposed to various stress related factors As individuals age they lose organ reserve. A stress related factor can now exceed the ability of the organ to maintain homeostasis. This loss of organ reserve can develop into a pathological process. Organ Reserve Biological Aging
  • 175. Contributing Factors that can Modify Organ Reserve 1 Diet: A) Most RDA’s for vitamins and minerals (cofactors), are inadequate for maintaining organ reserve in today’s environment. B) Proper glucose regulation is a key factor in determining enhanced organ reserve. C) Antioxidants are crucial in preventing free radical oxidative damage especially to mitochondrial DNA. 2 Environment: A) Stress increases production of hormones which can lead to altered cell physiology. B) Anxiety is physiologically similar to stress in it’s response. 3 Daily Activities: A) Increases in muscle mass and aerobic respiration are the two most important controllable biomarkers related to organ reserve. 1) Increase in bone density 2) Decrease in blood pressure 3) Better control of glucose and cholesterol 4) Increase in strength and REE
  • 176. Organ Reserve: At a younger age organ reserve provides a margin of defense to people exposed to various stress related factors As individuals age they lose organ reserve. A stress related factor can now exceed the ability of the organ to maintain homeostasis. This loss of organ reserve can develop into a pathological process. Organ Reserve Biological Aging
  • 177. Contributing Factors that can Modify Organ Reserve 1 Diet: A) Most RDA’s for vitamins and minerals are inadequate for maintaining organ reserve in today’s environment. B) Proper glucose regulation is a key factor in determining enhanced organ reserve. C) Antioxidants are crucial in preventing free radical oxidative damage especially to mitochondrial DNA. 2 Environment: A) Stress increases production of hormones which can lead to altered cell physiology. B) Anxiety is physiologically similar to stress in it’s response. 3 Daily Activities: A) Increases in muscle mass and aerobic respiration are the two most important controllable biomarkers related to organ reserve. 1) Increase in bone density 2) Decrease in blood pressure 3) Better control of glucose and cholesterol 4) Increase in strength and REE
  • 178. 178 Reduction of the toxic properties of a substance by chemical changes induced in the body, producing a compound which is less poisonous or is more readily eliminated. Nearly every organ of the body contains specific enzymes that participate in the detoxification process and help protect that organ against toxins that originate in the outside world or are produced inside the body. Depending on their inheritance factors, individuals have very different detoxification abilities. Factors can vary as much as 5 fold.
  • 179. 179 Total Load A single exposure or a single substance may not overburden the body and induce damage. It is the total exposure to the toxin and how effectively they can be detoxified that determines relative health risk.
  • 180. Diet, Lifestyle and Environmental Toxins; Causes of Most Diseases Environmental Toxins Pesticides Asbestos Chloroform Non-metallic inorganics Synthetic organic chemicals (SOCs) Radioactive materials 1. Heavy Metals Found in drinking water, fish, vaccines, pesticides, preserved wood, Can cause cancer, neurological disorders, Alzheimer’s disease, fatig 2. PCBs (Polychlorinated biphenyls) Molds, benzene styrene
  • 181. Phases of Treatment 2) Elimination Diet 1) Detoxification/Chelation Calorie Restriction Diet/Nutraceaticals OPTIMAL FUNCTIONAL HEALTH for WEIGHT MANAGEMENT 3) Low Glycemic, pH, Inflammatory, Organic Diet Digestion/Absorption Detoxification/Elimination Endocrine Imbalances Immune/Inflammatory Imbalance Lifestyle Reintroduction Environment
  • 182. Foods for Detox Influences of Hunger Hormones
  • 183. Elimination Diet Influences of Hunger Hormones
  • 184. Low Glycemic Diet Influences of Hunger Hormones
  • 185. Alkaline Diet Influences of Hunger Hormones
  • 187. • Water (pure) with Lemon 60 oz/Daily • Diet • 40 % Carbohydrates • 60% Complex Carbohydrates • 20% Fiber • 20 % Sugar (Low Glycemic Index) • 30% Protein • Consider Protein Powder Drink with Full Compliment of Amino Acids • 30% Fat • 80% Unsaturated Fatty Acids • 20% Saturated Fatty Acids •High Alkaline Foods •Juicing? •Lower Daily Caloric Intake DIET •Eat Organic Foods/Wash Fruits and Vegetables Daily Healthy-Aging Diet Recommendations (SUGGESTED)
  • 188. Daily Healthy-Aging Diet Recommendations •Reduce Intake Of Soft Drinks/Refined Sugars/Harmful Fats (Saturated, Hydrogenated Partially Hydrogenated) •Minimize use of Artificial Sweeteners DIET •Eat High Quality Breakfast ½ Hour after Awakening •Eat 6 Small Meals/Day Foods High in ORAC Scale (Oxygen Radical Absorbance Capacity) 3,000/Daily •Wolfberry 25,300 (3.5 oz) •Blueberries 2,400 (3.5 oz) •Garlic 1,939 (3.5 oz) •Spinach 1,260 (3.5 oz) • Thyme Oil 159,590 (3.5 oz.) •Bioflavonoids (Proanthocyanidins, Quercitin, Citrus flavonoids, and green tea polyphenols) • Carotenoids (beta-carotene, lycopene, lutein, and zeaxanthin) •Fiber Soluble >30g •Fiber Insoluble 10g •Eliminate Allergy Potential Foods