The President’s Emergency Plan for AIDS Relief aims to continue its commitment to its partner organisations. Please refer to this infographic for further information.
The Institute of Fundraising has found that women are more likely than men to donate to charity and to support organisations and causes:
For more information visit: https://www.joeyhorn.org/how-philanthropists-can-become-more-inspired-donors
Fluxx: Using Technology to Improve Philanthropy Joey Horn
Fluxx is a collaborative organisation that uses cloud technology to enable more funders and grantees. The cloud-based platform allows Fluxx to:
For more information visit: https://www.joeyhorn.org/women-in-philanthropy-moving-towards-collaborative-models-for-giving
The Creation of the International Monetary Fund Joey Horn
The International Monetary Fund was set up in order to address the following issues:
For more information visit: https://www.joeyhorn.org/christine-lagarde-on-the-importance-of-women-in-the-workplace
The Institute of Fundraising has found that women are more likely than men to donate to charity and to support organisations and causes:
For more information visit: https://www.joeyhorn.org/how-philanthropists-can-become-more-inspired-donors
Fluxx: Using Technology to Improve Philanthropy Joey Horn
Fluxx is a collaborative organisation that uses cloud technology to enable more funders and grantees. The cloud-based platform allows Fluxx to:
For more information visit: https://www.joeyhorn.org/women-in-philanthropy-moving-towards-collaborative-models-for-giving
The Creation of the International Monetary Fund Joey Horn
The International Monetary Fund was set up in order to address the following issues:
For more information visit: https://www.joeyhorn.org/christine-lagarde-on-the-importance-of-women-in-the-workplace
From 1900 to 1947 were the pre-independence years in India, and the effect of the country’s colonial past can be felt in its art. This infographic details more about art in pre-independence India.
Women have shown that they are more willing to compromise on returns on their investments in order to embrace impact investments, which are underperforming in indexes such as the S&P 500. For further details, please refer to this infographic.
The Speakers, Presenters and Organisers of the 2018 Women in Finance AwardsJoey Horn
The ‘Women in Finance Awards’ was established in 2017 with the aim of showcasing female leaders in the UK finance sector. For further details on the presenters and speakers at the 2018 event, please refer to this infographic.
The Harvard Art Fellows are a global art lovers’ community. The Fellows support the Harvard Art Museums’ mission to encourage the spread of art appreciation and knowledge via teaching, professional training, research, public education and exhibitions.
HBS is also part of the Magnificent Seven (M7). M7 is a group containing the best business schools, which acknowledges each other as peers. As well as HBS, the M7 includes Penn, MIT, Chicago, Stanford, Northwestern and Columbia. See the attached infographic for more facts about Harvard Business School.
The Yale School of Management has more than 8,000 former students who have established careers in multiple sectors. Read more about Yale SOM Alumni Profile here.
The Impact of Donations to mothers2mothers Joey Horn
mothers2mothers is a charitable organisation that works in several sub-Saharan African countries. You can find out what a difference every donation makes within this document.
The story of Saks Fifth Avenue began in 1867 when Andrew Saks, father of Horace Sak, opened his first store called Saks & Co in Washington. For further facts about Saks take a look at this infographic.
Singapore Management University in NumbersJoey Horn
SMU has ranked third for business and fourth for economics across the whole of Asia. In this infographic you can see how the university looks in numbers today.
Choate Rosemary Hall Statistics - Joey Horn Joey Horn
Joey Horn has contributed to the Parents Fund of Choate Rosemary Hall, as well as providing philanthropic support for the new auditorium capital project.
Williams College is a historic private American college established in 1793. Nestled in Williamstown, Massachusetts, the college is a liberal arts school with graduate programs in development economics and the history of art.
Interesting Facts About Offshore DrillingJoey Horn
Offshore drilling is increasingly important to meet our fuel needs. Offshore drilling sites are able to produce much more oil than on-land wells in the US, for example.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
From 1900 to 1947 were the pre-independence years in India, and the effect of the country’s colonial past can be felt in its art. This infographic details more about art in pre-independence India.
Women have shown that they are more willing to compromise on returns on their investments in order to embrace impact investments, which are underperforming in indexes such as the S&P 500. For further details, please refer to this infographic.
The Speakers, Presenters and Organisers of the 2018 Women in Finance AwardsJoey Horn
The ‘Women in Finance Awards’ was established in 2017 with the aim of showcasing female leaders in the UK finance sector. For further details on the presenters and speakers at the 2018 event, please refer to this infographic.
The Harvard Art Fellows are a global art lovers’ community. The Fellows support the Harvard Art Museums’ mission to encourage the spread of art appreciation and knowledge via teaching, professional training, research, public education and exhibitions.
HBS is also part of the Magnificent Seven (M7). M7 is a group containing the best business schools, which acknowledges each other as peers. As well as HBS, the M7 includes Penn, MIT, Chicago, Stanford, Northwestern and Columbia. See the attached infographic for more facts about Harvard Business School.
The Yale School of Management has more than 8,000 former students who have established careers in multiple sectors. Read more about Yale SOM Alumni Profile here.
The Impact of Donations to mothers2mothers Joey Horn
mothers2mothers is a charitable organisation that works in several sub-Saharan African countries. You can find out what a difference every donation makes within this document.
The story of Saks Fifth Avenue began in 1867 when Andrew Saks, father of Horace Sak, opened his first store called Saks & Co in Washington. For further facts about Saks take a look at this infographic.
Singapore Management University in NumbersJoey Horn
SMU has ranked third for business and fourth for economics across the whole of Asia. In this infographic you can see how the university looks in numbers today.
Choate Rosemary Hall Statistics - Joey Horn Joey Horn
Joey Horn has contributed to the Parents Fund of Choate Rosemary Hall, as well as providing philanthropic support for the new auditorium capital project.
Williams College is a historic private American college established in 1793. Nestled in Williamstown, Massachusetts, the college is a liberal arts school with graduate programs in development economics and the history of art.
Interesting Facts About Offshore DrillingJoey Horn
Offshore drilling is increasingly important to meet our fuel needs. Offshore drilling sites are able to produce much more oil than on-land wells in the US, for example.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html