The presentation discusses challenges with CSS architecture and the advantages of CSS-in-JS, such as scoped styles and smarter optimizations, while highlighting issues like bloated CSS and selector specificity. It introduces 'css-blocks' as a solution that enhances performance and development experience by utilizing component-oriented selectors and conflict resolution through a unique syntax. The talk emphasizes the importance of optimizing styles for performance, especially in large applications like LinkedIn, and provides insights into its implementation and benefits.